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The resin-bound BLM exhibits DNA cleavage properties quite similar to the free species. See
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The resin-bound BLM exhibits DNA cleavage properties quite similar to the free species. See: Tao, Z.-F.; Leitheiser, C. J.; Smith, K. L.; Hashimoto, S.; Hecht, S. M. Bioconjugate Chem. 2002, 13, 426.
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48249134110
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The extent of DNA cleavage by different BLMs (PAGE assay) versus intensity of fluorescence enhancement obtained with the fluorescent hairpin DNA indicated very similar cleavage efficiencies in both assay systems
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The extent of DNA cleavage by different BLMs (PAGE assay) versus intensity of fluorescence enhancement obtained with the fluorescent hairpin DNA indicated very similar cleavage efficiencies in both assay systems.
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23
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48249115714
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2+ (100%) (Figure 1).
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2+ (100%) (Figure 1).
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24
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48249128074
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While the initial experiments were carried out using hairpin DNAs isolated as outlined in Scheme 1, detailed characterization employed chemically synthesized DNAs prepared to verify the initial observations
-
While the initial experiments were carried out using hairpin DNAs isolated as outlined in Scheme 1, detailed characterization employed chemically synthesized DNAs prepared to verify the initial observations.
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25
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48249139163
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19,20 This method requires the assumption that bithiazole fluorescence quenching bears the same proportionality to DNA binding for all DNAs. The rather different efficiencies of quenching of bithiazole fluorescence by DNAs shown functionally to bind BLM with comparable affinities (Figure 1) suggests that this assumption is suspect.
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19,20 This method requires the assumption that bithiazole fluorescence quenching bears the same proportionality to DNA binding for all DNAs. The rather different efficiencies of quenching of bithiazole fluorescence by DNAs shown functionally to bind BLM with comparable affinities (Figure 1) suggests that this assumption is suspect.
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26
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0017385996
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Chien, M.; Grollman, A. P.; Horwitz, S. B. Biochemistry 1977, 16, 3641.
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27
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48249141537
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The apparent equilibrium constant is defined as 1/(C, 1/nK(D0)(B, 1/n(D0, where n, number of bound BLM/DNA nt, B, free BLM concn, C, bound BLM concn, D0, total DNA concn, B) and (C) were obtained from the fluorescence quenching caused by association between BLM and hairpin DNA and calculated from (B, F, Fc, Fb, Fc, B0) and C, Fb, F, Fb, Fc, B0, where F, quenched fluorescence intensity between BLM and hairpin DNA, Fb, fluorescence intensity of free BLM, Fc, fluorescence intensity of bound BLM, B0, total BLM concn
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0) = total BLM concn.
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