Effect of novel N-aryl sulfonamide substituted 3-morpholino arecoline derivatives as muscarinic receptor 1 agonists in Alzheimer's dementia models

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 9, 2008, Pages 5157-5163

  Kumar, Y C Sunil ^a   Malviya, Manish ^a   Chandra, J N Narendra Sharath ^a   Sadashiva, C T ^a   Kumar, C S Ananda ^a   Prasad, S B Benaka ^a   Prasanna, D S ^a   Subhash, M N ^b   Rangappa, K S ^a  

^a UNIVERSITY OF MYSORE   (India)

^b NATIONAL INSTITUTE OF MENTAL HEALTH AND NEUROSCIENCES   (India)

Author keywords

Alzheimer's diseases; Displacement assay; In vitro; In vivo; M1 agonists; Morpholino arecolines; Rat brain

Indexed keywords

4 (2 CHLOROBENZENSULFONYL) 2 (1 METHYL 1,2,5,6 TETRAHYDROPYRIDIN 3 YL)MORPHOLINE; 4 (2 NITROBENZENSULFONYL) 2 (1 METHYL 1,2,5,6 TETRAHYDROPYRIDIN 3 YL)MORPHOLINE; 4 (3 NITROBENZENSULFONYL) 2 (1 METHYL 1,2,5,6 TETRAHYDROPYRIDIN 3 YL)MORPHOLINE; 4 (4 METHYLBENZENSULFONYL) 2 (1 METHYL 1,2,5,6 TETRAHYDROPYRIDIN 3 YL)MORPHOLINE; 4 (4 NITROBENZENSULFONYL) 2 (1 METHYL 1,2,5,6 TETRAHYDROPYRIDIN 3 YL)MORPHOLINE; 4 (4 TERT BUTYL BENZENSULFONYL) 2 (1 METHYL 1,2,5,6 TETRAHYDROPYRIDIN 3 YL)MORPHOLINE; 4 BENZENSULFONYL 2 (1 METHYL 1,2,5,6 TETRAHYDROPYRIDIN 3 YL)MORPHOLINE; ARECOLINE; ESTER DERIVATIVE; MORPHOLINE DERIVATIVE; MUSCARINIC M1 RECEPTOR; MUSCARINIC M1 RECEPTOR AGONIST; NITROGEN;

ALZHEIMER DISEASE; AMNESIA; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ATOM; BINDING KINETICS; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG EFFECT; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; ELECTRON TRANSPORT; MALE; NONHUMAN; RAT; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

ALZHEIMER DISEASE; ANIMALS; BINDING, COMPETITIVE; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; MALE; MAZE LEARNING; MEMORY; MEMORY DISORDERS; MOLECULAR STRUCTURE; MORPHOLINES; RATS; RATS, WISTAR; RECEPTOR, MUSCARINIC M1; SCOPOLAMINE; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

RATTUS;

EID: 43049096780     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.03.019     Document Type: Article

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