IFN-γ acts as anti-angiogenic cytokine in the human cornea by regulating the expression of VEGF-A and sVEGF-R1

Biochemical and Biophysical Research Communications

Volumn 374, Issue 3, 2008, Pages 479-484

  Kommineni, Vijay K ^a   Nagineni, Chandrasekharam N ^a   William, Abitha ^a   Detrick, Barbara ^b   Hooks, John J ^a  

^a NATIONAL EYE INSTITUTE   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cornea; Corneal neovascularization; Fibroblasts; IFN ; IL 1; Inflammation; sVEGF R1; TNF ; VEGF A

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 1; JANUS KINASE; MESSENGER RNA; STAT PROTEIN; TUMOR NECROSIS FACTOR ALPHA; VASCULOTROPIN A; VASCULOTROPIN RECEPTOR 1;

ARTICLE; CONTROLLED STUDY; CORNEA; CORNEA NEOVASCULARIZATION; FIBROBLAST; HUMAN; HUMAN CELL; INFLAMMATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

CELL LINE; CORNEA; CORNEAL NEOVASCULARIZATION; FIBROBLASTS; HUMANS; INTERFERON TYPE II; INTERLEUKIN-1; JANUS KINASE 1; RECEPTOR, FIBROBLAST GROWTH FACTOR, TYPE 1; RNA, MESSENGER; TRANSFORMING GROWTH FACTOR BETA; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 48849104244     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2008.07.042     Document Type: Article

References (24)

1. Azar D.T. Corneal angiogenic privilege: angiogenic and antiangiogenic factors in corneal avascularity vasculogenesis, and wound healing (an American Ophthalmological Society thesis). Trans. Am. Ophthalmol. Soc. 104 (2006) 264-302
2. Zhang S.X., and Ma J.X. Ocular neovascularization: implication of endogenous angiogenic inhibitors and potential therapy. Prog. Retin. Eye Res. 26 (2007) 1-37
3. Ambati B.K., Patterson E., Jani P., Jenkins C., Higgins E., Singh N., Suthar T., Vira N., Smith K., and Caldwell R. Soluble vascular endothelial growth factor receptor-1 contributes to the corneal antiangiogenic barrier. Br. J. Ophthalmol. 91 (2007) 505-508
4. Cursiefen C., Kuchle M., and Naumann G.O. Angiogenesis in corneal diseases: histopathologic evaluation of 254 human corneal buttons with neovascularization. Cornea 17 (1998) 611-613
5. Cursiefen C., Rummelt C., and Kuchle M. Immunohistochemical localization of vascular endothelial growth factor, transforming growth factor alpha, and transforming growth factor beta1 in human corneas with neovascularization. Cornea 19 (2000) 526-533
6. Philipp W., Speicher L., and Humpel C. Expression of vascular endothelial growth factor and its receptors in inflamed and vascularized human corneas. Invest. Ophthalmol. Vis. Sci. 41 (2000) 2514-2522
7. Lai C.M., Brankov M., Zaknich T., Lai Y.K., Shen W.Y., Constable I.J., Kovesdi I., and Rakoczy P.E. Inhibition of angiogenesis by adenovirus-mediated sFlt-1 expression in a rat model of corneal neovascularization. Hum. Gene Ther. 12 (2001) 1299-1310
8. Yu H., Wu J., Li H., Wang Z., Chen X., Tian Y., Yi M., Ji X., Ma J., and Huang Q. Inhibition of corneal neovascularization by recombinant adenovirus-mediated sFlk-1 expression. Biochem. Biophys. Res. Commun. 361 (2007) 946-952
9. Ferrara N., Gerber H.P., and LeCouter J. The biology of VEGF and its receptors. Nat. Med. 9 (2003) 669-676
10. Araki-Sasaki K., Ohashi Y., Sasabe T., Hayashi K., Watanabe H., Tano Y., and Handa H. An SV40-immortalized human corneal epithelial cell line and its characterization. Invest. Ophthalmol. Vis. Sci. 36 (1995) 614-621
11. Djalilian A.R., Nagineni C.N., Mahesh S.P., Smith J.A., Nussenblatt R.B., and Hooks J.J. Inhibition of inflammatory cytokine production in human corneal cells by dexamethasone, but not cyclosporin. Cornea 25 (2006) 709-714
12. Kendall R.L., and Thomas K.A. Inhibition of vascular endothelial cell growth factor activity by an endogenously encoded soluble receptor. Proc. Natl. Acad. Sci. USA 90 (1993) 10705-10709
13. Nagineni C.N., Samuel W., Nagineni S., Pardhasaradhi K., Wiggert B., Detrick B., and Hooks J.J. Transforming growth factor-beta induces expression of vascular endothelial growth factor in human retinal pigment epithelial cells: involvement of mitogen-activated protein kinases. J. Cell. Physiol. 197 (2003) 453-462
14. Thompson J.E., Cubbon R.M., Cummings R.T., Wicker L.S., Frankshun R., Cunningham B.R., Cameron P.M., Meinke P.T., Liverton N., Weng Y., and DeMartino J.A. Photochemical preparation of a pyridone containing tetracycle: a Jak protein kinase inhibitor. Bioorg. Med. Chem. Lett. 12 (2002) 1219-1223
15. Nagineni C.N., Cherukuri K.S., Kutty V., Detrick B., and Hooks J.J. Interferon-gamma differentially regulates TGF-beta1 and TGF-beta2 expression in human retinal pigment epithelial cells through JAK-STAT pathway. J. Cell. Physiol. 210 (2007) 192-200
16. Sawyer J.S., Anderson B.D., Beight D.W., Campbell R.M., Jones M.L., Herron D.K., Lampe J.W., McCowan J.R., McMillen W.T., Mort N., Parsons S., Smith E.C., Vieth M., Weir L.C., Yan L., Zhang F., and Yingling J.M. Synthesis and activity of new aryl- and heteroaryl-substituted pyrazole inhibitors of the transforming growth factor-beta type I receptor kinase domain. J. Med. Chem. 46 (2003) 3953-3956
17. Biswas P.S., and Rouse B.T. Early events in HSV keratitis-setting the stage for a blinding disease. Microbes Infect. 7 (2005) 799-810
18. Lee P., Wang C.C., and Adamis A.P. Ocular neovascularization: an epidemiologic review. Surv. Ophthalmol. 43 (1998) 245-269
19. Friling R., Yassur Y., Levy R., Kost J., Schwartz B., Mikhailowsky R., and Lamprecht S.A. A role of transforming growth factor-beta 1 in the control of corneal neovascularization. In Vivo 10 (1996) 59-64
20. Sakamoto T., Ueno H., Sonoda K., Hisatomi T., Shimizu K., Ohashi H., and Inomata H. Blockade of TGF-beta by in vivo gene transfer of a soluble TGF-beta type II receptor in the muscle inhibits corneal opacification, edema and angiogenesis. Gene Ther. 7 (2000) 1915-1924
21. Nakao S., Hata Y., Miura M., Noda K., Kimura Y.N., Kawahara S., Kita T., Hisatomi T., Nakazawa T., Jin Y., Dana M.R., Kuwano M., Ono M., Ishibashi T., and Hafezi- Moghadam A. Dexamethasone inhibits interleukin-1beta-induced corneal neovascularization: role of nuclear factor-kappaB-activated stromal cells in inflammatory angiogenesis. Am. J. Pathol. 171 (2007) 1058-1065
22. Shibuya M. Vascular endothelial growth factor receptor-1 (VEGFR-1/Flt-1): a dual regulator for angiogenesis. Angiogenesis 9 (2006) 225-230 (discussion 231)
23. Sunderkotter C., Steinbrink K., Goebeler M., Bhardwaj R., and Sorg C. Macrophages and angiogenesis. J. Leukoc. Biol. 55 (1994) 410-422
24. Voest E.E., Kenyon B.M., O'Reilly M.S., Truitt G., D'Amato R.J., and Folkman J. Inhibition of angiogenesis in vivo by interleukin 12. J. Natl. Cancer Inst. 87 (1995) 581-586