Downregulation of Akt activity contributes to the growth arrest induced by FGF in chondrocytes

Journal of Cellular Physiology

Volumn 207, Issue 3, 2006, Pages 800-808

  Priore, Riccardo ^a   Dailey, Lisa ^a   Basilico, Claudio ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGENASE 3; CYCLIN E; FIBROBLAST GROWTH FACTOR; FIBROBLAST GROWTH FACTOR RECEPTOR 3; OSTEOPONTIN; PROTEIN KINASE B; PROTEIN P107; PROTEIN P130; PROTEIN P21; RETINOBLASTOMA PROTEIN; STAT1 PROTEIN;

ANIMAL CELL; ARTICLE; CANCER CELL CULTURE; CARTILAGE CELL; CELL DIFFERENTIATION; CELL GROWTH; CELL PROLIFERATION; CHONDRODYSPLASIA; CHONDROSARCOMA; CONTROLLED STUDY; DWARFISM; ENZYME ACTIVATION; ENZYME ACTIVITY; GENE MUTATION; GROWTH DISORDER; GROWTH INHIBITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION;

ANIMALS; CELL DIFFERENTIATION; CELL LINE, TUMOR; CELL PROLIFERATION; CHONDROCYTES; CYCLIN E; CYCLIN-DEPENDENT KINASE 2; DOWN-REGULATION; ENZYME ACTIVATION; FIBROBLAST GROWTH FACTORS; GENE EXPRESSION REGULATION; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RETINOBLASTOMA-LIKE PROTEIN P130; SIGNAL TRANSDUCTION;

ANIMALIA;

EID: 33646364795     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcp.20620     Document Type: Article

References (34)

1. Aikawa T, Segre GV, Lee K. 2001. Fibroblast growth factor inhibits chondrocytic growth through induction of p21 and subsequent inactivation of cyclin E-Cdk2. J Biol Chem 276:29347-29352.
2. Basilico C, Moscatelli D. 1992. The FGF family of growth factors and oncogenes. Adv Cancer Res 59:115-165.
3. Boonstra J. 2003. Progression through the G1-phase of the on-going cell cycle. J Cell Biochem 90:244-252.
4. Brazil DP, Hemmings BA. 2001. Ten years of protein kinase B signalling: A hard Akt to follow. Trends Biochem Sci 26:657-664.
5. Brazil DP, Park J, Hemmings BA. 2002. PKB binding proteins. Getting in on the Akt. Cell 111:293-303.
6. Chen Y, Miller WM, Aiyar A. 2005. Transduction efficiency of pantropic retroviral vectors is controlled by the envelope plasmid to vector plasmid ratio. Biotechnol Prog 21(1):274-282.
7. Cobrinik D, Lee MH, Hannon G, Mulligan G, Bronson RT, Dyson N, Harlow E, Beach D, Weinberg RA, Jacks T. 1996. Shared role of the pRB-related p130 and p107 proteins in limb development. Genes Dev 10:1633-1644.
8. Cross TG, Scheel-Toellner D, Henriquez NV, Deacon E, Salmon M, Lord JM. 2000. Serine/threonine protein kinases and apoptosis. Exp Cell Res 256:34-41.
9. Dailey L, Laplantine E, Priore R, Basilico C. 2003. A network of transcriptional and signaling events is activated by FGF to induce chondrocyte growth arrest and differentiation. J Cell Biol 161:1053-1066.
10. Dailey L, Ambrosetti D, Mansukhani A, Basilico C. 2005. Mechanisms underlying differential responses to FGF signaling. Cytokine Growth Factor Rev 16: 233-247.
11. Daughaday WH, Rotwein P. 1989. Insulin-like growth factors I and II. Peptide, messenger ribonucleic acid and gene structures, serum, and tissue concentrations. Endocr Rev 10:68-91.
12. Diehl JA, Cheng M, Roussel MF, Sherr CJ. 1998. Glycogen synthase kinase-3 beta regulates cyclin D1 proteolysis and subcellular localization. Genes Dev 12:3499-3511.
13. Eswarakumar VP, Lax I, Schlessinger J. 2005. Cellular signaling by fibroblast growth factor receptors. Cytokine Growth Factor Rev 16:139-149.
14. Koike M, Yamanaka Y, Inoue M, Tanaka H, Nishimura R, Seino Y. 2003. Insulin-like growth factor-1 rescues the mutated FGF receptor 3 (G380R) expressing ATDC5 cells from apoptosis through phosphatidylinositol 3-kinase and MAPK. J Bone Miner Res 18:2043-2051.
15. Krejci P, Bryja V, Pachernik J, Hampl A, Pogue R, Mekikian P, Wilcox WR. 2004. FGF2 inhibits proliferation and alters the cartilage-like phenotype of RCS cells. Exp Cell Res 297:152-164.
16. Laplantine E, Rossi F, Sahni M, Basilico C, Cobrinik D. 2002. FGF signaling targets the pRb-related p107 and pl30 proteins to induce chondrocyte growth arrest. J Cell Biol 158:741-750.
17. Li Y, Dowbenko D, Lasky LA. 2002. AKT/PKB phosphorylation of p21Cip/WAF1 enhances protein stability of p21Cip/WAF1 and promotes cell survival. J Biol Chem 277:11352-11361.
18. Liu JP, Baker J, Perkins AS, Robertson EJ, Efstratiadis A. 1993. Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1IGF receptor (Igflr). Cell 75:59-72.
19. Luo J, Manning BD, Cantley LC. 2003. Targeting the PI3K-Akt pathway in human cancer: Rationale and promise. Cancer Cell 4:257-262.
20. Majewski N, Nogueira V, Bhaskar P, Coy PE, Skeen JE, Gottlob K, Chandel NS, Thompson CB, Robey RB, Hay N. 2004. Hexokinase-mitochondria interaction mediated by Akt is required to inhibit apoptosis in the presence or absence of Bax and Bak. Mol Cell 16:819-830.
21. Meek DW, Knippschild U. 2003. Posttranslational modification of MDM2. Mol Cancer Res 1:1017-1026.
22. Mirza AM, Gysin S, Malek N, Nakayama K, Roberts JM, McMahon M. 2004. Cooperative regulation of the cell division cycle by the protein kinases RAF and AKT. Mol Cell Biol 24:10868-10881.
23. Mukhopadhyay K, Lefebvre V, Zhou G, Garofalo S, Kimura JH, de Crombrugghe B. 1995. Use of a new rat chondrosarcoma cell line to delineate a 119-base pair chondrosarcoma cell line to delineate a 119-base pair chondrocyte-specific enhancer element and to define active promoter segments in the mouse Pro-a1 (11) collagen gene. J. Biol Chem 270:27711-27719.
24. Murakami S, Balmes G, McKinney S, Zhang Z, Givol D, de Crombrugghe B. 2004. Constitutive activation of MEK1 in chondrocytes causes Stat1-independent achondroplasia-like dwarfism and rescues the FGFR3-deficient mouse phenotype. Genes Dev 18:290-305.
25. Ornitz DM. 2005. FGF signaling in the developing endochondral skeleton. Cytokine Growth Factor Rev 16:205-213.
26. Ornitz DM, Marie PJ. 2002. FGF signaling pathways in endochondral and intra-membranous bone development and human genetic disease. Genes Dev 16:1447-1465.
27. Peng XD, Xu PZ, Chen ML, Hahn-Windgassen A, Skeen J, Jacobs J, Sundararajan D, Chen WS, Crawford SE, Coleman KG, Hay N. 2003. Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2. Genes Dev 17:1352-1365.
28. Raucci A, Laplantine E, Mansukhani A, Basilico C. 2004. Activation of the ERK1/2 and p38 mitogen-activated protein kinase pathways mediates fibroblast growth factor-induced growth arrest of chondrocytes. J Biol Chem 279:1747-1756.
29. Rössig L, Jadidi AS, Urbich C, Badorff C, Zeiher AM, Dimmeler S. 2001. Akt-dependent phosphorylation of p21 (Cipl) regulates PCNA binding and proliferation of endothelial cells. Mol Cell Biol 21:5644-5657.
30. Russo VC, Andaloro E, Fornaro SA, Najdovska S, Newgreen DF, Bach LA, Werther GA. 2004. Fibroblast growth factor-2 over-rides insulin-like growth factor-I induced proliferation and cell survival in human neuroblastoma cells. J Cell Physiol 199:371-380.
31. Sahni M, Ambrosetti DC, Mansukhani A, Gertner R, Levy D, Basilico C. 1999. FGF signaling inhibits chondrocyte proliferation and regulates bone development through the STAT-1 pathway. Genes Dev 13:1361-1366.
32. Sahni M, Raz R, Coffin JD, Levy D, Basilico C. 2001. STAT1 mediates the increased apoptosis and reduced chondrocyte proliferation in mice overexpressing FGF2. Development 128:2119-2129.
33. Sears R, Nuckolls F, Haura E, Taya Y, Tamai K, Nevins JR. 2000. Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability. Genes Dev 14:2501-2514.
34. Yasoda A, Komatsu Y, Chusho H, Miyazawa T, Ozasa A, Miura M, Kurihara T, Rogi T, Tanaka S, Suda M, Tamura N, Ogawa Y, Nakao K. 2004. Overexpression of CNP in chondrocytes rescues achondroplasia through a MAPK-dependent pathway. Nat Med 10:80-86.