Improving the affinity of antigens for mutated antibodies by use of statistical molecular design

Journal of Peptide Science

Volumn 14, Issue 7, 2008, Pages 786-796

  Mandrika, Ilona ^a   Prusis, Peteris ^a   Bergström, Jakob ^a   Yahorava, Sviatlana ^a   Wikberg, Jarl E S ^a  

^a UPPSALA UNIVERSITY   (Sweden)

Author keywords

Fluorescence polarization; Mutagenesis; Peptide antigen; Single chain antibody; SPOT synthesis; Statistical molecular design

Indexed keywords

ANTIGEN P24; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY;

AMINO ACID SUBSTITUTION; ANTIBODY LIBRARY; ANTIGEN ANTIBODY COMPLEX; ANTIGEN BINDING; ARTICLE; BINDING AFFINITY; GENE MUTATION; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN MODIFICATION; PROTEIN STRUCTURE; SEQUENCE HOMOLOGY; STATISTICAL MOLECULAR DESIGN; STRUCTURE ANALYSIS;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANTIBODIES; ANTIGENS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; PEPTIDE LIBRARY; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY;

EID: 48249083022     PISSN: 10752617     EISSN: 10991387     Source Type: Journal    
DOI: 10.1002/psc.999     Document Type: Article

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