Rodent Anterior Ischemic Optic Neuropathy (rAION) induces regional retinal ganglion cell apoptosis with a unique temporal pattern

Investigative Ophthalmology and Visual Science

Volumn 49, Issue 8, 2008, Pages 3671-3676

  Slater, Bernard J ^a   Mehrabian, Zara ^a   Guo, Yan ^a   Hunter, Allan ^a   Bernstein, Steven L ^a,b  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b MSTF 5 65 ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN EXPRESSED X LINKED PROTEIN 1; BRAIN EXPRESSED X LINKED PROTEIN 2; BRAIN PROTEIN; CASPASE 3; FLUORESCEIN ISOTHIOCYANATE; FLUOROGOLD; LIPOCORTIN 5; UNCLASSIFIED DRUG; BEX2 PROTEIN, RAT; CARRIER PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTERIOR ISCHEMIC OPTIC NEUROPATHY; APOPTOSIS; ARTICLE; CELL DEATH; ENZYME ACTIVATION; IMMUNOREACTIVITY; ISCHEMIC OPTIC NEUROPATHY; ISOTOPE LABELING; MALE; MOLECULAR RECOGNITION; NICK END LABELING; NONHUMAN; OPTIC NERVE; OPTIC NERVE INFARCTION; OPTIC NERVE LESION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RETINA GANGLION CELL; WESTERN BLOTTING; WISTAR RAT; ANIMAL; FLUORESCENT ANTIBODY TECHNIQUE; METABOLISM; PATHOLOGY;

ANIMALS; ANNEXIN A5; APOPTOSIS; BLOTTING, WESTERN; CARRIER PROTEINS; CASPASE 3; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; IN SITU NICK-END LABELING; MALE; OPTIC NEUROPATHY, ISCHEMIC; RATS; RATS, WISTAR; RETINAL GANGLION CELLS;

EID: 49049094884     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.07-0504     Document Type: Article

References (24)

1. Berkelaar M, Clarke DB, Wang YC, Bray GM, Aguayo AJ. Axotomy results in delayed death and apoptosis of retinal ganglion cells in adult rats. J Neurosci. 1994;14:4368-4374.
2. Levin LE. Apoptosis of retinal ganglion cells in anterior ischemic optic neuropathy. Arch Ophthalmol. 1996;114:488-491.
3. Broker LE, Kruyt FA, Giaccone G. Cell death independent of caspases: a review. Clin Cancer Res. 2005;11:3155-3162.
4. Chen Y, Ginis I, Hallenbeck JM. The protective effect of ceramide in immature rat brain hypoxia-ischemia involves up-regulation of bcl-2 and reduction of TUNEL-positive cells. J Cereb Blood Flow Metab. 2001;21:34-40.
5. Vermes I, Haanen C, Steffens-Nakken H, Reutelingsperger C. A novel assay for apoptosis: flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labeled annexin V. J Immunol Methods. 1995;184:39-51.
6. Reichstein D, Ren L, Filippopoulos T, Mittag T, Danias J. Apoptotic retinal ganglion cell death in the DBA/2 mouse model of glaucoma. Exp Eye Res. 2007;84:13-21.
7. Tesser RA, Niendorf ER, Levin LA. The morphology of an infarct in nonarteritic anterior ischemic optic neuropathy. Ophthalmology. 2003;110:2031-2035.
8. Hayreh SS. Anterior Ischemic optic neuropathy. I. Terminology and pathogenesis. Br J Ophthalmol. 1974;58:955-963.
9. Miller N. Anterior ischemic optic neuropathy. In: Miller NR, ed. Walsh and Hoyt's Clinical Neuro-Ophthalmology. 4th ed. Vol 1. Baltimore: Williams and Wilkins; 1982:212-226.
10. Hattenhauer MG, Leavitt JA, Hodge DO, Grill R, Gray DT. Incidence of nonarteritic anterior ischemic optic neuropathy. Am J Ophthalmol. 1997;123:103-107.
11. Bernstein SL, Guo Y, Kelman SE, Flower RW, Johnson MA. Functional and cellular responses in a novel rodent model of anterior ischemic optic neuropathy. Invest Ophthalmol Vis Sci. 2003;44:4153-4162.
12. Goldenberg-Cohen N, Guo Y, Margolis FL, Miller NM, Cohen Y, Bernstein SL. Oligodendrocyte dysfunction following induction of experimental anterior optic nerve ischemia. Invest Ophthalmol Vis Sci. 2005;46:2716-2725.
13. Bernstein SL, Mehrabian Z, Guo Y, Moianie N. Estrogen is not neuroprotective in a rodent model of optic nerve stroke. Mol Vis. 2007;13:1920-1925.
14. Bernstein SL, Koo JH, Slater BJ, Guo Y, Margolis FL. Analysis of optic nerve stroke by retinal Bex expression. Mol Vis. 2006;12:147-155.
15. Muller GJ, Stadelmann C, Bastholm L, Elling F, Lassmann H, Johansen FF. Ischemia leads to apoptosis- and necrosis-like neuron death in the ischemic rat hippocampus. Brain Pathol. 2004;14:415-424.
16. Kruman I, Guo Q, Mattson MP. Calcium and reactive oxygen species mediate staurosporine-induced mitochondrial dysfunction and apoptosis in PC12 cells. J Neurosci Res. 1998;51:293-308.
17. Bernstein SL, Guo Y, Slater BJ, Puche A, Kelman SE. Neuron stress and loss following rodent anterior ischemic optic neuropathy in double reporter transgenic mice. Invest Ophthalmol Vis Sci. 2007;48:2304-2310.
18. Bonfanti L, Strettoi E, Chierzi S, et al. Protection of retinal ganglion cells from natural and axotomy-induced cell death in neonatal transgenic mice overexpressing bcl-2. J Neurosci. 1996;16:4186-4194.
19. Mattiasson G, Shamloo M, Gido G, et al. Uncoupling protein-2 prevents neuronal death and diminishes brain dysfunction after stroke and brain trauma. Nat Med. 2003;9:1062-1068.
20. Levkovitch-Verbin H, Quigley HA, Martin KR, Zack DJ, Pease ME, Valenta DF. A model to study differences between primary and secondary degeneration of retinal ganglion cells in rats by partial optic nerve transection. Invest Ophthalmol Vis Sci. 2003;44:3388-3393.
21. Watanabe M, Inukai N, Fukuda Y. Survival of retinal ganglion cells after transection of the optic nerve in adult cats: a quantitative study within two weeks. Vis Neurosci. 2001;18:137-145.
22. Ogden TE. Topography of the retina. In: Ryan SJ, Ogden TE, Schachat AP, eds. The Retina. Vol 1. St. Louis: CV Mosby Co.; 1994;32-36.
23. Varma R, Minckler DS. Anatomy and physiology of the retina and optic nerve. In: Ritch R, Shields MB, Krupin T, eds. The Glaucomas. St. Louis: CV Mosby Co.; 1996;2:139-175.
24. Goldberg JL, Espinosa JS, Xu Y, Davidson N, Kovacs GT, Barres BA. RGCs do not extend axons by default: promotion by neurotrophic signaling and electrical activity. Neuron. 2002;33:689-702.