Combining identity by descent and association in genetic case-control studies

BMC Genetics

Volumn 9, Issue , 2008, Pages

  Zhang, Qingrun ^a   Wang, Shuang ^b   Ott, Jurg ^a,c  

^a Chinese Academy of Sciences   (China)

^b Department of Medicine   (United States)

^c ROCKEFELLER UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLELE; ANALYTICAL ERROR; ARTICLE; CASE CONTROL STUDY; CHI SQUARE TEST; DOMINANT INHERITANCE; FALSE POSITIVE RESULT; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC TRAIT; GENOTYPE; HUMAN; MATHEMATICAL ANALYSIS; PROBABILITY; RECESSIVE INHERITANCE; STATISTICAL ANALYSIS; STATISTICAL MODEL; CHI SQUARE DISTRIBUTION; COMPARATIVE STUDY; DOMINANT GENE; GENETIC LINKAGE; METHODOLOGY; PEDIGREE; PENETRANCE; POPULATION GENETICS; RECESSIVE GENE; SINGLE NUCLEOTIDE POLYMORPHISM; STATISTICS;

CASE-CONTROL STUDIES; CHI-SQUARE DISTRIBUTION; GENE FREQUENCY; GENES, DOMINANT; GENES, RECESSIVE; GENETICS, POPULATION; GENOTYPE; HUMANS; LIKELIHOOD FUNCTIONS; LINKAGE (GENETICS); MODELS, STATISTICAL; PEDIGREE; PENETRANCE; POLYMORPHISM, SINGLE NUCLEOTIDE; RESEARCH DESIGN;

EID: 48549102703     PISSN: None     EISSN: 14712156     Source Type: Journal    
DOI: 10.1186/1471-2156-9-42     Document Type: Article

References (23)

1. Lander ES Botstein D Homozygosity mapping: A way to map human recessive traits with the DNA of inbred children Science 1987, 236:4808-1567 1570 10.1126/science.2884728 2884728
2. Houwen RH Baharloo S Blankenship K Raeymaekers P Juyn J Sandkuijl LA Freimer NB Genome screening by searching for shared segments: Mapping a gene for benign recurrent intrahepatic cholestasis Nat Genet 1994, 8(4):380-386 10.1038/ng1294-380 7894490
3. Broman KW Weber JL Long homozygous chromosomal segments in reference families from the centre d'Etude du polymorphisme humain Am J Hum Genet 1999, 65(6):1493-1500 1288359 10577902 10.1086/302661
4. Levran O Attwooll C Henry RT Milton KL Neveling K Rio P Batish SD Kalb R Velleuer E Barral S Ott J Petrini J Schindler D Hanenberg H Auerbach AD The BRCA1-interacting helicase BRIP1 is deficient in Fanconi anemia Nat Genet 2005, 37(9):931-3. Epub 2005 Aug 21. 10.1038/ng1624 16116424
5. Gibson J Morton NE Collins A Extended tracts of homozygosity in outbred human populations Hum Mol Genet 2006, 15(5):789-95. Epub 2006 Jan 25. 10.1093/hmg/ddi493 16436455
6. Woods CG Cox J Springell K Hampshire DJ Mohamed MD McKibbin M Stern R Raymond FL Sandford R Malik Sharif S Karbani G Ahmed M Bond J Clayton D Inglehearn CF Quantification of homozygosity in consanguineous individuals with autosomal recessive disease Am J Hum Genet 2006, 78(5):889-96. Epub 2006 Mar 21. 1474039 16642444 10.1086/503875
7. Li LH Ho SF Chen CH Wei CY Wong WC Li LY Hung SI Chung WH Pan WH Lee MT Tsai FJ Chang CF Wu JY Chen YT Long contiguous stretches of homozygosity in the human genome Hum Mutat 2006, 27(11):1115-1121 10.1002/humu.20399 16955415
8. Holmans P Asymptotic properties of affected-sib-pair linkage analysis Am J Hum Genet 1993, 52(2):362-374 1682211 8430697
9. Vogel F Motulsky AG Human genetics: Problems and approaches Berlin; New York, Springer 3rd completely rev. 1997, xxxvi, 851
10. Agarwala R Schaffer AA Tomlin JF Towards a complete North American Anabaptist Genealogy II: Analysis of inbreeding Hum Biol 2001, 73(4):533-545 10.1353/hub.2001.0045 11512680
11. Klein RJ Zeiss C Chew EY Tsai JY Sackler RS Haynes C Henning AK SanGiovanni JP Mane SM Mayne ST Bracken MB Ferris FL Ott J Barnstable C Hoh J Complement factor H polymorphism in age-related macular degeneration Science 2005, 308(5720):385-9. Epub 2005 Mar 10. 1512523 15761122 10.1126/science.1109557
12. Zou GY Donner A The merits of testing Hardy-Weinberg equilibrium in the analysis of unmatched case-control data: A cautionary note Ann Hum Genet 2006, 70(Pt 6):923-933 17044866
13. Online manual for FP test http://www.genemapping.cn/FPtest.html
14. Risch N Merikangas K The future of genetic studies of complex human diseases Science 1996, 273(5281):1516-1517 10.1126/science.273.5281.1516 8801636
15. Dewan A Liu M Hartman S Zhang SS Liu DT Zhao C Tam PO Chan WM Lam DS Snyder M Barnstable C Pang CP Hoh J HTRA1 promoter polymorphism in wet age-related macular degeneration Science 2006, 314(5801):989-92. Epub 2006 Oct 19 10.1126/science.1133807 17053108
16. Fung HC Scholz S Matarin M Simon-Sanchez J Hernandez D Britton A Gibbs JR Langefeld C Stiegert ML Schymick J Okun MS Mandel RJ Fernandez HH Foote KD Rodriguez RL Peckham E De Vrieze FW Gwinn-Hardy K Hardy JA Singleton A Genome-wide genotyping in Parkinson's disease and neurologically normal controls: First stage analysis and public release of data Lancet Neurol 2006, 5(11):911-916 10.1016/S1474-4422(06)70578-6 17052657
17. Simon-Sanchez J Scholz S Del Mar Matarin M Fung HC Hernandez D Gibbs JR Britton A Hardy J Singleton A Genomewide SNP assay reveals mutations underlying Parkinson disease Hum Mutat 2007, 9:9
18. Nijenhuis A Wilf HS Combinatorial algorithms for computers and calculators New York, Academic Press 2d 1978 xv, 302 p.
19. Online manual for sumstat program http://www.genemapping.cn/sumstat.html
20. Press WH Teukolsky SA Vetterling WT Flannery BP Numerical recipes 3rd edition: The art of scientific computing Cambridge, UK; New York, Cambridge University Press 3rd 2007 xxi, 1235
21. Hoh J Ott J Scan statistics to scan markers for susceptibility genes Proc Natl Acad Sci U S A 2000, 97(17):9615-9617 16913 10931953 10.1073/ pnas.170179197
22. Online manual for scanstat program http://www.genemapping.cn/ scanstat.html
23. Coriell NINDS Collection http://ccr.coriell.org/ninds