Intestinal colonization of IL-2 deficient mice with non-colitogenic B. vulgatus prevents DC maturation and T-cell polarization

PLoS ONE

Volumn 3, Issue 6, 2008, Pages

  Müller, Martina ^a   Fink, Kerstin ^a   Geisel, Julia ^a   Kahl, Frauke ^a   Jilge, Burghardt ^b   Reimann, Jörg ^b   Mach, Nicolas ^c   Autenrieth, Ingo B ^a   Frick, Julia S ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b UNIVERSITY OF ULM   (Germany)

^c GENEVA UNIVERSITY HOSPITALS   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CCR7; CYTOKINE; INTERLEUKIN 12; INTERLEUKIN 2; INTERLEUKIN 6; MESSENGER RNA; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL COLONIZATION; BACTEROIDES VULGATUS; CELL DIFFERENTIATION; CELL ISOLATION; CELL MIGRATION; CELLULAR DISTRIBUTION; COLITIS; CONTROLLED STUDY; DENDRITIC CELL; ESCHERICHIA COLI; FLOW CYTOMETRY; IN VITRO STUDY; INTESTINE; LYMPHOCYTE ACTIVATION; MESENTERY LYMPH NODE; MOUSE; NONHUMAN; PHENOTYPE; POLARIZATION; PROTEIN EXPRESSION; T LYMPHOCYTE; TH1 CELL; ANIMAL; BACILLUS; C57BL MOUSE; CYTOLOGY; GENETICS; ISOLATION AND PURIFICATION; METABOLISM; MICROBIOLOGY; MOUSE MUTANT; PHYSIOLOGY;

MUS;

ANIMALS; BACILLUS; DENDRITIC CELLS; INTERLEUKIN-2; INTERLEUKIN-6; INTESTINES; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; T-LYMPHOCYTES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 48649089796     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0002376     Document Type: Article

References (40)

1. Fiocchi C (1998) Inflammatory bowel disease: etiology and pathogenesis. Gastroenterology 115: 182-205.
2. MacDonald TT, Monteleone G, Pender SL (2000) Recent developments in the immunology of inflammatory bowel disease. Scand J Immunol 51: 2-9.
3. Waidmann M, Bechtold O, Frick JS, Lehr HA, Schubert S, et al. (2003) Bacteroides vulgatus protects against Escherichia coli-induced colitis in gnotobiotic interleukin-2-deficient mice. Gastroenterology 125: 162-177.
4. Sadlack B, Merz H, Schorle H, Schimpl A, Feller AC, et al. (1993) Ucerative colitis-like disease in mice with a disrupted interleukin-2 gene. Cell 75: 253-261.
5. Schultz M, Tonkonogy SL, Sellon RK, Veltkamp C, Godfrey VL, et al. (1999) IL-2-deficient mice raised under germfree conditions develop delayed mild focal intestinal inflammation. Am J Physiol 276: G1461-G1472.
6. Cella M, Sallusto F, Lanzavecchia A (1997) Origin, maturation and antigen presenting function of dendritic cells. Curr Opin Immunol 9: 10-16.
7. Vazquez-Torres A, Jones-Carson J, Baunder AJ, Falkow S, Valdivia R, et al. (1999) Extraintestinal dissemination of Salmonella by CD18-expressing phagocytes. Nature 401: 804-808.
8. Pulendran B, Palucka K, Banchercau J (2001) Sensing pathogens and tuning immune responses. Science 293: 253-256.
9. Taguchi H, Takahashi M, Yamaguchi H, Osaki T, Komatsu A, et al. (2002) Experimental infection of germ-free mice with hyper-toxigenic enterohaemorrhagic Escherichia coli O157:H7, strain 6. J Med Microbiol 51: 336-343.
10. Huang Q, Liu D, Majewski P, Schulte LC, Korn JM, et al. (2001) The plasticity of dendritic cell responses to pathogens and their components. Science 294: 870-875.
11. Gagliardi MC, Sallusto F, Marinaro M, Langenkamp A, Lanzavecchia A, et al. (2000) Cholera toxin induces maturation of human dendritic cells and licences them for Th2 priming. Eur J Immunol 30: 2394-2403.
12. de Jong EC, Vieira PL, Kalinski P, Schuitemaker JH, Tanaka Y, et al. (2002) Microbial compounds selectively induce Th1 cell-promoting or Th2 cell-promoting dendritic cells in vitro with diverse th cell-polarizing signals. J Immunol 168: 1704-1709.
13. Banchereau J, Steinman RM (1998) Dendritic cells and the control of immunity. Nature 392: 245-252.
14. Mahanty S, Hutchinson K, Agarwal S, McRae M, Rollin PE, et al. (2003) Cutting edge: impairment of sendritic cells and adaptive immunity by Ebola and Lassa viruses. J Immunol 170: 2797-2801.
15. Lanzavecchia A, Sallusto F (2001) The instructive role of dendritic cells on T cell responses: lineages, plasticity and kinetics. Curr Opin Immunol 13: 291-298.
16. Reis e Sousa (2001) Dendritic cells as sensors of infection. Immunity 14: 495-498.
17. Park SJ, Nakagawa T, Kitamura H, Atsumi T, Kamon H, et al. (2004) IL-6 regulates in vivo dendritic cell differentiation through STAT3 activation. J Immunol 173: 3844-3854.
18. Frick JS, Zahir N, Muller M, Kahl F, Bechtold O, et al. (2006) Colitogenic and non-colitogenic commensal bacteria differentially trigger DC maturation and Th cell polarization: An important role for IL-6. Eur J Immunol 36: 1537-1547.
19. Hegde S, Pahne J, Smola-Hess S (2004) Novel immunosuppressive properties of interleukin-6 in dendritic cells: inhibition of NF-kappaB binding activity and CCR7 expression. FASEB J 18: 1439-1441.
20. Geisel J, Kahl F, Muller M, Wagner H, Kirschning CJ, et al. (2007) IL-6 and Maturation Govern TLR2 and TLR4 Induced TLR Agonist Tolerance and Cross-Tolerance in Dendritic Cells. J Immunol 179: 5811-5818.
21. Veldhoen M, Hocking RJ, Flavell RA, Stockinger B (2006) Signals mediated by transforming growth factor-beta initiate autoimmunc encephalomyelitis, but chronic inflammation is needed to sustain disease. Nat Immunol 7: 1151-1156.
22. Bettelli E, Carrier Y, Gao W, Korn T, Strom TB, et al. (2006) Reciprocal developmental pathways for the generation or pathogenic efrector TH17 and regulatory T cells. Nature 441: 235-238.
23. Autenrieth IB, Bucheler N, Bohn E, Heinze G, Horak I (1997) Cytokine mRNA expression in intestinal tissue of interleukin-2 deficient mice with bowel inflammation. Gut 41: 793-800.
24. Kitamura H, Kamon H, Sawa S, Park SJ, Katunuma N, et al. (2005) IL-6-STAT3 controls intracellular MEC class II alphabeta dimer level through cathepsin S activity in dendritic cells. Immunity 23: 491-502.
25. Diehl S, Rincon M (2002) The two faces of IIA on Th1/Th2 diflerentiation Mol Immunol 39: 531-536.
26. Diehl S, AngutLa J, Hoffmeyer A, Zapton T, Ihle JN, et al. (2000) Inhibition of Th1 differentiation by IL-6 is mediated by SOCS1. Immunity 13: 805-815.
27. Atreya R, Mudter J, Finotto S, Mullberg J, Jostock T, et al. (2000) Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: evidence in crohn disease and experimental colitis in vivo. Nat Med 6: 583-588.
28. Yamamoto M, Yoshizaki K, Kishimoto T, Ito H (2000) IL-6 is required for the development of Th1 cell-mediated murine colitis. J Immunol 164: 4878-4882.
29. Naito Y, Takagi T, Uchiyama K, Kuroda M, Kokura S, et al. (2004) Reduced intestinal inflammation induced by dextran sodium sulfate in interlcukin-6-deficient mice. Int J Mol Med 14: 191-196.
30. Nair BC, Mayberry WR, Dziak R, Chen PB, Levine MJ, et al. (1983) Biological effects of a purified lipopolysaccharide from Bacteroides gingivalis. J Periodontal Res 18: 40-49.
31. Mansheim BJ, Onderdonk AB, Kasper DL (1978) Immunochemical and biologic studies of the lipopolysaccharide of Bacteroides melaninogenicus subspecies asaccharolyticus. J Immunol 120: 72-78.
32. Rakoff-Nahoum S, Hao L, Medzhitov R (2006) Role of toll-like receptors in spontaneous commensal-dependent colitis. Immunity 25: 319-329.
33. ForsLer R, Schubel A, Breitfeld D, Kremmer E, Renner-Muller I, et al. (1999) CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs. Cell 99: 23-33.
34. Yanagihara S, Komura E, Nagafune J, Watarai H, Yamaguchi Y (1998) EBI1/ CCR7 is a new member of dendritic cell chemokine receptor that is up-regulated upon maturation. J Immunol 161: 3096-3102.
35. jang NfH, Sougawa N, Tanaka T, Hirata T, Hiroi T, et al. (2006) CCR7 is critically important for migration of dendritic cells in intestinal lamina propria to mesenteric lymph nodes. J Immunol 176: 803-810.
36. Ito T, Yang M, Wang YH, Lande R, Gregorio J, et al. (2007) Plasmacytoid dendritic cells prime IL-10-producing T regulatory cells by inducible costimulator ligand. J Exp Med 204: 105-115.
37. Moseman EA, Liang X, Dawson AJ, Panoskaksis-MorLtri A, Krieg AM, et al. (2001) Human plasmacytoid dendritic cells activated by CpG oligodeoxynucleotides induce the generation of CD4-+CD25+ regulatory T cells. J Immunol 173: 1433-4442.
38. Krajina T, Leithauser F, Reimann J (2001) MHC class II-independent CD25+ CD4+ CD8alpha beta+ alpha beta T cells attenuate CD4+ T cell-induced transfer colitis. Eur J Immunol 34: 705-714.
39. Lutz MB, Kukutsch N, Ogilvie AL, Rossner S, Koch F, et al. (1999) An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow. J Immunol Mlethods 223: 77-92.
40. Mach N, Gillessen S, Wilson SB, Sheehan C, Mihm M, et al. (2000) Differences in dendritic cells stimulated in vivo by tumors engineered to secrete granulocyte-macrophage colony-stimulating factor or Flt3-ligand. Cancer Res 60: 3239-3246.