Plasma C5 glucose-to- 2H 2O ratio does not provide an accurate assessment of gluconeogenesis during hyperinsulinemic-euglycemic clamps in either nondiabetic or diabetic humans

Diabetes

Volumn 57, Issue 7, 2008, Pages 1800-1804

  Basu, Rita ^a   Chandramouli, Visvanathan ^b   Dicke, Betty ^a   Landau, Bernard R ^b   Rizza, Robert A ^a  

^a MAYO CLINIC   (United States)

^b CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON; DEUTERIUM OXIDE; GLUCOSE; INSULIN; DRUG DERIVATIVE; GLUCAGON; GLYCOGEN; HUMAN GROWTH HORMONE; SOMATOSTATIN; WATER;

ACCURACY; ARTICLE; CLINICAL ARTICLE; CLINICAL ASSESSMENT; CONTROLLED STUDY; COSMOLOGICAL PHENOMENA; DIABETES MELLITUS; GLUCONEOGENESIS; GLUCOSE BLOOD LEVEL; GLUCOSE CLAMP TECHNIQUE; GLUCOSE METABOLISM; GLYCOGENOLYSIS; HUMAN; HYPERINSULINEMIA; INFUSION RATE; INSULIN INFUSION; OUTCOME ASSESSMENT; PRIORITY JOURNAL; BLOOD; DRUG EFFECT; HYPERINSULINISM; INTRAVENOUS DRUG ADMINISTRATION; KINETICS; METABOLISM; METHODOLOGY; REFERENCE VALUE; REPRODUCIBILITY;

BLOOD GLUCOSE; DEUTERIUM OXIDE; DIABETES MELLITUS; GLUCAGON; GLUCONEOGENESIS; GLUCOSE CLAMP TECHNIQUE; GLYCOGEN; HUMAN GROWTH HORMONE; HUMANS; HYPERINSULINISM; INFUSIONS, INTRAVENOUS; INSULIN; KINETICS; REFERENCE VALUES; REPRODUCIBILITY OF RESULTS; SOMATOSTATIN; WATER;

EID: 48249108028     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db08-0195     Document Type: Article

References (24)

1. 2O for estimating rates of gluconeogenesis: application to the fasted state. J Clin Invest 95:172-178, 1995
2. Landau BR, Wahren J, Chandramouli V, Schumann WC, Ekberg K, Kalhan SC: Contributions of gluconeogenesis to glucose production in the fasted state. J Clin Invest 98:378-385, 1996
3. Boden G, Chen X, Capulong E, Mozzoli M: Effects of free fatty acids on gluconeogenesis and autoregulation of glucose production in type 2 diabetes. Diabetes 50:810-816, 2001
4. Gastaldelli A, Toschi E, Pettiti M, Frascerra S, Quinones-Galvan A, Sironi AM, Natali A, Ferrannini E: Effect of physiological hyperinsulinemia on gluconeogenesis in nondiabetic subjects and in type 2 diabetic patients. Diabetes 50:1807-1812, 2001
5. Boden G, Chen X, Stein TP: Gluconeogenesis in moderately and severely hyperglycemic patients with type 2 diabetes mellitus. Am J Physiol Endocrinol Metab 280:E23-E30, 2001
6. Boden G, Cheung P, Stein TP, Kresge K, Mozzoli M: FFA cause hepatic insulin resistance by inhibiting insulin suppression of glycogenolysis. Am J Physiol Endocrinol Metab 283:E12-E19, 2002
7. Adkins A, Basu R, Persson M, Dicke B, Shah P, Vella A, Schwenk WF, Rizza R: Higher insulin concentrations are required to suppress gluconeogenesis than glycogenolysis in non-diabetic humans. Diabetes 52:2213-2220, 2003
8. Wajngot A, Chandramouli V, Schumann WC, Ekberg K, Jones PK, Efendic S, Landau BR: Quantitative contributions of gluconeogenesis to glucose production during fasting in type 2 diabetes mellitus. Metab Clin Exp 50:47-52, 2001
9. Gastadelli A, Miyazaki Y, Pettiti M, Matsuda M, Mahankali S, Santini E, DeFronzo RA, Ferrannini E: Metabolic effects of visceral fat accumulation in type 2 diabetes. J Clin Endocrinol Metab 87:5098-5103, 2002
10. Gastaldelli A, Miyazaki Y, Pettiti M, Buzzigoli E, Mahankali S, Ferrannini E, DeFronzo RA: Separate contribution of diabetes, total fat mass, and fat topography to glucose production, gluconeogenesis, and glycogenolysis. J Clin Endocrinol Metab 89:3914-3921, 2004
11. Basu R, Schwenk F, Rizza RA: Both fasting glucose production and disappearance are abnormal in people with "mild" and "severe" type 2 diabetes. Am J Physiol Endocrinol Metab 287:E55-E62, 2004
12. Gastaldelli A, Miyazaki Y, Pettiti M, Santini E, Ciociaro D, DeFronzo RA, Ferrannini E: The effect of rosiglitazone on the liver: decreased glucone- ogenesis in patients with type 2 diabetes. J Clin Endocrinol Metab 91:806-812, 2006
13. Boden G: Role of fatty acids in the pathogenesis of insulin resistance and NIDDM. Diabetes 46:3-10, 1997
14. Allick G, van der Crabben SN, Ackermans MT, Endert E, Sauerwein HP: Measurement of gluconeogenesis by deuterated water: the effect of equilibration time and fasting period. Am J Physiol Endocrinol Metab 290:E1212-E1217, 2006
15. Jones JG, Fagulha A, Barosa C, Bastos M, Baptista C, Caldeira MM, Carvalheiro M: Noninasive analysis of hepatic glycogen kinetics before and after breakfast with deuterated water and acetaminophen. Diabetes 55: 2294-2300, 2006
16. Krebs M, Brehm A, Krssak M, Anderwald C, Bernroider E, Nowotny P, Roth E, Chandramouli V, Landau BR, Waldhausl W, Roden M: Direct and indirect effects of amino acids on hepatic glucose metabolism in humans. Diabetologia 46:917-925, 2003
17. Kalhan S, Rossi K, Gruca L, Burkett E, O'Brien A: Glucose turnover and gluconeogenesis in human pregnancy. J Clin Invest 100:1775-1781, 1997
18. Gastaldelli A, Miyazaki Y, Mahankali A, Berria R, Pettiti M, Buzzigoli E, Ferrannini E, DeFronzo RA: The effect of pioglitazone on the liver: role of adiponectin. Diabetes Care 29:2275-2281, 2006
19. Basu R, Shah P, Basu A, Norby B, Dicke B, Chandramouli V, Cohen O, Landau BR, Rizza RA: Comparison of the effects of pioglitazone and metformin on hepatic and extra-hepatic insulin action in people with type 2 diabetes. Diabetes 57:24-31, 2007
20. Basu A, Caumo A, Bettini F, Gelisio A, Alzaid A, Cobelli C: Impaired basal glucose effectiveness in NIDDM: contribution of defects in glucose disappearance and production, measured using an optimized minimal model independent protocol. Diabetes 46:421-432, 1997
21. 2O administration. Anal Biochem 297:195-197, 2001
22. Steele R, Wall J, DeBodo R, Altszuler N: Measurement of size and turnover rate of body glucose pool by the isotope dilution method. Am J Physiol 187:15-24, 1956
23. Cherrington AD, Williams PE, Harris MS: Relationship between the plasma glucose level and glucose uptake in the conscious dog. Metabolism 27:787-791, 1978
24. DeFronzo RA, Ferrannini E, Hendler R, Felig P, Wahren J: Regulation of splanchnic and peripheral glucose uptake by insulin and hyperglycemia in man. Diabetes 32:35-45, 1983