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Volumn 314, Issue 14, 2008, Pages 2652-2660

Mutations in the AF-2 region abolish ligand-induced intranuclear immobilization of the liver X receptor α

Author keywords

Activation function 2; DNA binding; Fluorescence recovery after photobleaching (FRAP); Liver X receptor; Nuclear receptor; Permeabilization; Trafficking

Indexed keywords

LIGAND; LIVER X RECEPTOR ALPHA; TRITON X 100; YELLOW FLUORESCENT PROTEIN;

EID: 48849095817     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.yexcr.2008.05.005     Document Type: Article
Times cited : (5)

References (39)
  • 1
    • 0029805887 scopus 로고    scopus 로고
    • An oxysterol signalling pathway mediated by the nuclear receptor LXR alpha
    • Janowski B.A., Willy P.J., Devi T.R., Falck J.R., and Mangelsdorf D.J. An oxysterol signalling pathway mediated by the nuclear receptor LXR alpha. Nature 383 (1996) 728-731
    • (1996) Nature , vol.383 , pp. 728-731
    • Janowski, B.A.1    Willy, P.J.2    Devi, T.R.3    Falck, J.R.4    Mangelsdorf, D.J.5
  • 4
    • 0013199471 scopus 로고    scopus 로고
    • Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha
    • Peet D.J., Turley S.D., Ma W., Janowski B.A., Lobaccaro J.M., Hammer R.E., and Mangelsdorf D.J. Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha. Cell 93 (1998) 693-704
    • (1998) Cell , vol.93 , pp. 693-704
    • Peet, D.J.1    Turley, S.D.2    Ma, W.3    Janowski, B.A.4    Lobaccaro, J.M.5    Hammer, R.E.6    Mangelsdorf, D.J.7
  • 7
  • 8
    • 33847006599 scopus 로고    scopus 로고
    • The Liver X Receptor (LXR) and Hepatic Lipogenesis: the carbohydrate-response element-binding protein is a target gene of LXR
    • Cha J.Y., and Repa J.J. The Liver X Receptor (LXR) and Hepatic Lipogenesis: the carbohydrate-response element-binding protein is a target gene of LXR. J. Biol. Chem. 282 (2007) 743-751
    • (2007) J. Biol. Chem. , vol.282 , pp. 743-751
    • Cha, J.Y.1    Repa, J.J.2
  • 9
    • 0033951112 scopus 로고    scopus 로고
    • Structural characterisation of the mouse nuclear oxysterol receptor genes LXRalpha and LXRbeta
    • Alberti S., Steffensen K.R., and Gustafsson J.A. Structural characterisation of the mouse nuclear oxysterol receptor genes LXRalpha and LXRbeta. Gene 243 (2000) 93-103
    • (2000) Gene , vol.243 , pp. 93-103
    • Alberti, S.1    Steffensen, K.R.2    Gustafsson, J.A.3
  • 11
    • 33845658998 scopus 로고    scopus 로고
    • Nuclear localization of liver X receptor alpha and beta is differentially regulated
    • Prufer K., and Boudreaux J. Nuclear localization of liver X receptor alpha and beta is differentially regulated. J. Cell. Biochem. 100 (2007) 69-85
    • (2007) J. Cell. Biochem. , vol.100 , pp. 69-85
    • Prufer, K.1    Boudreaux, J.2
  • 13
    • 33646204900 scopus 로고    scopus 로고
    • A novel principle for partial agonism of liver X receptor ligands. Competitive recruitment of activators and repressors
    • Albers M., Blume B., Schlueter T., Wright M.B., Kober I., Kremoser C., Deuschle U., and Koegl M. A novel principle for partial agonism of liver X receptor ligands. Competitive recruitment of activators and repressors. J. Biol. Chem. 281 (2006) 4920-4930
    • (2006) J. Biol. Chem. , vol.281 , pp. 4920-4930
    • Albers, M.1    Blume, B.2    Schlueter, T.3    Wright, M.B.4    Kober, I.5    Kremoser, C.6    Deuschle, U.7    Koegl, M.8
  • 14
    • 34547902154 scopus 로고    scopus 로고
    • Orchestration of chromatin-based processes: mind the TRRAP
    • Murr R., Vaissiere T., Sawan C., Shukla V., and Herceg Z. Orchestration of chromatin-based processes: mind the TRRAP. Oncogene 26 (2007) 5358-5372
    • (2007) Oncogene , vol.26 , pp. 5358-5372
    • Murr, R.1    Vaissiere, T.2    Sawan, C.3    Shukla, V.4    Herceg, Z.5
  • 15
    • 0037418589 scopus 로고    scopus 로고
    • Transcriptional activation: getting a grip on condensed chromatin
    • Peterson C.L. Transcriptional activation: getting a grip on condensed chromatin. Curr. Biol. 13 (2003) R195-R197
    • (2003) Curr. Biol. , vol.13
    • Peterson, C.L.1
  • 17
    • 14544308853 scopus 로고    scopus 로고
    • Composition and functional specificity of SWI2/SNF2 class chromatin remodeling complexes
    • Mohrmann L., and Verrijzer C.P. Composition and functional specificity of SWI2/SNF2 class chromatin remodeling complexes. Biochim. Biophys. Acta 1681 (2005) 59-73
    • (2005) Biochim. Biophys. Acta , vol.1681 , pp. 59-73
    • Mohrmann, L.1    Verrijzer, C.P.2
  • 18
    • 0343632400 scopus 로고    scopus 로고
    • Ligand-dependent interaction between the estrogen receptor and the human homologues of SWI2/SNF2
    • Ichinose H., Garnier J.M., Chambon P., and Losson R. Ligand-dependent interaction between the estrogen receptor and the human homologues of SWI2/SNF2. Gene 188 (1997) 95-100
    • (1997) Gene , vol.188 , pp. 95-100
    • Ichinose, H.1    Garnier, J.M.2    Chambon, P.3    Losson, R.4
  • 19
    • 0036683485 scopus 로고    scopus 로고
    • Targeting of SWI/SNF chromatin remodelling complexes to estrogen-responsive genes
    • Belandia B., Orford R.L., Hurst H.C., and Parker M.G. Targeting of SWI/SNF chromatin remodelling complexes to estrogen-responsive genes. EMBO J. 21 (2002) 4094-4103
    • (2002) EMBO J. , vol.21 , pp. 4094-4103
    • Belandia, B.1    Orford, R.L.2    Hurst, H.C.3    Parker, M.G.4
  • 20
    • 33747366671 scopus 로고    scopus 로고
    • The SWI/SNF chromatin remodeling subunit BAF57 is a critical regulator of estrogen receptor function in breast cancer cells
    • Garcia-Pedrero J.M., Kiskinis E., Parker M.G., and Belandia B. The SWI/SNF chromatin remodeling subunit BAF57 is a critical regulator of estrogen receptor function in breast cancer cells. J. Biol. Chem. 281 (2006) 22656-22664
    • (2006) J. Biol. Chem. , vol.281 , pp. 22656-22664
    • Garcia-Pedrero, J.M.1    Kiskinis, E.2    Parker, M.G.3    Belandia, B.4
  • 21
    • 0035924326 scopus 로고    scopus 로고
    • Selectivity of chromatin-remodelling cofactors for ligand-activated transcription
    • Lemon B., Inouye C., King D.S., and Tjian R. Selectivity of chromatin-remodelling cofactors for ligand-activated transcription. Nature 414 (2001) 924-928
    • (2001) Nature , vol.414 , pp. 924-928
    • Lemon, B.1    Inouye, C.2    King, D.S.3    Tjian, R.4
  • 22
    • 0029030016 scopus 로고
    • The N-terminal part of TIF1, a putative mediator of the ligand-dependent activation function (AF-2) of nuclear receptors, is fused to B-raf in the oncogenic protein T18
    • Le Douarin B., Zechel C., Garnier J.M., Lutz Y., Tora L., Pierrat P., Heery D., Gronemeyer H., Chambon P., and Losson R. The N-terminal part of TIF1, a putative mediator of the ligand-dependent activation function (AF-2) of nuclear receptors, is fused to B-raf in the oncogenic protein T18. EMBO J. 14 (1995) 2020-2033
    • (1995) EMBO J. , vol.14 , pp. 2020-2033
    • Le Douarin, B.1    Zechel, C.2    Garnier, J.M.3    Lutz, Y.4    Tora, L.5    Pierrat, P.6    Heery, D.7    Gronemeyer, H.8    Chambon, P.9    Losson, R.10
  • 23
    • 29244464325 scopus 로고    scopus 로고
    • Glucocorticoid receptor mutants demonstrate increased motility inside the nucleus of living cells: time of fluorescence recovery after photobleaching (FRAP) is an integrated measure of receptor function
    • Kino T., Liou S.H., Charmandari E., and Chrousos G.P. Glucocorticoid receptor mutants demonstrate increased motility inside the nucleus of living cells: time of fluorescence recovery after photobleaching (FRAP) is an integrated measure of receptor function. Mol. Med. 10 (2004) 80-88
    • (2004) Mol. Med. , vol.10 , pp. 80-88
    • Kino, T.1    Liou, S.H.2    Charmandari, E.3    Chrousos, G.P.4
  • 24
    • 12144290835 scopus 로고    scopus 로고
    • Rapid glucocorticoid receptor exchange at a promoter is coupled to transcription and regulated by chaperones and proteasomes
    • Stavreva D.A., Muller W.G., Hager G.L., Smith C.L., and McNally J.G. Rapid glucocorticoid receptor exchange at a promoter is coupled to transcription and regulated by chaperones and proteasomes. Mol. Cell. Biol. 24 (2004) 2682-2697
    • (2004) Mol. Cell. Biol. , vol.24 , pp. 2682-2697
    • Stavreva, D.A.1    Muller, W.G.2    Hager, G.L.3    Smith, C.L.4    McNally, J.G.5
  • 25
    • 0142093080 scopus 로고    scopus 로고
    • Compartment-specific phosphorylation of rat thyroid hormone receptor alpha1 regulates nuclear localization and retention
    • Nicoll J.B., Gwinn B.L., Iwig J.S., Garcia P.P., Bunn C.F., and Allison L.A. Compartment-specific phosphorylation of rat thyroid hormone receptor alpha1 regulates nuclear localization and retention. Mol. Cell. Endocrinol. 205 (2003) 65-77
    • (2003) Mol. Cell. Endocrinol. , vol.205 , pp. 65-77
    • Nicoll, J.B.1    Gwinn, B.L.2    Iwig, J.S.3    Garcia, P.P.4    Bunn, C.F.5    Allison, L.A.6
  • 28
    • 0026600841 scopus 로고
    • Identification of a conserved region required for hormone dependent transcriptional activation by steroid hormone receptors
    • Danielian P.S., White R., Lees J.A., and Parker M.G. Identification of a conserved region required for hormone dependent transcriptional activation by steroid hormone receptors. EMBO J. 11 (1992) 1025-1033
    • (1992) EMBO J. , vol.11 , pp. 1025-1033
    • Danielian, P.S.1    White, R.2    Lees, J.A.3    Parker, M.G.4
  • 29
    • 25444529284 scopus 로고    scopus 로고
    • The human ABCG1 gene: identification of LXR response elements that modulate expression in macrophages and liver
    • Sabol S.L., Brewer Jr. H.B., and Santamarina-Fojo S. The human ABCG1 gene: identification of LXR response elements that modulate expression in macrophages and liver. J. Lipid Res. 46 (2005) 2151-2167
    • (2005) J. Lipid Res. , vol.46 , pp. 2151-2167
    • Sabol, S.L.1    Brewer Jr., H.B.2    Santamarina-Fojo, S.3
  • 30
    • 0037072809 scopus 로고    scopus 로고
    • Increased hepatobiliary and fecal cholesterol excretion upon activation of the liver X receptor is independent of ABCA1
    • Plosch T., Kok T., Bloks V.W., Smit M.J., Havinga R., Chimini G., Groen A.K., and Kuipers F. Increased hepatobiliary and fecal cholesterol excretion upon activation of the liver X receptor is independent of ABCA1. J. Biol. Chem. 277 (2002) 33870-33877
    • (2002) J. Biol. Chem. , vol.277 , pp. 33870-33877
    • Plosch, T.1    Kok, T.2    Bloks, V.W.3    Smit, M.J.4    Havinga, R.5    Chimini, G.6    Groen, A.K.7    Kuipers, F.8
  • 32
    • 0036020491 scopus 로고    scopus 로고
    • Retinoid X receptor dominates the nuclear import and export of the unliganded vitamin D receptor
    • Prufer K., and Barsony J. Retinoid X receptor dominates the nuclear import and export of the unliganded vitamin D receptor. Mol. Endocrinol. 16 (2002) 1738-1751
    • (2002) Mol. Endocrinol. , vol.16 , pp. 1738-1751
    • Prufer, K.1    Barsony, J.2
  • 33
    • 0343415609 scopus 로고    scopus 로고
    • The glucocorticoid receptor: rapid exchange with regulatory sites in living cells
    • McNally J.G., Muller W.G., Walker D., Wolford R., and Hager G.L. The glucocorticoid receptor: rapid exchange with regulatory sites in living cells. Science 287 (2000) 1262-1265
    • (2000) Science , vol.287 , pp. 1262-1265
    • McNally, J.G.1    Muller, W.G.2    Walker, D.3    Wolford, R.4    Hager, G.L.5
  • 35
    • 0037372002 scopus 로고    scopus 로고
    • Molecular determinants of glucocorticoid receptor mobility in living cells: the importance of ligand affinity
    • Schaaf M.J., and Cidlowski J.A. Molecular determinants of glucocorticoid receptor mobility in living cells: the importance of ligand affinity. Mol. Cell. Biol. 23 (2003) 1922-1934
    • (2003) Mol. Cell. Biol. , vol.23 , pp. 1922-1934
    • Schaaf, M.J.1    Cidlowski, J.A.2
  • 36
    • 0037621888 scopus 로고    scopus 로고
    • Transcriptional activation by thyroid hormone receptor-beta involves chromatin remodeling, histone acetylation, and synergistic stimulation by p300 and steroid receptor coactivators
    • Lee K.C., Li J., Cole P.A., Wong J., and Kraus W.L. Transcriptional activation by thyroid hormone receptor-beta involves chromatin remodeling, histone acetylation, and synergistic stimulation by p300 and steroid receptor coactivators. Mol. Endocrinol. 17 (2003) 908-922
    • (2003) Mol. Endocrinol. , vol.17 , pp. 908-922
    • Lee, K.C.1    Li, J.2    Cole, P.A.3    Wong, J.4    Kraus, W.L.5
  • 37
    • 0037150683 scopus 로고    scopus 로고
    • Disassembly of transcriptional regulatory complexes by molecular chaperones
    • Freeman B.C., and Yamamoto K.R. Disassembly of transcriptional regulatory complexes by molecular chaperones. Science 296 (2002) 2232-2235
    • (2002) Science , vol.296 , pp. 2232-2235
    • Freeman, B.C.1    Yamamoto, K.R.2
  • 39
    • 20144364213 scopus 로고    scopus 로고
    • Activation of ATP-binding cassette transporter A1 transcription by chromatin remodeling complex
    • Huuskonen J., Vishnu M., Fielding P.E., and Fielding C.J. Activation of ATP-binding cassette transporter A1 transcription by chromatin remodeling complex. Arterioscler.Thromb.Vasc.Biol. 25 (2005) 1180-1185
    • (2005) Arterioscler.Thromb.Vasc.Biol. , vol.25 , pp. 1180-1185
    • Huuskonen, J.1    Vishnu, M.2    Fielding, P.E.3    Fielding, C.J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.