Aromatic 2-chloroethyl urea derivatives and bioisosteres. Part 2: Cytocidal activity and effects on the nuclear translocation of thioredoxin-1, and the cell cycle progression

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 15, 2008, Pages 7477-7488

  Fortin, Jessica S ^a,b   Côté, Marie France ^a   Lacroix, Jacques ^a   Petitclerc, Éric ^a,b   C Gaudreault, René ^a,b  

^a LAVAL UNIVERSITY   (Canada)

^b UNIVERSITÉ LAVAL   (Canada)

Author keywords

Alkylating agents; N Aryl 2 amino oxazolines; N Phenyl N (2 chloroacetyl)ureas; Thioredoxin

Indexed keywords

1 (2 CHLOROACETHYL) 3 (4 BIPHENYL)UREA; 1 (2 CHLOROACETHYL) 3 (4 CYCLOHEXYLPHENYL)UREA; 1 (2 CHLOROACETHYL) 3 (NAPHTHALEN 2 YL)UREA; 1 (2 CHLOROACETHYL) 3 [3 (CYCLOHEXYLOXY)PHENYL]UREA; 1 (2 CHLOROACETHYL) 3 [3 (CYCLOPENTYLOXY)PHENYL]UREA; 1 (2 CHLOROACETHYL) 3 [4 (CYCLOHEPTYLOXY)PHENYL]UREA; 1 (2 CHLOROACETHYL) 3 [4 (CYCLOHEXYLOXY)PHENYL]UREA; 1 (2 CHLOROACETHYL) 3 [4 (CYCLOPENTYLOXY)PHENYL]UREA; 1 (2 CHLOROETHYL) 3 (4 BIPHENYL)UREA; 1 ADAMANTAN 2 YL 3 (2 CHLOROETHYL)UREA; 1 [3 (BENZYLOXY)PHENYL] 3 (CHLOROETHYL)UREA; 1 [4 (BENZYLOXY)PHENYL] 3 (2 CHLOROETHYL)UREA; 4,5 DIHYDRO N (3 PHENOXYPHENYL)OXAZOL 2 AMINE; 4,5 DIHYDRO N (4 PHENOXYPHENYL)OXAZOL 2 AMINE; 4,5 DIHYDRO N (NAPHTHALEN 7 YL)OXAZOL 2 AMINE; N (1 ADAMANTAN 2 YL) 4,5 DIHYDROOXAZOL 2 AMINE; N (4 BIPHENYL) 4,5 DIHYDROOXAZOL 2 AMINE; N (4 CYCLOHEXYLPHENYL) 4,5 DIHYDROOXAZOL 2 AMINE; N PHENYL N' (2 CHLOROETHYL)UREA; N [3 (BENZYLOXY)PHENYL] 4,5 DIHYDROOXAZOL 2 AMINE; N [3 (CYCLOHEPTYLOXY)PHENYL] 4,5 DIHYDROOXAZOL 2 AMINE; N [3 (CYCLOHEXYLOXY)PHENYL] 4,5 DIHYDROOXAZOL 2 AMINE; N [3 (CYCLOPENTYLOXY)PHENYL] 4,5 DIHYDROOXAZOL 2 AMINE; N [4 (BENZYLOXY)PHENYL] 4,5 DIHYDROOXAZOL 2 AMINE; N [4 (CYCLOHEPTYLOXY)PHENYL] 4,5 DIHYDROOXAZOL 2 AMINE; N [4 (CYCLOHEXYLOXY)PHENYL] 4,5 DIHYDROOXAZOL 2 AMINE; N [4 (CYCLOPENTYLOXY)PHENYL] 4,5 DIHYDROOXAZOL 2 AMINE; THIOREDOXIN 1; UNCLASSIFIED DRUG; UNINDEXED DRUG; UREA DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL CYCLE PROGRESSION; CONTROLLED STUDY; CYTOTOXICITY; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY;

EID: 48449089646     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.06.006     Document Type: Article

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