Expansion of circulating Vγ9/Vδ1 T cells in a patient with a syndrome of recurrent fever: Evidence for an unusual antigen-driven process leading to selection of recurrent motifs within TCR junctional loops of diverse lengths

European Journal of Immunology

Volumn 29, Issue 10, 1999, Pages 3338-3349

  Jouen Beades, Fabienne ^a   Halary, Franck ^b   Drouot, Laurent ^a   Peyrat, Marie Alix ^b   Paris, Estelle ^a   Joly, Pascal ^a   Gilbert, Danièle ^a   Bonneville, Marc ^b   Tron, François ^a,c  

^a HÔPITAL CHARLES NICOLLE   (France)

^b INSTITUT DE BIOLOGIE   (France)

^c INSERM   (France)

Author keywords

T cell; Recurrent fever; V 1 repertoire; V 9 repertoire

Indexed keywords

CD3 ANTIGEN; T LYMPHOCYTE RECEPTOR;

ADULT; AMINO ACID COMPOSITION; ARTICLE; CASE REPORT; FEVER; GENETIC CONSERVATION; HUMAN; HUMAN CELL; IMMUNOPHENOTYPING; MALE; MEMORY CELL; MOLECULAR CLONING; PATHOPHYSIOLOGY; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; RECURRENT DISEASE; T LYMPHOCYTE;

AMINO ACID SEQUENCE; BASE SEQUENCE; CLONE CELLS; FEVER OF UNKNOWN ORIGIN; HUMANS; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA; REPETITIVE SEQUENCES, AMINO ACID; REPETITIVE SEQUENCES, NUCLEIC ACID; SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS, DNA; SYNDROME; T-LYMPHOCYTE SUBSETS;

EID: 0032861103     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-4141(199910)29:10<3338::AID-IMMU3338>3.0.CO;2-B     Document Type: Article

References (50)

1. Davis, M. M. and Bjorkman, P. J., T-cell antigen receptor genes and T-cell recognition. Nature 1988. 334: 395-402 and erratum 335: 744.
2. Haas, W., Pereira, P. and Tonegawa, S., Gamma/delta cells. Annu. Rev. Immunol. 1993. 11: 637-685.
3. Hata, S., Satyanarayana, K., Devlin, P., Band, H., McLean, J., Strominger, J. L., Brenner, M. B. and Krangel, M. S., Extensive junctional diversity of rearranged human T cell receptor delta genes. Science 1988. 240: 1541-1544.
4. + T cells is activated by Mycobacterium tuberculosis but not its 65-kd heat shock protein. J. Exp. Med. 1990. 171: 667-679.
5. Constant, P., Poquet, Y., Peyrat, M. A., Davodeau, F., Bonneville, M. and Fournié, J. J., The antituberculous BCG vaccine is an attenuated mycobacterial producer of phosphorylated nonpeptidic antigens for human γδ T cells. Infect. Immun. 1995. 63: 4628-4633.
6. Rust, C. J., Verreck, F., Vietor, H. and Koning, F., Specific recognition of staphylococcal enterotoxin A by T cells bearing receptor with the V gamma 9 region. Nature 1990. 346: 572-574.
7. Jouen-Beades, F., Paris, E., Dieulois, C., Lemeland, J. F., Farre-Dezelus, V., Marret, S., Humbert, G., Leroy, J. and Tron, F., In vivo and in vitro activation and expansion of gamma delta T cells during Listeria monocytogenes infection in human. Infect. Immun. 1997. 65: 4267-4272.
8. Pouquet, Y., Kroca, M., Halary, F., Stenmark, S., Peyrat, M. A., Bonneville, M., Fournié, J. J. and Sjosjedt, A., Expansion of Vγ9Vδ2 T cells is triggered by Francisella tularensis-derived phosphoantigens in Tularemia but not after tularemia vacciniation. Infect. Immun. 1998. 66: 2107-2114.
9. Behr, C., Poupot, R., Peyrat, M. A., Poquet, Y., Constant, P., Dubois, P., Bonneville, M. and Fournié, J. J., Plasmodium falciparum stimuli for human γδ T cells are related to phosphorylated antigens of mycobacteria. Infect. Immun. 1996. 64: 2892-2896.
10. Halary, F., Peyrat, M. A., Champagne, E., Lopez-Botet, M., Moretta, A., Moretta, L., Vie, H., Fournié, J. J. and Bonneville, M., Control of self-reactive cytotoxic T lymphocytes expressing γδ T cell receptors by natural killer inhibitory receptors. Eur. J. Immunol. 1997. 27: 2812-2821.
11. Fisch, P., Malkovsky, M., Kovats, S., Sturm, E., Braakman, E., Klein, B. S., Voss, S. D., Morrissey, L. W., DeMars, R., Welch, W. J., Bolhuis, R. L. H. and Sondel, P. M., Recognition by human Vgamma 9/Vdelta2 T cells of a GroEL homolog on Daudi Burkitt's lymphoma cells. Science 1990. 205: 1269-1273.
12. Fisch, P., Meuer, E., Pende, D., Rothenfusser, S., Viale, O., Kock, S., Ferrone, S., Fradelizi, D., Klein, G., Moretta, L., Rammensee, H. G., Boon, T., Coulie, P. and Van Der Bruggen, P., Control of B cell lymphoma recognition via natural killer inhibitory receptors implies a role for human Vgamma9/Vdelta2 T cells in tumor immunity. Eur. J. Immunol. 1997. 27: 3368-3379.
13. Parker, C. M., Groh, V., Band, H., Porcelli, S. A., Morita, C., Fabbi, M., Glass, D., Strominger, J. L. and Brenner, M. B., Evidence for extrathymic changes in the T cell receptor gamma/delta repertoire. J. Exp. Med. 1990. 171: 1597-1612.
14. Davodeau, F., Peyrat, M. A., Hallet, M. M., Houdé, I., Vié, H. and Bonneville, M., Peripheral selection of antigen receptor junctional features in a major human γδ subset. Eur. J. Immunol. 1993. 23: 804-808.
15. Delfau, M. H., Hance, A. J., Lecossier, D., Vilmer, E. and Grandchamp, B., Restricted diversity of Vγ9-JP rearrangements in unstimulated human γ/δ T lymphocytes. Eur. J. Immunol. 1992. 22: 2437-2443.
16. Constant, P., Davodeau, F., Peyrat, M. A., Poquet, Y., Puzo, G., Bonneville, M. and Fournié, J. J., Stimulation of human γδ T cells by nonpeptidic mycobacterial ligands. Science 1994. 264: 267-270.
17. Tanaka, Y., Morita, C. T., Tanaka, Y., Nieves, E., Brenner, M. B. and Bloom, B. R., Natural and synthetic non-peptide antigens recognized by human γδ T cells. Nature 1995. 375: 155-158.
18. Déchanet, J., Merville, P., Bonneville, M., Pellegrin, L. and Moreau, J. F., Major expansion of γδ T lymphocytes following CMV infection in kidney allograft recipients. J. Infect. Dis. 1999. 179: 1-8.
19. Autran, B., Triebel, F., Katlama, C., Rozenbaum, W., Hercend, T. and Debre, P., T cell receptor gamma delta lymphocytes subsets during HIV infection. Clin. Exp. Immunol. 1989. 75: 206-210.
20. + T cell expansion in the peripheral blood of HIV-infected persons. J. Immunol. 1995. 1418-1431.
21. Hinz, T., Wesch, D., Friese, K., Reckziegel, A., Arden, B. and Kabelitz, D., T cell receptor γδ repertoire in HIV-1 infected individuals. Eur. J. Immunol. 1994. 24: 3044-4049.
22. Uyemura, K., Klotz, J., Pirmez, C., Ohmen, J., Wang, X.-H., Ho, C., Hoffman, W. L. and Modlin, R. L., Microanatomic clonality of γδ T cells in human leishmaniasis lesions. J. Immunol. 1992. 148: 1205-1211.
23. Moreau, J. F., Taupin, J. L., Dupon, M., Carron, J. C., Ragneaud, J. M., Marimoutou, C., Bernard, N., Constans, J., Texier-Maugin, J., Barbeau, P., Journot, V., Dabois, F., Bonneville, M. and Pellegrin, J. L., Increases in CD3+CD4-CD8-T lymphocytes with Mycobacterium avium complex in patients with acquired immune deficiency syndrome. J. Infect. Dis. 1996. 174: 969-976.
24. Bucht, A., Söderström, K., Hultman, T., Uhle, M., Nilsson, E., Kiessling, R. and Gronberg, A., T cell receptor diversity and activation markers in the Vδ1 subset of rheumatoid synovial fluid and peripheral blood T lymphocytes. Eur. J. Immunol. 1992. 22: 567-574.
25. high γδ T cells in Lyme arthritis. J. Exp. Med. 1996. 184: 2109-2117.
26. + T cells in pulmonary sarcoidosis. J. Clin. Invest. 1993. 91: 292-300.
27. Shimonkevitz, R., Colburn, C., Burnham, J. A., Murray, R. S. and Kotzin, B. L., Clonal expansion of activated gamma delta T cells in recent-onset multiple sclerosis. Proc. Natl. Acad. Sci. USA 1993. 90: 923-927.
28. Choudary, A., Davodeau, F., Peyrat, M. A., Bonneville, M. and Jotereau, F., Selective lysis of autologous tumor cells by recurrent γδ tumor infiltating lymphocytes from renal carcinoma. J. Immunol. 1995. 154: 3932-3940.
29. Maevrer, M. J., Martin, D., Walter, W., Liu, K., Zitvogel, L., Haluczcak, K., Rabinovitch, H., Duquesnoy, R., Storkus, W. and Lotze, M. T., Human intestinal Vδ1 + T lymphocytes recognize tumor cells of epithelial origin. J. Exp. Med. 1996. 183: 1681-1696.
30. Groh, V., Steinle, A., Bauer, S. and Spies, T., Recognition of stress-induced MHC molecules by intestinal epithelial gammadelta T cells. Science 1988. 279: 1737-1740.
31. + cells with restricted T-cell receptor δ gene junctional repertoire in the peripheral blood of healthy donors. J. Exp. Med. 1993. 178: 121-127.
32. Yurovsky, V. V., Sutton, P. A., Schulze, D. H., Wigley, F. M., Wise, R. A., Howard, R. F. and White, B., Expansion of selected Vδ1 + γδ T cells in systemic sclerosis patients. J. Immunol. 1994. 153: 881-891.
33. Jouen-Beades, F., Gilbert, D., Ramzaoui, S., Borsa-Lebas, F., Humbert, G. and Tron, F., Similarity of expression of activation markers and CD28 on γδ- and αβ-receptor T cells in HIV infection. Clin. Immunol. Immunopathol. 1996. 79: 189-193.
34. Miyawaki, T., Kasahara, Y., Taga, K., Yachie, A. and Taniguchi, N., Differential expression of CD45RO (UCHL1) and its functional relevance in two subpopulations of circulating TCR-gamma/delta lymphocytes. J. Exp. Med. 1990. 171: 1833-1838.
35. Casorati, G., De Libero, G., Lanzavecchia, A. and Migone, N., Molecular analysis of human gamma/ delta+ clones from thymus and peripheral blood. J. Exp. Med. 1989. 170: 1521-1535.
36. Engel, I. and Hedrick, S. M., Site-directed mutations in the VDJ junctional region of a T cell receptor β chain cause changes in antigenic peptide recognition. Cell 1988. 54: 473-484.
37. Jorgensen, J. L., Esser, U., Fazekas de St Groth, B., Reay, P. A. and Davis, M. M., Mapping T-cell receptor-peptide contacts by variant peptide immunization of single-chain transgenics. Nature 1992. 355: 224-230.
38. McHeyzer-Williams, M. G. and Davis, M. M., Antigen-specific development of primary and memory T cells in vivo. Science 1995. 268: 106-111.
39. Chothia, C. and Lesk, A. M., Canonical structures for the hypervariable regions of immunoglobulins. J. Mol. Biol. 1987. 196: 901-917.
40. Chien, Y. H., Jores, R. and Crowley, M. P., Recognition by gamma/delta T cells. Annu. Rev. Immunol. 1996. 14: 511-532.
41. + T lymphocytes during progression of HIV infection. J. Immunol. 1997. 158: 464-474.
42. Sciammas, R., Johnson, R. M., Sperling, A. I., Brady, W., Linsley, P. S., Spear, P. G., Fitch, F. W. and Bluestone, J. A., Unique antigen recognition by a herpes virus-specific TCR-gamma delta cell. J. Immunol. 1994. 152: 5392-5397.
43. WHO-IUIS nomenclature sub-committee on TCR designation. Nomenclature for T cell receptor (TCR) gene segments of the immune system. Immunogenetics 1995. 42: 451-453.
44. Loh, E. Y., Cwirla, S., Serafini, A. T., Phillips, J. H. and Lanier, L. L., Human T cell receptor δ chain: genomic organization, diversity and expression in population of cells. Proc. Natl. Acad. Sci. USA 1988. 85: 9714-9718.
45. Chowers, Y., Holtmeier, W., Harwood, J., Morzycka-Wrobleska, E. and Kagnoff, M. F., The Vδ1 T cell receptor repertoire of human small intestine and colon. J. Exp. Med. 1994. 180: 183-190.
46. Orsini, D. L., van Gils, M., Kooy, Y. M. C., Struyk, L., Klein, G., van den Elsen, P. and Koning, F., Functional and molecular characterization of B-cell responsive Vδ1 + γδ T cells. Eur. J. Immunol. 1994. 24: 3199-3204.
47. Holtmeier, W., Chowers, Y., Lumeng, A., Morzycka-Wroblewska, E. and Kagnoff, M. F., The δ T cell receptor repertoire in human colon and peripheral blood is oligoclonal irrespective of V region usage. J. Clin. Invest. 1995. 96: 1108-1117.
48. Stinissen, P., Vandevyver, C., Medaer, R., Vandegaer, L., Nies, J., Tuyls, L., Hafler, D. A., Raus, J. and Zhang, J., Increased frequency of γδ T cells in cerebrospinal fluid and peripheral blood of patients with multiple sclerosis. J. Immunol. 1995. 154: 4883-4894.
49. Wucherpfennig, K. W., Newcombe, J., Li, H., Keddy, C., Cuzner, M. L. and Hafler, D. A., γδ T cell receptor repertoire in acute multiple sclerosis lesions. Proc. Natl. Acad. Sci. USA 1992. 89: 4588-4592.
50. Sioud, M., Forre, O. and Natvig, J. B., T cell receptor delta diversity of freshly isolated T lymphocytes in rheumatoid synovitis. Eur. J. Immunol. 1991. 21: 239-241.