Ferric reductase activity of low molecular weight human milk fraction is associated with enhanced iron solubility and uptake in Caco-2 cells

Biochemical and Biophysical Research Communications

Volumn 374, Issue 2, 2008, Pages 369-372

  Pullakhandam, Raghu ^a   Nair, Madhavan Krishnapillai ^a   Kasula, Sunanda ^b   Kilari, Sreenivasulu ^a   Thippande, Tippeswamy Gowda ^a  

^a NATIONAL INSTITUTE OF NUTRITION   (India)

^b Gandhi Hosp   (India)

Author keywords

Caco 2 cells; Ferric reductase; Human milk; Iron absorption

Indexed keywords

ASCORBIC ACID; FERRIC ION; IRON REDUCTASE; MILK PROTEIN; OXIDOREDUCTASE;

ABSORPTION; ARTICLE; CELL STRAIN CACO 2; CONTROLLED STUDY; ENZYME ACTIVITY; GEL FILTRATION CHROMATOGRAPHY; HUMAN; HUMAN CELL; IRON TRANSPORT; MEMBRANE; MILK; MOLECULAR WEIGHT; PRIORITY JOURNAL; SOLUBILITY; SOLUBILIZATION; ULTRAFILTRATION;

CACO-2 CELLS; FMN REDUCTASE; HUMANS; IRON; MILK, HUMAN; MOLECULAR WEIGHT; SOLUBILITY;

EID: 48349108448     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2008.07.029     Document Type: Article

References (20)

1. Saarinen U.M., Siimes M.A., and Dallman P.R. Iron absorption in infants: high bioavailability of breast milk iron as indicated by the extrinsic tag method of iron absorption and by the concentration of serum ferritin. J. Pediatr. 91 (1977) 36-39
2. Abrams S.A., Wen J., and Stuff J.E. Absorption of calcium, zinc, and iron from breast milk by five- to seven-month-old infants. Pediatr. Res. 41 (1997) 384-390
3. Fomon S.J., Ziegler E.E., Nelson S.E., Serfass R.E., and Frantz J.A. Erythrocyte incorporation of iron by 56-day-old infants fed a 58Fe labeled supplement. Pediatr. Res. 38 (1995) 373-378
4. McMillan J.A., Oski F.A., Lourie G., Tomarelli R.M., and A Landaw S. Iron absorption from human, milk simulated human milk and proprietary formulas. Pediatrics 60 (1977) 896-900
5. Davidsson L., Kastenmayer P., Yuen M., Lonnerdal B., and Hurrell R.F. Influence of lactoferrin on iron absorption from human milk in infants. Pediatr. Res. 35 (1994) 117-124
6. Argyri K., Miller D.D., Glahn R.P., Zhu L., and Kapsokefalou M. Peptides isolated from in vitro digests of milk enhance iron uptake by Caco-2 cells. J. Agric. Food Chem. 55 (2007) 10221-10225
7. Yeung A.C., Glahn R.P., and Miller D.D. Dephosphorylation of sodium caseinate, enzymatically hydrolyzed casein and casein phosphopeptides by intestinal alkaline phosphatase: implications for iron bioavailability. J. Nutr. Biochem. 12 (2001) 292-299
8. Hunt J.R. How important is dietary iron bioavailability?. Am. J. Clin. Nutr. 73 (2001) 3-4
9. Sharp P., and Srai S.K. Molecular mechanisms involved in intestinal iron absorption. World J. Gastroenterol. 13 (2007) 4716-4724
10. Han O., Failla M.L., Hill A.D., Morris E.R., and Smith Jr. J.C. Reduction of Fe(III) is required for uptake of nonheme iron by Caco-2 cells. J. Nutr. 125 (1995) 1291-1299
11. Swain J.H., Tabatabai L.B., and Reddy M.B. Histidine content of low-molecular-weight beef proteins influences nonheme iron bioavailability in Caco-2 cells. J. Nutr. 132 (2002) 245-251
12. Glahn R.P., and Van Campen D.R. Iron uptake is enhanced in Caco-2 cell monolayers by cysteine and reduced cysteinyl glycine. J. Nutr. 127 (1997) 642-647
13. Serfass R.E., and Reddy M.B. Breast milk fractions solubilize Fe(III) and enhance iron flux across Caco-2 cells. J. Nutr. 133 (2003) 449-455
14. Etcheverry P., Miller D.D., and Glahn R.P. A low-molecular-weight factor in human milk whey promotes iron uptake by Caco-2 cells. J. Nutr. 134 (2004) 93-98
15. Timmerman M.M., and Woods J.P. Ferric reduction is a potential iron acquisition mechanism for Histoplasma capsulatum. Infect Immun. 67 (1999) 6403-6408
16. Bejjani S., Pullakhandam R., Punjal R., and Nair K.M. Gastric digestion of pea ferritin and modulation of its iron bioavailability by ascorbic and phytic acids in Caco-2 cells. World J. Gastroenterol. 13 (2007) 2083-2088
17. McKie A.T., Barrow D., Latunde-Dada G.O., Rolfs A., Sager G., M udaly E., Mudaly M., Richardson C., Barlow D., Bomford A., Peters T.J., Raja K.B., Shirali S., Hediger M.A., Farzaneh F., and Simpson R.J. An iron-regulated ferric reductase associated with the absorption of dietary iron. Science 291 (2001) 1755-1759
18. Latunde-Dada G.O., Simpson R.J., and McKie A.T. Duodenal cytochrome B expression stimulates iron uptake by human intestinal epithelial cells. J. Nutr. 138 (2008) 991-995
19. Domellöf M., Lönnerdal B., Abrams S.A., and Hernell O. Iron absorption in breast-fed infants: effects of age, iron status, iron supplements, and complementary foods. Am. J. Clin. Nutr. 76 (2002) 198-204
20. Leong W.I., Bowlus C.L., Tallkvist J., and Lönnerdal B. DMT1 and FPN1 expression during infancy: developmental regulation of iron absorption. Am. J. Physiol. Gastrointest. Liver Physiol. 285 (2003) G1153-G1161