Neuroprotection by Spirulina platensis protean extract and phycocyanin against iron-induced toxicity in SH-SY5Y neuroblastoma cells

Toxicology in Vitro

Volumn 22, Issue 6, 2008, Pages 1496-1502

  Bermejo Bescós, Paloma ^a   Piñero Estrada, Enrique ^a   Villar del Fresno, Ángel Ma ^a  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

Author keywords

Catalase; Glutathione; Glutathione peroxidase; Glutathione reductase; Lipid peroxidation; Neuroprotection; Phycocyanin; SH SY5Y neuroblastoma; Spirulina platensis; Superoxide dismutase

Indexed keywords

CATALASE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; IRON; PHYCOCYANIN; PROTEAN EXTRACT; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE;

ANTIOXIDANT ACTIVITY; ARTICLE; CELL DEATH; CELL STRAIN SH SY5Y; DEGENERATIVE DISEASE; HUMAN; HUMAN CELL; LIPID PEROXIDATION; NEUROBLASTOMA CELL; NEUROPATHOLOGY; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; SPIRULINA PLATENSIS;

ANTIOXIDANTS; CELL DEATH; CELL LINE, TUMOR; FERROUS COMPOUNDS; GLUTATHIONE; HUMANS; LIPID PEROXIDATION; NEUROBLASTOMA; NEUROPROTECTIVE AGENTS; OXIDATIVE STRESS; PHYCOCYANIN; SPIRULINA;

PROTEA; SPIRULINA PLATENSIS;

EID: 49149083439     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tiv.2008.05.004     Document Type: Article

References (56)

1. Aebi H. Catalase in vitro. Method Enzymol. 105 (1984) 121-126
2. Amoroso S., Gioielli A., Cataldi M., Di Renzo G., and Annunziato L. In the neuronal cell line SH-SY5Y, oxidative stress-induced free radical overproduction causes cell death without any participation of intracellular Ca(2+) increase. Biochim. Biophys. Acta 1452 (1999) 151-160
3. Annapurna V.V., Deosthale Y.G., and Bamji M.S. Spirulina as a source of vitamin A. Plant Foods Human Nutr. 41 (1991) 125-134
4. Aust S.D., Morehouse L.A., and Thomas C.E. Role of metals in oxygen radical reactions. J. Free Radic. Biol. Med. 1 (1985) 3-25
5. Barja de Quiroga G., Perez-Campo R., and Lopez Torres M. Anti-oxidant defences and peroxidation in liver and brain of aged rats. Biochem. J. 272 (1990) 247-250
6. Berg D. In vivo detection of iron and neuromelanin by transcranial sonography - a new approach for early detection of substantia nigra damage. J. Neural. Transm. 113 (2006) 775-780
7. Berg D., and Youdim M.B. Role of iron in neurodegenerative disorders. Top Magn. Reson. Imaging 17 (2006) 5-17
8. Bermejo P., Pinero E., and Villar A.M. Iron-chelating ability and antioxidant properties of phycocyanin isolated from a protean extract of Spirulina platensis. Food Chem. 110 (2008) 436-445
9. Bhat V.B., and Madyastha K.M. C-phycocyanin: a potent peroxyl radical scavenger in vivo and in vitro. Biochem. Biophys. Res. Commun. 275 (2000) 20-25
10. Bhat V.B., and Madyastha K.M. Scavenging of peroxynitrite by phycocyanin and phycocyanobilin from Spirulina platensis: protection against oxidative damage to DNA. Biochem. Biophys. Res. Commun. 285 (2001) 262-266
11. Binder A., Wilson K., and Zuber H. C-phycocyanin from the thermophilic blue-green alga Mastigocladus laminosus, isolation, characterization and subunit composition. FEBS Lett. 20 (1972) 111-116
12. Boussiba S., and Richmond A.E. Isolation and characterization of phycocyanins from the blue-green alga Spirulina platensis. Arch. Microbiol. 120 (1979) 155-159
13. Braughler J.M., Duncan L.A., and Chase R.L. The involvement of iron in lipid peroxidation. Importance of ferric to ferrous ratios in initiation. J. Biol. Chem. 261 (1986) 10282-10289
14. Castellani R.J., Moreira P.I., Liu G., Dobson J., Perry G., Smith M.A., and Zhu X. Iron: the Redox-active center of oxidative stress in Alzheimer disease. Neurochem. Res. 32 (2007) 1640-1645
15. Ceriello A., and Motz E. Is oxidative stress the pathogenic mechanism underlying insulin resistance, diabetes, and cardiovascular disease? The common soil hypothesis revisited. Arterioscler. Thromb. Vasc. Biol. 24 (2004) 816-823
16. Cornett C.R., Markesbery W.R., and Ehmann W.D. Imbalances of trace elements related to oxidative damage in Alzheimer's disease brain. Neurotoxicology 19 (1998) 339-345
17. Choi J.Y., Neuhouser M.L., Barnett M., Hong C.C., Kristal A.R., Thornquist M., King I.B., Goodman G., and Ambrosone C.B. Iron intake, oxidative stress-related genes MnSOD and MPO and prostate cancer risk in CARET cohort. Carcinogenesis (2008)
18. Choudhary M., Jetley U.K., Abash Khan M., Zutshi S., and Fatma T. Effect of heavy metal stress on proline, malondialdehyde, and superoxide dismutase activity in the cyanobacterium Spirulina platensis-S5. Ecotoxicol. Environ. Saf. 66 (2007) 204-209
19. Davies K.J. Oxidative stress, antioxidant defenses, and damage removal, repair, and replacement systems. IUBMB Life. 50 (2000) 279-289
20. Double K.L., Gerlach M., Youdim M.B., and Riederer P. Impaired iron homeostasis in Parkinson's disease. J. Neural. Transm. Suppl. (2000) 37-58
21. Eisele L.E., Bakhru S.H., Liu X., MacColl R., and Edwards M.R. Studies on C-phycocyanin from cyanidium caldarium, a eukaryote at the extremes of habitat. Biochim. Biophys. Acta 1456 (2000) 99-107
22. Fraga C.G., and Oteiza P.I. Iron toxicity and antioxidant nutrients. Toxicology 180 (2002) 23-32
23. Halliwell B. How to characterize a biological antioxidant. Free Radic. Res. Commun. 9 (1990) 1-32
24. Herbert V., Shaw S., Jayatilleke E., and Stopler-Kasdan T. Most free-radical injury is iron-related: it is promoted by iron, hemin, holoferritin and vitamin C, and inhibited by desferoxamine and apoferritin. Stem Cells 12 3 (1994) 289-303
25. Hirsch E.C., and Faucheux B.A. Iron metabolism and Parkinson's disease. Mov Disord. 13 Suppl. 1 (1998) 39-45
26. Jonas C.R., and Ziegler T.R. Nutrition support and antioxidant defenses: a cause for concern?. Am. J. Clin. Nutr. 68 (1998) 765-767
27. Khan Z., Bhadouria P., and Bisen P.S. Nutritional and therapeutic potential of Spirulina. Curr. Pharm. Biotechnol. 6 (2005) 373-379
28. Kudo H., Suzuki S., Watanabe A., Kikuchi H., Sassa S., and Sakamoto S. Effects of colloidal iron overload on renal and hepatic siderosis and the femur in male rats. Toxicology 246 (2008) 143-147
29. Lowry O.H., Rosebrough N.J., Farr A.L., and Randall R.J. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193 (1951) 265-275
30. Marklund S., and Marklund G. Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur. J. Biochem. 47 (1974) 469-474
31. Marnett L.J. Lipid peroxidation-DNA damage by malondialdehyde. Mutat. Res. 424 (1999) 83-95
32. Massey V., and Williams Jr. C.H. On the reaction mechanism of yeast glutathione reductase. J. Biol. Chem. 240 (1965) 4470-4480
33. Mihara M., and Uchiyama M. Determination of malonaldehyde precursor in tissues by thiobarbituric acid test. Anal Biochem. 86 (1978) 271-278
34. Miranda M.S., Cintra R.G., Barros S.B., and Mancini Filho J. Antioxidant activity of the microalga Spirulina maxima. Braz. J. Med. Biol. Res. 31 (1998) 1075-1079
35. Opara E.C. Oxidative stress. Dis Mon. 52 (2006) 183-198
36. Perry J.J., Fan L., and Tainer J.A. Developing master keys to brain pathology, cancer and aging from the structural biology of proteins controlling reactive oxygen species and DNA repair. Neuroscience 145 (2007) 1280-1299
37. Pinero Estrada J.E., Bermejo Bescos P., and Villar del Fresno A.M. Antioxidant activity of different fractions of Spirulina platensis protean extract. Il Farmaco. 56 (2001) 497-500
38. Rasmussen M.L., Folsom A.R., Catellier D.J., Tsai M.Y., Garg U., and Eckfeldt J.H. A prospective study of coronary heart disease and the hemochromatosis gene (HFE) C282Y mutation: the Atherosclerosis Risk in Communities (ARIC) study. Atherosclerosis 154 (2001) 739-746
39. Rimbau V., Camins A., Romay C., Gonzalez R., and Pallas M. Protective effects of C-phycocyanin against kainic acid-induced neuronal damage in rat hippocampus. Neurosci. Lett. 276 (1999) 75-78
40. Riss J., Decorde K., Sutra T., Delage M., Baccou J.C., Jouy N., Brune J.P., Oreal H., Cristol J.P., and Rouanet J.M. Phycobiliprotein C-phycocyanin from Spirulina platensis is powerfully responsible for reducing oxidative stress and NADPH oxidase expression induced by an atherogenic diet in hamsters. J. Agric. Food Chem. 55 (2007) 7962-7967
41. Shachar D.B., Kahana N., Kampel V., Warshawsky A., and Youdim M.B. Neuroprotection by a novel brain permeable iron chelator, VK-28, against 6-hydroxydopamine lession in rats. Neuropharmacology 46 (2004) 254-263
42. Simpore J., Kabore F., Zongo F., Dansou D., Bere A., Pignatelli S., Biondi D.M., Ruberto G., and Musumeci S. Nutrition rehabilitation of undernourished children utilizing Spiruline and Misola. Nutr. J. 5 (2006) 3
43. Smith M.A., and Perry G. Free radical damage, iron, and Alzheimer's disease. J. Neurol. Sci. 134 Suppl. (1995) 92-94
44. Smith M.A., Wehr K., Harris P.L., Siedlak S.L., Connor J.R., and Perry G. Abnormal localization of iron regulatory protein in Alzheimer's disease. Brain Res. 788 (1998) 232-236
45. Sun A.Y., Chen Y.M., James-Kracke M., Wixom P., and Cheng Y. Ethanol-induced cell death by lipid peroxidation in PC12 cells. Neurochem. Res. 22 (1997) 1187-1192
46. Trushina E., and McMurray C.T. Oxidative stress and mitochondrial dysfunction in neurodegenerative diseases. Neuroscience 145 (2007) 1233-1248
47. Upasani C.D., and Balaraman R. Protective effect of Spirulina on lead induced deleterious changes in the lipid peroxidation and endogenous antioxidants in rats. Phytother. Res. 17 (2003) 330-334
48. Ursini F., Davies K.J., Maiorino M., Parasassi T., and Sevanian A. Atherosclerosis: another protein misfolding disease?. Trends Mol. Med. 8 (2002) 370-374
49. Valko M., Rhodes C.J., Moncol J., Izakovic M., and Mazur M. Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chem. Biol. Interact. 160 (2006) 1-40
50. Van Campenhout A., Van Campenhout C., Lagrou A., and Manuel Y.K.B. Iron-induced oxidative stress in haemodialysis patients: a pilot study on the impact of diabetes. Biometals 21 (2008) 159-170
51. Walker Jr. E.M., and Walker S.M. Effects of iron overload on the immune system. Ann. Clin. Lab Sci. 30 (2000) 354-365
52. Wu L.C., Ho J.A., Shieh M.C., and Lu I.W. Antioxidant and antiproliferative activities of Spirulina and Chlorella water extracts. J. Agric. Food Chem. 53 (2005) 4207-4212
53. Yu B.P. Cellular defenses against damage from reactive oxygen species. Physiol. Rev. 74 (1994) 139-162
54. Zhang X., Xie W., Qu S., Pan T., Wang X., and Le W. Neuroprotection by iron chelator against proteasome inhibitor-induced nigral degeneration. Biochem. Biophys. Res. Commun. 333 (2005) 544-549
55. Zheng H., Weiner L.M., Bar-Am O., Epsztejn S., Cabantchik Z.I., Warshawsky A., Youdim M.B., and Fridkin M. Design, synthesis, and evaluation of novel bifunctional iron-chelators as potential agents for neuroprotection in Alzheimer's, Parkinson's, and other neurodegenerative diseases. Bioorg. Med. Chem. 13 (2005) 773-783
56. Zheng H., Blat D., and Fridkin M. Novel neuroprotective neurotrophic NAP analogs targeting metal toxicity and oxidative stress: potential candidates for the control of neurodegenerative diseases. J. Neural. Transm. Suppl. (2006) 163-172