Thrombopoietin inhibits murine mast cell differentiation

Stem Cells

Volumn 26, Issue 4, 2008, Pages 912-919

  Martelli, Fabrizio ^a   Ghinassi, Barbara ^a,c   Lorenzini, Rodolfo ^a   Vannucchi, Alessandro M ^b   Rana, Rosa Alba ^c   Nishikawa, Mitsuo ^d   Partamian, Sandra ^e   Migliaccio, Giovanni ^a   Migliaccio, Anna Rita ^a,e,f  

^a ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^b UNIVERSITY OF FLORENCE   (Italy)

^c UNIVERSITY OF CHIETI   (Italy)

^d KIRIN BREWERY CO LTD   (Japan)

^e Myeloproliferative Disease Research Consortium

^f MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; Bcl2; Mast cells; Mitf; Mpl; Thrombopoietin

Indexed keywords

MICROPHTHALMIA ASSOCIATED TRANSCRIPTION FACTOR; THROMBOPOIETIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BCL2 GENE; CELL CULTURE; CELL DIFFERENTIATION; CONTROLLED STUDY; GENE; GENE CONTROL; MAST CELL; MOUSE; NONHUMAN; PROTEIN EXPRESSION; ANIMAL; COMPARATIVE STUDY; CYTOLOGY; DRUG EFFECT; MALE; MOUSE MUTANT; PHYSIOLOGY; STEM CELL;

MURINAE; MUS;

ANIMALS; CELL DIFFERENTIATION; CELLS, CULTURED; MALE; MAST CELLS; MICE; MICE, KNOCKOUT; STEM CELLS; THROMBOPOIETIN;

EID: 49249094401     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1634/stemcells.2007-0777     Document Type: Article

References (47)

1. Kitamura Y, Yokoyama M, Matsuda H et al. Spleen colony-forming cell as common precursor for tissue mast cells and granulocytes. Nature 1981;291:159-160.
2. Gurish MF, Austen KF. The diverse roles of mast cells. J Exp Med 2001;194:F1-F5.
3. Galli SJ, Nakae S, Tsai M. Mast cells in the development of adaptive immune responses. Nat Immunol 2005;6:135-142.
4. Chen CC, Grimbaldeston MA, Tsai M et al. Identification of mast cell progenitors in adult mice. Proc Natl Acad Sci U S A 2005;102:11408-11413.
5. Rodewald HR, Dessing M, Dvorak AM et al. Identification of a committed precursor for the mast cell lineage. Science 1996;271:818-822.
6. Dayton ET, Pharr P, Ogawa M et al. 3T3 fibroblasts induce cloned interleukin 3-dependent mouse mast cells to resemble connective tissue mast cells in granular constituency. Proc Natl Acad Sci U S A 1988;85:569-572.
7. Nocka K, Buck J, Levi E et al. Candidate ligand for the c-kit transmembrane kinase receptor: KL, a fibroblast derived growth factor stimulates mast cells and erythroid progenitors. EMBO J 1990;9:3287-3294.
8. Durand B, Migliaccio G, Yee NS et al. Long-term generation of human mast cells in serum-free cultures of CD34+ cord blood cells stimulated with stem cell factor and interleukin-3. Blood 1994;84:3667-3674.
9. Besmer P. The kit ligand encoded at the murine Steel locus: A pleiotropic growth and differentiation factor. Curr Opin Cell Biol 1991;3:939-946.
10. 41 and W. EMBO J 1990;9:1805-1813.
11. Kimura Y, Jones N, Kluppel M et al. Targeted mutations of the juxtamembrane tyrosines in the Kit receptor tyrosine kinase selectively affect multiple cell lineages. Proc Natl Acad Sci U S A 2004;101:6015-6020.
12. Kohno M, Yamasaki S, Tybulewicz VL et al. Rapid and large amount of autocrine IL-3 production is responsible for mast cell survival by IgE in the absence of antigen. Blood 2005;105:2059-2065.
13. Lantz CS, Boesiger J, Song CH et al. Role for interleukin-3 in mast cell and basophil development and in immunity to parasites. Nature 1998;392:90-93.
14. Kitaura J, Song J, Tsai M et al. Evidence that IgE molecules mediate a spectrum of effects on mast cell survival and activation via aggregation of the FcεRI. Proc Natl Acad Sci U S A 2003;100:12911-12916.
15. Rottem M, Barbieri S, Kinet JP et al. Kinetics of the appearance of Fc epsilon RI-bearing cells in interleukin-3-dependent mouse bone marrow cultures: Correlation with histamine content and mast cell maturation. Blood 1992;79:972-980.
16. v mice. Evidence that cultured mast cells can give rise to both connective tissue type and mucosal mast cells. J Exp Med 1985;162:1025-1043.
17. Reynolds DS, Stevens RL, Lane WS et al. Different mouse mast cell populations express various combinations of at least six distinct mast cell serine proteases. Proc Natl Acad Sci U S A 1990;87:3230-3234.
18. Tsai M, Takeishi T, Thompson H et al. Induction of mast cell proliferation, maturation, and heparin synthesis by the rat c-kit ligand, stem cell factor. Proc Natl Acad Sci U S A 1991;88:6382-6386.
19. Yee NS, Paek I, Besmer P. Role of kit-ligand in proliferation and suppression of apoptosis in mast cells: Basis for radiosensitivity of white spotting and steel mutant mice. J Exp Med 1994;179:1777-1787.
20. Möller C, Alfredsson J, Engstrom M et al. Stem cell factor promotes mast cell survival via inactivation of FOXO3a-mediated transcriptional induction and MEK-regulated phosphorylation of the proapoptotic protein Bim. Blood 2005;106:1330-1336.
21. Suzuki K, Nakajima H, Watanabe N et al. Role of common cytokine receptor gamma chain (gamma(c))- and Jak3-dependent signalling in the proliferation and survival of murine mast cells. Blood 2000;96:2172-2180.
22. Kitamura Y, Morii E, Jippo T et al. Regulation of mast cell phenotype by MITF. Int Arch Allergy Immunol 2002;127:106-109.
23. Tsai FY, Orkin SH. Transcription factor GATA-2 is required for proliferation/survival of early hematopoietic cells and mast cell formation, but not for erythroid and myeloid terminal differentiation. Blood 1997;89:3636-3643.
24. Harigae H, Takahashi S, Suwabe N et al. Differential roles of GATA-1 and GATA-2 in growth and differentiation of mast cells. Genes Cells 1998;3:39-50.
25. low mouse mutant. J Exp Med 2003;197:281-296.
26. Morii E, Jippo T, Tsujimura T et al. Abnormal expression of mouse mast cell protease 5 gene in cultured mast cells derived from mutant mi/mi mice. Blood 1997;90:3057-3066.
27. Ogihara H, Morii E, Kim DK et al. Inhibitory effect of the transcription factor encoded by the mutant mi microphthalmia allele on transactivation of mouse mast cell protease 7 gene. Blood 2001;97:645-651.
28. Adams JM, Cory S. The Bcl-2 protein family: Arbiters of cell survival. Science 1998;281:1322-1326.
29. Weiss MJ, Orkin SH. GATA transcription factors: Key regulators of hematopoiesis. Exp Hematol 1995;23:99-107.
30. Jippo T, Mizuno H, Xu Z et al. Abundant expression of transcription factor GATA-2 in proliferating but not in differentiated mast cells in tissues of mice: Demonstration by in situ hybridization. Blood 1996;87:993-998.
31. Zon LI, Gurish MF, Stevens RL et al. GATA-binding transcription factors in mast cells regulate the promoter of the mast cell carboxypeptidase A gene. J Biol Chem 1991;266:22948-22953.
32. Nishiyama C, Yokota T, Okumura K et al. The transcription factors Elf-1 and GATA-1 bind to cell-specific enhancer elements of human high-affinity IgE receptor alpha-chain gene. J Immunol 1999;163:623-630.
33. Maeda K, Nishiyama C, Tokura T et al. Regulation of cell type-specific mouse FcεRI beta-chain gene expression by GATA-1 via four GATA motifs in the promoter. J Immunol 2003;170:334-340.
34. Migliaccio AR, Rana RA, Vannucchi AM et al. Role of thrombopoietin in mast cell differentiation. Ann NY Acad Sci 2007;1106:152-174.
35. Vannucchi AM, Bianchi L, Paoletti F et al. A pathobiologic pathway linking thrombopoietin, GATA-1, and TGF-β1 in the development of myelofibrosis. Blood 2005;105:3493-3501.
36. Kaushansky K, Drachman JG. The molecular and cellular biology of thrombopoietin: The primary regulator of platelet production. Oncogene 2002;3359-3367.
37. Sonnenblick A, Levy C, Razin E. Interplay between MITF, PIAS3 and STAT3 in mast cells and melanocytes. Mol Cell Biol 2004;24:10584-10592.
38. Alexander WS, Roberts AW, Nicola NA et al. Deficiencies in progenitor cells of multiple hematopoietic lineages and defective megakaryocytopoiesis in mice lacking the thrombopoietic receptor c-Mpl. Blood 1996;87:2162-2170.
39. Sanchez M, Weissman IL, Pallavicini M et al. Differential amplification of murine bipotent megakaryocytic/erythroid progenitor and precursors cells during recovery from acute and chronic erythroid stress. STEM CELLS 2006;24:337-348.
40. Ghinassi B, Sanchez M, Martelli F et al. The hypomorphic Gata1low mutation alters the proliferation/differentiation potential of the common megakaryocytic-erythroid progenitor. Blood 2007;109:1460-1471.
41. Sawai N, Koike K, Mwamtemi HH et al. Thrombopoietin augments stem cell factor-dependent growth of human mast cells from bone marrow multipotential hematopoietic progenitors. Blood 1999;93:3703-3712.
42. + human mast cells from hematopoietic progenitor cells. Exp Hematol 2005;33:413-421.
43. Ballmaier M, Germeshausen M, Schulze H et al. c-mpl mutation are the cause of congenital amegakaryocytic thrombocytopenia. Blood 2001;97:139-146.
44. Pardanani AD, Levine RL, Lasho T et al. MPL515 mutations in myeloproliferative and other myeloid disorders: A study of 1182 patients. Blood 2006;108:3472-3476.
45. Kaushansky K. On the molecular origins of the chronic myeloproliferative disorders: It all makes sense. Blood 2005;105:4187-4190.
46. Arai F, Suda T. Maintenance of quiescent hematopoietic stem cells in the osteoblastic niche. Ann N Y Acad Sci 2007;1106:41-53.
47. +/CD49d(hi)/ beta7+ mucosal mast cell precursors from the bone marrow following infection with the intestinal nematode Trichinella spiralis. Blood 2004; 103:2655-2660.