Control of mucin production by ocular surface epithelial cells

Experimental Eye Research

Volumn 78, Issue 2, 2004, Pages 173-185

  Dartt, Darlene A ^a  

^a SCHEPENS EYE RESEARCH INSTITUTE   (United States)

Author keywords

Conjunctival epithelial cell; Mucin; Mucous layer

Indexed keywords

MUCIN;

CELL COUNT; CELL MEMBRANE; CELL PROLIFERATION; CELL SECRETION; CELL STIMULATION; CELL TYPE; CONJUNCTIVA; CONJUNCTIVA EPITHELIUM; CORNEA CELL; CYTOPLASM; ENVIRONMENT; ENZYME ACTIVATION; EPITHELIUM CELL; EYE; GOBLET CELL; HISTOCHEMISTRY; HUMAN; HYDRATION; LACRIMAL GLAND; NEUROTRANSMISSION; NONHUMAN; PATHOGENESIS; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROCESSING; PROTEIN SECRETION; PROTEIN SYNTHESIS; REGULATORY MECHANISM; REVIEW; SQUAMOUS EPITHELIUM; SURFACE PROPERTY; TEAR FILM;

EID: 0345760081     PISSN: 00144835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exer.2003.10.005     Document Type: Review

References (86)

1. Allansmith M.R., Baird R.S., Greiner J.V. Density of goblet cells in vernal conjunctivitis and contact lens-associated giant papillary conjunctivitis. Arch. Ophthalmol. 99:1981;884-885.
2. Araki-Sasaki K., Ohashi Y., Sasabe T., Hayashi K., Watanabe H., Tano Y., Handa H. An SV40-immortalized human corneal epithelial cell line and its characterization. Invest. Ophthalmol. Vis. Sci. 36:1995;614-621.
3. Argueso P., Balaram M., Spurr-Michaud S., Keutmann H.T., Dana M.R., Gipson I.K. Decreased levels of the goblet cell mucin MUC5AC in tears of patients with Sjogren Syndrome. Invest. Ophthalmol. Vis. Sci. 43:2002;1004-1011.
4. Argueso P., Gipson I.K. Epithelial mucins of the ocular surface: structure, biosynthesis and function. Exp. Eye Res. 73:2001;281-289.
5. Argueso P., Spurr-Michaud S., Russo C.L., Tisdale A., Gipson I.K. MUC16 mucin is expressed by the human ocular surface epithelia and carries the H185 carbohydrate epitope. Invest. Ophthalmol. Vis. Sci. 44:2003;2487-2495.
6. Ayers M.M., Jeffery P.K. Proliferation and differentiation in mammalian airway epithelium. Eur. Respir. J. 1:1988;58-80.
7. Black R.A., White J.M. ADAMs: focus on the protease domain. Curr. Opin. Cell. Biol. 10:1998;654-659.
8. Capper R., Guo L., Pearson J.P., Birchall J.P. Effect of nitric oxide donation on mucin production in vitro. Clin. Otolaryngol. 28:2003;51-54.
9. Carraway K.L., Carvajal M.E., Li P., Carraway C.A. ErbB2 and its ligand Muc4 (sialomucin complex) in rat lacrimal gland. Adv. Exp. Med. Biol. 506:2002;289-295.
10. Danjo S., Friend J., Thoft R.A. Conjunctival epithelium in healing of corneal epithelial wounds. Invest. Ophthalmol. Vis. Sci. 28:1987;1445-1449.
11. Dartt D.A., Kessler T.L., Chung E.H., Zieske J.D. Vasoactive intestinal peptide-stimulated glycoconjugate secretion from conjunctival goblet cells. Exp. Eye Res. 63:1996;27-34.
12. Dartt D.A., McCarthy D.M., Mercer H.J., Kessler T.L., Chung E.H., Zieske J.D. Localization of nerves adjacent to goblet cells in rat conjunctiva. Curr. Eye Res. 14:1995;993-1000.
13. 2+ and protein kinase C. Exp. Eye Res. 71:2000;619-628.
14. Denis P., Dussaillant M., Nordmann J.P., Elena P.P., Saraux H., Rostene W. Autoradiographic characterization and localization of vasoactive intestinal peptide binding sites in albino rat and rabbit eyes. Exp. Eye Res. 52:1991;357-366.
15. Deplancke B., Gaskins H.R. Microbial modulation of innate defense: goblet cells and the intestinal mucus layer. Am. J. Clin. Nutr. 73:2001;1131S-1141S.
16. Diebold Y., Calonge M., Fernandez N., Lazaro M.C., Callejo S., Herreras J.M., Pastor J.C. Characterization of epithelial primary cultures from human conjunctiva. Graefes Arch. Clin. Exp. Ophthalmol. 235:1997;268-276.
17. Diebold Y., Rios J.D., Hodges R.R., Rawe I., Dartt D.A. Presence of nerves and their receptors in mouse and human conjunctival goblet cells. Invest. Ophthalmol. Vis. Sci. 42:2001;2270-2282.
18. Dilly P.N. On the nature and the role of the subsurface vesicles in the outer epithelial cells of the conjunctiva. Br. J. Ophthalmol. 69:1985;477-481.
19. Gendler S.J., Spicer A.P. Epithelial mucin genes. Ann. Rev. Physiol. 57:1995;607-634.
20. Gipson, I.K., 1983. In: Smolen, G., and Thoft, R. (Eds.), The Cornea, Little, Brown and Company, Boston, MA, pp 3-23.
21. Gipson I.K., Spurr-Michaud S., Argueso P., Tisdale A., Ng T.F., Russo C.L. Mucin gene expression in immortalized human corneal-limbal and conjunctival epithelial cell lines. Invest. Ophthalmol. Vis. Sci. 44:2003;2496-2506.
22. Gipson I.K., Yankauckas M., Spurr-Michaud S.J., Tisdale A.S., Rinehart W. Characteristics of a glycoprotein in the ocular surface glycocalyx. Invest. Ophthalmol. Vis. Sci. 33:1992;218-227.
23. Greiner J.V., Weidman T.A., Korb D.R., Allansmith M.R. Histochemical analysis of secretory vesicles in nongoblet conjunctival epithelial cells. Acta Ophthalmol. (Copenhagen). 63:1985;89-92.
24. Han S.Y., Lee M.S., Kim H.R., Baek S.H., Ahn D.H., Chae H.S., Erickson R.H., Sleisenger M.H., Kim Y.S. Phorbol 12-myristate 13-acetate induces alteration in mucin gene expression and biological properties of colon cancer cells. Int. J. Oncol. 17:2000;487-494.
25. Haynes R.J., Tighe P.J., Dua H.S. Antimicrobial defensin peptides of the human ocular surface. Br. J. Ophthalmol. 83:1999;737-741.
26. Horibe Y., Hosoya K., Kim K.J., Ogiso T., Lee V.H. Polar solute transport across the pigmented rabbit conjunctiva: size dependence and the influence of 8-bromo cyclic adenosine monophosphate. Pharm. Res. 14:1997;1246-1251.
27. Horikawa Y., Shatos M.A., Hodges R.R., Zoukhri D., Rios J.D., Chang E.L., Bernardino C.R., Rubin P.A.D., Dartt D.A. Activation of mitogen-activated protein kinase by cholinergic agonists and EGF in human compared with rat cultured conjunctival goblet cells. Invest. Ophthalmol. Vis. Sci. 44:2003;2535-2544.
28. Huang A.J., Tseng S.C., Kenyon K.R. Morphogenesis of rat conjunctival goblet cells. Invest. Ophthalmol. Vis. Sci. 29:1988;969-975.
29. Ichikawa T., Ishihara K., Kusakabe T., Kurihara M., Kawakami T., Takenaka T., Saigenji K., Hotta K. Distinct effects of tetragastrin, histamine, and CCh on rat gastric mucin synthesis and contribution of NO. Am. J. Physiol. Gastrointest. Liver Physiol. 274:1998;G138-G146.
30. Inatomi T., Spurr-Michaud S., Tisdale A.S., Zhan Q., Feldman S.T., Gipson I.K. Expression of secretory mucin genes by human conjunctival epithelia. Invest. Ophthalmol. Vis. Sci. 37:1996;1684-1692.
31. Iwata T., Ohkawa K., Uyama M. The fine structural localization of peroxidase activity in goblet cells of the conjunctival epithelium of rats. Invest. Ophthalmol. 15:1976;40-44.
32. Joussen A.M., Poulaki V., Mitsiades N., Stechschulte S.U., Kirchhof B., Dartt D.A., Fong G.H., Rudge J., Wiegand S.J., Yancopoulos G.D., Adamis A.P. VEGF-dependent conjunctivalization of the corneal surface. Invest. Ophthalmol. Vis. Sci. 44:2003;117-123.
33. Jumblatt J.E., Cunningham L.T., Li Y., Jumblatt M.M. Characterization of human ocular mucin secretion mediated by 15(S)-HETE. Cornea. 21:2002;818-824.
34. Jumblatt J.E., Jumblatt M.M. Detection and quantification of conjunctival mucins. Adv. Exp. Med. Biol. 438:1998;239-246.
35. Jumblatt J.E., Jumblatt M.M. Regulation of ocular mucin secretion by P2Y2 nucleotide receptors in rabbit and human conjunctiva. Exp. Eye Res. 67:1998;341-346.
36. Jumblatt M.M., McKenzie R.W., Steele P.S., Emberts C.G., Jumblatt J.E. MUC7 expression in the human lacrimal gland and conjunctiva. Cornea. 22:2003;41-45.
37. Kanno H., Horikawa Y., Hodges R.R., Zoukhri D., Shatos M.A., Rios J.D., Dartt D.A. Cholinergic agonists transactivate the EGFR and stimulate MAPK to induce goblet cell secretion. Am. J. Physiol. Cell Physiol. 2003;. in press.
38. Kessler T.L., Mercer H.J., Zieske J.D., McCarthy D.M., Dartt D.A. Stimulation of goblet cell mucous secretion by activation of nerves in rat conjunctiva. Curr. Eye Res. 14:1995;985-992.
39. Kim Y.D., Kwon E.J., Park D.W., Song S.Y., Yoon S.K., Baek S.H. Interleukin-1beta induces MUC2 and MUC5AC synthesis through cyclooxygenase-2 in NCI-H292 cells. Mol. Pharmacol. 62:2002;1112-1118.
40. Komatsu M., Arango M.E., Carraway K.L. Synthesis and secretion of Muc4/sialomucin complex: implication of intracellular proteolysis. Biochem. J. 368:2002;41-48.
41. Koo J.S., Kim Y.D., Jetten A.M., Belloni P., Nettesheim P. Overexpression of mucin genes induced by interleukin-1 beta, tumor necrosis factor-alpha, lipopolysaccharide, and neutrophil elastase is inhibited by a retinoic acid receptor alpha antagonist. Exp. Lung Res. 28:2002;315-332.
42. Kunert K.S., Keane-Myers A.M., Spurr-Michaud S., Tisdale A.S., Gipson I.K. Alteration in goblet cell numbers and mucin gene expression in a mouse model of allergic conjunctivitis. Invest. Ophthalmol. Vis. Sci. 42:2001;2483-2489.
43. Laboisse C., Jarry A., Branka J.E., Merlin D., Bou-Hanna C., Vallette G. Regulation of mucin exocytosis from intestinal goblet cells. Biochem. Soc. Trans. 23:1995;810-813.
44. Lamberts, D., 1994. In: Smolen, G., and Thoft, R. (Eds.), The Cornea, Little, Brown and Company, Boston, MA, pp 439-483.
45. Langer G., Jagla W., Behrens-Baumann W., Walter S., Hoffmann W. Secretory peptides TFF1 and TFF3 synthesized in human conjunctival goblet cells. Invest. Ophthalmol. Vis. Sci. 40:1999;2220-2224.
46. Lee H.M., Choi J.H., Chae S.W., Hwang S.J., Lee S.H. Expression of epidermal growth factor receptor and its ligands in chronic sinusitis. Ann. Otol. Rhinol. Laryngol. 112:2003;132-138.
47. Lemp, M.A., 1992. The Dry Eye: A Comprehensive Guide, Springer, Heidelberg.
48. McKenzie R.W., Jumblatt J.E., Jumblatt M.M. Quantification of MUC2 and MUC5AC transcripts in human conjunctiva. Invest. Ophthalmol. Vis. Sci. 41:2000;703-708.
49. McNamara N., Van R., Tuchin O., Fleiszig S. Ocular surface epithelia express mRNA for human beta defensin-2. Exp. Eye Res. 69:1999;483-489.
50. Miyashita K., Azuma N., Hida T. Morphological and histochemical studies of goblet cells in developing human conjunctiva. Jpn. J. Ophthalmol. 36:1992;169-174.
51. Nadel J. Role of epidermal growth factor receptor activation in regulating mucin synthesis. Respir. Res. 2:2001;85-89.
52. Narawane M.A., Lee V.H. IGF-I and EGF receptors in the pigmented rabbit bulbar conjunctiva. Curr. Eye Res. 14:1995;905-910.
53. Ohashi Y., Motokura M., Kinoshita Y., Mano T., Watanabe H., Kinoshita S., Manabe R., Oshiden K., Yanaihara C. Presence of epidermal growth factor in human tears. Invest. Ophthalmol. Vis. Sci. 30:1989;1879-1882.
54. Pellegrini G., Golisano O., Paterna P., Lambiase A., Bonini S., Rama P., De Luca M. Location and clonal analysis of stem cells and their differentiated progeny in the human ocular surface. J. Cell Biol. 145:1999;769-782.
55. Pflugfelder S.C., Liu Z., Monroy D., Li D.Q., Carvajal M.E., Price-Schiavi S.A., Idris N., Solomon A., Perez A., Carraway K.L. Detection of sialomucin complex (MUC4) in human ocular surface epithelium and tear fluid. Invest. Ophthalmol. Vis. Sci. 41:2000;1316-1326.
56. Potten C.S. Regeneration in epithelial proliferative units as exemplified by small intestinal crypts. Ciba Found. Symp. 160:1991;54-71. discussion-6.
57. Prenzel N., Zwick E., Daub H., Leserer M., Abraham R., Wallasch C., Ullrich A. EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF. Nature. 402:1999;884-888.
58. Rios J.D., Forde K., Diebold Y., Lightman J., Zieske J.D., Dartt D.A. Development of conjunctival goblet cells and their neuroreceptor subtype expression. Invest. Ophthalmol. Vis. Sci. 41:2000;2127-2137.
59. Rios J.D., Zoukhri D., Rawe I.M., Hodges R.R., Zieske J.D., Dartt D.A. Immunolocalization of muscarinic and VIP receptor subtypes and their role in stimulating goblet cell secretion. Invest. Ophthalmol. Vis. Sci. 40:1999;1102-1111.
60. Rogers D.F. Motor control of airway goblet cells and glands. Respir. Physiol. 125:2001;129-144.
61. Rogers D.F. The airway goblet cell. Int. J. Biochem. Cell Biol. 35:2003;1-6.
62. Saha P., Kim K.J., Lee V.H. A primary culture model of rabbit conjunctival epithelial cells exhibiting tight barrier properties. Curr. Eye Res. 15:1996;1163-1169.
63. van Setten G.B. Basic fibroblast growth factor in human tear fluid: detection of another growth factor. Graefes Arch. Clin. Exp. Ophthalmol. 234:1996;275-277.
64. van Setten G., Schultz G. Transforming growth factor-alpha is a constant component of human tear fluid. Graefes Arch. Clin. Exp. Ophthalmol. 232:1994;523-526.
65. van Seuningen I., Pigny P., Perrais M., Porchet N., Aubert J.-P. Transcriptional regulation of the 11P15 mucin genes. Towards new biological tools in human therapy, in inflammatory diseases and cancer? Front. Biosci. 6:2001;D1216-D1234.
66. Shatos M.A., Rios J.D., Horikawa Y., Hodges R.R., Chang E.L., Bernardino C.R., Rubin P.A.D., Dartt D.A. Isolation and characterization of cultured human conjunctival goblet cells. Invest. Ophthalmol. Vis. Sci. 44:2003;2477-2486.
67. Shatos M.A., Rios J.D., Tepavcevic V., Kano H., Hodges R., Dartt D.A. Isolation, characterization, and propagation of rat conjunctival goblet cells in vitro. Invest. Ophthalmol. Vis. Sci. 42:2001;1455-1464.
68. Sheng Z.Q., Hull S.R., Carraway K.L. Biosynthesis of the cell surface sialomucin complex of ascites 13762 rat mammary adenocarcinoma cells from a high molecular weight precursor. J. Biol. Chem. 265:1990;8505-8510.
69. Sherblom A.P., Carraway K.L. A complex of two cell surface glycoproteins from ascites mammary adenocarcinoma cells. J. Biol. Chem. 255:1980;12051-12059.
70. Slomiany B.L., Slomiany A. Nitric oxide interferes with salivary mucin synthesis: involvement of ERK and p38 mitogen-activated protein kinase. J. Physiol. Pharmacol. 53:2002;325-336.
71. Specian R.D., Neutra M.R. Mechanism of rapid mucus secretion in goblet cells stimulated by acetylcholine. J. Cell Biol. 85:1980;626-640.
72. Specian R.D., Oliver M.G. Functional biology of intestinal goblet cells. Am. J. Physiol. 260:1991;C183-C193.
73. Strous G.J., Dekker J. Mucin-type glycoproteins. Crit. Rev. Biochem. Mol. Biol. 27:1992;57-92.
74. Tei M., Spurr-Michaud S.J., Tisdale A.S., Gipson I.K. Vitamin A deficiency alters the expression of mucin genes by the rat ocular surface epithelium. Invest. Ophthalmol. Vis. Sci. 41:2000;82-88.
75. Thathiah A., Blobel C.P., Carson D.D. Tumor necrosis factor-alpha converting enzyme (TACE)/ADAM 17 mediates MUC1 shedding. J. Biol. Chem. 278:2003;3386-3394.
76. Tsai R.J., Tseng S.C. Substrate modulation of cultured rabbit conjunctival epithelial cell differentiation and morphology. Invest. Ophthalmol. Vis. Sci. 29:1988;1565-1576.
77. Vesaluoma M., Teppo A.M., Gronhagen-Riska C., Tervo T. Platelet-derived growth factor-BB (PDGF-BB) in tear fluid: a potential modulator of corneal wound healing following photorefractive keratectomy. Curr. Eye Res. 16:1997;825-831.
78. Watanabe H., Ohashi Y., Kinoshita S., Manabe R., Ohshiden K. Distribution of epidermal growth factor in rat ocular and periocular tissues. Graefes Arch. Clin. Exp. Ophthalmol. 231:1993;228-232.
79. Watsky M.A., Jablonski M.M., Edelhauser H.F. Comparison of conjunctival and corneal surface areas in rabbit and human. Curr. Eye Res. 7:1988;483-486.
80. Wei Z.G., Cotsarelis G., Sun T.T., Lavker R.M. Label-retaining cells are preferentially located in fornical epithelium: implications on conjunctival epithelial homeostasis. Invest. Ophthalmol. Vis. Sci. 36:1995;236-246.
81. Wei Z.G., Lin T., Sun T.T., Lavker R.M. Clonal analysis of the in vivo differentiation potential of keratinocytes. Invest. Ophthalmol. Vis. Sci. 38:1997;753-761.
82. Wilson S.E., Li Q., Mohan R.R., Tervo T., Vesaluoma M., Bennett G.L., Schwall R., Tabor K., Kim J., Hargrave S., Cuevas K.H. Lacrimal gland growth factors and receptors: lacrimal fibroblastic cells are a source of tear HGF. Adv. Exp. Med. Biol. 438:1998;625-628.
83. Xu K.P., Zoukhri D., Zieske J.D., Dartt D.A., Sergheraert C., Loing E., Yu F.S. A role for MAP kinase in regulating ectodomain shedding of APLP2 in corneal epithelial cells. Am. J. Physiol. Cell Physiol. 281:2001;C603-C614.
84. Yang J.J., Ueda H., Kim K., Lee V.H. Meeting future challenges in topical ocular drug delivery: development of an air-interfaced primary culture of rabbit conjunctival epithelial cells on a permeable support for drug transport studies. J. Control. Release. 65:2000;1-11.
85. Zen Y., Harada K., Sasaki M., Tsuneyama K., Katayanagi K., Yamamoto Y., Nakanuma Y. Lipopolysaccharide induces overexpression of MUC2 and MUC5AC in cultured biliary epithelial cells: possible key phenomenon of hepatolithiasis. Am. J. Pathol. 161:2002;1475-1484.
86. Zhao H., Jumblatt J.E., Wood T.O., Jumblatt M.M. Quantification of MUC5AC protein in human tears. Cornea. 20:2001;873-877.