Augmented muscle vasodilatory responses in obese children with Glu27 β2-adrenoceptor polymorphism

Pediatric Exercise Science

Volumn 20, Issue 2, 2008, Pages 157-168

  Da Silva, Alexandre G ^a   Ribeiro, Mauricio M ^a   Trombetta, Ivani C ^a   Nicolau, Christiane ^a   Frazzatto, Eliana ^a   Guazzelli, Isabel ^a   Matos, Luciana N J ^a   Halpern, Alfredo ^a   Negrão, Carlos E ^a   Villares, Sandra M F ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR;

ALLELE; AMINO ACID SUBSTITUTION; ARTICLE; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CONDUCTANCE; CONTROLLED STUDY; EXERCISE TEST; FEMALE; FOREARM; FOREARM BLOOD FLOW; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; HAND GRIP; HEMODYNAMIC PARAMETERS; HOMOZYGOTE; HUMAN; ISOMETRIC EXERCISE; MAJOR CLINICAL STUDY; MALE; MENTAL STRESS; MENTAL TEST; MUSCLE BLOOD VESSEL; OBESITY; SCHOOL CHILD; VASCULAR CONDUCTANCE; VASODILATATION; ANTHROPOMETRY; BODY MASS; CHILD; CHILD WELFARE; COGNITION; COMPARATIVE STUDY; EXERCISE; GENETICS; HAND STRENGTH; HEMODYNAMICS; METABOLISM; PATHOPHYSIOLOGY; PSYCHOMETRY; SKELETAL MUSCLE; VASCULARIZATION;

ANTHROPOMETRY; BODY MASS INDEX; CHILD; CHILD WELFARE; COGNITION; EXERCISE; EXERCISE TEST; FEMALE; FOREARM; HAND STRENGTH; HEMODYNAMICS; HUMANS; MALE; MUSCLE, SKELETAL; OBESITY; POLYMORPHISM, GENETIC; PSYCHOMETRICS; RECEPTORS, ADRENERGIC, BETA-2; STRESS, PSYCHOLOGICAL; VASODILATION;

EID: 49249112676     PISSN: 08998493     EISSN: 15432920     Source Type: Journal    
DOI: 10.1123/pes.20.2.157     Document Type: Article

References (39)

1. Atabek, M.E., and O. Pirgom. Assessment of insulin sensitivity from measurements in fasting state and during an oral glucose tolerance test in obese children. Pediatric Endocrinol Metab. 20:187-195, 2007.
2. 2 adrenoceptor polymorphism determines vascular reactivity in humans. Hypertension. 36:371-375, 2000.
3. Cole, T.J., M.C. Bellizzi, K.M. Flegal, and W.M. Deitz. Establishing a standard definition for child overweight and obesity worldwide: international survey. BMJ. 320:1240-1243, 2000.
4. Cole, T.J. The LMS method for constructing normalized growth standards. Eur. J. Clin. Nutr. 44:45-60, 1990.
5. Conwell, L.S., S.G. Tros, W.J. Brow, and J.A. Batch. Indexes of insulin resistance and secretion in obese children and adolescents. Diabetes Care. 27:314-319, 2004.
6. Cutfield, W.S., R.N. Bergman, R.K. Menon, and M.A. Sperling. The modified minimal model: application to measurement of insulin sensitivity in children. J. Clin. Endocrinol. Metab. 70:1644-1650, 1990.
7. Daniels, S.R., J.A. Morrison, D.L. Sprecher, P. Khoury, and T.R. Kimball. Association of body fat distribution and cardiovascular risk factors in children and adolescents. Circulation. 99:541-545, 1999.
8. Dishy, V., G.G. Sofowora, H. Xie, et al. The effect of common polymorphisms of the beta2-adrenergic receptor on agonist-mediated vascular desensitization. N. Engl. J. Med. 345:1030-1035, 2001.
9. Ferreira, W.P., M.C. Bertolami, S.N. Santos, et al. One-month therapy with simvastatin restores endothelial function in hypercholesterolemic children and adolescents. Pediatr. Cardiol. 28:8-13, 2007.
10. Finegood, D.T., I.M. Hramiak, and J. Dupre. A modified protocol for estimation of insulin sensitivity with the minimal model of glucose kinetics in patients with insulin-dependent diabetes. J. Clin. Endocrinol. Metab. 70:1538-1549, 1990.
11. Freyschuss, U., P. Hjemdahl, A. Juhlin-Dannfelt, and B. Linde. Cardiovascular and sympathoadrenal responses to mental stress: influence of β-blockade. Am. J. Physiol. 255:H1443-H1451, 1988.
12. Gratze, G., J. Fortin, R. Labugger, et al. β-2 adrenergic receptor variants affect resting blood pressure and agonist-induced vasodilation in young adult Caucasians. Hypertension. 33:1425-1430, 1999.
13. 2-adrenergic receptor impart distinct agonist promoted regulatory properties. Biochemistry. 33:9414-9419, 1994.
14. Green, S.A., J. Turki, P. Bejarano, I.P. Hall, and S.B. Liggett. Influence of β2-adrenergic receptor genotypes on signal transduction in human airway smoot muscle cells. Am. J. Respir. Cell Mol. Biol. 13:25-33, 1995.
15. 2- Adrenergic receptor polymorphisms and risk of incident cardiovascular events in the elderly. Circulation. 107:2021-2024, 2003.
16. Hellstrom, L., V. Large, S. Reynisdottir, H. Wahrenberg, and P. Arner. The different effects of a Gln27Glu beta 2-adrenoceptor gene polymorphism on obesity in males and in females. J. Intern. Med. 245:253-259, 1999.
17. Hoit, B.D., D.P. Suresh, L. Craft, R.A. Walsh, and S.B. Liggett. Beta 2-Adrenergic receptor polymorphisms at amino acid 16 differentially influence agonist-stimulated blood pressure and peripheral blood flow in normal individuals. Am. Heart J. 139:537-542, 2000.
18. Joyner, M.J., and J.R. Halliwill. Sympathetic vasodilatation in human limbs. J. Physiol. 526(Pt.3):471-480, 2000.
19. Kawamura, T., G. Egusa, R. Fujikawa, and M. Okubo. Gln27Glu variant of the beta2-adrenergic receptor gene is not associated with obesity and diabetes in Japanese-Americans. Metabolism. 50:443-446, 2001.
20. Large, V., L. Hellstrom, S. Reynisdottir, F. Lonnqvist, and P. Eriksson, L. Lannfelt, and P. Arner. Human beta-2 adrenoceptor gene polymorphism are highly frequent in obesity and associate with altered adipocity beta-2 adrenoceptor function. J. Clin. Invest. 100:3005-3013, 1997.
21. Linde, B., P. Hjemdahl, U. Freyschuss, and A. Juhlin-Dannfelt. Adipose tissue and skeletal muscle blood flow during mental stress. Am. J. Physiol. Endocrinol. Metab. 256:E12-E18, 1989.
22. Matthews, D.R., J.P. Hosker, A.S. Rudenski, B.A. Naylor, D.F. Treacher, and R.C. Turner. Homaostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man. Diabetoligia. 28:412-419, 1985.
23. Middlekauff, H.R., A.H. Nguyen, C.E. Negrão, et al. Impact of acute mental stress on sympathetic nerve activity and regional blood flow in advanced heart failure. Circulation. 96:1835-1842, 1997.
24. Negrão, C.E., I.C. Trombetta, L.T. Batalha, et al. Muscle metaboreflex control is diminished in normotensive obese women. Am. J. Physiol. 281:H469-H475, 2001a.
25. Negrão, C.E., M. Hamilton, G. Foranow, A. Hage, J.D. Moriguchi, and H.R. Middlekauff. Impaired endothelium-mediated vasodilation is not the principal cause of vasoconstriction in hear failure. Am. J. Physiol. Heart Circ. Physiol. 278:H168-H174, 2000.
26. Negrão, C.E., M.U.P.B. Rondon, T. Tinucci, L. Nastari, A.C.P. Barretto, E.M. Krieger, and H.R. Middlekauff, et al.. Abnormal neurovascular control during exercise is linked to heart failure severity. Am. J. Physiol. Heart Circ. Physiol. 280:H1286-H1292, 2001b.
27. Oberkofler, H., H. Esterbauer, E. Hell, F. Krempler, and W. Patsch. The Gln27Glu polymorphism in the beta2-adrenergic receptor gene is not associated with morbid obesity in Austrian women. Int. J. Obes. Relat. Metab. Disord. 24:388-390, 2000.
28. Reed, A.S., M.E. Tschakovsky, C.T. Mixson, et al. Skeletal muscle vasodilation during sympathoexcitation is not neurally mediated in humans. J. Physiol. 525:253-262, 2000.
29. Ribeiro, M.M., I.C. Trombetta, L.T. Batalha, M.U.P.B. Rondon, C.L.M. Forjaz, A.C.P. Barretto, S.M.F. Villares, and C.E. Negrão. Muscle sympathetic nerve activity and hemodynamics alterations in middle-aged obese women. Braz. J. Med. Biol. Res. 34:475-478, 2001.
30. Ribeiro, M.M., A.G. Silva, N.S. Santos, I. Guazzelle, L.N. Matos, I.C. Trombetta, A. Halpern, C.E. Negrão, and S.M. Villares. Diet and exercise training restore blood pressure and vasodilatory responses during physiological maneuvers in obese children. Circulation. 111(15):1915-1923, 2005.
31. Rodríguez, A., A. Fortuño, J. Gómez-Ambrosi, G. Zalba, J. Díez, and G. Frühbeck. The inhibitory effect of leptin on angiotensin II-induced vasoconstriction in vascular smooth muscle cells is mediated via a nitric oxide-dependent mechanism. Endocrinology. 148(1):324-331, 2007.
32. Tai, M.M. A mathematical model for the determination of total area under glucose tolerance and other metabolic curves. Diabetes Care. 17:152-154, 1994.
33. Trombetta, I.C., L.T. Batalha, M.U. Rondon, M.C. Laterza, E. Frazzatto, M.J. Alves, A.C. Santos, P.C. Brum, A.C. Barretto, A. Halpern, S.M. Villares., and C.E. Negrão. Gly 16 + Glu27 beta2-adrenoceptor polymorphisms cause increased forearm blood flow responses to mental stress and handgrip in humans. J Appl Physiol. 98(3):787-794, 2005.
34. Trombetta, I.C., L.T. Batalha, M.U.P.B. Rondon, et al. Weight loss improves neurovascular and muscle metaborreflex control in obesity. Am. J. Physiol. Heart Circ. Physiol. 285:H974-H982, 2003.
35. Whitney, R.J. The measurement of change in human limbs. J. Physiol. 121:1-7, 1953.
36. Whitney, R.J. The measurement of changes in human limb-volume by means of a mercury-in-rubber strain gauge. J. Physiol. 109(1-2):Proc, 5. 1949.
37. Woo, K.S., P. Chook, C.W. Yu, C. Metreweli, D.S. Celermajer, et al. Effects of diet and exercise on obesity-related vascular dysfunction in children. Circulation. 109:1981-1986, 2004.
38. Xekouki, P., N.M. Nikolakopoulou, A. Papageorgiou, S. Livadas, A. Voutetakis, M.A. Magiakou, G.P. Chrousos, B.E. Spiliotis, and C. Dacou-Voutetakis. Glucose dysregulation in obese children: predictive, risk, and potential protective factors. Obesity. 15(4):860-869, 2007.
39. Yu, Y., L. Suo, H. Yu, C. Wang, and H. Tang. Insulin resistance and endothelial dysfunction in type 2 diabetes patients with or without microalbuminuria. Diabetes Res. Clin. Pract. 65(2):95-104, 2004.