Discovery of imidazole vinyl pyrimidines as a novel class of kinase inhibitors which inhibit Tie-2 and are orally bioavailable

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 16, 2008, Pages 4723-4726

  Buttar, David ^a   Edge, Mike ^a   Emery, Steve C ^a   Fitzek, Martina ^a   Forder, Cheryl ^a   Griffen, Alison ^a   Hayter, Barry ^a   Hayward, Chris F ^a   Hopcroft, Philip J ^a   Luke, Richard W A ^a   Page, Ken ^a   Stawpert, John ^a   Wright, Andy ^a  

^a ASTRAZENECA   (United Kingdom)

Author keywords

Alkene; Angiogenesis; Imidazole; Inhibitor; Kinase; Pyrimidine; Tie 2

Indexed keywords

ALDEHYDE DERIVATIVE; ANGIOPOIETIN RECEPTOR; PHOSPHOTRANSFERASE INHIBITOR; PYRIMIDINE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; DRUG BIOAVAILABILITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; POLYMERIZATION; RAT;

ADMINISTRATION, ORAL; BIOLOGICAL AVAILABILITY; CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; HUMANS; IMIDAZOLES; INHIBITORY CONCENTRATION 50; MODELS, CHEMICAL; MOLECULAR CONFORMATION; NEOVASCULARIZATION, PATHOLOGIC; PROTEIN KINASE INHIBITORS; PYRIMIDINES; RECEPTOR, TIE-2; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 48849109469     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.06.106     Document Type: Article

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