Dimerization of endogenous MT1-MMP is a regulatory step in the activation of the 72-kDa gelatinase MMP-2 on fibroblasts and fibrosarcoma cells

Biological Chemistry

Volumn 389, Issue 7, 2008, Pages 943-953

  Ingvarsen, Signe ^a   Madsen, Daniel H ^a   Hillig, Thore ^a   Lund, Leif R ^b   Holmbeck, Kenn ^b   Behrendt, Niels ^a   Engelholm, Lars H ^a,c  

^a FINSEN LABORATORY   (Denmark)

^b NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH   (United States)

^c Rigshospitalet   (Denmark)

Author keywords

Collagenase; Gelatinase A; Immunofluorescence; MMP 14; Pro enzyme activation; TIMP 2

Indexed keywords

GELATINASE; IMMUNOGLOBULIN F(AB) FRAGMENT; MATRIX METALLOPROTEINASE 14; MATRIX METALLOPROTEINASE 15; MONOCLONAL ANTIBODY;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIGEN BINDING; ANTIGEN EXPRESSION; ARTICLE; DIMERIZATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME SYNTHESIS; FEMALE; FIBROBLAST; FIBROBLAST CULTURE; FIBROSARCOMA; GENE OVEREXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN SYNTHESIS REGULATION;

ANIMALS; ANTIBODIES, MONOCLONAL; CATTLE; CELL LINE, TUMOR; DIMERIZATION; ENZYME ACTIVATION; ENZYME PRECURSORS; FIBROBLASTS; HEMOPEXIN; HUMANS; IMMUNIZATION; MATRIX METALLOPROTEINASE 14; MATRIX METALLOPROTEINASE 2; MICE; MOLECULAR WEIGHT; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, TERTIARY;

EID: 49149106418     PISSN: 14316730     EISSN: 14374315     Source Type: Journal    
DOI: 10.1515/BC.2008.097     Document Type: Article

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