Differentially modulated dendritic cells induce regulatory T cells with different characteristics

Transplant Immunology

Volumn 19, Issue 3-4, 2008, Pages 220-228

  Roelen, Dave L ^a   van den Boogaardt, Daniëlle E M ^a   van Miert, Paula P M C ^a   Koekkoek, Karin ^a   Offringa, Rienk ^a   Claas, Frans H J ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

DC Regulatory T cells; Glucocorticoid hormone; Transplantation

Indexed keywords

DEXAMETHASONE; GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 12P70; LIPOPOLYSACCHARIDE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2;

ALLOIMMUNITY; ARTICLE; CELL ADHESION; CELL CONTACT; CELL STIMULATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; EFFECTOR CELL; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOLOGICAL TOLERANCE; LYMPHOCYTE PROLIFERATION; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; T LYMPHOCYTE; TRANSPLANTATION;

ANTIGEN PRESENTATION; CELL COMMUNICATION; CELL DIFFERENTIATION; CELL PROLIFERATION; CELLS, CULTURED; CYTOKINES; DENDRITIC CELLS; DEXAMETHASONE; HUMANS; IMMUNE TOLERANCE; IMMUNOPHENOTYPING; LIPOPOLYSACCHARIDES; LYMPHOCYTE ACTIVATION; T-CELL ANTIGEN RECEPTOR SPECIFICITY; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, REGULATORY;

EID: 48149115842     PISSN: 09663274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.trim.2008.06.004     Document Type: Article

References (40)

1. Bernard A., Lamy A.L., and Alberti I. The two-signal model of T-cell activation after 30 years. Transplantation 73 1 Suppl (2002) S31-S35
2. Banchereau J., and Steinman R.M. Dendritic cells and the control of immunity. Nature 392 6673 (1998) 245-252
3. Clark G.J., Angel N., Kato M., Lopez J.A., MacDonald K., Vuckovic S., et al. The role of dendritic cells in the innate immune system. Microbes Infect 2 3 (2000) 257-272
4. Hart D.N. Dendritic cells: unique leukocyte populations which control the primary immune response. Blood 90 9 (1997) 3245-3287
5. Lu L., McCaslin D., Starzl T.E., and Thomson A.W. Bone marrow-derived dendritic cell progenitors (NLDC 145+, MHC class II+, B7-1dim, B7-2-) induce alloantigen-specific hyporesponsiveness in murine T lymphocytes. Transplantation 60 12 (1995) 1539-1545
6. Fu F., Li Y., Qian S., Lu L., Chambers F., Starzl T.E., et al. Costimulatory molecule-deficient dendritic cell progenitors (MHC class II+, CD80dim, CD86-) prolong cardiac allograft survival in nonimmunosuppressed recipients. Transplantation 62 5 (1996) 659-665
7. Lutz M.B., Suri R.M., Niimi M., Ogilvie A.L., Kukutsch N.A., Rossner S., et al. Immature dendritic cells generated with low doses of GM-CSF in the absence of IL-4 are maturation resistant and prolong allograft survival in vivo. Eur J Immunol 30 7 (2000) 1813-1822
8. Woltman A.M., and van Kooten C. Functional modulation of dendritic cells to suppress adaptive immune responses. J Leukoc Biol 73 4 (2003) 428-441
9. Allavena P., Piemonti L., Longoni D., Bernasconi S., Stoppacciaro A., Ruco L., et al. IL-10 prevents the differentiation of monocytes to dendritic cells but promotes their maturation to macrophages. Eur J Immunol 28 1 (1998) 359-369
10. Buelens C., Verhasselt V., De G.D., Thielemans K., Goldman M., and Willems F. Interleukin-10 prevents the generation of dendritic cells from human peripheral blood mononuclear cells cultured with interleukin-4 and granulocyte/macrophage-colony-stimulating factor. Eur J Immunol 27 3 (1997) 756-762
11. Geissmann F., Revy P., Regnault A., Lepelletier Y., Dy M., Brousse N., et al. TGF-beta 1 prevents the noncognate maturation of human dendritic Langerhans cells. J Immunol 162 8 (1999) 4567-4575
12. Woltman A.M., de Fijter J.W., Kamerling S.W., Paul L.C., Daha M.R., and van Kooten C. The effect of calcineurin inhibitors and corticosteroids on the differentiation of human dendritic cells. Eur J Immunol 30 7 (2000) 1807-1812
13. Matyszak M.K., Citterio S., Rescigno M., and Ricciardi-Castagnoli P. Differential effects of corticosteroids during different stages of dendritic cell maturation. Eur J Immunol 30 4 (2000) 1233-1242
14. Rea D., van Kooten C., van Meijgaarden K.E., Ottenhoff T.H., Melief C.J., and Offringa R. Glucocorticoids transform CD40-triggering of dendritic cells into an alternative activation pathway resulting in antigen-presenting cells that secrete IL-10. Blood 95 10 (2000) 3162-3167
15. Griffin M.D., Lutz W., Phan V.A., Bachman L.A., McKean D.J., and Kumar R. Dendritic cell modulation by 1alpha,25 dihydroxyvitamin D3 and its analogs: a vitamin D receptor-dependent pathway that promotes a persistent state of immaturity in vitro and in vivo. Proc Natl Acad Sci U S A 98 12 (2001) 6800-6805
16. Penna G., and Adorini L. 1 Alpha,25-dihydroxyvitamin D3 inhibits differentiation, maturation, activation, and survival of dendritic cells leading to impaired alloreactive T cell activation. J Immunol 164 5 (2000) 2405-2411
17. Roelen D.L., Schuurhuis D.H., van den Boogaardt D.E., Koekkoek K., van Miert P.P., van Schip J.J., et al. Prolongation of skin graft survival by modulation of the alloimmune response with alternatively activated dendritic cells. Transplantation 76 11 (2003) 1608-1615
18. Langenkamp A., Messi M., Lanzavecchia A., and Sallusto F. Kinetics of dendritic cell activation: impact on priming of TH1, TH2 and nonpolarized T cells. Nat Immunol 1 4 (2000) 311-316
19. + Tr cells. Blood 105 3 (2005) 1162-1169
20. Kalinski P., Hilkens C.M., Snijders A., Snijdewint F.G., and Kapsenberg M.L. L-12-deficient dendritic cells, generated in the presence of prostaglandin E2, promote type 2 cytokine production in maturing human naive T helper cells. J Immunol 159 1 (1997) 28-35
21. Vieira P.L., Kalinski P., Wierenga E.A., Kapsenberg M.L., and de Jong E.C. Glucocorticoids inhibit bioactive IL-12p70 production by in vitro-generated human dendritic cells without affecting their T cell stimulatory potential. J Immunol 161 10 (1998) 5245-5251
22. Moore K.W., de Waal M.R., Coffman R.L., and O'Garra A. Interleukin-10 and the interleukin-10 receptor. Annu Rev Immunol (2001) 19683-19765
23. Roncarolo M.G., Levings M.K., and Traversari C. Differentiation of T regulatory cells by immature dendritic cells. J Exp Med 193 2 (2001) F5-F9
24. Corinti S., Albanesi C., la S.A., Pastore S., and Girolomoni G. Regulatory activity of autocrine IL-10 on dendritic cell functions. J Immunol 166 7 (2001) 4312-4318
25. Battaglia M.G., and Roncarolo M. The role of cytokines (and not only) in inducing and expanding T regulatory type 1 cells. Transplantation 77 1 Suppl (2004) S16-S18
26. Karim M., Bushell A.R., and Wood K.J. Regulatory T cells in transplantation. Curr Opin Immunol 14 5 (2002) 584-591
27. Bach J.F. Regulatory T cells under scrutiny. Nat Rev Immunol 3 3 (2003) 189-198
28. + regulatory T cells: implications for transplantation tolerance. Transpl Immunol 11 3-4 (2003) 277-285
29. Suciu-Foca N., Manavalan J.S., and Cortesini R. Generation and function of antigen-specific suppressor and regulatory T cells. Transpl Immunol 11 3-4 (2003) 235-244
30. Thompson C., and Powrie F. Regulatory T cells. Curr Opin Pharmacol 4 4 (2004) 408-414
31. + T cells with regulatory properties by repetitive stimulation with allogeneic immature human dendritic cells. J Exp Med 192 9 (2000) 1213-1222
32. +. J Immunol 161 10 (1998) 5193-5202
33. Li J., Liu Z., Jiang S., Cortesini R., Lederman S., and Suciu-Foca N. T suppressor lymphocytes inhibit NF-kappa B-mediated transcription of CD86 gene in APC. J Immunol 163 12 (1999) 6386-6392
34. Burrows S.R., Khanna R., Burrows J.M., and Moss D.J. An alloresponse in humans is dominated by cytotoxic T lymphocytes (CTL) cross-reactive with a single Epstein-Barr virus CTL epitope: implications for graft-versus-host disease. J Exp Med 179 4 (1994) 1155-1161
35. Page K.R., Scott A.L., and Manabe Y.C. The expanding realm of heterologous immunity: friend or foe?. Cell Microbiol 8 2 (2006) 185-196
36. Dankers M.K., Roelen D.L., Korfage N., de Lange P., Witvliet M., Sandkuijl L., et al. Differential immunogenicity of paternal HLA Class I antigens in pregnant women. Hum Immunol 64 6 (2003) 600-606
37. Claas F.H., Dankers M.K., Oudshoorn M., van Rood J.J., Mulder A., Roelen D.L., et al. Differential immunogenicity of HLA mismatches in clinical transplantation. Transpl Immunol 14 3-4 (2005) 187-191
38. Kuningas M., Mooijaart S.P., Slagboom P.E., Westendorp R.G., and van H.D. Genetic variants in the glucocorticoid receptor gene (NR3C1) and cardiovascular disease risk. The Leiden 85-plus Study. Biogerontology 7 4 (2006) 231-238
39. van den Akker E.L., Russcher H., van Rossum E.F., Brinkmann A.O., de Jong F.H., Hokken A., et al. Glucocorticoid receptor polymorphism affects transrepression but not transactivation. J Clin Endocrinol Metab 91 7 (2006) 2800-2803
40. Mirenda V., Berton I., Read J., Cook T., Smith J., Dorling A., et al. Modified dendritic cells coexpressing self and allogeneic major histocompatability complex molecules: an efficient way to induce indirect pathway regulation. J Am Soc Nephrol 15 4 (2004) 987-997