The role of thyroid hormone receptor DNA binding in negative thyroid hormone-mediated gene transcription

Journal of Molecular Endocrinology

Volumn 41, Issue 1-2, 2008, Pages 25-34

  Wulf, Anne ^a   Wetzel, Marianne G ^a   Kebenko, Maxim ^a   Kröger, Meike ^a   Harneit, Angelika ^a   Merz, Jennifer ^b   Weitzel, Joachim M ^a,b,c  

^a UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^c FBN Dummerstorf ^*  (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; GLYCEROL 3 PHOSPHATE DEHYDROGENASE; LIOTHYRONINE; THYROID HORMONE; THYROID HORMONE RECEPTOR; THYROTROPIN; TRANSCRIPTION FACTOR GAL4; DNA BINDING PROTEIN;

ANIMAL CELL; ARTICLE; CELL STRAIN HEPG2; CONTROLLED STUDY; DNA ISOLATION; DNA SEQUENCE; GENE CONTROL; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; MAMMAL; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA BINDING; PROTEIN DOMAIN; RAT; RECEPTOR INTRINSIC ACTIVITY; WESTERN BLOTTING; AMINO ACID SUBSTITUTION; CELL LINE; COMPARATIVE STUDY; DOWN REGULATION; GENETICS; METABOLISM; PHYSIOLOGY; PROTEIN BINDING; TUMOR CELL LINE; UPREGULATION;

AMINO ACID SUBSTITUTION; CELL LINE; CELL LINE, TUMOR; DNA, NEOPLASM; DNA-BINDING PROTEINS; DOWN-REGULATION; HUMANS; PROTEIN BINDING; RECEPTORS, THYROID HORMONE; TRANSCRIPTION, GENETIC; TRIIODOTHYRONINE; UP-REGULATION;

EID: 48949100589     PISSN: 09525041     EISSN: None     Source Type: Journal    
DOI: 10.1677/JME-08-0023     Document Type: Article

References (36)

1. Christiaens V, Bevan CL, Callewaert L, Haelens A, Verrijdt G, Rombauts W & Claessens F 2002 Characterization of the two coactivator-interacting surfaces of the androgen receptor and their relative role in transcriptional control. Journal of Biological Chemistry 277 49230-49237.
2. Feng X, Jiang Y, Meltzer P & Yen PM 2000 Thyroid hormone regulation of hepatic genes in vivo detected by complementary DNA microarray. Molecular Endocrinology 14 947-955.
3. Flores-Morales A, Gullberg H, Fernandez L, Stahlberg N, Lee NH, Vennstrom B & Norstedt G 2002 Patterns of liver gene expression governed by TRβ. Molecular Endocrinology 16 1257-1268.
4. Furumoto H, Ying H, Chandramouli GV, Zhao L, Walker RL, Meltzer PS, Willingham MC & Cheng SY 2005 An unliganded thyroid hormone beta receptor activates the cyclin D1/cyclin-dependent kinase/retinoblastoma/ E2F pathway and induces pituitary tumorigenesis. Molecular and Cellular Biology 25 124-135.
5. Hashimoto K, Yamada M, Matsumoto S, Monden T, Satoh T & Mori M 2006 Mouse sterol response element binding protein-1c gene expression is negatively regulated by thyroid hormone. Endocrinology 147 4292-4302.
6. Hiroi Y, Kim HH, Ying H, Furuya F, Huang Z, Simoncini T, Noma K, Ueki K, Nguyen NH, Scanlan TS et al. 2006 Rapid nongenomic actions of thyroid hormone. PNAS 103 14104-14109.
7. Iwasaki T, Takeshita A, Miyazaki W, Chin WW & Koibuchi N 2006 The interaction of TRbeta1-N terminus with steroid receptor coactivator-1 (SRC-1) serves a full transcriptional activation function of SRC-1. Endocrinology 147 1452-1457.
8. Kenessey A & Ojamaa K 2006 Thyroid hormone stimulates protein synthesis in the cardiomyocyte by activating the Akt-mTOR and p70S6K pathways. Journal of Biological Chemistry 281 20666-20672.
9. Kim SW, Hong SJ, Kim KM, Ho SC, So EC, Harney JW & Larsen PR 2004 A novel cell type-specific mechanism for thyroid hormone-dependent negative regulation of the human type 1 deiodinase gene. Molecular Endocrinology 18 2924-2936.
10. Kim SW, Ho SC, Hong SJ, Kim KM, So EC, Christoffolete M & Harney JW 2005 A novel mechanism of thyroid hormone-dependent negative regulation by thyroid hormone receptor, nuclear receptor corepressor (NCoR), and GAGA-binding factor on the rat cD44 promoter. Journal of Biological Chemistry 280 14545-14555.
11. Lazar MA 2003 Thyroid hormone action: a binding contract. Journal of Clinical Investigation 112 497-499.
12. Liu Y, Takeshita A, Nagaya T, Baniahmad A, Chin WW & Yen PM 1998 An inhibitory region of the DNA-binding domain of thyroid hormone receptor blocks hormone-dependent transactivation. Molecular Endocrinology 12 34-44.
13. Matsushita A, Sasaki S, Kashiwabara Y, Nagayama K, Ohba K, Iwaki H, Misawa H, Ishizuka K & Nakamura H 2007 Essential role of GATA2 in the negative regulation of thyrotropin beta gene by thyroid hormone and its receptors. Molecular Endocrinology 21 865-884.
14. Mendez-Pertuz M, Sanchez-Pacheco A & Aranda A 2003 The thyroid hormone receptor antagonizes CREB-mediated transcription. EMBO Journal 22 3102-3112.
15. Miller LD, Park KS, Guo QM, Alkharouf NW, Malek RL, Lee NH, Liu ET & Cheng SY 2001 Silencing of Wnt signaling and activation of multiple metabolic pathways in response to thyroid hormone-stimulated cell proliferation. Molecular and Cellular Biology 21 6626-6639.
16. Moeller LC, Dumitrescu AM & Refetoff S 2005 Cytosolic action of thyroid hormone leads to induction of hypoxia-inducible factor-1alpha and glycolytic genes. Molecular Endocrinology 19 2955-2963.
17. Nakano K, Matsushita A, Sasaki S, Misawa H, Nishiyama K, Kashiwabara Y & Nakamura H 2004 Thyroid-hormone-dependent negative regulation of thyrotropin beta gene by thyroid hormone receptors: study with a new experimental system using CV1 cells. Biochemical Journal 378 549-557.
18. Nygard M, Becker N, Demeneix B, Pettersson K & Bondesson M 2006 Thyroid hormone-mediated negative transcriptional regulation of Necdin expression. Journal of Molecular Endocrinology 36 517-530.
19. Poirier MB, Hamann G, Domingue ME, Roy M, Bardati T & Langlois MF 2005 General receptor for phosphoinositides 1, a novel repressor of thyroid hormone receptor action that prevents deoxyribonucleic acid binding. Molecular Endocrinology 19 1991-2005.
20. Reichardt HM, Kaestner KH, Tuckermann J, Kretz O, Wessely O, Bock R, Gass P, Schmid W, Herrlich P, Angel P et al. 1998 DNA binding of the glucocorticoid receptor is not essential for survival. Cell 93 531-541.
21. Rosenfeld MG, Lunyak VV & Glass CK 2006 Sensors and signals: a coactivator/ corepressor/ epigenetic code for integrating signal-dependent programs of transcriptional response. Genes and Development 20 1405-1428.
22. Sanchez-Pacheco A, Palomino T & Aranda A 1995 Negative regulation of expression of the pituitary-specific transcription factor GHF-1/Pit-1 by thyroid hormones through interference with promoter enhancer elements. Molecular and Cellular Biology 15 6322-6330.
23. Santos GM, Afonso V, Barra GB, Togashi M, Webb P, Neves FA, Lomri N & Lomri A 2006 Negative regulation of superoxide dismutase-1 promoter by thyroid hormone. Molecular Pharmacology 70 793-800.
24. Sasaki S, Lesoon-Wood LA, Dey A, Kuwata T, Weintraub BD, Humphrey G, Yang WM, Seto E, Yen PM, Howard BH et al. 1999 Ligand-induced recruitment of a histone deacetylase in the negative-feedback regulation of the thyrotropin beta gene. EMBO Journal 18 5389-5398.
25. Satoh T, Monden T, Ishizuka T, Mitsuhashi T, Yamada M & Mori M 1999 DNA binding and interaction with the nuclear receptor corepressor of thyroid hormone receptor are required for ligand-independent stimulation of the mouse preprothyrotropin-releasing hormone gene. Molecular and Cellular Endocrinology 154 137-149.
26. Shibusawa N, Hollenberg AN & Wondisford FE 2003a Thyroid hormone receptor DNA binding is required for both positive and negative gene regulation. Journal of Biological Chemistry 278 732-738.
27. Shibusawa N, Hashimoto K, Nikrodhanond AA, Liberman MC, Applebury ML, Liao XH, Robbins JT, Refetoff S, Cohen RN & Wondisford FE 2003b Thyroid hormone action in the absence of thyroid hormone receptor DNA-binding in vivo. Journal of Clinical Investigation 112 588-597.
28. Storey NM, Gentile S, Ullah H, Russo A, Muessel M, Erxleben C & Armstrong DL 2006 Rapid signaling at the plasma membrane by a nuclear receptor for thyroid hormone. PNAS 103 5197-5201.
29. Tagami T, Park Y & Jameson JL 1999 Mechanisms that mediate negative regulation of the thyroid-stimulating hormone alpha gene by the thyroid hormone receptor. Journal of Biological Chemistry 274 22345-22353.
30. Villa A, Santiago J, Belandia B & Pascual A 2004 A response unit in the first exon of the beta-amyloid precursor protein gene containing thyroid hormone receptor and Sp1 binding sites mediates negative regulation by 3,5,3′-triiodothyronine. Molecular Endocrinology 18 863-873.
31. Weitzel JM, Radtke C & Seitz HJ 2001 a Two thyroid hormone-mediated gene expression patterns in vivo identified by cDNA expression arrays in rat. Nucleic Acids Research 29 5148-5155.
32. Weitzel JM, Kutz S, Radtke C, Grott S & Seitz HJ 2001b Hormonal regulation of multiple promoters of the rat mitochondrial glycerol-3-phosphate dehydrogenase gene: identification of a complex hormone-response element in the ubiquitous promoter B. European Journal of Biochemistry 268 4095-4103.
33. Weitzel JM, Hamann S, Jauk M, Lacey M, Filbry A, Radtke C, Iwen KA, Kutz S, Harneit A, Lizardi PM et al. 2003 Hepatic gene expression patterns in thyroid hormone-treated hypothyroid rats. Journal of Molecular Endocrinology 31 291-303.
34. Wulf A, Harneit A & Weitzel JM 2007 T3-mediated gene expression is iodependent of PGC-1alpha. Molecular and Cellular Endocrinology 270 57-63.
35. Yen PM 2001 Physiological and molecular basis of thyroid hormone action. Physiological Reviews 81 1097-1142.
36. Zhang J & Lazar MA 2000 The mechanism of action of thyroid hormones. Annual Review of Physiology 62 439-466.