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Volumn 104, Issue 6, 2008, Pages 2059-2070

Advances in the treatment of acute myeloid leukemia: From chromosomal aberrations to biologically targeted therapy

Author keywords

Myelodysplasia; Translocations

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; ANTHRACYCLINE; ANTINEOPLASTIC AGENT; ARSENIC TRIOXIDE; AZACITIDINE; CYTARABINE; DEPSIPEPTIDE; HISTONE DEACETYLASE INHIBITOR; IMATINIB; LENALIDOMIDE; NUCLEOSIDE; PROTEIN TYROSINE KINASE INHIBITOR; RETINOIC ACID; THALIDOMIDE DERIVATIVE; VALPROIC ACID;

EID: 49049100885     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.21770     Document Type: Conference Paper
Times cited : (22)

References (72)
  • 2
    • 31844449339 scopus 로고    scopus 로고
    • Expansion of human umbilical cord blood SCID-repopulating cells using chromatin-modifying agents
    • Araki H, Mahmud N, Milhem M, Nunez R, Xu M, Beam CA, Hoffman R. 2006. Expansion of human umbilical cord blood SCID-repopulating cells using chromatin-modifying agents. Exp Hematol 34:140-149.
    • (2006) Exp Hematol , vol.34 , pp. 140-149
    • Araki, H.1    Mahmud, N.2    Milhem, M.3    Nunez, R.4    Xu, M.5    Beam, C.A.6    Hoffman, R.7
  • 3
    • 33846820578 scopus 로고    scopus 로고
    • Reversal of p15/INK4b hypermethylation in AML1/ETO-positive and -negative myeloid leukemia cell lines
    • Berg T, Guo Y, Abdelkarim M, Fliegauf M, Lübbert M. 2007. Reversal of p15/INK4b hypermethylation in AML1/ETO-positive and -negative myeloid leukemia cell lines. Leuk Res 31:497-506.
    • (2007) Leuk Res , vol.31 , pp. 497-506
    • Berg, T.1    Guo, Y.2    Abdelkarim, M.3    Fliegauf, M.4    Lübbert, M.5
  • 6
    • 33947205565 scopus 로고    scopus 로고
    • Comparison of low-dose cytarabine and hydroxyurea with or without all-trans retinoic acid for acute myeloid leukemia and high-risk myelodysplastic syndrome in patients not considered fit for intensive treatment
    • Burnett AK, Milligan D, Prentice AG, Goldstone AH, McMullin MF, Hills RK, Wheatley KA. 2007. Comparison of low-dose cytarabine and hydroxyurea with or without all-trans retinoic acid for acute myeloid leukemia and high-risk myelodysplastic syndrome in patients not considered fit for intensive treatment. Cancer 109(6):1114-1124.
    • (2007) Cancer , vol.109 , Issue.6 , pp. 1114-1124
    • Burnett, A.K.1    Milligan, D.2    Prentice, A.G.3    Goldstone, A.H.4    McMullin, M.F.5    Hills, R.K.6    Wheatley, K.A.7
  • 7
    • 32044437861 scopus 로고    scopus 로고
    • Recruitment of the histone methyltransferase SUV39H1 and its role in the oncogenic properties of the leukemia-associated PML-retinoic acid receptor fusion protein
    • Carbone R, Botrugno OA, Ronzoni S, Insinga A, Di Croce L, Pelicci PG, Minucci S. 2006. Recruitment of the histone methyltransferase SUV39H1 and its role in the oncogenic properties of the leukemia-associated PML-retinoic acid receptor fusion protein. Mol Cell Biol 26:1288-1296.
    • (2006) Mol Cell Biol , vol.26 , pp. 1288-1296
    • Carbone, R.1    Botrugno, O.A.2    Ronzoni, S.3    Insinga, A.4    Di Croce, L.5    Pelicci, P.G.6    Minucci, S.7
  • 9
    • 33845195718 scopus 로고    scopus 로고
    • Inhibitors of DNA methylation and histone deacetylation independently relieve AML1/ETO-mediated lysozyme repression
    • Claus R, Fliegauf M, Stock M, Duque JA, Kolanczyk M, Lübbert M. 2006. Inhibitors of DNA methylation and histone deacetylation independently relieve AML1/ETO-mediated lysozyme repression. J Leukoc Biol 80:1462-1472.
    • (2006) J Leukoc Biol , vol.80 , pp. 1462-1472
    • Claus, R.1    Fliegauf, M.2    Stock, M.3    Duque, J.A.4    Kolanczyk, M.5    Lübbert, M.6
  • 10
    • 33750530369 scopus 로고    scopus 로고
    • Acute myeloid leukemia: Epidemiology and etiology
    • Deschler B, Lübbert M. 2006. Acute myeloid leukemia: Epidemiology and etiology. Cancer 107:2099-2107.
    • (2006) Cancer , vol.107 , pp. 2099-2107
    • Deschler, B.1    Lübbert, M.2
  • 11
    • 33750949551 scopus 로고    scopus 로고
    • Treatment decision-making for older patients with high-risk myelodysplastic syndrome or acute myeloid leukemia: Problems and approaches
    • Deschler B, de Witte T, Mertelsmann R, Lübbert M. 2006. Treatment decision-making for older patients with high-risk myelodysplastic syndrome or acute myeloid leukemia: Problems and approaches. Haematologica 91:1513-1522.
    • (2006) Haematologica , vol.91 , pp. 1513-1522
    • Deschler, B.1    de Witte, T.2    Mertelsmann, R.3    Lübbert, M.4
  • 14
    • 0032822953 scopus 로고    scopus 로고
    • The AML1-ETO chimaeric transcription factor in acute myeloid leukaemia: Biology and clinical significance
    • Downing JR. 1999. The AML1-ETO chimaeric transcription factor in acute myeloid leukaemia: Biology and clinical significance. Br J Haematol 106:296-308.
    • (1999) Br J Haematol , vol.106 , pp. 296-308
    • Downing, J.R.1
  • 16
    • 0026757174 scopus 로고
    • Identification of breakpoints in t(8;21) acute myelogenous leukemia and isolation of a fusion transcript, AML1/ETO, with similarity to Drosophila segmentation gene, runt
    • Erickson P, Gao J, Chang KS, Look T, Whisenant E, Raimondi S, Lasher R, Trujillo J, Rowley J, Drabkin H. 1992. Identification of breakpoints in t(8;21) acute myelogenous leukemia and isolation of a fusion transcript, AML1/ETO, with similarity to Drosophila segmentation gene, runt. Blood 80:1825-1831.
    • (1992) Blood , vol.80 , pp. 1825-1831
    • Erickson, P.1    Gao, J.2    Chang, K.S.3    Look, T.4    Whisenant, E.5    Raimondi, S.6    Lasher, R.7    Trujillo, J.8    Rowley, J.9    Drabkin, H.10
  • 17
    • 0033560841 scopus 로고    scopus 로고
    • Randomized phase II study of fludarabine + cytosine arabinoside + idarubicin +/- all-trans retinoic acid +/- granulocyte colony-stimulating factor in poor prognosis newly diagnosed acute myeloid leukemia and myelodysplastic syndrome
    • Estey EH, Thall PF, Pierce S, Cortes J, Beran M, Kantarjian H, Keating MJ, Andreeff M, Freireich E. 1999. Randomized phase II study of fludarabine + cytosine arabinoside + idarubicin +/- all-trans retinoic acid +/- granulocyte colony-stimulating factor in poor prognosis newly diagnosed acute myeloid leukemia and myelodysplastic syndrome. Blood 93(8):2478-2484.
    • (1999) Blood , vol.93 , Issue.8 , pp. 2478-2484
    • Estey, E.H.1    Thall, P.F.2    Pierce, S.3    Cortes, J.4    Beran, M.5    Kantarjian, H.6    Keating, M.J.7    Andreeff, M.8    Freireich, E.9
  • 19
    • 15744378043 scopus 로고    scopus 로고
    • EGR1 predicts PTEN and survival in patients with non-small-cell lung cancer
    • Ferraro B, Bepler G, Sharma S, Cantor A, Haura EB. 2005. EGR1 predicts PTEN and survival in patients with non-small-cell lung cancer. J Clin Oncol 23:1921-1926.
    • (2005) J Clin Oncol , vol.23 , pp. 1921-1926
    • Ferraro, B.1    Bepler, G.2    Sharma, S.3    Cantor, A.4    Haura, E.B.5
  • 20
    • 10944271468 scopus 로고    scopus 로고
    • Williams-Beuren syndrome critical region-5/non-T-cell activation linker: A novel target gene of AML1/ETO
    • Fliegauf M, Stock M, Berg T, Lübbert M. 2004. Williams-Beuren syndrome critical region-5/non-T-cell activation linker: A novel target gene of AML1/ETO. Oncogene 23:9070-9081.
    • (2004) Oncogene , vol.23 , pp. 9070-9081
    • Fliegauf, M.1    Stock, M.2    Berg, T.3    Lübbert, M.4
  • 22
    • 0027320110 scopus 로고
    • The acute promyelocytic leukemia-specific PML-RAR alpha fusion protein inhibits differentiation and promotes survival of myeloid precursor cells
    • Grignani F, Ferrucci PF, Testa U, Talamo G, Fagioli M, Alcalay M, Mencarelli A, Grignani F, Peschle C, Nicoletti I., et al. 1993. The acute promyelocytic leukemia-specific PML-RAR alpha fusion protein inhibits differentiation and promotes survival of myeloid precursor cells. Cell 74:423-431.
    • (1993) Cell , vol.74 , pp. 423-431
    • Grignani, F.1    Ferrucci, P.F.2    Testa, U.3    Talamo, G.4    Fagioli, M.5    Alcalay, M.6    Mencarelli, A.7    Grignani, F.8    Peschle, C.9    Nicoletti, I.10
  • 24
    • 0038047685 scopus 로고    scopus 로고
    • AML1/MTG8 oncogene suppression by small interfering RNAs supports myeloid differentiation of t(8;21)-positive leukemic cells
    • Heidenreich O, Krauter J, Riehle H, Hadwiger P, John M, Heil G, Vornlocher HP, Nordheim A. 2003. AML1/MTG8 oncogene suppression by small interfering RNAs supports myeloid differentiation of t(8;21)-positive leukemic cells. Blood 101:3157-3163.
    • (2003) Blood , vol.101 , pp. 3157-3163
    • Heidenreich, O.1    Krauter, J.2    Riehle, H.3    Hadwiger, P.4    John, M.5    Heil, G.6    Vornlocher, H.P.7    Nordheim, A.8
  • 27
    • 2442478144 scopus 로고    scopus 로고
    • PML-RARA-RXR oligomers mediate retinoid and rexinoid/cAMP cross-talk in acute promyelocytic leukemia cell differentiation
    • Kamashev D, Vitoux D, de The H. 2004. PML-RARA-RXR oligomers mediate retinoid and rexinoid/cAMP cross-talk in acute promyelocytic leukemia cell differentiation. J Exp Med 199:1163-1174.
    • (2004) J Exp Med , vol.199 , pp. 1163-1174
    • Kamashev, D.1    Vitoux, D.2    de The, H.3
  • 30
    • 0020506009 scopus 로고
    • Induction of differentiation of human acute myelogenous leukemia cells: Therapeutic implications
    • Koeffler HP. 1983. Induction of differentiation of human acute myelogenous leukemia cells: Therapeutic implications. Blood 62:709-721.
    • (1983) Blood , vol.62 , pp. 709-721
    • Koeffler, H.P.1
  • 32
    • 4444309863 scopus 로고    scopus 로고
    • Treatment of myelodysplastic syndromes with valproic acid alone or in combination with all-trans retinoic acid
    • Kuendgen A, Strupp C, Aivado M, Bernhardt A, Hildebrandt B, Haas R, Germing U, Gattermann N. 2004. Treatment of myelodysplastic syndromes with valproic acid alone or in combination with all-trans retinoic acid. Blood 104:1266-1269.
    • (2004) Blood , vol.104 , pp. 1266-1269
    • Kuendgen, A.1    Strupp, C.2    Aivado, M.3    Bernhardt, A.4    Hildebrandt, B.5    Haas, R.6    Germing, U.7    Gattermann, N.8
  • 33
    • 29144481615 scopus 로고    scopus 로고
    • Results of a phase 2 study of valproic acid alone or in combination with all-trans retinoic acid in 75 patients with myelodysplastic syndrome and relapsed or refractory acute myeloid leukemia
    • Kuendgen A, Knipp S, Fox F, Strupp C, Hildebrandt B, Steidl C, Germing U, Haas R, Gattermann N. 2005. Results of a phase 2 study of valproic acid alone or in combination with all-trans retinoic acid in 75 patients with myelodysplastic syndrome and relapsed or refractory acute myeloid leukemia. Ann Hematol 84 (Suppl 1):61-66.
    • (2005) Ann Hematol , vol.84 , Issue.SUPPL. 1 , pp. 61-66
    • Kuendgen, A.1    Knipp, S.2    Fox, F.3    Strupp, C.4    Hildebrandt, B.5    Steidl, C.6    Germing, U.7    Haas, R.8    Gattermann, N.9
  • 34
    • 33644767919 scopus 로고    scopus 로고
    • ELA2 is regulated by hematopoietic transcription factors, but not repressed by AML1-ETO
    • Lausen J, Liu S, Fliegauf M, Lübbert M, Werner MH. 2006. ELA2 is regulated by hematopoietic transcription factors, but not repressed by AML1-ETO. Oncogene 25:1349-1357.
    • (2006) Oncogene , vol.25 , pp. 1349-1357
    • Lausen, J.1    Liu, S.2    Fliegauf, M.3    Lübbert, M.4    Werner, M.H.5
  • 35
    • 34548128327 scopus 로고    scopus 로고
    • Common deleted genes in the 5q-syndrome: Thrombocytopenia and reduced erythroid colony formation in SPARC null mice
    • Lehmann S, O'Kelly J, Raynaud S, Funk SE, Sage EH, Koeffler HP. 2007. Common deleted genes in the 5q-syndrome: Thrombocytopenia and reduced erythroid colony formation in SPARC null mice. Leukemia 21:1931-1936.
    • (2007) Leukemia , vol.21 , pp. 1931-1936
    • Lehmann, S.1    O'Kelly, J.2    Raynaud, S.3    Funk, S.E.4    Sage, E.H.5    Koeffler, H.P.6
  • 38
    • 20344387822 scopus 로고    scopus 로고
    • Combined targeting of the epigenetic silence in leukemia: Cooperating activities of DNA methylation and histone deacetylation inhibitors
    • Lübbert M. 2005. Combined targeting of the epigenetic silence in leukemia: Cooperating activities of DNA methylation and histone deacetylation inhibitors. Leuk Res 29:727-728.
    • (2005) Leuk Res , vol.29 , pp. 727-728
    • Lübbert, M.1
  • 39
    • 0026016670 scopus 로고
    • Expression and regulation of myeloid-specific genes in normal and leukemic myeloid cells
    • Lübbert M, Herrmann F, Koeffler HP. 1991. Expression and regulation of myeloid-specific genes in normal and leukemic myeloid cells. Blood 77:909-924.
    • (1991) Blood , vol.77 , pp. 909-924
    • Lübbert, M.1    Herrmann, F.2    Koeffler, H.P.3
  • 40
    • 0034883005 scopus 로고    scopus 로고
    • Cytogenetic normalization in high-risk myelodysplastic syndrome following continued low-dose treatment with the DNA methylation inhibitor 5-aza-2′-deoxycytidine (decitabine)
    • Lübbert M, Wijermans P, Kunzmann R, Verhoef G, Bosly S, Ravoet C, Andre M, Ferrant A. 2001. Cytogenetic normalization in high-risk myelodysplastic syndrome following continued low-dose treatment with the DNA methylation inhibitor 5-aza-2′-deoxycytidine (decitabine). Br J Haemat 114:349-357.
    • (2001) Br J Haemat , vol.114 , pp. 349-357
    • Lübbert, M.1    Wijermans, P.2    Kunzmann, R.3    Verhoef, G.4    Bosly, S.5    Ravoet, C.6    Andre, M.7    Ferrant, A.8
  • 42
    • 0034254368 scopus 로고    scopus 로고
    • Selection and characterization of BCR-ABL positive cell lines with differential sensitivity to the tyrosine kinase inhibitor ST I571:diverse mechanisms of resistance
    • Mahon FX, Deininger MW, Schultheis B, Chabrol J, Reiffers J, Goldman JM, Melo JV. 2000. Selection and characterization of BCR-ABL positive cell lines with differential sensitivity to the tyrosine kinase inhibitor ST I571:diverse mechanisms of resistance. Blood 96:1070-1079.
    • (2000) Blood , vol.96 , pp. 1070-1079
    • Mahon, F.X.1    Deininger, M.W.2    Schultheis, B.3    Chabrol, J.4    Reiffers, J.5    Goldman, J.M.6    Melo, J.V.7
  • 44
    • 0027383818 scopus 로고
    • Identification of AML-1 and the (8;21) translocation protein (AML-1/ETO) as sequence-specific DNA-binding proteins: The runt homology domain is required for DNA binding and protein-protein interactions
    • Meyers S, Downing JR, Hiebert SW. 1993. Identification of AML-1 and the (8;21) translocation protein (AML-1/ETO) as sequence-specific DNA-binding proteins: The runt homology domain is required for DNA binding and protein-protein interactions. Mol Cell Biol 13:6336-6345.
    • (1993) Mol Cell Biol , vol.13 , pp. 6336-6345
    • Meyers, S.1    Downing, J.R.2    Hiebert, S.W.3
  • 47
    • 0025746321 scopus 로고
    • t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, A ML1
    • Miyoshi H, Shimizu K, Kozu T, Maseki N, Kaneko Y, Ohki M. 1991. t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, A ML1. Proc Natl Acad Sci USA 88:10431-10434.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 10431-10434
    • Miyoshi, H.1    Shimizu, K.2    Kozu, T.3    Maseki, N.4    Kaneko, Y.5    Ohki, M.6
  • 49
    • 0242579152 scopus 로고    scopus 로고
    • Comparative analysis of genes regulated by PML/RAR alpha and PLZF/RAR alpha in response to retinoic acid using oligonucleotide arrays
    • Park DJ, Vuong PT, de Vos S, Douer D, Koeffler HP. 2003. Comparative analysis of genes regulated by PML/RAR alpha and PLZF/RAR alpha in response to retinoic acid using oligonucleotide arrays. Blood 102:3727-3736.
    • (2003) Blood , vol.102 , pp. 3727-3736
    • Park, D.J.1    Vuong, P.T.2    de Vos, S.3    Douer, D.4    Koeffler, H.P.5
  • 51
    • 2942516037 scopus 로고    scopus 로고
    • The 8;21 translocation in leukemogenesis
    • Peterson LF, Zhang DE. 2004. The 8;21 translocation in leukemogenesis. Oncogene 23:4255-4262.
    • (2004) Oncogene , vol.23 , pp. 4255-4262
    • Peterson, L.F.1    Zhang, D.E.2
  • 52
  • 53
    • 34548131144 scopus 로고    scopus 로고
    • CDKN2B methylation status and isolated chromosome 7 abnormalities predict responses to treatment with 5-azacytidine
    • Raj K, John A, Ho A, Chronis C, Khan S, Samuel J, Pomplun S, Thomas NS, Mufti GJ. 2007. CDKN2B methylation status and isolated chromosome 7 abnormalities predict responses to treatment with 5-azacytidine. Leukemia 21:1937-1944.
    • (2007) Leukemia , vol.21 , pp. 1937-1944
    • Raj, K.1    John, A.2    Ho, A.3    Chronis, C.4    Khan, S.5    Samuel, J.6    Pomplun, S.7    Thomas, N.S.8    Mufti, G.J.9
  • 54
    • 23844518684 scopus 로고    scopus 로고
    • Early growth response gene 1 (EGR1) is deleted in estrogen receptor-negative human breast carcinoma
    • Ronski K, Sanders M, Burleson JA, Moyo V, Benn P, Fang M. 2005. Early growth response gene 1 (EGR1) is deleted in estrogen receptor-negative human breast carcinoma. Cancer 104:925-930.
    • (2005) Cancer , vol.104 , pp. 925-930
    • Ronski, K.1    Sanders, M.2    Burleson, J.A.3    Moyo, V.4    Benn, P.5    Fang, M.6
  • 57
    • 0034661487 scopus 로고    scopus 로고
    • Analysis of genes under the downstream control of the t(8;21) fusion protein AML1-MT G8:overexpression of the TIS11b (ERF-1, cMG1) gene induces myeloid cell proliferation in response to G-CSF
    • Shimada H, Ichikawa H, Nakamura S, Katsu R, Iwasa M, Kitabayashi I, Ohki M. 2000. Analysis of genes under the downstream control of the t(8;21) fusion protein AML1-MT G8:overexpression of the TIS11b (ERF-1, cMG1) gene induces myeloid cell proliferation in response to G-CSF. Blood 96:655-663.
    • (2000) Blood , vol.96 , pp. 655-663
    • Shimada, H.1    Ichikawa, H.2    Nakamura, S.3    Katsu, R.4    Iwasa, M.5    Kitabayashi, I.6    Ohki, M.7
  • 58
    • 0027154222 scopus 로고
    • Effects of treatment with 5-azacytidine on the in vivo and in vitro hematopoiesis in patients with myelodysplastic syndromes
    • Silverman LR, Holland JF, Weinberg RS, et al. 1993. Effects of treatment with 5-azacytidine on the in vivo and in vitro hematopoiesis in patients with myelodysplastic syndromes. Leukemia 7:S21-S29.
    • (1993) Leukemia , vol.7
    • Silverman, L.R.1    Holland, J.F.2    Weinberg, R.S.3
  • 59
    • 49049100140 scopus 로고    scopus 로고
    • Silverman LR, Holland JF, Demakos EP. 1994. Azacitidine (AzaC) in myelodysplastic syndromes (MDS), CALGB Studies 8421 and 8921. Ann Hemat 68:S21a.
    • Silverman LR, Holland JF, Demakos EP. 1994. Azacitidine (AzaC) in myelodysplastic syndromes (MDS), CALGB Studies 8421 and 8921. Ann Hemat 68:S21a.
  • 62
    • 1442335997 scopus 로고    scopus 로고
    • Gene expression-based high-throughput screening(GE-HTS) and application to leukemia differentiation
    • Stegmaier K, Ross KN, Colavito SA, O'Malley S, Stockwell BR, Golub TR. 2004. Gene expression-based high-throughput screening(GE-HTS) and application to leukemia differentiation. Nat Genet 36:257-263.
    • (2004) Nat Genet , vol.36 , pp. 257-263
    • Stegmaier, K.1    Ross, K.N.2    Colavito, S.A.3    O'Malley, S.4    Stockwell, B.R.5    Golub, T.R.6
  • 63
    • 21744442937 scopus 로고    scopus 로고
    • The histone deacetylase inhibitor valproic acid alters sensitivity towards all trans retinoic acid in acute myeloblastic leukemia cells
    • Trus MR, Yang L, Suarez Saiz F, Bordeleau L, Jurisica I, Minden MD. 2005. The histone deacetylase inhibitor valproic acid alters sensitivity towards all trans retinoic acid in acute myeloblastic leukemia cells. Leukemia 19:1161-1168.
    • (2005) Leukemia , vol.19 , pp. 1161-1168
    • Trus, M.R.1    Yang, L.2    Suarez Saiz, F.3    Bordeleau, L.4    Jurisica, I.5    Minden, M.D.6
  • 64
    • 33745033595 scopus 로고    scopus 로고
    • Pro-proliferative function of the long isoform of PML-RARalpha involved in acute promyelocytic leukemia
    • Tussie-Luna MI, Rozo L, Roy AL. 2006. Pro-proliferative function of the long isoform of PML-RARalpha involved in acute promyelocytic leukemia. Oncogene 25:3375-3386.
    • (2006) Oncogene , vol.25 , pp. 3375-3386
    • Tussie-Luna, M.I.1    Rozo, L.2    Roy, A.L.3
  • 66
    • 10044281766 scopus 로고    scopus 로고
    • Expression profiling of murine acute promyelocytic leukemia cells reveals multiple model-dependent progression signatures
    • Walter MJ, Park JS, Lau SK, Li X, Lane AA, Nagarajan R, Shannon WD, Ley TJ. 2004. Expression profiling of murine acute promyelocytic leukemia cells reveals multiple model-dependent progression signatures. Mol Cell Biol 24:10882-10893.
    • (2004) Mol Cell Biol , vol.24 , pp. 10882-10893
    • Walter, M.J.1    Park, J.S.2    Lau, S.K.3    Li, X.4    Lane, A.A.5    Nagarajan, R.6    Shannon, W.D.7    Ley, T.J.8
  • 67
    • 0032169858 scopus 로고    scopus 로고
    • ETO, fusion partner in t(8;21) acute myeloid leukemia, represses transcription by interaction with the human N-CoR/mSin3/HDAC1 complex
    • Wang J, Hoshino T, Redner RL, Kajigaya S, Liu JM. 1998. ETO, fusion partner in t(8;21) acute myeloid leukemia, represses transcription by interaction with the human N-CoR/mSin3/HDAC1 complex. Proc Natl Acad Sci USA 95:10860-10865.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 10860-10865
    • Wang, J.1    Hoshino, T.2    Redner, R.L.3    Kajigaya, S.4    Liu, J.M.5
  • 69
    • 29144473297 scopus 로고    scopus 로고
    • An epigenetic approach to the treatment of advanced MDS; the experience with the DNA demethylating agent 5-aza-2′-deoxycytidine (decitabine) in 177 patients
    • Wijermans PW, Lübbert M, Verhoef G, Klimek V, Bosly A. 2005. An epigenetic approach to the treatment of advanced MDS; the experience with the DNA demethylating agent 5-aza-2′-deoxycytidine (decitabine) in 177 patients. Ann Hematol 84 (Suppl 1):9-17.
    • (2005) Ann Hematol , vol.84 , Issue.SUPPL. 1 , pp. 9-17
    • Wijermans, P.W.1    Lübbert, M.2    Verhoef, G.3    Klimek, V.4    Bosly, A.5
  • 71
    • 33745161824 scopus 로고    scopus 로고
    • Dimerization-induced corepressor binding and relaxed DNA-binding specificity are critical for PML/RARA-induced immortalization
    • Zhou J, Peres L, Honore N, Nasr R, Zhu J, de The H. 2006. Dimerization-induced corepressor binding and relaxed DNA-binding specificity are critical for PML/RARA-induced immortalization. Proc Natl Acad Sci USA 103:9238-9243.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 9238-9243
    • Zhou, J.1    Peres, L.2    Honore, N.3    Nasr, R.4    Zhu, J.5    de The, H.6


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