메뉴 건너뛰기




Volumn 75, Issue 3, 2008, Pages 156-170

Comparative efficacy of two microdoses of a potentized homeopathic drug, arsenicum album, to ameliorate toxicity induced by repeated sublethal injections of arsenic trioxide in mice

Author keywords

Arsenic toxicity; Biomarkers; Homeopathy; Matrix metalloproteinase; Mice

Indexed keywords

ACID PHOSPHATASE; ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ARSENIC TRIOXIDE; ASPARTATE AMINOTRANSFERASE; CATALASE; ESTRADIOL; GLUTATHIONE; SUCCINATE DEHYDROGENASE; TESTOSTERONE;

EID: 48749092565     PISSN: 10152008     EISSN: None     Source Type: Journal    
DOI: 10.1159/000124976     Document Type: Article
Times cited : (13)

References (41)
  • 1
    • 0032939812 scopus 로고    scopus 로고
    • Hypertension and arsenic exposure in Bangladesh
    • Rahman M, Tondel M, Ahmad SA: Hypertension and arsenic exposure in Bangladesh. Hypertension 1999;33:74-78.
    • (1999) Hypertension , vol.33 , pp. 74-78
    • Rahman, M.1    Tondel, M.2    Ahmad, S.A.3
  • 2
    • 0028004014 scopus 로고
    • Arsenic in drinking water and mortality from vascular disease: An ecologic analysis in 30 counties in the United States
    • Engel RR, Smith AH: Arsenic in drinking water and mortality from vascular disease: an ecologic analysis in 30 counties in the United States. Arch Environ Health 1994;49:418-427.
    • (1994) Arch Environ Health , vol.49 , pp. 418-427
    • Engel, R.R.1    Smith, A.H.2
  • 3
    • 0024802195 scopus 로고
    • Dose-response relation between arsenic concentration in well water and mortality from cancers and vascular diseases
    • Wu MM, Kuo TL, Hwang YH, Chen CJ: Dose-response relation between arsenic concentration in well water and mortality from cancers and vascular diseases. Am J Epidemiol 1989;130:1123-1132.
    • (1989) Am J Epidemiol , vol.130 , pp. 1123-1132
    • Wu, M.M.1    Kuo, T.L.2    Hwang, Y.H.3    Chen, C.J.4
  • 4
    • 0034537505 scopus 로고    scopus 로고
    • Exposure to metals
    • Hu H: Exposure to metals. Prim Care 2000;27:983-996.
    • (2000) Prim Care , vol.27 , pp. 983-996
    • Hu, H.1
  • 5
    • 0025171686 scopus 로고
    • Ecological correlation between arsenic level in well water and age-adjusted mortality from malignant neoplasms
    • Chen CJ, Wang CJ: Ecological correlation between arsenic level in well water and age-adjusted mortality from malignant neoplasms. Cancer Res 1990;50:5470-5474.
    • (1990) Cancer Res , vol.50 , pp. 5470-5474
    • Chen, C.J.1    Wang, C.J.2
  • 6
    • 79958861776 scopus 로고
    • Inorganic Arsenic Compounds Other than Arsine
    • International Programme on Chemical Safety:, Geneva, World Health Organization
    • International Programme on Chemical Safety: Inorganic Arsenic Compounds Other than Arsine. Health and Safety Guide No. 70. Geneva, World Health Organization, 1992.
    • (1992) Health and Safety Guide , Issue.70
  • 8
    • 0003372991 scopus 로고
    • International Agency for Research on Cancer:, Lyon, International Agency for Research on Cancer
    • International Agency for Research on Cancer: Summaries and Evaluations: Arsenic and Arsenic Compounds. Lyon, International Agency for Research on Cancer, 1987.
    • (1987) Summaries and Evaluations: Arsenic and Arsenic Compounds
  • 10
    • 0033508570 scopus 로고    scopus 로고
    • Important considerations in the development of public health advisories for arsenic and arsenic containing compounds in drinking water
    • Tchounwou PB, Wilson BA, Ishaque A: Important considerations in the development of public health advisories for arsenic and arsenic containing compounds in drinking water. Rev Environ Health 1999;14:1-19.
    • (1999) Rev Environ Health , vol.14 , pp. 1-19
    • Tchounwou, P.B.1    Wilson, B.A.2    Ishaque, A.3
  • 11
    • 48749084854 scopus 로고    scopus 로고
    • National Academy of Sciences: Arsenic. Washington, National Academy of Sciences, 1977.
    • National Academy of Sciences: Arsenic. Washington, National Academy of Sciences, 1977.
  • 12
    • 48749094407 scopus 로고    scopus 로고
    • Overall evaluation of carcinogenicity: an update of IARC monographs. IARC Monogr Eval Carcinog Risks Hum 1989;47: 1-42.
    • Overall evaluation of carcinogenicity: an update of IARC monographs. IARC Monogr Eval Carcinog Risks Hum 1989;47: 1-42.
  • 13
    • 0032416371 scopus 로고    scopus 로고
    • Efficacy of a potentized homeopathic drug (arsenicum album-30) in reducing toxic effects produced by arsenic trioxide in mice: I. On the rate of accumulation of arsenic in certain vital organs
    • Mitra K, Kundu SN, Khuda-Bukhsh AR: Efficacy of a potentized homeopathic drug (arsenicum album-30) in reducing toxic effects produced by arsenic trioxide in mice: I. On the rate of accumulation of arsenic in certain vital organs. Complement Ther Med 1998;6:178-184.
    • (1998) Complement Ther Med , vol.6 , pp. 178-184
    • Mitra, K.1    Kundu, S.N.2    Khuda-Bukhsh, A.R.3
  • 14
    • 0033030666 scopus 로고    scopus 로고
    • Efficacy of a potentized homeopathic drug (arsenicum album-30) in reducing toxic effects produced by arsenic trioxide in mice: II. On alterations of body weight, tissue weight and total protein
    • Mitra K, Kundu SN, Khuda-Bukhsh AR: Efficacy of a potentized homeopathic drug (arsenicum album-30) in reducing toxic effects produced by arsenic trioxide in mice: II. On alterations of body weight, tissue weight and total protein. Complement Ther Med 1999;7:24-34.
    • (1999) Complement Ther Med , vol.7 , pp. 24-34
    • Mitra, K.1    Kundu, S.N.2    Khuda-Bukhsh, A.R.3
  • 15
    • 0033911089 scopus 로고    scopus 로고
    • Efficacy of a potentized homeopathic drug (arsenicum album-30) in reducing cytotoxic effects produced by arsenic trioxide in mice: III. Enzymatic changes and recovery of tissue damage in liver
    • Kundu SN, Mitra K, Khuda-Bukhsh AR: Efficacy of a potentized homeopathic drug (arsenicum album-30) in reducing cytotoxic effects produced by arsenic trioxide in mice: III. Enzymatic changes and recovery of tissue damage in liver. Complement Ther Med 2000;8:76-81.
    • (2000) Complement Ther Med , vol.8 , pp. 76-81
    • Kundu, S.N.1    Mitra, K.2    Khuda-Bukhsh, A.R.3
  • 16
    • 0033829824 scopus 로고    scopus 로고
    • Efficacy of a potentized homeopathic drug (arsenicum album-30) in reducing cytotoxic effects produced by arsenic trioxide in mice: IV. Pathological changes, protein profiles and content of DNA and RNA
    • Kundu SN, Mitra K, Khuda-Bukhsh AR: Efficacy of a potentized homeopathic drug (arsenicum album-30) in reducing cytotoxic effects produced by arsenic trioxide in mice: IV. Pathological changes, protein profiles and content of DNA and RNA. Complement Ther Med 2000;8:157-175.
    • (2000) Complement Ther Med , vol.8 , pp. 157-175
    • Kundu, S.N.1    Mitra, K.2    Khuda-Bukhsh, A.R.3
  • 17
    • 0032776809 scopus 로고    scopus 로고
    • Efficacy of a potentized homeopathic drug (arsenicum album-30) in reducing genotoxic effects produced by arsenic trioxide in mice: Comparative studies of pre-, post- and combined pre- and post-oral administration and comparative efficacy of two microdoses
    • Datta S, Mallick P, Khuda-Bukhsh AR: Efficacy of a potentized homeopathic drug (arsenicum album-30) in reducing genotoxic effects produced by arsenic trioxide in mice: comparative studies of pre-, post- and combined pre- and post-oral administration and comparative efficacy of two microdoses. Complement Ther Med 1999;7:62-75.
    • (1999) Complement Ther Med , vol.7 , pp. 62-75
    • Datta, S.1    Mallick, P.2    Khuda-Bukhsh, A.R.3
  • 18
    • 20244385773 scopus 로고    scopus 로고
    • Ameliorating effect of microdoses of a potentized homeopathic drug, arsenicum album, on arsenic induced toxicity in mice
    • Mallick P, Chakrabarti Mallick J, Guha B, Khuda-Bukhsh AR: Ameliorating effect of microdoses of a potentized homeopathic drug, arsenicum album, on arsenic induced toxicity in mice. BMC Complement Altern Med 2003;3:1-19.
    • (2003) BMC Complement Altern Med , vol.3 , pp. 1-19
    • Mallick, P.1    Chakrabarti Mallick, J.2    Guha, B.3    Khuda-Bukhsh, A.R.4
  • 19
    • 33646191834 scopus 로고    scopus 로고
    • Protective potentials of a potentized homeopathic drug, Lycopodium-30, in ameliorating azo dye induced hepatocarcinogenesis in mice
    • Pathak S, Das JK, Biswas SJ, Khuda-Bukhsh AR: Protective potentials of a potentized homeopathic drug, Lycopodium-30, in ameliorating azo dye induced hepatocarcinogenesis in mice. Mol Cell Biochem 2006;258:121-131.
    • (2006) Mol Cell Biochem , vol.258 , pp. 121-131
    • Pathak, S.1    Das, J.K.2    Biswas, S.J.3    Khuda-Bukhsh, A.R.4
  • 20
    • 8644283540 scopus 로고    scopus 로고
    • Assessment of the genotoxic and cytotoxic potential of an antiepileptic drug phenobarbital, in mice: A time course study
    • Biswas SJ, Pathak S, Khuda-Bukhsh AR: Assessment of the genotoxic and cytotoxic potential of an antiepileptic drug phenobarbital, in mice: a time course study. Mutat Res 2004;563:1-11.
    • (2004) Mutat Res , vol.563 , pp. 1-11
    • Biswas, S.J.1    Pathak, S.2    Khuda-Bukhsh, A.R.3
  • 22
    • 0026039082 scopus 로고
    • Human fibroblasts contain a proteolytic activity, which is inhibited by the Bowman-Birk protease inhibitor
    • Billings PC, Habres JM, Liao DC, Tuttle SW: Human fibroblasts contain a proteolytic activity, which is inhibited by the Bowman-Birk protease inhibitor. Cancer Res 1991;51:5539-5543.
    • (1991) Cancer Res , vol.51 , pp. 5539-5543
    • Billings, P.C.1    Habres, J.M.2    Liao, D.C.3    Tuttle, S.W.4
  • 23
    • 0000850118 scopus 로고
    • The determination of eight elements in human liver tissue by flame atomic absorption spectrometry in sulphuric acid solution
    • Locke J: The determination of eight elements in human liver tissue by flame atomic absorption spectrometry in sulphuric acid solution. Anal Chem Acta 1979;104:225-231.
    • (1979) Anal Chem Acta , vol.104 , pp. 225-231
    • Locke, J.1
  • 24
    • 0019548586 scopus 로고
    • Voltametric trace analysis in ecological chemistry of toxic metals
    • Nurenberg WH: Voltametric trace analysis in ecological chemistry of toxic metals. Pure Appl Chem 1982;54:853-878.
    • (1982) Pure Appl Chem , vol.54 , pp. 853-878
    • Nurenberg, W.H.1
  • 26
    • 0036226578 scopus 로고    scopus 로고
    • Evidence for induction of oxidative stress caused by chronic exposure of Chinese residents to arsenic contained in drinking water
    • Pi JB, Yamauchi H, Kumagai Y: Evidence for induction of oxidative stress caused by chronic exposure of Chinese residents to arsenic contained in drinking water. Environ Health Perspect 2002;110:331-336.
    • (2002) Environ Health Perspect , vol.110 , pp. 331-336
    • Pi, J.B.1    Yamauchi, H.2    Kumagai, Y.3
  • 27
    • 0032693563 scopus 로고    scopus 로고
    • Arsenic-induced oxidative stress and its reversibility following combined administration of N-acetylcysteine and meso 2,3-dimercaptosuccinic acid in rats
    • Flora SJS: Arsenic-induced oxidative stress and its reversibility following combined administration of N-acetylcysteine and meso 2,3-dimercaptosuccinic acid in rats. Clin Exp Pharmacol Physiol 1999;26:865-869.
    • (1999) Clin Exp Pharmacol Physiol , vol.26 , pp. 865-869
    • Flora, S.J.S.1
  • 28
    • 0034764618 scopus 로고    scopus 로고
    • Effects on levels of glutathione and some related enzymes in tissues after an acute arsenic exposure in rats and their relationship to dietary protein deficiency
    • Maiti S, Chatterjee AK: Effects on levels of glutathione and some related enzymes in tissues after an acute arsenic exposure in rats and their relationship to dietary protein deficiency. Arch Toxicol 2001;75:531-537.
    • (2001) Arch Toxicol , vol.75 , pp. 531-537
    • Maiti, S.1    Chatterjee, A.K.2
  • 30
    • 0035188727 scopus 로고    scopus 로고
    • How matrix metalloproteases regulate cell behaviour
    • Sternlicht MD, Werb Z: How matrix metalloproteases regulate cell behaviour. Annu Rev Cell Dev Biol 2001;17:463-516.
    • (2001) Annu Rev Cell Dev Biol , vol.17 , pp. 463-516
    • Sternlicht, M.D.1    Werb, Z.2
  • 31
    • 0026027556 scopus 로고
    • Cancer metastasis and angiogenesis: An imbalance of positive and negative regulation
    • Liotta LA, Steeg PS, Stetler-Stevenson WG: Cancer metastasis and angiogenesis: an imbalance of positive and negative regulation. Cell 1991;64:327-336.
    • (1991) Cell , vol.64 , pp. 327-336
    • Liotta, L.A.1    Steeg, P.S.2    Stetler-Stevenson, W.G.3
  • 32
    • 0025230509 scopus 로고
    • Metalloproteinases and their inhibitors in matrix remodeling (review)
    • Matrisian LM: Metalloproteinases and their inhibitors in matrix remodeling (review). Trends Genet 1990;6:121-125.
    • (1990) Trends Genet , vol.6 , pp. 121-125
    • Matrisian, L.M.1
  • 33
    • 0025847582 scopus 로고
    • Matrix metalloproteinases and their inhibitors in connective tissue remodeling
    • Woessner JF Jr: Matrix metalloproteinases and their inhibitors in connective tissue remodeling. FASEB J 1991;5:2145-2154.
    • (1991) FASEB J , vol.5 , pp. 2145-2154
    • Woessner Jr, J.F.1
  • 34
    • 0031002066 scopus 로고    scopus 로고
    • Intracellular activation of gelatinase A (72-kDa type IV collagenase) by normal fibroblasts
    • Lee AY, Akers KT, Collier M, Li L, Eisen AZ, Seltzer JL: Intracellular activation of gelatinase A (72-kDa type IV collagenase) by normal fibroblasts. Proc Natl Acad Sci USA 1997;94:4424-4429.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 4424-4429
    • Lee, A.Y.1    Akers, K.T.2    Collier, M.3    Li, L.4    Eisen, A.Z.5    Seltzer, J.L.6
  • 35
    • 0028067549 scopus 로고
    • Activation of 72-kDa type IV collagenase/gelatinase by normal fibroblasts in collagen lattices is mediated by integrin receptors but is not related to lattice contraction
    • Seltzer JL, Lee AY, Akers KT, Sudbeck B, Southon EA, Wayner EA, Eisen AZ: Activation of 72-kDa type IV collagenase/gelatinase by normal fibroblasts in collagen lattices is mediated by integrin receptors but is not related to lattice contraction. Exp Cell Res 1994;213:365-374.
    • (1994) Exp Cell Res , vol.213 , pp. 365-374
    • Seltzer, J.L.1    Lee, A.Y.2    Akers, K.T.3    Sudbeck, B.4    Southon, E.A.5    Wayner, E.A.6    Eisen, A.Z.7
  • 36
    • 0029150795 scopus 로고
    • Proteolytic remodeling of extracellular matrix
    • Birkedal-Hansen H: Proteolytic remodeling of extracellular matrix. Curr Opin Cell Biol 1995;7:728-735.
    • (1995) Curr Opin Cell Biol , vol.7 , pp. 728-735
    • Birkedal-Hansen, H.1
  • 37
    • 0028073883 scopus 로고
    • The role of matrix metalloproteases and their inhibitors in tissue invasion, metastasis and angiogenesis
    • Ray JM, Stetler-Stevenson WG: The role of matrix metalloproteases and their inhibitors in tissue invasion, metastasis and angiogenesis. Eur Respir J 1994;7:2062-2072.
    • (1994) Eur Respir J , vol.7 , pp. 2062-2072
    • Ray, J.M.1    Stetler-Stevenson, W.G.2
  • 38
    • 0034714202 scopus 로고    scopus 로고
    • TIMP-2 is required for efficient activation of pro-MMP-2 in vivo
    • Wang Z, Juttermann R, Soloway PD: TIMP-2 is required for efficient activation of pro-MMP-2 in vivo. J Biol Chem 2000;275:26411-26415.
    • (2000) J Biol Chem , vol.275 , pp. 26411-26415
    • Wang, Z.1    Juttermann, R.2    Soloway, P.D.3
  • 39
    • 0030970288 scopus 로고    scopus 로고
    • Potentized homeopathic drugs act through regulation of gene expression: A hypothesis to explain their mechanism and pathways of action in vivo
    • Khuda-Bukhsh AR: Potentized homeopathic drugs act through regulation of gene expression: a hypothesis to explain their mechanism and pathways of action in vivo. Complement Ther Med 1997;5:43-46.
    • (1997) Complement Ther Med , vol.5 , pp. 43-46
    • Khuda-Bukhsh, A.R.1
  • 40
    • 0142243234 scopus 로고    scopus 로고
    • Towards understanding molecular mechanisms of action of homeopathic drugs: An overview
    • Khuda-Bukhsh AR: Towards understanding molecular mechanisms of action of homeopathic drugs: an overview. Mol Cell Biochem 2003;253:339-345.
    • (2003) Mol Cell Biochem , vol.253 , pp. 339-345
    • Khuda-Bukhsh, A.R.1
  • 41
    • 33750861301 scopus 로고    scopus 로고
    • Laboratory research in homeopathy: Pro
    • Khuda-Bukhsh AR: Laboratory research in homeopathy: pro. Integr Cancer Ther 2006;5:320-332.
    • (2006) Integr Cancer Ther , vol.5 , pp. 320-332
    • Khuda-Bukhsh, A.R.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.