Pioglitazone, a PPARγ ligand, suppresses NFκB activation through inhibition of IκB kinase activation in cerulein-treated AR42J cells

Biomedicine and Pharmacotherapy

Volumn 62, Issue 7, 2008, Pages 466-472

  Wan, Hongyu ^a   Yuan, Yaozong ^a   Qian, Aihua ^a   Sun, Yan ^a   Qiao, Minmin ^a  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

Author keywords

AR42J; Cerulein; GW9662; Inflammation; NF B; Pioglitazone; PPAR

Indexed keywords

2 CHLORO 5 NITROBENZANILIDE; CERULETIDE; I KAPPA B KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA ANTAGONIST; PIOGLITAZONE; 2,4 THIAZOLIDINEDIONE DERIVATIVE; ANTIDIABETIC AGENT; LIGAND; NUCLEAR PROTEIN; RECEPTOR ACTIVATOR OF NUCLEAR FACTOR KAPPA B; TRANSCRIPTION FACTOR RELA;

ANIMAL CELL; ARTICLE; CANCER CELL CULTURE; CELL NUCLEUS; CELL STRAIN AR42J; CONTROLLED STUDY; DRUG EFFECT; FLUORESCENCE MICROSCOPY; IMMUNOBLOTTING; INFLAMMATION; NONHUMAN; PANCREATITIS; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DNA BINDING; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; TRANSACTIVATION; ANIMAL; BIOSYNTHESIS; CELL LINE; CYTOPLASM; DRUG ANTAGONISM; ENZYME ACTIVATION; GENETICS; IMMUNOPRECIPITATION; PHOSPHORYLATION; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CAERULEIN; CELL LINE; CYTOPLASM; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENZYME ACTIVATION; HYPOGLYCEMIC AGENTS; I-KAPPA B KINASE; IMMUNOPRECIPITATION; LIGANDS; NF-KAPPA B; NF-KAPPA B P50 SUBUNIT; NUCLEAR PROTEINS; PHOSPHORYLATION; PPAR GAMMA; RATS; RECEPTOR ACTIVATOR OF NUCLEAR FACTOR-KAPPA B; THIAZOLIDINEDIONES; TRANSCRIPTION FACTOR RELA;

EID: 48249130758     PISSN: 07533322     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biopha.2007.10.012     Document Type: Article

References (28)

1. Gorelick F.S., Adler G., and Kerin H.F. Cerulein-induced pancreatitis. In: Go V.W., DiMagno E.P., Gardner J.D., Lebenthal E., Reber H.A., and Scheele G.A. (Eds). The pancreas: biology, pathobiology, and disease. 2nd ed. (1993), Raven Press, New York 501-526
2. Willemer S., Elsasser H.P., and Adler G. Hormone-induced pancreatitis. Eur Surg Res 24 Suppl. 1 (1992) 29-49
3. Yu J.H., Lim J.W., Namkung W., Kim H., and Kim K.H. Suppression of cerulein-induced cytokine expression by antioxidants in pancreatic acinar cells. Lab Invest 82 (2002) 1359-1368
4. Blinman T.A., Gukovsky I., Mouria M., Zaninovic V., Livingston E., Pandol S.J., et al. Activation of pancreatic acinar cells on isolation from tissue: cytokine upregulation via p38 MAP kinase. Am J Physiol, Cell Physiol 279 (2000) C1993-C2003
5. Ben-Neriah Y. Regulatory functions of ubiquitination in the immune system. Nat Immunol 3 (2002) 20-26
6. Quivy V., and Van Lint C. Regulation at multiple levels of NF-kappaB mediated transactivation by protein acetylation. Biochem Pharmacol 68 (2004) 1221-1229
7. Lee J., Seo J., Kim H., Chung J.B., and Kim K.H. Signal transduction of cerulein-induced cytokine expression and apoptosis in pancreatic acinar cells. Ann N Y Acad Sci 1010 (2003) 104-108
8. Pascual G., Fong A.L., Ogawa S., Gamliel A., Li A.C., Perissi V., et al. A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-gamma. Nature 437 (2005) 759-763
9. Freshney R.I. Culture of animal cells; a manual for basic technique. 3rd ed. (1994), John Wiley, New York p. 71-103
10. Saban M.R., Hellmich H., Nguyen N.B., Winston J., Hammond T.G., and Saban R. Time course of LPS-induced gene expression in a mouse model of genitourinary inflammation. Physiol Genomics 5 (2001) 147-160
11. Sánchez-Hidalgo M., Martín A.R., Villegas I., and de la Lastra C.A. Rosiglitazone, a PPARγ ligand, modulates signal transduction pathways during the development of acute TNBS-induced colitis in rats. Eur J Pharmacol 562 (2007) 247-258
12. Christophe J. Pancreatic tumoral cell line AR42J: an amphicrine model. Am J Phys 2 66 (1994) G963-G971
13. Hashimoto K., Ethridge R.T., Saito H., Rajaraman S., and Evers B.M. The PPARgamma ligand, 15d-PGJ2, attenuates the severity of cerulein-induced acute pancreatitis. Pancreas 27 1 (2003) 58-66
14. Cuzzocrea S., Pisano B., Dugo L., Ianaro A., Britti D., Patel N.S., et al. Rosiglitazone, a ligand of the peroxisome proliferator-activated receptor-gamma, reduces acute pancreatitis induced by cerulein. Intensive Care Med 30 5 (2004) 951-956
15. Tirona R.G., and Kim R.B. Nuclear receptors and drug disposition gene regulation. J Pharm Sci 94 (2005) 1169-1186
16. Chung S.W., Kang B.Y., Kim S.H., Pak Y.K., Cho D., Trinchieri G., et al. Oxidized low density lipoprotein inhibits interleukin-12 production in lipopolysaccharide-activated mouse macrophages via direct interactions between peroxisome proliferator-activated receptor-gamma and nuclear factor-κ B. J Biol Chem 275 42 (2000) 32681-32687
17. Hayden M.S., and Ghosh S. Signaling to NF-kappaB. Genes Dev 18 (2004) 2195-2224
18. Schwab M., Reynders V., Loitsch S., Steinhilber D., Stein J., and Schröder O. Involvement of different nuclear hormone receptors in butyrate-mediated inhibition of inducible NFκB signaling. Mol Immunol 44 (2007) 3625-3632
19. Gustin J.A., Ozes O.N., Akca H., Pincheira R., Mayo L.D., Li Q., et al. Cell type-specific expression of the IkappaB kinases determines the significance of phosphatidylinositol 3-kinase/Akt signaling to NF-kappa B activation. J Biol Chem 279 (2004) 1615-1620
20. 2 production as a mechanism for cell type-specific inhibition of tumor necrosis factor alpha-induced but not interleukin-1beta-induced IkappaB kinase complex/nuclear factor-kappaB activation. J Biol Chem 280 (2005) 2912-2923
21. Collino M., Aragno M., Mastrocola R., Gallicchio M., Rosa A.C., Dianzani C., et al. Modulation of the oxidative stress and inflammatory response by PPAR-γ agonists in the hippocampus of rats exposed to cerebral ischemia/reperfusion. Eur J Pharmacol 530 (2006) 70-80
22. Liu D., Zeng B.X., Zhang S.H., and Yao S.L. Rosiglitazone, an agonist of peroxisome proliferator-activated receptor g, reduces pulmonary inflammatory response in a rat model of endotoxemia. Inflamm Res 54 (2005) 464-470
23. Arnold R., and König W. Peroxisome-proliferator-activated receptor-g agonists inhibit the release of proinflammatory cytokines from RSV-infected epithelial cells. Virology 346 (2006) 427-439
24. Ghosh S., and Karin M. Missing pieces in the NF-kappaB puzzle. Cell 109 Suppl. (2002) S81-S96
25. Gimble J.M., Robinson C.E., Wu X., Kelly K.A., Rodriguez B.R., Kliewer S.A., et al. Peroxisome proliferator-activated receptor-g activation by thiazolidinediones induces adipogenesis in bone marrow stromal cells. Mol Pharmacol 50 (1996) 1087-1094
26. Tanaka T., Itoh H., Doi K., Fukunaga Y., Hosoda K., Shintani M., et al. Down regulation of peroxisome proliferator-activated receptor gamma expression by inflammatory cytokines and its reversal by thiazolidinediones. Diabetologia 42 (1999) 702-710
27. Dehmer T., Heneka M.T., Sastre M., Dichgans J., and Schulz J.B. Protection by pioglitazone in the MPTP model of Parkinson's disease correlates with I kappa B alpha induction and block of NF kappa B and iNOS activation. J Neurochem 88 (2004) 494-501
28. Masamune A., Satoh K., Sakai Y., Yoshida M., Satoh A., and Shimosegawa T. Ligands of peroxisome proliferator-activated receptor-[gamma] induce apoptosis in AR42J cells. Pancreas 24 2 (2002) 130-138