메뉴 건너뛰기




Volumn 31, Issue 6, 2008, Pages 1209-1218

Defective phosphatidylinositol 3-kinase signaling in central control of cardiovascular effects in the nucleus tractus solitarii of spontaneously hypertensive rats

Author keywords

Central cardiovascular regulation; Insulin; Nucleus tractus solitarii; Phosphatidylinositol 3 kinase; Spontaneously hypertensive rat

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; INSULIN; INSULIN RECEPTOR SUBSTRATE 1; INSULIN RECEPTOR SUBSTRATE 2; INSULIN RECEPTOR SUBSTRATE 3; INSULIN RECEPTOR SUBSTRATE 4; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE; PROTEIN KINASE B; URETHAN;

EID: 48349104934     PISSN: 09169636     EISSN: 13484214     Source Type: Journal    
DOI: 10.1291/hypres.31.1209     Document Type: Article
Times cited : (8)

References (26)
  • 1
    • 0028882894 scopus 로고
    • Experimental types of hypertension - models for essential hypertension in the human?
    • Rupp H, Brilla CG: Experimental types of hypertension - models for essential hypertension in the human? Herz 1995; 20: 315-321.
    • (1995) Herz , vol.20 , pp. 315-321
    • Rupp, H.1    Brilla, C.G.2
  • 2
    • 0023271871 scopus 로고
    • Localization and characterization of insulin receptors in rat brain and pituitary gland using in vitro autoradiography and computerized densitometry
    • Werther GA, Hogg A, Oldfield BJ, et al: Localization and characterization of insulin receptors in rat brain and pituitary gland using in vitro autoradiography and computerized densitometry. Endocrinology 1987; 121: 1562-1570.
    • (1987) Endocrinology , vol.121 , pp. 1562-1570
    • Werther, G.A.1    Hogg, A.2    Oldfield, B.J.3
  • 3
    • 6444220103 scopus 로고    scopus 로고
    • In situ Akt phosphorylation in the nucleus tractus solitarii is involved in central control of blood pressure and heart rate
    • Huang HN, Lu PJ, Lo WC, Lin CH, Hsiao M, Tseng CJ: In situ Akt phosphorylation in the nucleus tractus solitarii is involved in central control of blood pressure and heart rate. Circulation 2004; 110: 2476-2483.
    • (2004) Circulation , vol.110 , pp. 2476-2483
    • Huang, H.N.1    Lu, P.J.2    Lo, W.C.3    Lin, C.H.4    Hsiao, M.5    Tseng, C.J.6
  • 4
    • 0011910306 scopus 로고
    • Developmemof a strain of spontaneously hypertensive rats
    • Okamoto K, Aoki K: Developmemof a strain of spontaneously hypertensive rats. Jpn Circ J 1963; 27: 282-293.
    • (1963) Jpn Circ J , vol.27 , pp. 282-293
    • Okamoto, K.1    Aoki, K.2
  • 5
    • 0015510847 scopus 로고
    • Central adrenergic neurones and the initiation and development of experimental hypertension
    • Haeusler G, Finch L, Thoenen H: Central adrenergic neurones and the initiation and development of experimental hypertension. Experientia 1972; 28: 1200-1203.
    • (1972) Experientia , vol.28 , pp. 1200-1203
    • Haeusler, G.1    Finch, L.2    Thoenen, H.3
  • 6
    • 0032958470 scopus 로고    scopus 로고
    • Identification of Cd36 (Fat) as an insulin-resistance gene causing defective fatty acid and glucose metabolism in hypertensive rats
    • Aitman TJ, Glazier AM, Wallace CA, et al: Identification of Cd36 (Fat) as an insulin-resistance gene causing defective fatty acid and glucose metabolism in hypertensive rats. Nat Genet 1999; 21: 76-83.
    • (1999) Nat Genet , vol.21 , pp. 76-83
    • Aitman, T.J.1    Glazier, A.M.2    Wallace, C.A.3
  • 7
    • 23744511665 scopus 로고    scopus 로고
    • Insulin resistance in spontaneously hypertensive rats is associated with endothelial dysfunction characterized by imbalance between NO and ET-1 production
    • Potenza MA, Marasciulo FL, Chieppa DM, et al: Insulin resistance in spontaneously hypertensive rats is associated with endothelial dysfunction characterized by imbalance between NO and ET-1 production. Am J Physiol Heart Circ Physiol 2005; 289: H813-H822.
    • (2005) Am J Physiol Heart Circ Physiol , vol.289
    • Potenza, M.A.1    Marasciulo, F.L.2    Chieppa, D.M.3
  • 8
    • 0013054309 scopus 로고    scopus 로고
    • Mice with gene disruption of both endothelial and neuronal nitric oxide synthase exhibit insulin resistance
    • Shankar RR, Wu Y, Shen HQ, Zhu JS, Baron AD: Mice with gene disruption of both endothelial and neuronal nitric oxide synthase exhibit insulin resistance. Diabetes 2000; 49: 684-687.
    • (2000) Diabetes , vol.49 , pp. 684-687
    • Shankar, R.R.1    Wu, Y.2    Shen, H.Q.3    Zhu, J.S.4    Baron, A.D.5
  • 9
    • 0345192295 scopus 로고    scopus 로고
    • A common variant of the endothelial nitric oxide synthase (Glu298→Asp) is a major risk factor for coronary artery disease in the UK
    • Hingorani AD, Liang CF, Fatibene J, et al: A common variant of the endothelial nitric oxide synthase (Glu298→Asp) is a major risk factor for coronary artery disease in the UK. Circulation 1999; 100: 11515-1520.
    • (1999) Circulation , vol.100 , pp. 11515-11520
    • Hingorani, A.D.1    Liang, C.F.2    Fatibene, J.3
  • 10
    • 0033968126 scopus 로고    scopus 로고
    • Insulin resistance differentially affects the PI 3-kinase- and MAP kinase-mediated signaling in human muscle
    • Cusi K, Maezono K, Osman A, et al: Insulin resistance differentially affects the PI 3-kinase- and MAP kinase-mediated signaling in human muscle. J Clin Invest 2000; 105: 311-320.
    • (2000) J Clin Invest , vol.105 , pp. 311-320
    • Cusi, K.1    Maezono, K.2    Osman, A.3
  • 11
    • 4644287668 scopus 로고    scopus 로고
    • Increased insulin receptor substrate 1 serine phospborylation and stress-activated protein kinase/c-Jun N-terminal kinase activation associated with vascular insulin resistanee in spontaneously hypertensive rats
    • Sugita M, Sugita H, Kaneki M: Increased insulin receptor substrate 1 serine phospborylation and stress-activated protein kinase/c-Jun N-terminal kinase activation associated with vascular insulin resistanee in spontaneously hypertensive rats. Hypertension 2004; 44: 484-489.
    • (2004) Hypertension , vol.44 , pp. 484-489
    • Sugita, M.1    Sugita, H.2    Kaneki, M.3
  • 13
    • 0031840214 scopus 로고    scopus 로고
    • Upregulation of renal and vascular nitric oxide synthase in young spontaneously hypertensive rats
    • Vaziri ND, Ni Z, Oveisi F: Upregulation of renal and vascular nitric oxide synthase in young spontaneously hypertensive rats. Hypertension 1998; 31: 1248-1254.
    • (1998) Hypertension , vol.31 , pp. 1248-1254
    • Vaziri, N.D.1    Ni, Z.2    Oveisi, F.3
  • 14
    • 33745270090 scopus 로고    scopus 로고
    • Induction of heme oxygenase-1 is involved in carbon monoxide-mediated central cardiovascular regulation
    • Lo WC, Lu PJ, Ho WY, Hsia M, Tseng CJ: Induction of heme oxygenase-1 is involved in carbon monoxide-mediated central cardiovascular regulation. J Pharmacol Exp Ther 2006; 318: 8-16.
    • (2006) J Pharmacol Exp Ther , vol.318 , pp. 8-16
    • Lo, W.C.1    Lu, P.J.2    Ho, W.Y.3    Hsia, M.4    Tseng, C.J.5
  • 15
    • 12144290448 scopus 로고    scopus 로고
    • Role for neuronal insulin resistance in neurodegenerative diseases
    • Schubert M, Gautam D, Sudo D, et al: Role for neuronal insulin resistance in neurodegenerative diseases. Proc Natl Acad Sci U S A 2004; 101: 3100-3105.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 3100-3105
    • Schubert, M.1    Gautam, D.2    Sudo, D.3
  • 16
    • 0028344810 scopus 로고
    • Loss of insulin receptor immunoreactivity from the substantia nigra pars compacta neurons in Parkinson's disease
    • Moroo I, Yamada T, Makino H, et al: Loss of insulin receptor immunoreactivity from the substantia nigra pars compacta neurons in Parkinson's disease. Acta Neuropathol 1994; 87: 343-348.
    • (1994) Acta Neuropathol , vol.87 , pp. 343-348
    • Moroo, I.1    Yamada, T.2    Makino, H.3
  • 17
    • 0024357713 scopus 로고
    • VIP-mRNA is increased in hypertensive rats
    • Avidor R, Eilam R, Malach R, Gozes I: VIP-mRNA is increased in hypertensive rats. Brain Res 1989; 503: 304-307.
    • (1989) Brain Res , vol.503 , pp. 304-307
    • Avidor, R.1    Eilam, R.2    Malach, R.3    Gozes, I.4
  • 18
    • 0030900338 scopus 로고    scopus 로고
    • Quantitative trait loci for cellular defects in glucose and fatty acid metabolism in hypertensive rats
    • Aitman TJ, Gotoda T, Evans AL, et al: Quantitative trait loci for cellular defects in glucose and fatty acid metabolism in hypertensive rats. Nat Genet 1997; 16: 197-201.
    • (1997) Nat Genet , vol.16 , pp. 197-201
    • Aitman, T.J.1    Gotoda, T.2    Evans, A.L.3
  • 19
    • 0037183970 scopus 로고    scopus 로고
    • A missense mutation in kynurenine aminotransferase-1 in spontaneously hypertensive rats
    • Kwok JB, Kapoor R, Gotoda T, et al: A missense mutation in kynurenine aminotransferase-1 in spontaneously hypertensive rats. J Biol Chem 2002; 277: 35779-35782.
    • (2002) J Biol Chem , vol.277 , pp. 35779-35782
    • Kwok, J.B.1    Kapoor, R.2    Gotoda, T.3
  • 20
    • 0032523085 scopus 로고    scopus 로고
    • Hypertension, hypertriglyceridemia, and impaired endothelium-dependent vascular relaxation in mice lacking insulin receptor substrate-
    • Abe H, Yamada N, Kamata K, et al: Hypertension, hypertriglyceridemia, and impaired endothelium-dependent vascular relaxation in mice lacking insulin receptor substrate-. J Clin Invest 1998; 101: 1784-1788.
    • (1998) J Clin Invest , vol.101 , pp. 1784-1788
    • Abe, H.1    Yamada, N.2    Kamata, K.3
  • 21
    • 0034013943 scopus 로고    scopus 로고
    • Detective nitric oxide synthesis: A link between metabolic insulin resistance, sympathetic overactivity and cardiovascular morbidity
    • Scherrer U, Sartori C: Detective nitric oxide synthesis: a link between metabolic insulin resistance, sympathetic overactivity and cardiovascular morbidity. Eur J Endocrinol 2000; 142, 315-323.
    • (2000) Eur J Endocrinol , vol.142 , pp. 315-323
    • Scherrer, U.1    Sartori, C.2
  • 22
    • 0038463820 scopus 로고    scopus 로고
    • Rho/Kho-kinase pathway in brain stern contributes to blood pressure regulation via sympathetic nervous system: Possible involvement in neural mechanisms of hypertension
    • Ito K. Hirooka Y, Sakai K. et al: Rho/Kho-kinase pathway in brain stern contributes to blood pressure regulation via sympathetic nervous system: possible involvement in neural mechanisms of hypertension. Circ Res 2003; 92: 1337-1343.
    • (2003) Circ Res , vol.92 , pp. 1337-1343
    • Ito, K.1    Hirooka, Y.2    Sakai, K.3
  • 24
    • 0030760392 scopus 로고    scopus 로고
    • Insulin receptor gene in hypertension
    • Morris BJ: Insulin receptor gene in hypertension. Clin Exp Hypertens 1997; 19: 551-565.
    • (1997) Clin Exp Hypertens , vol.19 , pp. 551-565
    • Morris, B.J.1
  • 25
    • 0033119104 scopus 로고    scopus 로고
    • Role of phosphatidylinositol 3-kinase in angiotensin II regulation of neuropinephrine neuromodulation in brain neurons of the spontaneously hypertensive rat
    • Yang H, Raizada MK: Role of phosphatidylinositol 3-kinase in angiotensin II regulation of neuropinephrine neuromodulation in brain neurons of the spontaneously hypertensive rat. J Neurosci 1999; 19: 2413-2423.
    • (1999) J Neurosci , vol.19 , pp. 2413-2423
    • Yang, H.1    Raizada, M.K.2
  • 26
    • 85047693533 scopus 로고    scopus 로고
    • Hypothalamic P13K and MAPK differentially mediate regional sympathethic activation to insulin
    • Rahmouni K, Morgan DA, Morgan GM, et al: Hypothalamic P13K and MAPK differentially mediate regional sympathethic activation to insulin. J Clin Invest 2004; 114: 652-658.
    • (2004) J Clin Invest , vol.114 , pp. 652-658
    • Rahmouni, K.1    Morgan, D.A.2    Morgan, G.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.