Effects of exercise and insulin on insulin signaling proteins in human skeletal muscle

Medicine and Science in Sports and Exercise

Volumn 31, Issue 7, 1999, Pages 998-1004

  Koval, Janice A ^c   Maezono, Katsumi ^c   Patti, Mary Elizabeth ^c   Pendergrass, Merri ^b   DeFronzo, Ralph A ^c   Mandarino, Lawrence J ^a  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^b TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c NONE

Author keywords

Exercise; Insulin Receptor; Insulin Signaling; Skeletal Muscle

Indexed keywords

GLUCOSE; GLYCOGEN SYNTHASE; INSULIN; INSULIN RECEPTOR; INSULIN RECEPTOR SUBSTRATE 1; PHOSPHATIDYLINOSITOL 3 KINASE;

ADULT; ARTICLE; ENZYME ACTIVITY; EXERCISE; FEMALE; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; HUMAN; HUMAN EXPERIMENT; HYPERINSULINEMIA; INSULIN BLOOD LEVEL; INSULIN SENSITIVITY; MALE; MUSCLE METABOLISM; NORMAL HUMAN; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SKELETAL MUSCLE; VASTUS LATERALIS MUSCLE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ADULT; ANAEROBIC THRESHOLD; BLOOD GLUCOSE; BODY MASS INDEX; EXERCISE; FEMALE; GLUCOSE CLAMP TECHNIQUE; GLYCOGEN SYNTHASE; HUMANS; INFUSIONS, INTRAVENOUS; INSULIN; LEG; MALE; MUSCLE, SKELETAL; PHOSPHORYLATION; PHOSPHOTYROSINE; RECEPTOR, INSULIN; SIGNAL TRANSDUCTION;

EID: 0033010155     PISSN: 01959131     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005768-199907000-00012     Document Type: Article

References (38)

1. ARONSON, D., M. A. VIOLAN, S. D. DUFRESNE, D. ZANGEN, R. A. FIELDING, and L. J. GOODYEAR. Exercise stimulates the mitogen-activated protein kinase pathway in human skeletal muscle. J. Clin. Invest. 99:1251-1257, 1997.
2. BACKER, J., M. G. MYERS, S. E. SHOELSON, et al. Phosphatidylinositol 3-kinase is activated by association with IRS-1 during insulin stimulation. EMBO J. 11:3469-3479, 1992.
3. BAK, J. F., and O. PEDERSEN. Exercise-enhanced activation of glycogen synthase in human skeletal muscle. Am. J. Physiol. 258:E957-E963, 1990.
4. BEAVER W., K. WASSERMAN, and B. WHIPP. A new method for detecting anaerobic threshold by gas exchange. J. Appl. Physiol, 60:2020-2027, 1986.
5. BLOM, P., N. K. VOLLESTAD, and D. L. COSTILL. Factors affecting changes in muscle glycogen concentration during and after prolonged exercise. Acta Physiol. Scand. 128(Suppl. 556):67-74, 1986.
6. CHEATHAM, B., C. VLAHOS, and L. CHEATHAM. Phosphatidylinositol 3′-kinase is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation. Mol. Cell Biol. 14:4902-4911, 1994.
7. CLELAND, P. J., G. J. APPLEBY, S. RATTIGAN, and M. G. CLARK. Exercise-induced translocation of protein kinase C and production of diacylglycerol and phosphatidic acid in rat skeletal muscle in vivo: relationship to changes in glucose transport. J. Biol. Chem. 264:17704-17711, 1989.
8. CODERRE, L., K. V. KANDROR, G. VALLEGA, and P. F. PILCH. Identification and characterization of an exercise-sensitive pool of glucose transporters in skeletal muscle. J. Biol. Chem. 270:27584-27588, 1995.
9. 14C glucose. Rec. Prog. Horm. Res. 19:445-448, 1964.
10. DEFRONZO, R., J. TOBIN, and R. ANDRES. Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am. J. Physiol. 237:E214-E223, 1979.
11. DEVLIN, J., and E. HORTON. Effects of prior high intensity exercise on glucose metabolism in normal and insulin resistant men. Diabetes 34:973-979, 1985.
12. DORRESTIJN, J., D. OUWENS, N. VAN DEN BERGHE, J. BOS, and J. MAASSEN. Expression of a dominant-negative ras mutant does not affect stimulation of glucose uptake and glycogen synthesis by insulin. Diabetologia 39:558-563, 1996.
13. DOIJEN, G. G., T. RAMLAL, G. D. CARTEE, and A. KLIP. Exercise modulates the insulin-induced translocation of glucose transporters in rat skeletal muscle. FEBS Lett. 261:256-260, 1990.
14. GAO, J., J. REN, E. GULVE, and J. HOLLOSZY. Additive effect of contractions and insulin on GLUT4 translocation into the sarcolemma, J. Appl. Physiol. 77:1597-1601, 1994.
15. GOODYEAR, L., F. GIORGINO, T. BALON, G. CONDORELLI, and R. SMITH. Effects of contractile activity on tyrosine phosphoproteins and PI 3′-kinase activity in rat skeletal muscle. Am. J. Physiol. 268:E987-E995, 1995.
16. GOODYEAR, L., P. CHANG, D. SHERWOOD, S. DUFRESNE, and D. MOLLER. Effect of exercise and insulin on mitogen-activated protein kinase signaling pathways in rat skeletal muscle. Am. J. Physiol. 271:E403-E408, 1996.
17. GOODYEAR, L. J., M. F. HIRSHMAN, and E. S. HORTON. Exercise-induced translocation of skeletal muscle glucose transporters. Am. J. Physiol. 261:E795-E799, 1991.
18. HICKEY, M., C. J. TANNER, D. S. O'NEILL, L. J. MORGAN, G. L. DOHM, and J. A. HOUMARD. Insulin activation of phosphatidylino-sitol 3-kinase in human skeletal muscle in vivo. J. Appl. Physiol. 83:718-722, 1997.
19. IVY, J. L., A. KATZ, C. CUTLER, W. SHERMAN, and E. F. COYLE. Muscle glycogen synthesis after exercise: effect of time and carbohydrate ingestion. J. Appl. Physiol. 64:1480-1485, 1988.
20. LAZAR, D., R. WEISE, M. BRADY, et al. Mitogen-activated protein kinase inhibition does not block the stimulation of glucose utilization by insulin. J. Biol. Chem. 270:20801-20807, 1995.
21. LEE, A. D., P. A. HANSON, and J. O. HOLLOSZY. Wortmannin inhibits insulin-stimulated but not contraction-stimulated glucose transport activity in skeletal muscle. FEBS Lett. 361:51-54, 1995.
22. LUND, S., G. D. HOLMAN, O. SCHMITZ, and O. PEDERSEN. Contraction stimulates translocation of glucose transporter GLUT4 in skeletal muscle through a mechanism distinct from that of insulin. Proc. Natl. Acad. Sci. USA 92:5817-5821, 1995.
23. MANDARINO, L., K. WRIGHT, L. VERITY, J. NICHOLS, J. BELL, O. KOLTERMAN, and H. BECK-NIELSEN. Effects of insulin infusion on human skeletal muscle pyruvate dehydrogenase, phosphofructokinase and glycogen synthase. J. Clin. Invest. 80:655-663, 1987.
24. MARGOLIS, B., and E. SKOLNIK. Activation of ras by receptor tyrosine kinases. J. Am. Soc. Nephrol. 5:1288-1299, 1994.
25. MIKINES, K., B. SONNE, P. FARRELL, B. TRONIER, and H. GALBO. Effect of physical exercise on sensitivity and responsiveness in humans. Am. J. Physiol. 254:E248-E259, 1988.
26. NOLAN, J. J., B. LUDVIK, J. BALOGA, D. REICHART, J. M. OLEFSKY. Mechanisms of the kinetic defect in insulin action in obesity and NIDDM. Diabetes 46:994-1000, 1997.
27. c-src complexes and PI3-kinase. Cell 65:91-104, 1991.
28. PASSONEAU, J. Lactate. In: Methods of Enzymatic Analysis, H. Bergmeyer (Ed.). New York, Academic Press, 1972, pp. 1468-1472.
29. SHEPERD, P, B. NAVE, and K. SIDDLE. Insulin stimulation of glycogen synthesis and glycogen synthase activity is blocked by wortmannin and rapamycin in 3T3-L1 adipocytes. Biochem. J. 305:25-28, 1995.
30. SKOLNIK, E. Y., C. H. LEE, A. G. BATZER, et al. The SH2/SH3 domain-containing protein Grb2 interacts with tyrosine phosphorylated IRS-1 and Shc: implications for insulin control of ras signaling. EMBO J. 12:1929-1936, 1993.
31. SUN, X. J., L. M. WANG, Y. ZHANG, et al. Role of IRS-2 in insulin and cytokine signaling. Nature 377:173-177, 1995.
32. SUN, X. J., P. ROTHENBERG, C. R. KAHN, et al. Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein. Nature 352:73-77, 1991.
33. VERGAUWEN, L., P. HESPEL, and E. A. RICHTER. Adenosine receptors mediate synergistic stimulation of glucose uptake and transport by insulin and by contractions in rat skeletal muscle. J. Clin. Invest. 93:974-981, 1994.
34. WOJTASEWSKI, J. F. P., B. F. HANSEN, B. KIENS, and E. A. RICHTER. Insulin signaling in human muscle: time course and effect of exercise. Diabetes 46:1775-1781, 1997.
35. WOJTASEWSKI, J. F. P., B. F. HANSEN, B. URSO, and E. A. RICHTER. Wortmannin inhibits both insulin-and contraction-stimulated glucose uptake and transport in rat skeletal muscle. J. Appl. Physiol. 81:1501-1509, 1996.
36. WOJTASEWSKI, J. F. P., J. L. LAUSTSEN, W. DERAVE, and E. A. RICHTER. Hypoxia and contractions do not utilize the same signaling mechanism in stimulating skeletal muscle glucose transport. Biochim. Biophys. Acta 1380:396-404, 1998.
37. WRIGHT, K. S., H. BECK-NIELSEN, O. G. KOLTERMAN, and L. J. MANDARINO. Decreased activation of skeletal muscle glycogen synthase by mixed-meal ingestion in NIDDM. Diabetes 37:436-440, 1988.
38. + current and is enhanced by insulin. Pflugers Arch. Eur. J. Physiol. 422:267-272, 1992.