Low-dose radiation and its clinical implications: Diabetes

Human and Experimental Toxicology

Volumn 27, Issue 2, 2008, Pages 135-142

  Wang, Guan Jun ^a   Li, Xiao Kun ^b   Sakai, Kazuo ^c   Cai, Lu ^a,b,d  

^a JILIN UNIVERSITY   (China)

^b JINAN UNIVERSITY   (China)

^c CENTRAL RESEARCH INSTITUTE OF ELECTRIC POWER INDUSTRY   (Japan)

^d University of Louisville School of Medicine   (United States)

Author keywords

Adaptive response; Diabetes; Diabetic complications; Hormesis; Low dose radiation

Indexed keywords

ALLOXAN; GLUCOSE; INSULIN; RADON;

ALLOXAN DIABETES MELLITUS; ANTIOXIDANT ACTIVITY; CARDIOVASCULAR DISEASE; CELL DAMAGE; CELL PROLIFERATION; CELL STIMULATION; CROSS RESISTANCE; DIABETES MELLITUS; DIABETIC NEUROPATHY; DIABETIC PATIENT; DISEASE COURSE; ELECTROMAGNETIC FIELD; EXPERIMENTAL MOUSE; GAMMA RADIATION; GLUCOSE BLOOD LEVEL; GLUCOSE URINE LEVEL; HORMESIS; HUMAN; HYPERGLYCEMIA; IMMUNOMODULATION; INSULIN BLOOD LEVEL; IONIZING RADIATION; LASER; LOW ENERGY RADIATION; LOW LEVEL LASER THERAPY; MICROCIRCULATION; NONHUMAN; OXIDATIVE STRESS; PANCREAS FUNCTION; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; RADIATION DOSE; REVIEW; SKIN INJURY; SKIN ULCER; THERMAL SPRING; VASODILATATION; WOUND HEALING; ADAPTATION; ANIMAL; DISEASE MODEL; RADIATION EXPOSURE; RADIATION INJURY; RADIATION RESPONSE;

ANIMALIA; MUS;

ADAPTATION, PHYSIOLOGICAL; ANIMALS; DIABETES COMPLICATIONS; DIABETES MELLITUS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, RADIATION; HUMANS; RADIATION INJURIES;

EID: 48249129181     PISSN: 09603271     EISSN: None     Source Type: Journal    
DOI: 10.1177/0960327108090752     Document Type: Review

References (74)

1. Luckey TD Physiological benefits from low levels of ionizing radiation. Health Phys 1982 ; 43: 771-89.
2. Cai L. Research of the adaptive response induced by low-dose radiation: where have we been and where should we go ? Hum Exp Toxicol 1999 ; 18: 419-25.
3. Calabrese EJ Hormesis: changing view of the dose-response, a personal account of the history and current status. Mutat Res 2002 ; 511: 181-9.
4. Calabrese EJ, Baldwin LA Hormesis: the dose-response revolution. Annu Rev Pharmacol Toxicol 2003 ; 43: 175-97.
5. Olivieri G., Bodycote J., Wolff S. Adaptive response of human lymphocytes to low concentrations of radioactive thymidine. Science 1984 ; 223: 594-7.
6. Cai L., Liu SZ Induction of cytogenetic adaptive response of somatic and germ cells in vivo and in vitro by low-dose X-irradiation. Int J Radiat Biol 1990 ; 58: 187-94.
7. Cai L., Wang P., Piao XG Cytogenetic adaptive response with multiple small X-ray doses in mouse germ cells and its biological influence on the offspring of adapted males. Mutat Res 1994 ; 324: 13-7.
8. Cai L., Jiang J. Mild hyperthermia can induce adaptation to cytogenetic damage caused by subsequent X irradiation. Radiat Res 1995 ; 143: 26-33.
9. Cai L., Wang P. Induction of a cytogenetic adaptive response in germ cells of irradiated mice with very low-dose rate of chronic gamma-irradiation and its biological influence on radiation-induced DNA or chromosomal damage and cell killing in their male offspring. Mutagenesis 1995 ; 10: 95-100.
10. Cai L., Cherian MG Adaptive response to ionizing radiation-induced chromosome aberrations in rabbit lymphocytes: effect of pre-exposure to zinc, and copper salts. Mutat Res 1996 ; 369: 233-41.
11. Cai L., Feinendegen LE, Ikusshima T., et al. Special issue: adaptive response induced by low levels of radiation. BELLE Newsletter 1999 ; 7 (3). 2-31.
12. Calabrese EJ, Baldwin LA Applications of hormesis in toxicology, risk assessment and chemotherapeutics. Trends Pharmacol Sci 2002 ; 23: 331-7.
13. Calabrese EJ Hormesis: a revolution in toxicology, risk assessment and medicine. EMBO Rep 2004 ; 5: Spec No. S37-40.
14. Richaud PM, Soubeyran P., Eghbali H., et al. Place of low-dose total body irradiation in the treatment of localized follicular non-Hodgkin's lymphoma: results of a pilot study. Int J Radiat Oncol Biol Phys 1998 ; 40: 387-90.
15. Kennerdell JS, Flores NE, Hartsock RJ Low-dose radiotherapy for lymphoid lesions of the orbit and ocular adnexa. Ophthal Plast Reconstr Surg 1999 ; 15: 129-33.
16. Girinsky T., Guillot-Vals D., Koscielny S., et al. A high and sustained response rate in refractory or relapsing low-grade lymphoma masses after low-dose radiation: analysis of predictive parameters of response to treatment. Int J Radiat Oncol Biol Phys 2001 ; 51: 148-55.
17. Kojima S., Matsuki O., Nomura T., Yamaoka K., Takahashi M., Niki E. Elevation of antioxidant potency in the brain of mice by low-dose gamma-ray irradiation and its effect on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced brain damage. Free Radic Biol Med 1999 ; 26: 388-95.
18. Yamaoka K., Mori S., Nomura T., et al. Elevation of antioxidant potency in mice brain by low-dose X-ray irradiation and its effect on Fe-NTA-induced brain damage. Physiol Chem Phys Med NMR 2002 ; 34: 119-32.
19. Wei L., Zha Y., Yao Z., et al. High Backgroud Radiation Research in Yangjiang, China. Atomic Energy Press, 1996.
20. Bardsley JK, Want LL Overview of diabetes. Crit Care Nurs Q 2004 ; 27: 106-12.
21. Shafrir E. Diabetes in animas. In: Rifkin H, Porte D. Jr. eds. Diabetes Mellitus: Theory and Practice, fourth edition. Elsevier, 1990: 299-340.
22. Haskins K., Bradley B., Powers K., et al. Oxidative stress in type 1 diabetes. Ann N Y Acad Sci 2003 ; 1005: 43-54.
23. Rosen et al. (2003).
24. Cai L., Kang YJ Oxidative stress and diabetic cardiomyopathy: a brief review. Cardiovasc Toxicol. 2001 ; 1: 181-93.
25. Takehara Y., Yamaoka K., Hiraki Y., Yoshioka T., Utsumi K. Protection against alloxan diabetes by low-dose 60Co gamma irradiation before alloxan administration. Physiol Chem Phys Med NMR 1995 ; 27: 149-59.
26. Yamaoka et al. (1996).
27. Takahashi M., Kojima S., Yamaoka K., Niki E. Prevention of type I diabetes by low-dose gamma irradiation in NOD mice. Radiat Res 2000 ; 154: 680-5.
28. Sakai K., Normura T., Ina Y. Enhancement of bio-protective functions by low-dose/dose-rate radiation. Abstracts of the 14th Pacific Basin Nuclear Conference, Honolulu, Hawaii, March 21-25, 2004, 364-7.
29. Kurrer MO, Pakala SV, Hanson HL, Katz JD Beta cell apoptosis in T cell-mediated autoimmune diabetes. Proc Natl Acad Sci U S A 1997 ; 94: 213-8.
30. Nakayama M., Nagata M., Yasuda H., et al. Fas/Fas ligand interactions play an essential role in the initiation of murine autoimmune diabetes. Diabetes 2002, 51: 1391-7.
31. Yamaoka K., Komoto Y. Experimental study of alleviation of hypertension, diabetes and pain by radon inhalation. Physiol Chem Phys Med NMR 1996 ; 28: 1-5.
32. Reddy GK Comparison of the photostimulatory effects of visible He-Ne and infrared Ga-As lasers on healing impaired diabetic rat wounds. Lasers Surg Med 2003 ; 33: 344-51.
33. Stadler I., Lanzafame RJ, Evans R., Narayan V., Dailey B., Buehner N., Naim JO 830-nm irradiation increases the wound tensile strength in a diabetic murine model. Lasers Surg Med 2001 ; 28: 220-6.
34. Byrnes KR, Barna L., Chenault VM, et al. Photobiomodulation improves cutaneous wound healing in an animal model of type II diabetes. Photomed Laser Surg 2004 ; 22: 281-90.
35. Kawalec JS, Hetherington VJ, Pfennigwerth TC, Dockery DS, Dolce M. Effect of a diode laser on wound healing by using diabetic and non-diabetic mice. J Foot Ankle Surg 2004 ; 43: 214-20.
36. Schindl A., Schindl M., Schind L. Phototherapy with low intensity laser irradiation for a chronic radiation ulcer in a patient with lupus erythematosus and diabetes mellitus. Br J Dermatol 1997 ; 137: 840-1.
37. Schindl A., Schindl M., Schon H., Knobler R., Havelec L., Schindl L. Low-intensity laser irradiation improves skin circulation in patients with diabetic microangiopathy. Diabetes Care 1998, 21: 580-4.
38. Schindl A., Schindl M., Pernerstorfer-Schon H., Kerschan K., Knobler R., Schindl L. Diabetic neuropathic foot ulcer: successful treatment by low-intensity laser therapy. Dermatology 1999 a; 198: 314-6.
39. Schindl M., Kerschan K., Schindl A., Schon H., Heinzl H., Schindl L. Induction of complete wound healing in recalcitrant ulcers by low-intensity laser irradiation depends on ulcer cause and size. Photodermatol Photoimmunol Photomed 1999 b; 15: 18-21.
40. Schindl A., Heinze G., Schindl M., Pernerstorfer-Schon H., Schindl L. Systemic effects of low-intensity laser irradiation on skin microcirculation in patients with diabetic microangiopathy. Microvasc Res 2002 ; 64: 240-6.
41. Zinman LH, Ngo M., Ng ET, Nwe KT, Gogov S., Bril V. Low-intensity laser therapy for painful symptoms of diabetic sensorimotor polyneuropathy: a controlled trial. Diabetes Care 2004 ; 27: 921-4.
42. Chebotar'ova LL, Chebotar'ov HIe. Use of low-power electromagnetic therapy in diabetic polyneuropathy. Fiziol Zh 2003 ; 49: 85-90.
43. Rosen P., Nawroth PP, King G., Moller W., Tritschler HJ, Packer L. The role of oxidative stress in the onset and progression of diabetes and its complications: a summary of a Congress Series sponsored by UNESCO-MCBN, the American Diabetes Association and the German Diabetes Society. Diabetes Metab Res Rev 2001 ; 17: 189-212.
44. Lenzen S., Drinkgern J., Tiedge M. Low antioxidant enzyme gene expression in pancreatic islets compared with various other mouse tissues. Free Radic Biol Med 1996 ; 20: 463-6.
45. Tiedge M., Lortz S., Drinkgern J., Lenzen S. Relation between antioxidant enzyme gene expression and antioxidative defense status of insulin-producing cells. Diabetes 1997 ; 46: 1733-42.
46. Kubisch HM, Wang J., Bray TM, Phillips JP Targeted overexpression of Cu/Zn superoxide dismutase protects pancreatic beta-cells against oxidative stress. Diabetes 1997 ; 46: 1563-6.
47. Hotta M., Tashiro F., Ikegami H., et al. Pancreatic beta cell-specific expression of thioredoxin, an antioxidative and antiapoptotic protein, prevents autoimmune and streptozotocin-induced diabetes. J Exp Med 1998 ; 188: 1445-51.
48. Yamaoka K., Edamatsu R., Mori A. Increased SOD activities and decreased lipid peroxide levels induced by low dose X irradiation in rat organs. Free Radic Biol Med 1991 ; 11: 299-306.
49. Yamaoka K., Kojima S., Takahashi M., Nomura T., Iriyama K. Change of glutathione peroxidase synthesis along with that of superoxide dismutase synthesis in mice spleens after low-dose X-ray irradiation. Biochim Biophys Acta 1998 ; 1381: 265-70.
50. Yamaoka K., Kojima S., Nomura T. Changes of SOD-like substances in mouse organs after low-dose X-ray irradiation. Physiol Chem Phys Med NMR 1999 ; 31: 23-8.
51. Yamaoka K., Kataoka T., Nomura T., et al. Inhibitory effects of prior low-dose X-ray irradiation on carbon tetrachloride-induced hepatopathy in acatalasemic mice. J Radiat Res (Tokyo) 2004 a; 45: 89-95.
52. Kojima S., Matsuki O., Nomura T., Kubodera A., Yamaoka K. Elevation of mouse liver glutathione level by low-dose gamma-ray irradiation and its effect on CCl4-induced liver damage. Anticancer Res 1998 ; 18 (4A). 2471-6.
53. Zhang H., Zheng RL, Wei ZQ, et al. Effects of pre-exposure of mouse testis with low-dose (16)O8+ ions or 60Co gamma-rays on sperm shape abnormalities, lipid peroxidation and superoxide dismutase (SOD) activity induced by subsequent high-dose irradiation. Int J Radiat Biol 1998 ; 73: 163-7.
54. Yamaoka K., Mitsunobu F., Hanamoto K., Shibuya K., Mori S., Tanizaki Y., Sugita K. Biochemical comparison between radon effects and thermal effects on humans in radon hot spring therapy. J Radiat Res (Tokyo) 2004 b; 45: 83-8.
55. Li H., Kaufman CL, Boggs SS, Johnson PC, Patrene KD, Ildstad ST Mixed allogeneic chimerism induced by a sublethal approach prevents autoimmune diabetes and reverses insulitis in non-obese diabetic (NOD) mice. J Immunol 1996 ; 156: 380-8.
56. Chilton PM, Rezzoug F., Fugier-Vivier I., et al. Flt3-ligand treatment prevents diabetes in NOD mice. Diabetes 2004 ; 53: 1995-2002.
57. Nikolic B., Takeuchi Y., Leykin I., Fudaba Y., Smith RN, Sykes M. Mixed hematopoietic chimerism allows cure of autoimmune diabetes through allogeneic tolerance and reversal of autoimmunity. Diabetes 2004 ; 53: 376-83.
58. Li W., Wang G., Cui J., Xue L., Cai L. Low-dose radiation (LDR) induces hematopoietic hormesis: LDR-induced mobilization of hematopoietic progenitor cells into peripheral blood circulation. Exp Hematol 2004 ; 32: 1088-96.
59. Ina Y., Sakai K. Prolongation of life span associated with immunological modification by chronic low-dose-rate irradiation in MRL-lpr/lpr mice. Radiat Res 2004 ; 161: 168-73.
60. Wilden L., Karthein R. Import of radiation phenomena of electrons and therapeutic low-level laser in regard to the mitochondrial energy transfer. J Clin Laser Med Surg 1998 ; 16: 159-65.
61. Callaghan GA, Riordan C., Gilmore WS, McIntyre IA, Allen JM, Hannigan BM Reactive oxygen species inducible by low-intensity laser irradiation alter DNA synthesis in the haemopoietic cell line U937. Lasers Surg Med 1996 ; 19: 201-6.
62. Vladimirov IuA, Klebanov GI, Borisenko GG, Osipov AN Molecular and cellular mechanisms of the low intensity laser radiation effect. Biofizika 2004 ; 49: 339-50.
63. Karageuzyan KG, Sekoyan ES, Karagyan AT, et al. Phospholipid pool, lipid peroxidation, and superoxide dismutase activity under various types of oxidative stress of the brain and the effect of low-energy infrared laser irradiation. Biochemistry (Mosc) 1998 ; 63: 1226-32.
64. Fujimaki Y., Shimoyama T., Liu Q., Umeda T., Nakaji S., Sugawara K. Low-level laser irradiation attenuates production of reactive oxygen species by human neutrophils. J Clin Laser Med Surg 2003 ; 21: 165-70.
65. Kao MJ, Sheen LY Effects of infrared and low-power laser irradiation on cell viability, glutathione and glutathione-related enzyme activities in primary rat hepatocytes. J Formos Med Assoc 2003 ; 102: 486-91.
66. Duan R., Liu TC, Li Y., Guo H., Yao LB Signal transduction pathways involved in low intensity He-Ne laser-induced respiratory burst in bovine neutrophils: a potential mechanism of low intensity laser biostimulation. Lasers Surg Med 2001 ; 29: 174-8.
67. Pereira AN, Eduardo Cde P., Matson E., Marques MM Effect of low-power laser irradiation on cell growth and procollagen synthesis of cultured fibroblasts. Lasers Surg Med 2002 ; 31: 263-7.
68. Schindl A., Merwald H., Schindl L., Kaun C., Wojta J. Direct stimulatory effect of low-intensity 670 nm laser irradiation on human endothelial cell proliferation. Br J Dermatol 2003 ; 148: 334-6.
69. Vinck EM, Cagnie BJ, Cornelissen MJ, Declercq HA, Cambier DC Increased fibroblast proliferation induced by light emitting diode and low power laser irradiation. Lasers Med Sci 2003 ; 18 (2). 95-9.
70. Galeano M., Altavilla D., Cucinotta D., et al. Recombinant human erythropoietin stimulates angiogenesis and wound healing in the genetically diabetic mouse. Diabetes 2004 a; 53: 2509-17.
71. Galiano RD, Tepper OM, Pelo CR, et al. Topical vascular endothelial growth factor accelerates diabetic wound healing through increased angiogenesis and by mobilizing and recruiting bone marrow-derived cells. Am J Pathol 2004 b; 164: 1935-47.
72. Johansson L. Hormesis, an update of the present position. Eur J Nucl Med Mol Imaging 2003 ; 30: 921-33.
73. Poumadere M. Hormesis: public health policy, organizational safety and risk communication. Hum Exp Toxicol 2003 ; 22: 39-41.
74. Zhou H., Randers-Pehrson G., Geard CR, Brenner DJ, Hall EJ, Hei TK Interaction between radiation-induced adaptive response and bystander mutagenesis in mammalian cells. Radiat Res 2003 ; 160: 512-6.