Sputum levels of reduced glutathione increase 24 hours after allergen challenge in isolated early, but not dual asthmatic responders

International Archives of Allergy and Immunology

Volumn 135, Issue 1, 2004, Pages 30-35

  Beier, Jutta ^a,b   Beeh, Kai Michael ^a   Semmler, David ^a   Buhl, Roland ^a  

^a UNIVERSITY MEDICAL CENTER MAINZ   (Germany)

^b Institut fur Atemwegsforschung INSAF   (Germany)

Author keywords

Allergen challenge; Antioxidants; Glutathione; Induced sputum

Indexed keywords

ALLERGEN; GLUTATHIONE; NITRIC OXIDE;

ADULT; ARTICLE; ASTHMA; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; EOSINOPHIL; FORCED EXPIRATORY VOLUME; HUMAN; MALE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SPUTUM ANALYSIS;

ADMINISTRATION, INHALATION; ADULT; ALLERGENS; ASTHMA; BREATH TESTS; EOSINOPHILS; GLUTATHIONE; GLUTATHIONE DISULFIDE; HUMANS; MALE; NITRIC OXIDE; S-NITROSOTHIOLS; SPUTUM; TIME FACTORS;

EID: 4644367899     PISSN: 10182438     EISSN: None     Source Type: Journal    
DOI: 10.1159/000080040     Document Type: Article

References (21)

1. Bousquet J, Chanez P, Lacoste JY, Barneon G, Ghavanian N, Enander I, et al: Eosinophilic inflammation in asthma. N Engl J Med 1990;323:1033-1039.
2. Hansel TT: The allergen challenge. Clin Exp Allergy 2002;32:162-167.
3. Leckie MJ, ten Brinke A, Khan J, Diamant Z, O'Connor BJ, Walls CM, et al: Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response. Lancet 2000;356:2144-2148.
4. Casoni GL, Chitano P, Pinamonti S, Chicca M, Ciaccia A, Fabbri LM, et al: Reducing agents inhibit the contractile response of isolated guinea-pig main bronchi. Clin Exp Allergy 2003;33:999-1004.
5. Davis WB, Pacht ER: Extracellular antioxidant defenses; in Crystal RG, West JB (eds): The Lung. Scientific Foundations. New York, Raven, 1991, pp 1821-1828.
6. Singh SP, Wishnok JS, Keshive M, Deen WM, Tannenbaum SR: The chemistry of the S-nitrosoglutathione/glutathione system. Proc Natl Acad Sci USA 1996;93:14428-14433.
7. Gaston B, Reilly J, Drazen JM, Fackler J, Ramdev P, Arnelle S, et al: Endogenous nitrogen oxides and bronchodilator S-nitrosothiols in human airways. Proc Natl Acad Sci USA 1993;90:10957-10961.
8. Beier J, Beeh KM, Kornmann O, Buhl R: Glutathione (GSH) measurement in induced sputum: Validity, stability and reproducibility. Am J Respir Crit Care Med 2002;165:A345.
9. Dauletbaev N, Rickmann J, Viel K, Buhl R, Wagner TO, Bargon J: Glutathione in induced sputum of healthy individuals and patients with asthma. Thorax 2001;56:13-18.
10. National Institutes of Health, National Heart, Lung, and Blood Institute: Global Initiative for Asthma: Global Strategy for Asthma Management and Prevention. Bethsda, US Department of Health and Human Services, Public Health Service, 2002, NIH Publication No. 02-3659.
11. Taylor DA, McGrath JL, O'Connor BJ, Barnes PJ: Allergen-induced early and late asthmatic responses are not affected by inhibition of endogenous nitric oxide. Am J Respir Crit Care Med 1998;158:99-106.
12. Beeh KM, Beier J, Haas IC, Kornmann O, Micke P, Buhl R: Glutathione deficiency of the lower respiratory tract in patients with idiopathic pulmonary fibrosis. Eur Respir J 2002;19:1119-1123.
13. Buhl R, Jaffe HA, Holroyd KJ, Wells FB, Mastrangeli A, Saltini C, et al: Systemic glutathione deficiency in symptom-free HIV-seropositive individuals. Lancet 1989;ii:1294-1298.
14. Griffith OW: Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine. Anal Biochem 1980;106:207-212.
15. Recommendations for standardized procedures for the on-line and off-line measurement of exhaled lower respiratory nitric oxide in adults and children - 1999. This official statement of the American Thoracic Society was adopted by the ATS Board of Directors, July 1999. Am J Respir Crit Care Med 1999;160:2104-2117.
16. Bland JM, Altman DC: Transformations, means, and confidence intervals. BMJ 1996;312:1079.
17. Gaston B, Sears S, Wodds J, Hunt J, Stamler JS: Bronchodilator S-nitrosothiol deficiency in asthmatic respiratory failure. Lancet 1998;351:1317-1319.
18. Bowler RP, Crapo JD: Oxidative stress in allergic respiratory diseases. J Allergy Clin Immunol 2002;110:349-356.
19. Marrades RM, Roca J, Barbera JA, de Jover L, MacNee W, Rodriguez-Roisin R: Nebulized glutathione induces bronchoconstriction in patients with mild asthma. Am J Respir Crit Care Med 1997;156:425-430.
20. Keatings VM, O'Connor BJ, Wright LG, Huston DP, Corrigan CJ, Barnes PJ: Late response to allergen is associated with increased concentrations of tumor necrosis factor-alpha and IL-5 in induced sputum. J Allergy Clin Immunol 1997;99:693-698.
21. Rahman I, MacNee W: Oxidative stress and regulation of glutathione in lung inflammation. Eur Respir J 2000;16:534-554.