A natural PPAR-γ agonist, 15-deoxy-delta 12,14-prostaglandin J2, may act as an enhancer of PAI-1 in human proximal renal tubular cells under hypoxic and inflammatory conditions

Nephrology Dialysis Transplantation

Volumn 23, Issue 8, 2008, Pages 2496-2503

  Kimura, Hideki ^a   Li, Xuan ^a   Torii, Kunio ^a   Okada, Toshiharu ^a   Takahashi, Naoki ^a   Fujii, Hiroshi ^b   Ishihara, Shunji ^c   Yoshida, Haruyoshi ^a  

^a UNIVERSITY OF FUKUI   (Japan)

^b NIIGATA UNIVERSITY   (Japan)

^c SHIMANE UNIVERSITY FACULTY OF MEDICINE   (Japan)

Author keywords

15d PGJ2; Human proximal tubular cells; Hypoxia; PAI 1; PPAR

Indexed keywords

15 DEOXY DELTA 12,14 PROSTAGLANDIN J2; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 CHLORO 5 NITROBENZANILIDE; GENISTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA AGONIST; PIOGLITAZONE; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROSTAGLANDIN J2; PROTEIN TYROSINE KINASE INHIBITOR;

ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; HUMAN; HUMAN CELL; HYPOXIA; KIDNEY TUBULE CELL; NEPHRITIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL;

CELL HYPOXIA; CELLS, CULTURED; FLAVONOIDS; GENISTEIN; HUMANS; INFLAMMATION; KIDNEY TUBULES, PROXIMAL; MAP KINASE KINASE 1; PLASMINOGEN ACTIVATOR INHIBITOR 1; PPAR GAMMA; PROSTAGLANDIN D2; PROTEIN KINASE INHIBITORS; PROTEIN-TYROSINE KINASES; THIAZOLIDINEDIONES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 48749125609     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gfn139     Document Type: Article

References (39)

1. Eddy AA. Plasminogen activator inhibitor-1 and the kidney. Am J Physiol Renal Physiol 2002; 283: F209-F220
2. Moll S, Menoud PA, Fulpius T et al. Induction of plasminogen activator inhibitor type 1 in murine lupus-like glomerulonephritis. Kidney Int 1995; 48: 1459-1468
3. Rondeau E, Mougenot B, Lacave R et al. Plasminogen activator inhibitor 1 in renal fibrin deposits of human nephropathies. Clin Nephrol 1990; 33: 55-60
4. Feng L, Tang WW, Loskutoff DJ et al. Dysfunction of glomerular fibrinolysis in experimental antiglomerular basement membrane antibody glomerulonephritis. J Am Soc Nephrol 1993; 3: 1753-1764
5. Yamamoto T, Nakamura T, Noble NA et al. Expression of transforming growth factor beta is elevated in human and experimental diabetic nephropathy. Proc Natl Acad Sci USA 1993; 90: 1814-1818
6. Revelo MP, Federspiel C, Helderman H et al. Chronic allograft nephropathy: expression and localization of PAI-1 and PPAR-gamma. Nephrol Dial Transplant 2005; 20: 2812-2819
7. Oda T, Jung YO, Kim HS et al. PAI-1 deficiency attenuates the fibrogenic response to ureteral obstruction. Kidney Int 2001; 60: 587-596
8. Nicholas SB, Aguiniga E, Ren Y et al. Plasminogen activator inhibitor-1 deficiency retards diabetic nephropathy. Kidney Int 2005; 67: 1297-1307
9. Meulders Q, He CJ, Adida C et al. Tumor necrosis factor alpha increases antifibrinolytic activity of cultured human mesangial cells. Kidney Int 1992; 42: 327-334
10. Kanalas JJ, Hopfer U. Effect of TGF-beta 1 and TNF-alpha on the plasminogen system of rat proximal tubular epithelial cells. J Am Soc Nephrol 1997; 8: 184-192
11. Nordt TK, Klassen KJ, Schneider DJ et al. Augmentation of synthesis of plasminogen activator inhibitor type-1 in arterial endothelial cells by glucose and its implications for local fibrinolysis. Arterioscler Thromb 1993; 13: 1822-1828
12. Li X, Kimura H, Hirota K et al. Synergistic effect of hypoxia and TNF-alpha on production of PAI-1 in human proximal renal tubular cells. Kidney Int 2005; 68: 569-583
13. Nangaku M. Chronic hypoxia and tubulointerstitial injury: a final common pathway to end-stage renal failure. J Am Soc Nephrol 2006; 17: 17-25
14. Guan Y, Breyer MD. Peroxisome proliferator-activated receptors (PPARs): novel therapeutic targets in renal disease. Kidney Int 2001; 60: 14-30
15. Rovin BH, Lu L, Cosio A. Cyclopentenone prostaglandins inhibit cytokine-induced nf-kappab activation and chemokine production by human mesangial cells. J Am Soc Nephrol 2001; 12: 1659-1667
16. Stamatakis K, Sanchez-Gomez FJ, Perez-Sala D. Identification of novel protein targets for modification by 15-deoxy-delta 12,14-prostaglandin J2 in mesangial cells reveals multiple interactions with the cytoskeleton. J Am Soc Nephrol 2006; 17: 89-98
17. Guan Y. Peroxisome proliferator-activated receptor family and its relationship to renal complications of the metabolic syndrome. J Am Soc Nephrol 2004; 15: 2801-2815
18. Ricote M, Li AC, Willson TM et al. The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation. Nature 1998; 391: 79-82
19. Marx N, Bourcier T, Sukhova GK et al. PPARgamma activation in human endothelial cells increases plasminogen activator inhibitor type-1 expression: PPARgamma as a potential mediator in vascular disease. Arterioscler Thromb Vasc Biol 1999; 19: 546-551
20. Ye P, Hu X, Liu Y et al. Activation of peroxisome proliferator-activated receptor alpha in human endothelial cells increases plasminogen activator inhibitor type-1 expression. Chin Med J (Engl) 2003; 116: 29-33
21. Kato K, Satoh H, Endo Y et al. Thiazolidinediones down-regulate plasminogen activator inhibitor type 1 expression in human vascular endothelial cells: a possible role for PPARgamma in endothelial function. Biochem Biophys Res Commun 1999; 258: 431-435
22. Zirlik A, Leugers A, Lohrmann J et al. Direct attenuation of plasminogen activator inhibitor type-1 expression in human adipose tissue by thiazolidinediones. Thromb Haemost 2004; 91: 674-682
23. He G, Pedersen SB, Bruun JM et al. Metformin, but not thiazolidinediones, inhibits plasminogen activator inhibitor-1 production in human adipose tissue in vitro. Horm Metab Res 2003; 35: 18-23
24. Li Y, Wen X, Spataro BC et al. Hepatocyte growth factor is a downstream effector that mediates the antifibrotic action of peroxisome proliferator-activated receptor-gamma agonists. J Am Soc Nephrol 2006; 17: 54-65
25. Dore-Duffy P, Balabanov R, Beaumont T et al. The CNS pericyte response to low oxygen: early synthesis of cyclopentenone prostaglandins of the J-series. Microvasc Res 2005; 69: 79-88
26. Tanaka Y, Maher JM, Chen C et al. Hepatic ischemia-reperfusion induces renal heme oxygenase-1 via NF-E2-related factor 2 in rats and mice. Mol Pharmacol 2007; 71: 817-825
27. Li X, Kimura H, Hirota K et al. Hypoxia reduces the expression and anti-inflammatory effects of peroxisome proliferator-activated receptor-{gamma} in human proximal renal tubular cells. Nephrol Dial Transplant 2007; 22: 1041-1051
28. Rumi MA, Ishihara S, Kadowaki Y et al. Peroxisome proliferator-activated receptor gamma-dependent and -independent growth inhibition of gastrointestinal tumour cells. Genes Cells 2004; 9: 1113-1123
29. Ono T, Sogabe M, Ogura M et al. Automated latex photometric immunoassay for total plasminogen activator inhibitor-1 in plasma. Clin Chem 2003; 49: 987-989
30. Ma J, Weisberg A, Griffin JP et al. Plasminogen activator inhibitor-1 deficiency protects against aldosterone-induced glomerular injury. Kidney Int 2006; 69: 1064-1072
31. Xin X, Yang S, Kowalski J et al. Peroxisome proliferator-activated receptor gamma ligands are potent inhibitors of angiogenesis in vitro and in vivo. J Biol Chem 1999; 274: 9116-9121
32. Takeda K, Ichiki T, Tokunou T et al. 15-Deoxy-delta 12,14-prostaglandin J2 and thiazolidinediones activate the MEK/ERK pathway through phosphatidylinositol 3-kinase in vascular smooth muscle cells. J Biol Chem 2001; 276: 48950-48955
33. Kutz SM, Hordines J, McKeown-Longo PJ et al. TGF-beta1-induced PAI-1 gene expression requires MEK activity and cell-to-substrate adhesion. J Cell Sci 2001; 114: 3905-3914
34. Uchiyama T, Kurabayashi M, Ohyama Y et al. Hypoxia induces transcription of the plasminogen activator inhibitor-1 gene through genistein-sensitive tyrosine kinase pathways in vascular endothelial cells. Arterioscler Thromb Vasc Biol 2000; 20: 1155-1161
35. Honn KV, Marnett LJ. Requirement of a reactive alpha, beta-unsaturated carbonyl for inhibition of tumor growth and induction of differentiation by "A" series prostaglandins. Biochem Biophys Res Commun 1985; 129: 34-40
36. Yu K, Bayona W, Kallen CB et al. Differential activation of peroxisome proliferator-activated receptors by eicosanoids. J Biol Chem1995; 270: 23975-23983
37. Wei JL, Ma CY, Zhang YD et al. Synergistic effects of pravastatin and pioglitazone in renal tubular epithelial cells induced by transforming growth factor-beta1. Cell Biol Int 2007; 31: 451-458
38. Murdoch C, Muthana M, Lewis CE. Hypoxia regulates macrophage functions in inflammation. J Immunol 2005; 175: 6257-6263
39. Bell-Parikh LC, Ide T, Lawson JA et al. Biosynthesis of 15-deoxy-delta 12,14-PGJ2 and the ligation of PPARgamma. J Clin Invest 2003; 112: 945-955