Allergen inhalation decreases adenosine receptor expression in sputum and blood of asthma patients

Allergy: European Journal of Allergy and Clinical Immunology

Volumn 63, Issue 9, 2008, Pages 1186-1194

  Versluis, M ^a   Van Den Berge, M ^a   Timens, W ^a   Luijk, B ^b   Rutgers, B ^a   Lammers, J W J ^b   Postma, D S ^a   Hylkema, M N ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

Adenosine; Adenosine receptors; Allergen challenge; Asthma; Thymic stromal lymphopoietin

Indexed keywords

ADENOSINE A2 RECEPTOR; ALLERGEN; CYTOKINE; INTERLEUKIN 8;

ADULT; ARTICLE; ASTHMA; BLOOD ANALYSIS; CELL COUNT; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENVIRONMENTAL EXPOSURE; ENZYME LINKED IMMUNOSORBENT ASSAY; EOSINOPHIL; FLOW CYTOMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; IMMUNOCYTOCHEMISTRY; INFLAMMATORY CELL; INHALATION; MACROPHAGE; NEUTROPHIL; PRIORITY JOURNAL; SPUTUM CULTURE; STATISTICAL SIGNIFICANCE; T LYMPHOCYTE;

ADULT; ALLERGENS; ASTHMA; BRONCHIAL PROVOCATION TESTS; DOWN-REGULATION; FEMALE; GENE EXPRESSION; HUMANS; MALE; MIDDLE AGED; RECEPTOR, ADENOSINE A1; RECEPTOR, ADENOSINE A2A; RECEPTOR, ADENOSINE A2B; RECEPTORS, PURINERGIC P1; SPUTUM;

EID: 49249095670     PISSN: 01054538     EISSN: 13989995     Source Type: Journal    
DOI: 10.1111/j.1398-9995.2008.01735.x     Document Type: Article

References (35)

1. Bousquet J, Jeffery PK, Busse WW, Johnson M, Vignola AM. Asthma. From bronchoconstriction to airways inflammation and remodeling. Am J Respir Crit Care Med 2000 161: 1720 1745.
2. Driver AG, Kukoly CA, Ali S, Mustafa SJ. Adenosine in bronchoalveolar lavage fluid in asthma. Am Rev Respir Dis 1993 148: 91 97.
3. van den Berge M, Kerstjens HA, Postma DS. Provocation with adenosine 5'-monophosphate as a marker of inflammation in asthma, allergic rhinitis and chronic obstructive pulmonary disease. Clin Exp Allergy 2002 32: 824 830.
4. Polosa R. Adenosine-receptor subtypes: their relevance to adenosine-mediated responses in asthma and chronic obstructive pulmonary disease. Eur Respir J 2002 20: 488 496.
5. Luijk B, van den Berge M, Kerstjens HA, Postma DS, Cass L, Sabin A et al. Effect of an inhaled adenosine A2A agonist on the allergen-induced late asthmatic response. Allergy 2008 63: 75 80.
6. Rimmer J, Peake HL, Santos CM, Lean M, Bardin P, Robson R et al. Targeting adenosine receptors in the treatment of allergic rhinitis: a randomized, double-blind, placebo-controlled study. Clin Exp Allergy 2007 37: 8 14.
7. Rutgers SR, Timens W, Kaufmann HF, van der Mark TW, Koeter GH, Postma DS. Comparison of induced sputum with bronchial wash, bronchoalveolar lavage and bronchial biopsies in COPD. Eur Respir J 2000 15: 109 115.
8. Hoekstra MO, Hovenga H, Gerritsen J, Kauffman HF. Eosinophils and eosinophil-derived proteins in children with moderate asthma. Eur Respir J 1996 9: 2231 2235.
9. Silvestri M, Bontempelli M, Giacomelli M, Malerba M, Rossi GA, Di SA et al. High serum levels of tumour necrosis factor-alpha and interleukin-8 in severe asthma: markers of systemic inflammation? Clin Exp Allergy 2006 36: 1373 1381.
10. Yoo Y, Koh YY, Kang H, Yu J, Nah KM, Kim CK. Sputum eosinophil counts and eosinophil cationic protein levels in cough-variant asthma and in classic asthma, and their relationships to airway hypersensitivity or maximal airway response to methacholine. Allergy 2004 59: 1055 1062.
11. Sedgwick JB, Vrtis RF, Jansen KJ, Kita H, Bartemes K, Busse WW. Peripheral blood eosinophils from patients with allergic asthma contain increased intracellular eosinophil-derived neurotoxin. J Allergy Clin Immunol 2004 114: 568 574.
12. Kikuchi S, Nagata M, Kikuchi I, Hagiwara K, Kanazawa M. Association between neutrophilic and eosinophilic inflammation in patients with severe persistent asthma. Int Arch Allergy Immunol 2005 137 (Suppl 17 20.
13. Toungoussova O, Migliori GB, Foschino Barbaro MP, Esposito LM, Dragonieri S, Carpagnano GE et al. Changes in sputum composition during 15 min of sputum induction in healthy subjects and patients with asthma and chronic obstructive pulmonary disease. Respir Med 2007 101: 1543 1548.
14. Fortuna AM, Feixas T, Gonzalez M, Casan P. Diagnostic utility of inflammatory biomarkers in asthma: exhaled nitric oxide and induced sputum eosinophil count. Respir Med 2007 101: 2416 2421.
15. Beier J, Beeh KM, Semmler D, Buhl R. Sputum levels of reduced glutathione increase 24 hours after allergen challenge in isolated early, but not dual asthmatic responders. Int Arch Allergy Immunol 2004 135: 30 35.
16. Lopuhaa CE, Out TA, Jansen HM, Aalberse RC, van der Zee JS. Allergen-induced bronchial inflammation in house dust mite-allergic patients with or without asthma. Clin Exp Allergy 2002 32: 1720 1727.
17. Alvarez MJ, Olaguibel JM, Garcia BE, Tabar AI, Urbiola E. Comparison of allergen-induced changes in bronchial hyperresponsiveness and airway inflammation between mildly allergic asthma patients and allergic rhinitis patients. Allergy 2000 55: 531 539.
18. Bettiol J, Sele J, Henket M, Louis E, Malaise M, Bartsch P et al. Cytokine production from sputum cells after allergenic challenge in IgE-mediated asthma. Allergy 2002 57: 1145 1150.
19. Kawayama T, O'Byrne PM, Watson RM, Killian KJ, Duong M, Yoshida M et al. Effects of inhaled ciclesonide on circulating T-helper type 1/T-helper type 2 cells in atopic asthmatics after allergen challenge. Clin Exp Allergy 2006 36: 1417 1424.
20. Oosterhoff Y, Kauffman HF, Rutgers B, Zijlstra FJ, Koeter GH, Postma DS. Inflammatory cell number and mediators in bronchoalveolar lavage fluid and peripheral blood in subjects with asthma with increased nocturnal airways narrowing. J Allergy Clin Immunol 1995 96: 219 229.
21. Aalbers R, Kauffman HF, Vrugt B, Koeter GH, De Monchy JG. Allergen-induced recruitment of inflammatory cells in lavage 3 and 24 h after challenge in allergic asthmatic lungs. Chest 1993 103: 1178 1184.
22. Wong CK, Cheung PF, Ip WK, Lam CW. Intracellular signaling mechanisms regulating toll-like receptor-mediated activation of eosinophils. Am J Respir Cell Mol Biol 2007 37: 85 96.
23. Idzko M, Panther E, Bremer HC, Sorichter S, Luttmann W, Virchow CJ Jr. et al. Stimulation of P2 purinergic receptors induces the release of eosinophil cationic protein and interleukin-8 from human eosinophils. Br J Pharmacol 2003 138: 1244 1250.
24. Kobayashi T, Takaku Y, Kikuchi I, Soma T, Hagiwara K, Kanazawa M et al. Eosinophils do not enhance the trans-basement-membrane migration of neutrophils. Int Arch Allergy Immunol 2007 143 (Suppl. 138 143.
25. Takahashi HK, Iwagaki H, Hamano R, Kanke T, Liu K, Sadamori H et al. Effect of adenosine receptor subtypes stimulation on mixed lymphocyte reaction. Eur J Pharmacol 2007 564: 204 210.
26. Cronstein BN, Levin RI, Philips M, Hirschhorn R, Abramson SB, Weissmann G. Neutrophil adherence to endothelium is enhanced via adenosine A1 receptors and inhibited via adenosine A2 receptors. J Immunol 1992 148: 2201 2206.
27. Cronstein BN, Daguma L, Nichols D, Hutchison AJ, Williams M. The adenosine/neutrophil paradox resolved: human neutrophils possess both A1 and A2 receptors that promote chemotaxis and inhibit O2 generation, respectively. J Clin Invest 1990 85: 1150 1157.
28. Salmon JE, Brogle N, Brownlie C, Edberg JC, Kimberly RP, Chen BX et al. Human mononuclear phagocytes express adenosine A1 receptors. A novel mechanism for differential regulation of Fc gamma receptor function. J Immunol 1993 151: 2775 2785.
29. Cronstein BN, Haines KA, Kolasinski S, Reibman J. Occupancy of G alpha s-linked receptors uncouples chemoattractant receptors from their stimulus-transduction mechanisms in the neutrophil. Blood 1992 80: 1052 1057.
30. Fredholm BB, Zhang Y, van dP I. Adenosine A2A receptors mediate the inhibitory effect of adenosine on formyl-Met-Leu-Phe-stimulated respiratory burst in neutrophil leucocytes. Naunyn Schmiedebergs Arch Pharmacol 1996 354: 262 267.
31. Bazzichi L, Trincavelli L, Rossi A, De FF, Lucacchini A, Bombardieri S et al. A2B adenosine receptor activity is reduced in neutrophils from patients with systemic sclerosis. Arthritis Res Ther 2005 7: R189 R195.
32. Wakai A, Wang JH, Winter DC, Street JT, O'Sullivan RG, Redmond HP. Adenosine inhibits neutrophil vascular endothelial growth factor release and transendothelial migration via A2B receptor activation. Shock 2001 15: 297 301.
33. Hasko G, Szabo C, Nemeth ZH, Kvetan V, Pastores SM, Vizi ES. Adenosine receptor agonists differentially regulate IL-10, TNF-alpha, and nitric oxide production in RAW 264.7 macrophages and in endotoxemic mice. J Immunol 1996 157: 4634 4640.
34. Johnston JB, Silva C, Gonzalez G, Holden J, Warren KG, Metz LM et al. Diminished adenosine A1 receptor expression on macrophages in brain and blood of patients with multiple sclerosis. Ann Neurol 2001 49: 650 658.
35. Ying S, O'Connor B, Ratoff J, Meng Q, Mallett K, Cousins D et al. Thymic stromal lymphopoietin expression is increased in asthmatic airways and correlates with expression of Th2-attracting chemokines and disease severity. J Immunol 2005 174: 8183 8190.