Structure of the Brachydanio rerio Polo-like kinase 1 (Plk1) catalytic domain in complex with an extended inhibitor targeting the adaptive pocket of the enzyme

Acta Crystallographica Section F: Structural Biology and Crystallization Communications

Volumn 64, Issue 8, 2008, Pages 686-691

  Elling, Robert A ^a   Fucini, Raymond V ^a   Hanan, Emily J ^a   Barr, Kenneth J ^a,b   Zhu, Jiang ^a   Paulvannan, Kumar ^a,c   Yang, Wenjin ^a   Romanowski, Michael J ^a  

^a Sunesis Pharmaceuticals Inc   (United States)

^b Amplyx Pharmaceuticals Inc   (United States)

^c Tandem Sciences Inc   (United States)

Author keywords

Polo like kinase 1; Small molecule inhibitors; Zebrafish

Indexed keywords

CELL CYCLE PROTEIN; ONCOPROTEIN; POLO LIKE KINASE 1; POLO-LIKE KINASE 1; PRIMER DNA; PROTEIN SERINE THREONINE KINASE; ZEBRAFISH PROTEIN;

ANIMAL; ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; ENZYME ACTIVE SITE; ENZYME SPECIFICITY; GENETICS; METABOLISM; NUCLEOTIDE SEQUENCE; PROTEIN CONFORMATION; SITE DIRECTED MUTAGENESIS; X RAY CRYSTALLOGRAPHY; ZEBRA FISH;

ANIMALS; BASE SEQUENCE; CATALYTIC DOMAIN; CELL CYCLE PROTEINS; CRYSTALLOGRAPHY, X-RAY; DNA PRIMERS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PROTEIN CONFORMATION; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; SUBSTRATE SPECIFICITY; ZEBRAFISH; ZEBRAFISH PROTEINS;

DANIO RERIO;

EID: 49249110328     PISSN: 17443091     EISSN: 17443091     Source Type: Journal    
DOI: 10.1107/S1744309108019623     Document Type: Article

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