Expression of 5-lipoxygenase in pulmonary artery endothelial cells

Biochemical Journal

Volumn 361, Issue 2, 2002, Pages 267-276

  Zhang, Ying Yi ^a   Walker, Jennifer L ^a   Huang, Annong ^a   Keaney Jr , John F ^a   Clish, Clary B ^a   Serhan, Charles N ^a   Loscalzo, Joseph ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Adenovirus; cGMP; Leukotrienes

Indexed keywords

CELL CULTURE; CELLS; PULMONARY DISEASES; RNA;

HYPERTENSION;

ENZYME KINETICS;

5 HYDROXYICOSATETRAENOIC ACID; ARACHIDONATE 5 LIPOXYGENASE; ARACHIDONIC ACID; CALCIMYCIN; LEUKOTRIENE; LEUKOTRIENE A4; LEUKOTRIENE B4; MESSENGER RNA; PEPTIDOLEUKOTRIENE;

ADENOVIRUS; ARTICLE; CELL NUCLEUS; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME LOCALIZATION; GENE SEQUENCE; GENE TRANSFER; HUMAN; HUMAN CELL; LUNG ARTERY; LUNG BLOOD VESSEL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PULMONARY HYPERTENSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ADENOVIRIDAE; ANIMALS; ARACHIDONATE 5-LIPOXYGENASE; BASE SEQUENCE; CELLS, CULTURED; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYCLIC GMP; DNA PRIMERS; DNA, COMPLEMENTARY; ENDOTHELIUM, VASCULAR; GENE TRANSFER TECHNIQUES; HUMANS; LEUKOTRIENES; MASS SPECTROMETRY; PULMONARY ARTERY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SUBCELLULAR FRACTIONS; SWINE;

ADENOVIRIDAE; SIGANUS;

EID: 0037081856     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3610267     Document Type: Article

References (51)

1. Leukotriene B, a potent chemokinetic and aggregating substance released from polymorphonuclear leukocytes
2. Leukotriene C: A slow-reacting substance from murine mastocytoma cells
3. Leukotrienes are potent constrictors of human bronchi
4. Prostacyclin modulation of contractions of the human pulmonary artery by cysteinyl-leukotrienes
5. Leukotriene C4 affects pulmonary and cardiovascular dynamics in monkey
6. Differential activity of leukotrienes upon human pulmonary vein and artery
7. Comparative effects of leukotrienes on porcine pulmonary circulation in vitro and in vivo
8. Effects of the leukotrienes on the vasculature and blood pressure of different species
9. Growth control of lung cancer by interruption of 5-lipoxygenase-mediated growth factor signaling
10. 5-Lipoxygenase inhibitors reduce PC-3 cell proliferation and initiate nonnecrotic cell death
11. Relationship of arachidonic acid metabolizing enzyme expression in epithelial cancer cell lines to the growth effect of selective biochemical inhibitors
12. Inhibition of arachidonate 5-lipoxygenase triggers massive apoptosis in human prostate cancer cells
13. Lipoxygenase inhibitors abolish proliferation of human pancreatic cancer cells
14. 5-Lipoxygenase contains a functional Src homology 3-binding motif that interacts with the Src homology 3 domain of Grb2 and cytoskeletal proteins
15. Epidermal growth factor-induced actin remodeling is regulated by 5-lipoxygenase and cyclooxygenase products
16. 5-Lipoxygenase interacts with coactosin-like protein
17. Expression of 5-lipoxygenase in differentiating human skin keratinocytes
18. Arachidonate 5-lipoxygenase and its activating protein: Prominent hippocampal expression and role in somatostatin signaling
19. Reperfusion induces 5-lipoxygenase translocation and leukotriene C4 production in ischemic brain
20. HIV-1 coat glycoprotein gp120 induces apoptosis in rat brain neocortex by deranging the arachidonate cascade in favor of prostanoids
21. Circadian expression of pineal 5-lipoxygenase mRNA
22. Relationship of arachidonic acid metabolizing enzyme expression in epithelial cancer cell lines to the growth effect of selective biochemical inhibitors
23. Lipoxygenase-5 is overexpressed in prostate adenocarcinoma
24. Expression of 5-lipoxygenase by human colorectal carcinoma Caco-2 cells during butyrate-induced cell differentiation
25. Differential expression of arachidonate 5-lipoxygenase transcripts in human brain tumors: Evidence for the expression of a multitranscript family
26. Leukotriene synthesis by isolated perinatal ovine intrapulmonary vessels correlates with age-related changes in 5-lipoxygenase protein
27. Production of leukotriene B4 in parenchymal and sinusoidal cells of the liver in rats treated simultaneously with D-galactosamine and endotoxin
28. Expression and regulation of leukotriene-synthesis enzymes in rat liver cells
29. Human endothelial cells stimulate leukotriene synthesis and convert granulocyte released leukotriene A4 into leukotrienes B4, C4, D4 and E4
30. Endothelial cell leukotriene C4 synthesis results from intercellular transfer of leukotriene A4 synthesized by polymorphonuclear leukocytes
31. 5-Lipoxygenase and 5-lipoxygenase activating protein (FLAP) immunoreactivity in lungs from patients with primary pulmonary hypertension
32. Inhibition of 5-lipoxygenase-activating protein (FLAP) reduces pulmonary vascular reactivity and pulmonary hypertension in hypoxic rats
33. In situ amplification of 5-lipoxygenase and 5-lipoxygenase-activating protein in allergic airway inflammation and inhibition by leukotriene blockade
34. Analysis of a nucleotide-binding site of 5-lipoxygenase by affinity labelling: Binding characteristics and amino acid sequences
35. Mutagenesis of some conserved residues in human 5-lipoxygenase: Effects on enzyme activity
36. Efficient generation of recombinant adenovirus vectors by homologous recombination in Escherichia coli
37. Stabilization of purified human 5-lipoxygenase with glutathione peroxidase and superoxide dismutase
38. Local and systemic delivery of a stable aspirin-triggered lipoxin prevents neutrophil recruitment in vivo
39. Optimization of transfection of human endothelial cells
40. Dexamethasone increases expression of 5-lipoxygenase and its activating protein in human monocytes and THP-1 cells
41. The PPARα - Leukotriene B4 pathway to inflammation control
42. Expression of 5-lipoxygenase and biosynthesis of leukotriene B4 in human monomorphonuclear leukocytes
43. Regulation of leukotriene A4 hydrolase activity in endothelial cells by phosphorylation
44. cDNA cloning, expression, mutagenesis, intracellular localization, and gene chromosomal assignment of mouse 5-lipoxygenase
45. 5-Lipoxygenase is located in the euchromatin of the nucleus in resting human alveolar macrophages and translocates to the nuclear envelope upon cell activation
46. Reversible translocation of 5-lipoxygenase in mast cells upon IgE/antigen stimulation
47. Reversible membrane association of neutrophil 5-lipoxygenase is accompanied by retention of activity and a change in substrate specificity
48. Capacity for repeatable leukotriene generation alter transient stimulation of mast cells and macrophages
49. Nitric oxide inhibition of lipid peroxidation: Kinetics of reaction with lipid peroxyl radicals and comparison with α-tocopherol
50. 15-Lipoxygenase catalytically consumes nitric oxide and impairs activation of guanylate cyclase
51. Nitric oxide regulation of superoxide and peroxynitrite-dependent lipid peroxidation. Formation of novel nitrogen-containing oxidized lipid derivatives