Weightlessness acts on human breast cancer cell line MCF-7

Advances in Space Research

Volumn 32, Issue 8, 2003, Pages 1595-1603

  Vassy, J ^a   Portet, S ^a,d   Beil, M ^b   Millot, G ^a   Fauvel Lafeve, F ^a   Gasset, G ^c   Schoevaert, D ^a  

^a SAINT LOUIS HOSPITAL   (France)

^b UNIVERSITY HOSPITAL ULM   (Germany)

^c UNIVERSITÉ DE TOULOUSE   (France)

^d UNIVERSITY OF ALBERTA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; DIFFUSION; FLUORESCENCE; IMAGE ANALYSIS; LABELING; MATHEMATICAL MODELS; PROTEINS; TUMORS; WEIGHTLESSNESS;

MICROTUBULES; STRESS-DEPENDENT CELL CHANGES;

SPACE RESEARCH;

EXOBIOLOGY;

EID: 0348171037     PISSN: 02731177     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0273-1177(03)90400-5     Document Type: Article

References (50)

1. Alli E., J. Bash-Babula, J.M. Yang and W.N. Hait, Effect of stathmin on the sensitivity to antimicrotubule drugs in human breast cancer. Cancer Res., 62, 6864-6869, 2002.
2. Amos, L.A., and W.B. Amos, Molecules of the cytoskeleton. Guilford press, New York, 1991.
3. Andersen, S.S.L., Spindle assembly and the art of regulating microtubule dynamics by MAPs and Stathmin/Op18. Trends Cell Biol. 10, 261-267, 2000.
4. Beil, M., T. Irinopoulou, J. Vassy, and J.P. Rigaut, Application of confocal scanning laser microscopy for an automated nuclear grading of prostate lesions in three dimensions. J. Microsc. 183, 231-240, 1996.
5. Bieche I, S. Lachkar, C. Cifuentes-Diaz, A. Sobel, R. Lidereau and P.A. Curmi, Overexpression of the stathmin gene in a subset of human breast cancer. Br. J. Cancer, 78, 701-709, 1998.
6. Boonstra, J., Growth factor-induced signal transduction in adherent mammalian cells is sensitive to gravity. FASEB J. 13 (Suppl.), S35-S42, 1999.
7. Carmeliet, G., and R. Bouillon, The effect of microgravity on morphology and gene expression of osteoblasts in vitro. FASEB J. 13 (Suppl.), S129-S134, 1999.
8. Cau, J., S. Faure, M. Comps, C. Delsert and N. Morin, A novel p21-activated kinase binds the actin and microtubules networks and induces microtubule stabilization. J. Cell Biol. 155, 1029-1042, 2001.
9. Cogoli, A., and M. Cogoli-Greuter, Activation and proliferation of lymphocytes and other mammalian cells in microgravity. Adv. Space Biol. Med 6, 33-79, 1997.
10. Cogoli-Greuter, M., M.A. Meloni, L. Sciola, A. Spano, P. Pippia, G. Monaco, and A. Cogoli, Movements and interactions of leukocytes in microgravity. J. Biotechnol. 47, 279-287, 1996.
11. Cubano, L.A., and M.L. Lewis, Fas/APO-1 protein is increased in space flown lyphocytes (Jurkat). Exp. Greontol. 35, 389-400, 2000.
12. Daub, H., K. Gevaert, J. Vandekerckhove, A. Sobel and A. Hall, Rac/Cdc42 and p65PAK regulate the microtubule-destabilizing protein stathmin through phosphorylation at serine 16, J. Biol. Chem., 276, 1677-1680, 2001.
13. De Groot, R.P., P.J. Rijken, J. Boonstra, A.J. Verkleij, S.W. de Laat, and W. Kruijer, Epidermal growth factor-induced expression of c-fos is influenced by altered gravity conditions. Aviat. Space Environ. Med 62, 37-40, 1991.
14. Doxley, S., Re-evaluating centrosome function, Nature Rev. Mol. Cell. Biol., 2, 688-698, 2001.
15. Edelstein-Keshet, L., Mathematical models in biology. Random House, New York. 1988.
16. 2+ signaling in tracheal epithelial cells in simulated microgravity. J. Appl. Physiol., 89, 855-863, 2000.
17. Gavet, O., S. Ozon, V. Manceau, P. Curmi and A. Sobel, The stathmin phosphoprotein family: intracellular localization and effects on the microtubule network. J. Cell Sci., 111, 3333-3346, 1998.
18. Goldman, R.D., S. Khuon, Y.H. Chou, P. Opal, and P.M. Steinert, The function of intermediate filaments in cell shape and cytoskeletal integrity. J. Cell Biol. 134, 971-983, 1996.
19. Gonzalez, A.E., Colloidal aggregation in the presence of a gravitational field. J. Phys.: Condens. Matter. 14, 2335-2345, 2002.
20. Guignandon, A., M.H. Lafarge-Proust, Y. Usson, N. Laroche, A. Caillot-Augusseau, C. Alexandre, and L. Vico, Cell cycling determines integrin-mediated adhesion in osteoblastic ROS 17/2.8 cells exposed to space-related conditions. FASEB J, 15, 2036-2038, 2001, 10.1096/fj.00-0837fje.
21. Gundersen, G.G., Evolutionary conservation of microtubule-capture mechanisms. Nature Rev. Mol. Cell Bid.3, 6-14, 2003.
22. Hall, A., Rho GTPases and the actin cytoskeleton. Science, 279, 509-514, 1998.
23. Hatton, J.P., F. Gaubert, M.L. Lewis, Y. Darsel, P. Ohlmann, J.P. Cazenave, and D. Schmitt, The kinetics of translocation and cellular quantity of protein kinase C in human leukocytes are modified during spaceflight. FASEB J. 13 (Suppl), S23-S33, 1999.
24. Holmfeldt P., N. Larsson, B. Segerman, B. Howell, J. Morabito, L. Cassimeris and M. Gullberg, The catastrophe-promoting activity of ectopic Op18/stathmin is required for disruption of mitotic spindles but not interphase microtubules. Mol. Biol. Cell, 12, 73-83, 2001.
25. Hughes-Fulford, M., and M.L. Lewis, Effects of microgravity on osteoblast growth activation. Exp. Cell Res. 224, 103-109, 1996.
26. Iancu C., S.J. Mistry, S. Arkin, S. Wallenstein and G.F. Atweh, Effects of stathmin inhibition on the mitotic spindle. J. Cell Sci., 114, 909-916, 2000.
27. Ingber, D., Cellular tensegrity: defining new rules of biological design that govern the cytoskeleton. J. Cell Sci. 104, 613-627, 1993.
28. Ingber, D., How cells (might) sense microgravity. FASEB J. 13 (Suppl.), S3-S15, 1999.
29. Janmey, P.A., U. Euteneuer, P. Traub, and M. Schliwa, Viscoelastic properties of vimentin compared with other filamentous biopolymer networks. J. Cell Biol. 113, 155-160, 1991.
30. Kinoshita, K., I. Arnal, A. Desai, D.N. Drechsel, and A.A. Hyman, Reconstitution of physiological microtubule dynamic using purified components. Science, 294, 1340-1343, 2001.
31. Kondepudi, D.K., and I. Prigogine, Sensitivity of nonequilibrium systems. Physica A,.107, 1-24, 1981.
32. Küntziger, T., O. Gavet, V. Manceau, A. Sobel and M. Bornens, Stathmin/Op18 phosphorylation is regulated by microtubule assembly. Mol. Biol. Cell, 12, 437-448, 2001.
33. Lelievre, S., V.M. Weaver, J.A. Nickerson, C.A. Larabell, A. Bhaumik, O.W. Petersen, and M.J. Bissell, Tissue phenotype depends on reciprocal interactions between the extracellular matrix and the structural organization of the nucleus. Proc. Natl. Acad. Sci. U.S.A.95, 14711-14716, 1998.
34. Lewis, M.L., L.A. Cubano, B. Zhao, H.K. Dinh, J.G. Pabalan, E.H. Piepmeier, and P.D. Bowman, cDNA microarray reveals altered cytoskeletal gene expression in space-flown leukemic T lymphocytes (Jurkat). FASEB J., 15, 1783-1785, 2001, 10.1096/fj.00-0820fje.
35. Lewis, M.L., J.L. Reynolds, L.A. Cubano, J.P. Hatton, B.D. Lawless, and E.H. Piepmeier, Spaceflight alters microtubules and increases apoptosis in human lymphocytes (Jurkat). FASEB J. 12, 1007-1018, 1998.
36. Ma, L., J. Xu, P.A. Coulombe, and D. Wirtz, Keratin filament suspensions show unique micromechanical properties. J. Biol. Chem. 274, 19145-19151, 1999.
37. Maniotis, A., C. Chen, and D. Ingber, Demonstration of mechanical connections between integrins, cytoskeletal filaments, and nucleoplasm that stabilize nuclear structure. Proc. Natl. Acad. Sci. U.S.A.94, 849-854, 1997.
38. Palazzo, A.F., T.A. Cook, A.S. Alberts and G.G. Gundersen, mDia mediates Rho-regulated formation and orientation of stable microtubules. Nature Cell Biol, 3, 723-729, 2001.
39. Papaseit, C., N. Pochon, and J. Tabony, Microtubule self-organization is gravity dependent. Proc. Natl. Acad. Sci. U.S.A, 97, 8364-8368, 2000.
40. th Conference of Mathematical Modelling & Computing in Biology and Medecinȩ Milano, Italy (private communication, 2002)
41. Portet, S., J. Vassy, M. Beil, G. Millot, A. Hebbache, J.P. Rigaut, and D. Schoevaert, Quantitative analysis of cytokeratin network topology in the MCF-7 cell line. Cytometry 35, 203-213, 1999.
42. Roskelley, C.D., P.Y. Desprez, and M. Bissell, Extracellular matrix-dependent tissue-specific gene expression in mammary epithelial cells requires both physical and biochemical signal transduction. Proc. Natl. Acad. Sci. U.S.A. 91, 12378-12382, 1994.
43. Schatten, H., M.L. Lewis, and A. Chakrabarti, Spaceflight and clinorotation cause cytoskeleton and mitochondria changes and increases in apoptosis in cultured cells. Acta Austronaut., 49, 399-418, 2001.
44. Soule, H.D., J. Vazguez, A. Long, S. Albert, and M. Brennan, A human cell line from pleural effusion derived from a breast carcinoma J. Natl. Cancer Inst. 51, 1409-1416, 1973.
45. Stein, G.S., A.J. van Wijnen, J.L. Stein, J.B. Lian, S.H. Pockwinse, and S. McNeil, Implications for interrelationships between nuclear architecture and control of gene expression under microgravity conditions. FASEB J. 13 (Suppl.), S157-S166, 1999.
46. Tabony, J., Morphological bifurcations involving reaction-diffusion processes during microtubule formation. Science 264, 245-248, 1994.
47. Vassy, J., S. Portet, M. Beil, G. Millot, F. Fauvel-Lafeve, A. Karniguian, G. Gasset, T. Irinopoulou, F. Calvo, J.P. Rigaut, and D. Schoevaert, The effect of weightlessness on cytoskeleton architecture and proliferation of human breast cancer cell line MCF-7. FASEB J, 15, 1104-1106, 2001, 10.1096/fj.00-0527fje.
48. Wang, N., and D. Stamenovic, Contribution of intermediate filaments to cell stiffness, stiffening and growth. Am. J. Physiol. Cell Physiol. 279, C188-C194, 2000.
49. Waterman-Storer, C.M., R.A. Worthylake, B.P. Liu, K. Burridge, and E.D. Salmon, Microtubule growth activates Rac1 to promote lamellipodial protusion in fibroblasts. Nature Cell Biol. 1, 45-50, 1999.
50. Weaver, V.M., O.W. Petersen, F. Wang, C.A. Larabell, P. Briand, C. Damsky, and M.J. Bissell, Reversion of the malignant phenotype of human breast cells in three-dimensional culture and in vivo by integrin blocking antibodies. J. Cell Biol. 137, 231-245, 1997.