Regenerative growth of corticospinal tract axons via the ventral column after spinal cord injury in mice

Journal of Neuroscience

Volumn 28, Issue 27, 2008, Pages 6836-6847

  Steward, Oswald ^a   Zheng, Binhai ^b   Tessier Lavigne, Marc ^c   Hofstadter, Maura ^a   Sharp, Kelli ^a   Yee, Kelly Matsudaira ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c GENENTECH INC   (United States)

Author keywords

Axon regeneration; BDA; Biotinylated dextran amine; Corticospinal tract; Mice; Motor system; Spinal cord injury; Sprouting; Tract tracing

Indexed keywords

DEXTRAN; BIOTIN; BIOTINYLATED DEXTRAN AMINE; DRUG DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTERIOR HYPOTHALAMUS; ARTICLE; BIOTINYLATION; CELL GROWTH; CONTROLLED STUDY; GRAY MATTER; HEMISPHERE; MOUSE; NERVE FIBER; NONHUMAN; PRIORITY JOURNAL; PYRAMIDAL TRACT; REGENERATION; SENSORIMOTOR CORTEX; SPINAL CORD INJURY; SPINAL CORD LESION; ANIMAL; C57BL MOUSE; CELL COUNT; CONVALESCENCE; DISEASE MODEL; HEMISPHERIC DOMINANCE; HISTOLOGY; MOUSE MUTANT; MYELINATED NERVE; NERVE CELL PLASTICITY; NERVE FIBER TRANSPORT; NERVE REGENERATION; PATHOPHYSIOLOGY; PHYSIOLOGY; SPINAL CORD; SYNAPTOSOME; ULTRASTRUCTURE;

ANIMALS; AXONAL TRANSPORT; AXONS; BIOTIN; CELL COUNT; DEXTRANS; DISEASE MODELS, ANIMAL; FUNCTIONAL LATERALITY; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NERVE FIBERS, MYELINATED; NERVE REGENERATION; NEURONAL PLASTICITY; PRESYNAPTIC TERMINALS; PYRAMIDAL TRACTS; RECOVERY OF FUNCTION; SPINAL CORD; SPINAL CORD INJURIES;

EID: 49049110770     PISSN: 02706474     EISSN: 02706474     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.5372-07.2008     Document Type: Article

References (32)

1. Bareyre FM, Kerschensteiner M, Raineteau O, Mettenleiter TC, Weinmann O, Schwab ME (2004) The injured spinal cord spontaneously forms a new intraspinal circuit in adult rats. Nat Neurosci 7:269-277.
2. Bareyre FM, Kerschensteiner M, Misgeld T, Sanes JR (2005) Transgenic labeling of the corticospinal tract for monitoring axonal responses to spinal cord injury. Nat Med 11:1355-1360.
3. Brösamle C, Schwab ME (2000) Ipsilateral, ventral corticospinal tract of the adult rat: ultrastructure, myelination and synaptic connections. J Neurocytol 29:499-507.
4. Brösamle C, Huber AB, Fiedler M, Skerra A, Schwab ME (2000) Regeneration of lesioned corticospinal tract fibers in the adult rat induced by a recombinant, humanized IN-1 antibody fragment. J Neurosci 20:8061-8068.
5. Bulsara KR, Iskandar BJ, Villavicencio AT, Skene JH (2002) A new millenium for spinal cord regeneration: growth-associated genes. Spine 27:1946-1949.
6. Cafferty WB, Kim JE, Lee JK, Strittmatter SM (2007) Response to correspondence: Kim et al., "axon regeneration in young adult mice lacking Nogo-A/B," Neuron 38, 187-199. Neuron 54:195-199.
7. Davies SJ, Goucher DR, Doller C, Silver J (1999) Robust regeneration of adult sensory axons in degenerating white matter of the adult rat spinal cord. J Neurosci 19:5810-5822.
8. Dimou L, Schnell L, Montani L, Duncan C, Simonen M, Schneider R, Liebscher T, Gullo M, Schwab ME (2006) Nogo-A-deficient mice reveal strain-dependent differences in axonal regeneration. J Neurosci 26:5591-5603.
9. Fernandes KJ, Fan DP, Tsui BJ, Cassar SL, Tetzlaff W (1999) Influence of the axotomy to cell body distance in rat rubrospinal and spinal motoneurons: differential regulation of GAP-43, tubulins, and neurofilament-M. J Comp Neurol 414:495-510.
10. Fitch MT, Silver J (2008) CNS injury, glial scars, and inflammation: Inhibitory extracellular matrices and regeneration failure. Exp Neurol 209:294-301.
11. Fouad K, Pedersen V, Schwab ME, Brösamle C (2001) Cervical sprouting of corticospinal fibers after thoracic spinal cord injury accompanies shifts in evoked motor responses. Curr Biol 11:1766-1770.
12. Fu Q, Hue J, Li S (2007) Nonsteroidal anti-inflammatory drugs promote axon regeneration via RhoA inhibition. J Neurosci 27:4154-4164.
13. Hains BC, Black JA, Waxman SG (2003) Primary cortical motor neurons undergo apoptosis after axotomizing spinal cord injury. J Comp Neurol 462:328-341.
14. Harel NY, Strittmatter SM (2006) Can regenerating axons recapitulate developmental guidance during recovery from spinal cord injury? Nat Rev Neurosci 7:603-616.
15. He Z, Koprivica V (2004) The Nogo signaling pathway for regeneration block. Annu Rev Neurosci 27:341-368.
16. Kim JE, Li S, GrandPré T, Qiu D, Strittmatter SM (2003) Axon regeneration in young adult mice lacking Nogo-A/B. Neuron 38:187-199.
17. Li S, Strittmatter SM (2003) Delayed systemic Nogo-66 receptor antagonist promotes recovery from spinal cord injury. J Neurosci 23:4219-4227.
18. Liebscher T, Schnell L, Schnell D, Scholl J, Schneider R, Gullo M, Fouad K, Mir A, Rausch M, Kindler D, Hamers FP, Schwab ME (2005) Nogo-A antibody improves regeneration and locomotion of spinal cord-injured rats. Ann Neurol 58:706-719.
19. McDonald JW (1999) Repairing the damaged spinal cord. Sci Am 281:64-73.
20. Schwab JM, Brechtel K, Mueller CA, Failli V, Kaps HP, Tuli SK, Schluesener HJ (2006) Experimental strategies to promote spinal cord regeneration - an integrative perspective. Prog Neurobiol 78:91-116.
21. Sicotte M, Tsatas O, Jeong SY, Cai CQ, He Z, David S (2003) Immunization with myelin or recombinant Nogo-66/Mag in alum promotes axon regeneration and sprouting after corticospinal tract lesion in the spinal cord. Mol Cell Neurosci 23:251-263.
22. Silver J, Miller JH (2004) Regeneration beyond the glial scar. Nat Rev Neurosci 5:146-156.
23. Simonen M, Pedersen V, Weinmann O, Schnell L, Buss A, Ledermann B, Christ F, Sansig G, van der Putten H, Schwab ME (2003) Systemic deletion of the myelin-associated outgrowth inhibitor Nogo-A improves regenerative and plastic responses after spinal cord injury. Neuron 38:201-211.
24. Steward O (2006) Anatomical and biochemical plasticity of neurons: regenerative growth of axons, sprouting, pruning, and denervation supersensitivity. In: Textbook of neural repair and rehabilitation, Vol I, Neural repair and plasticity (Selzer M, Clarke S, Cohen L, Duncan P, Gage F, eds), pp 5-25. New York: Cambridge UP.
25. Steward O, Zheng B, Tessier-Lavigne M (2003) False resurrections: distinguishing regenerated from spared axons in the injured CNS. J Comp Neurol 459:1-8.
26. Steward O, Zheng B, Ho C, Anderson K, Tessier-Lavigne M (2004) The dorsolateral cortico-spinal tract in mice: an alternative route for corticospinal input to caudal segments following dorsal column lesions. J Comp Neurol 472:463-477.
27. Steward O, Zheng B, Banos K, Yee KM (2007) Response to: Kim et al., "axon regeneration in young adult mice lacking Nogo-A/B," Neuron 38, 187-199. Neuron 54:191-195.
28. Steward O, Sharp K, Yee KM, Hofstadter M (2008) A re-assessment of the effects of a Nogo-66 receptor antagonist on regenerative growth of axons and locomotor recovery after spinal cord injury in mice. Exp Neurol 209:446-468.
29. Weidner N, Ner A, Salimi N, Tuszynski MH (2001) Spontaneous corticospinal axonal plasticity and functional recovery after adult central nervous system injury. Proc Natl Acad Sci U S A 98:3513-3518.
30. Yiu G, He Z (2006) Glial inhibition of CNS axon regeneration. Nat Rev Neurosci 7:617-627.
31. Zheng B, Ho C, Li S, Keirstead H, Steward O, Tessier-Lavigne M (2003) Lack of enhanced spinal regeneration in Nogo-deficient mice. Neuron 38:213-224.
32. Zheng B, Lee JK, Xie F (2006) Genetic mouse models for studying inhibitors of spinal axon regeneration. Trends Neurosci 29:640-646.