Oligodendrocyte dysfunction after induction of experimental anterior optic nerve ischemia

Investigative Ophthalmology and Visual Science

Volumn 46, Issue 8, 2005, Pages 2716-2725

  Goldenberg Cohen, Nitza ^a,d,e   Guo, Yan ^c   Margolis, Frank ^c   Cohen, Yoram ^b,d,e   Miller, Neil R ^a,b   Bernstein, Steven L ^c  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^d SCHNEIDER CHILDREN S MEDICAL CENTER OF ISRAEL   (Israel)

^e TEL AVIV UNIVERSITY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DEMYELINATION; ELECTRON MICROSCOPY; GENE EXPRESSION; HISTOLOGY; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; ISCHEMIC OPTIC NEUROPATHY; MOUSE; MOUSE STRAIN; NERVE DEGENERATION; NEUROPATHY; NICK END LABELING; NONHUMAN; OLIGODENDROGLIA; ONCOGENE C FOS; OPTIC NERVE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RETINA GANGLION CELL; RETINA NERVE CELL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STRESS; ANIMAL; APOPTOSIS; C57BL MOUSE; CONFOCAL MICROSCOPY; DISEASE MODEL; FLUORESCENCE ANGIOGRAPHY; GENETICS; METABOLISM; ONCOGENE; PATHOLOGY; RETINA; TRANSGENIC MOUSE;

MYELIN BASIC PROTEIN; PROTEIN C FOS;

ANIMALS; APOPTOSIS; DISEASE MODELS, ANIMAL; FLUORESCEIN ANGIOGRAPHY; GENES, FOS; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MICROSCOPY, CONFOCAL; MYELIN BASIC PROTEINS; OLIGODENDROGLIA; OPTIC NERVE; OPTIC NEUROPATHY, ISCHEMIC; PROTO-ONCOGENE PROTEINS C-FOS; RETINA; RETINAL GANGLION CELLS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 24644434478     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: 10.1167/iovs.04-0547     Document Type: Article

References (48)

1. Miller NR, Newman NJ. Walsh and Hoyt's Clinical Neuro-ophthalmology: the Essentials. 5th ed. Baltimore: Williams & Wilkins; 1999.
2. McLeod D, Marshall J, Kohner EM. Role of axoplasmic transport in the pathophysiology of ischaemic disc swelling. Br J Ophthalmol. 1980;64:247-261.
3. Hayreh SS. Blood supply of the optic nerve head and its role in optic atrophy, glaucoma, and oedema of the optic disc. Br J Ophthalmol. 1969;53:721-748.
4. Foulds WS, Chisholm IA, Stewart JB, Wilson TM. The optic neuropathy of pernicious anemia. Arch Ophthalmol. 1969;82:427-432.
5. Eagling EM, Sanders MD, Miller SJ. Ischaemic papillopathy: clinical and fluorescein angiographic review of forty cases. Br J Ophthalmol. 1974;58:990-1008.
6. Barron KD, Dentinger MP, Krohel G, Easton SK, Mankes R. Qualitative and quantitative ultrastructural observations on retinal ganglion cell layer of rat after intraorbital optic nerve crush. J Neurocytol. 1986;15:345-362.
7. Yoshida K, Behrens A, Le-Niculescu H, et al. Amino-terminal phosphorylation of c-Jun regulates apoptosis in the retinal ganglion cells by optic nerve transection. Invest Ophthalmol Vis Sci. 2002; 43:1631-1635.
8. Levin LA. Mechanisms of optic neuropathy. Curr Opin Ophthalmol. 1997;8:9-15.
9. Levkovitch-Verbin H, Harris-Cerruti C, Groner Y, Wheeler LA, Schwartz M, Yoles E. RGC death in mice after optic nerve crush injury: oxidative stress and neuroprotection. Invest Ophthalmol Vis Sci. 2000;41:4169-4174.
10. Selles-Navarro I, Ellezam B, Fajardo R, Latour M, McKerracher L. Retinal ganglion cell and nonneuronal cell responses to a microcrush lesion of adult rat optic nerve. Exp Neural. 2001;167:282-289.
11. Morrison JC, Moore CG, Deppmeier LM, Gold BG, Meshul CK, Johnson EC. A rat model of chronic pressure-induced optic nerve damage. Exp Eye Res. 1997;64:85-96.
12. Hayreh SS, Baines JA. Occlusion of the posterior ciliary artery. 3. Effects on the optic nerve head. Br J Ophthalmol. 1972;56:754-764.
13. Stys PK, Waxman SG, Ransom BR. Ionic mechanisms of anoxic injury in mammalian CNS white matter: role of Na+ channels and Na(+)-Ca2+ exchanger. J Neurosci. 1992;12:430-439.
14. Bernstein SL, Guo Y, Kelman SE, Flower RW, Johnson MA. Functional and cellular responses in a novel rodent model of anterior ischemic optic neuropathy. Invest Ophtbalmol Vis Sci. 2003;44:4153-4162.
15. Smeyne RJ, Vendrell M, Hayward M, et al. Continuous c-fos expression precedes programmed cell death in vivo. Nature. 1993; 363:166-169.
16. Oshitari T, Dezawa M, Okada S, et al. The role of c-fos in cell death and regeneration of retinal ganglion cells. Invest Ophthalmol Vis Sci. 2002;43:2442-2449.
17. Zhang J, Zhang D, McQuade JS, Behbehani M, Tsien JZ, Xu M. c-fos regulates neuronal excitability and survival. Nat Genet. 2002;30:416-420.
18. Hafezi F, Steinbach JP, Marti A, et al. The absence of c-fos prevents light-induced apoptotic cell death of photoreceptors in retinal degeneration in vivo. Nat Med. 1997;3:346-349.
19. Kasof GM, Mandelzys A, Maika SD, Hammer RE, Curran T, Morgan JI. Kainic acid-induced neuronal death is associated with DNA damage and a unique immediate-early gene response in c-fos-lacZ transgenic rats. J Neurosci. 1995;15:4238-4249.
20. Smeyne RJ, Schilling K, Robertson L, et al. Fos-lacZ transgenic mice: mapping sites of gene induction in the central nervous system. Neuron. 1992;8:13-23.
21. Sidman RI, Green MC. Retinal degeneration in mice. J Hered. 1965;56:23-29.
22. Smeyne RJ, Schilling K, Oberdick J, et al. A fos-lac Z transgenic mouse that can be used for neuroanatomic mapping. Adv Neurol. 1993;59:285-291.
23. Sheskin DJ. Handbook of Parametric and Nonparametric Statistical Procedures. 2nd ed. Oxford, UK: CRC Press, 2000.
24. Rice DS, Williams RW, Goldowitz D. Genetic control of retinal projections in inbred strains of albino mice. J Comp Neurol. 1995;354:459-469.
25. Knox DL, Kerrison JB, Green WR. Histopathologic studies of ischemic optic neuropathy. Trans Am Opbthalmol Soc. 2000;98:203-220.
26. Matsuno H, Uematsu T, Umemura K, et al. A simple and reproducible cerebral thrombosis model in rats induced by a photochemical reaction and the effect of a plasminogen-plasminogen activator chimera in this model. J Pharmacol Toxicol Methods. 1993;29:165-173.
27. Schlotzer-Schrehardt U, Viestenz A, Naumann GO, Laqua H, Michels S, Schmidt-Erfurth U. Dose-related structural effects of photodynamic therapy on choroidal and retinal structures of human eyes. Graefes Arch Clin Exp Ophthalmol. 2002;240:748-757.
28. Kikuchi S, Umemura K, Kondo K, Saniabadi AR, Nakashima M. Photochemically induced endothelial injury in the mouse as a screening model for inhibitors of vascular intimai thickening. Arterioscler Thromb Vasc Biol. 1998;18:1069-1078.
29. Frontczak-Baniewicz M. Focal ischemia in the cerebral cortex has an effect on the neurohypophysis. I. Ultrastructural changes in capillary vessels of the neurohypophysis after focal ischemia of the cerebral cortex. Neuroendocrinology. 2001;22:81-86.
30. Wilson CA, Saloupis P, Hatchell DL. Treatment of experimental preretinal neovascularization using photodynamic thrombosis. Invest Ophthalmol Vis Sci. 1991;32:2530-2535.
31. Schilling K, Luk D, Morgan JI, Curran T. Regulation of a fos-lacZ fusion gene: a paradigm for quantitative analysis of stimulus-transcription coupling. Proc Natl Acad Sci USA. 1991;88:5665-5669.
32. Cui J, Holmes EH, Liu PK. Oxidative damage to the c-fos gene and reduction of its transcription after focal cerebral ischemia. J Neurochem. 1999;73:1164-1174.
33. Dewar D, Underbill SM, Goldberg MP. Oligodendrocytes and ischemic brain injury. Cereb Blood Flow Metab. 2003;23:263-274.
34. Wakita H, Tomimoto H, Akiguchi I, et al. Axonal damage and demyelination in the white matter after chronic cerebral hypoperfusion in the rat. Brain Res. 2002;924:63-70.
35. Fern R, Moller T. Rapid ischemic cell death in immature Oligodendrocytes: a fatal glutamate release feedback loop. J Neurosci. 2000;20:34-42.
36. Lyons SA, Kettenmann H. Oligodendrocytes and microglia are selectively vulnerable to combined hypoxia and hypoglycemia injury in vitro. J Cereb Blood Flow Metab. 1998;18:521-530.
37. McDonald JW, Althomsons SP, Hyrc KL, Choi DW, Goldberg MP. Oligodendrocytes from forebrain are highly vulnerable to AMPA/kainate receptor-mediated excitotoxicity. Nat Med. 1998;4:291-297.
38. Meyer R, Weissert R, Diem R, et al. Acute neuronal apoptosis in a rat model of multiple sclerosis. J Neurosci. 2001;21:6214-6220.
39. Lappe-Siefke C, Goebbels S, Gravel M, et al. Disruption of Cnp1 uncouples oligodendroglial functions in axonal support and myelination. Nat Genet. 2003;33:366-374.
40. Matute C, Alberdi E, Domercq M, Perez-Cerda F, Perez-Samartin A, Sanchez-Gomez MV. The link between excitotoxic oligodendroglial death and demyelinating diseases. Trends Neurosci. 2001;24:224-230.
41. Lucchinetti C, Bruck W, Parisi J, Scheithauer B, Rodriguez M, Lassmann H. Heterogeneity of multiple sclerosis lesions: implications for the pathogenesis of demyelination. Ann Neurol. 2000; 47:707-717.
42. Knox DL, Duke JR. Slowly progressive ischemic optic neuropathy: a clinicopathologic case report. Trans Am Acad Ophthalmol Otolaryngol. 1971;75:1065-1068.
43. May CA, Lütjen-Drecoll E. Morphology of the murine optic nerve. Invest Ophthalmol Vis Sci. 2002;43:2206-2212.
44. Narciso MS, Hokoc JN, Martinez AM. Watery and dark axons in Wallerian degeneration of the opossum's optic nerve: different patterns of cytoskeletal breakdown? Ann Acad Bras Cienc. 2001; 73:231-243.
45. Tsao JW, George EB, Griffin JW. Temperature modulation reveals three distinct stages of Wallerian degeneration. J Neurosci. 1999; 19:4718-4726.
46. George R, Griffin JW. Delayed macrophage responses and myelin clearance during Wallerian degeneration in the central nervous system: the dorsal radiculotomy model. Exp Neurol. 1994;129:225-236.
47. Wang S, Villegas-Perez MP, Vidal-Sanz M, Lund RD. Progressive optic axon dystrophy and vascular changes in rd mice. Invest Ophthalmol Vis Sci. 2000;41:537-545.
48. Kipnis J, Yoles E, Porat Z, et al. T cell immunity to copolymer 1 confers neuroprotection on the damaged optic nerve: possible therapy for optic neuropathies. Proc Natl Acad Sci USA. 2000;20:7446-7451.