Inhibition of receptor tyrosine kinases in combination with chemotherapy for the treatment of breast cancer

Anti-Cancer Agents in Medicinal Chemistry

Volumn 8, Issue 5, 2008, Pages 481-487

  Moulder, S L ^a   Craft, B S ^b   Hortobagyi, G N ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b UNIVERSITY OF MISSISSIPPI MEDICAL CENTER   (United States)

Author keywords

Bevacizumab; Biotherapy; Breast cancer; Lapatinib; Targeted therapy; Trastuzumab; Tyrosine kinase

Indexed keywords

ANTHRACYCLINE DERIVATIVE; BEVACIZUMAB; CAPECITABINE; CARBOPLATIN; CETUXIMAB; CISPLATIN; CYCLOPHOSPHAMIDE; DOCETAXEL; DOXORUBICIN; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; EPIRUBICIN; ERLOTINIB; FLUOROURACIL; GEFITINIB; GEMCITABINE; IRINOTECAN; LAPATINIB; NAVELBINE; PACLITAXEL; PERTUZUMAB; PLATELET DERIVED GROWTH FACTOR RECEPTOR; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; SOMATOMEDIN RECEPTOR; SUNITINIB; TRASTUZUMAB; VANDETANIB; VASCULOTROPIN RECEPTOR; ANTINEOPLASTIC AGENT; PROTEIN KINASE INHIBITOR;

ADJUVANT THERAPY; ANEMIA; ANTINEOPLASTIC ACTIVITY; BREAST CANCER; CANCER CHEMOTHERAPY; CANCER RECURRENCE; CANCER RESISTANCE; CARDIOTOXICITY; CLINICAL TRIAL; COMBINATION CHEMOTHERAPY; CONGESTIVE HEART FAILURE; DIARRHEA; DISEASE FREE SURVIVAL; DRUG EFFICACY; DRUG MECHANISM; DRUG RESPONSE; DRUG SAFETY; DRUG STRUCTURE; DRUG TARGETING; DRUG TOLERABILITY; HALF LIFE TIME; HUMAN; HYPERTENSION; LEUKOPENIA; LOADING DRUG DOSE; LUNG NON SMALL CELL CANCER; MOLECULAR BIOLOGY; MONOTHERAPY; MULTIPLE CYCLE TREATMENT; NONHUMAN; OVERALL SURVIVAL; PAIN; REVIEW; SOLID TUMOR; ADJUVANT CHEMOTHERAPY; BREAST TUMOR; DRUG ANTAGONISM; MULTIMODALITY CANCER THERAPY;

ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; CHEMOTHERAPY, ADJUVANT; CLINICAL TRIALS AS TOPIC; COMBINED MODALITY THERAPY; HUMANS; PROTEIN KINASE INHIBITORS; RECEPTOR PROTEIN-TYROSINE KINASES;

EID: 48049109636     PISSN: 18715206     EISSN: None     Source Type: Journal    
DOI: 10.2174/187152008784533080     Document Type: Review

References (57)

1. Baselga, J.; Arteaga, C.L. J. Clin. Oncol., 2005, 23(11), 2445-59.
2. Pawson, T.; Scott, J.D. Science, 1997, 278(5346), 2075-80.
3. Krause, D.S.; Van Etten, R.A. N. Engl. J. Med., 2005, 353(2), 172-87.
4. Alvarez, R.H.; Kantarjian, H.M.; Cortes, J.E. Cancer, 2006, 107(8), 1918-29.
5. Roussel, M.F.; Downing, J.R.; Rettenmier, C.W.; Sherr, C.J. Cell, 1988, 55(6), 979-88.
6. Bargmann, C.I.; Hung, M.C.; Weinberg, R.A. Cell, 1986, 45(5), 649-57.
7. Santoro, M.; Carlomagno, F.; Romano, A.; Bottaro, D.P.; Dathan, N.A.; Grieco, M.; Fusco, A.; Vecchio, G.; Matoskova, B.; Kraus, M.H.; Di Flore, P.P. Science, 1995, 267(5196), 381-3.
8. Atalay, G.; Cardoso, F.; Awada, A.; Piccart, M.J. Ann. Oncol., 2003, 14(9), 1346-63.
9. Hobday, T.J.; Perez, E.A. Cancer Control, 2005, 12(2), 73-81.
10. Yang, W.; Klos, K.S.; Zhou, X.; Yao, J.; Yang, Y.; Smith, T.L.; Shi, D.; Yu, D. Cancer, 2003, 98(6), 1123-30.
11. Menard, S.; Fortis, S.; Castiglioni, F.; Agresti, R.; Balsari, Oncology, 2001, 61(Suppl 2), 67-72.
12. Harris, A.L.; Nicholson, S.; Sainsbury, J.R.; Farndon, J.; Wright, C. J. Steroid Biochem., 1989, 34(1-6), 123-31.
13. Nicholson, S.; Sainsbury, J.R; Halcrow, P.; Chambers P, Farndon J.R.; Harris A.L. Lancet, 1989, 1(8631), 182-5.
14. Moulder, S.L.; Yakes, F.M.; Muthuswamy, S.K.; Bianco, R.; Simpson, J.F.; Arteaga C.L. Cancer Res., 2001, 61(24), 8887-95.
15. Ferrara, N.; Gerber, H.P.; LeCouter, J. Nat. Med., 2003, 9(6), 669-76.
16. Folkman, J. Nat. Med., 1995, 1(1), 27-31.
17. Brem, S.S.; Gullino, P.M.; Medina, D. Science, 1977, 195(4281), 880-2.
18. Weinstat-Saslow, D.L.; Zabrenetzky, V.S.; VanHoutte, K.; Frazier, W.A.; Roberts, D.D.; Steeg, P.S. Cancer Res., 1994, 54(24), 6504-11.
19. Weidner, N.; Semple, J.P.; Welch, W.R.; Folkman, J. N. Engl. J. Med., 1991, 324(1), 1-8.
20. Lev, D.C.; Kim, S.J.; Onn, A.; Stone, V.; Nam, D.H.; Yazici, S.; Fider, I.J.; Price, J.E. Clin. Cancer Res., 2005, 11(1), 306-14.
21. Yi, B.; Williams, P.J.; Niewolna, M.; Wang, Y.; Yoneda, T. Cancer Res., 2002, 62(3), 917-23.
22. Ullrich, A.; Bell, J.R.; Chen E.Y.; Herrera, R.; Petruzzelli, L.M.; Dull, T.J.; Gray, A.; Coussens, L.; Liao, Y.-C.; Tsubokawa, M.; Mason, A.; Seeburg, P.H.; Grunfeld, C.; Rosen, O.M. Nature, 1985, 313(6005), 756-61.
23. Pandini, G.; Vigneri, R.; Costantino, A.; Frasca, F.; Ippolito, A.; Fujita-Yamaguchi, Y.; Siddle, K.; Goldfine, I.D.; Belfiore, A. Clin. Cancer Res., 1999, 5(7), 1935-44.
24. Sachdev, D.; Yee, D. J. Mammary Gland Biol. Neoplasia., 2006, 11(1), 27-39.
25. Arteaga, C.L.; Kitten, L.J.; Coronado, E.B.; Jacobs, S.; Kull, F.C.; Jr., Allred, D.C.; Osborne, C.K. J. Clin. Invest., 1989, 84(5), 1418-23.
26. Salatino, M.; Schillaci, R; Proietti, C.J.; Carnevale, R.; Frahm, I.; Molinolo, A.A.; Iribarren, A.; Charreau, E.H.; Elizalde, P.V. Oncogene, 2004, 23(30), 5161-74.
27. Bonneterre, J.; Peyrat, J.P.; Beuscart, R.; Demaille, A. Cancer Res., 1990, 50(21), 6931-5.
28. Emens, L.A.; Davidson, N.E. Oncology (Williston Park), 2004, 18(9), 1117-28, discussion 1131-2, 1137-8.
29. Smith, I.E. Anticancer Drugs, 2001, 12(Suppl 4), S3-10.
30. Vogel, C.L.; Cobleigh, M.A.; Tripathy, D.; Gutheil, J.C.; Harris, L.N.; Fehrenbacher, L.; Slamon, D.J.; Murphy, M.; Novotny, W.F.; Burchmore, M.; Shak, S.; Stewart, S.J.; Press M. J. Clin. Oncol., 2002, 20(3), 719-26.
31. Cobleigh M.A.; Vogel C.L.; Tripathy, D.; Robert, N.J.; Scholl, S.; Fehrenbacher, L.; Wolter, J.M.; Paton, V.; Shak, S.; Lieberman, G.; Salmon, D.J. J. Clin. Oncol., 1999, 17(9), 2639-48.
32. Baselga J, Carbonell X, Castaneda-Soto N.J.; Clemens M, Green M, Harvey V, Morales S, Barton C, Ghahramani P. J. Clin. Oncol., 2005, 23(10), 2162-71.
33. Slamon D.J.; Leyland-Jones B, Shak S, Fuchs H, Paton V, Bajamonde A, Fleming T, Eiermann W, Wolter J, Pegram M, Baslega J, Norton L. N. Engl. J. Med., 2001, 344(11), 783-92.
34. Romond E.H.; Perez E.A.; Bryant J, Suman V.J.; Geyer C.E.; Jr., Davidson N.E.; Tanchiu E, Martino S, Paik S, Kaufman P.A.; Swain S.M.; Pisansky T.M.; Fehrenbacher L, Kutteh L.A.; Vogel V.G.; Visscher D.W.; Yothers G, Jenkins R.B.; Brown A.M.; Dakhil S.R.; Mamounas E.P.; Lingle W.L.; Klein P.M.; Ingle J.N.; Wolmark N. N. Engl. J. Med., 2005, 353(16), 1673-84.
35. Joensuu H, Kellokumpu-Lehtinen P.L.; Bono P, Alanko T, Kataja V, Asola R, Utriainen T, Kokko R, Hemminki A, Tarkkanen M, Turpeenniemi-Hujanen T, Jyrkkio S, Flander, M.; Helle, L.; Ingalsuo, S.; Johansson, K.; Jaakskelainen, A.S.; Pajunen, M.; Rauhala, M.; Kaleva-Kerola, J.; Salminen, T.; Leinonen, M.; Elomaa, I.; Isola, J.; FinHer Study Investigators. N. Engl. J. Med., 2006, 354(8), 809-20.
36. Buzdar, A.U.; Ibrahim, N.K.; Francis D, Booser D.J.; Thomas E.S.; Theriault R.L.; Pusztai, L.; Green, M.C.; Arun, B.K.; Giordano, S.H.; Cristofanilli, M.; Frye, D.K.; Smith, T.L.; Hunt, K.K.; Singletary, S.E.; Sahin, A.A.; Ewer, M.S.; Buchholz, T.A.; Berry, D.; Hortobagyi, G.N. J. Clin. Oncol., 2005, 23(16), 3676-85.
37. Agus, D.B.; Gordon, M.S.; Taylor, C.; Natale,R.B.; Karlan B, Mendelson, D.S.; Press, M.F.; Allison, D.E.; Sliwkowski, M.X.; Lieberman, G.; Kelsey, S.M.; Fyfe, G. J. Clin. Oncol., 2005, 23(11), 2534-43.
38. Rusnak, D.W.; Lackey, K.; Affleck, K.; Wood, E.R.; Alligood, K.J.; Rhodes, N.; Keith, B.R.; Murray, D.M.; Knight, W.B.; Mullin, R.J.; Gilmer, T.M. Mol. Cancer Ther., 2001, 1(2), 85-94.
39. Xia, W.; Mullin, R.J.; Keith, B.R.; Liu, L.H.; Ma, H.; Rusnak, D.W.; Owens, G.; Alligood, K.J.; Spector, N.L. Oncogene, 2002, 21(41), 6255-63.
40. Burris, H.A.; 3rd, Hurwitz, H.I.; Dees, E.C.; Dowlati, A.; Blackwell, K.L.; O'Neil, B.; Marcom, P.K.; Ellis, M.J.; Overmoyer, B.; Jones, S.F.; Harris, J.L.; Smith, D.A.; Koch, K.M.; Stead, A.; Mangum, S.; Spector, N.L. J. Clin. Oncol., 2005, 23(23), 5305-13.
41. Geyer, C.E.; Forster, J.; Lindquist, D.; Chan, S.; Romieu, C.G.; Pienkowski, T.; Jagiello-Gruszfeld, A.; Crown, J.; Chan, A.; Kaufman, B.; Skarlos, D.; Campone, M.; Davidson, N.; Berger, M.; Oliva, C.; Rubin, S.D.; Stein, S.; Cameron, D. N. Engl. J. Med., 2006, 355(26), 2733-43.
42. Baselga, J.; Albanell, J.; Ruiz, A.; Lluch, A.; Gascon, P.; Guillem, V.; Gonzalez, S.; Sauleda, S.; Marimon, I.; Tabernero, J.M.; Keohler, M.T.; Rojo, F. J. Clin. Oncol., 2005, 23(23), 5323-33.
43. Von Minckwitz, G.; Jonat, W.; Fasching, P.; du Bois, A.; Kleeberg, U.; Luck, H.J.; Kettner, E.; Hilfrich, J.; Eiermann, W.; Torode, J.; Schneeweiss, A. Breast Cancer Res. Treat., 2005, 89(2), 165-72.
44. Ciardiello, F.; Troiani, T.; Caputo, F.; De Laurentiis, M.; Tortora, G.; Palmieri, G.; De Vita, F, Diadema, M.R.; Orditura, M.; Colantuoni, G.; Gridelli, C.; Catalano, G.; De Placido, S.; Bianco, A.R.; Br. J. Cancer, 2006, 94(11), 1604-9.
45. Fountzilas, G.; Pectasides, D.; Kalogera-Fountzila, A.; Skarlos, D.; Kalofonos, H.P.; Papadimitriou, C.; Bafalouks, D.; Lambropoluos, S.; Oavlidis, N.; Razis, E.; Kosmidis, P.; Gogas, H. Breast Cancer Res. Treat., 2005, 92(1), 1-9.
46. Guarneri, V.; Frassoldati, A.; Ficarra, G.; Puglisi, F.; Andreetta, C.; Michelotti, A.; Cresti, N.; Boni, C.; Bisagni, G.; Berardi, R.; Battelli, N.; Santoro, A.; Banna, G.; Bottini, A.; Blasio, B.D.; Maiorana, A.; Piacentini, F.; Giovannelli, S.; Jvic, G.; Conte, P. Breast Cancer Res. Treat., 2007.
47. Cobleigh, M.A.; Langmuir, V.K.; Sledge, G.W.; Miller, K.D.; Haney, L.; Novotny, W.F.; Reimann J.D.; Vassel, A. Semin. Oncol., 2003, 30(5 Suppl 16), 117-24.
48. Miller, K.; Wang, M.; Gralow, J.; Dickler, M.; Cobleigh, M.; Perez, E.A.; Shenkier, T.; Cella, D.; Davidson, N.E. N. Engl. J. Med., 2007, 357(26), 2666-76.
49. Miller, K.D.; Chap, L.I.; Holmes, F.A.; Cobleigh, M.A.; Marcom, P.K.; Fehrenbacher, L.; Dickler, M.; Overmoyer, B.A.; Reimann, J.D.; Sing, A.P.; Langmuir, V.; Rugo, H.S. J. Clin. Oncol., 2005, 23(4), 792-9.
50. Wedam, S.B.; Low, J.A.; Yang, S.X.; Chow, C.K.; Choyke, P.; Danforth, D.; Hewitt, S.M.; Berman, A.; Steinberg, Sm.; Liewehr, D.J.; Plehn, J.; Doshi, A.; Thomasson, D.; MeCarthy, N.; Koeppen, H.; Sherman, M.; Zujewski, J.; Camphausen, K.; Chen, H.; Swain, S.M. J. Clin. Oncol., 2006, 24(5), 769-77.
51. Miller, K.D.; Trigo, J.M.; Wheeler, C.; Barge, A.; Rowbottom, J.; Sledge, G.; Baselga, J. Clin. Cancer Res., 2005, 11(9), 3369-76.
52. Giaccone, G.; Herbst, R.S.; Manegold, C.; Scagliotti, G.; Rosell, R.; Miller, V.; Natale, R.B.; Schiller, J.H.; Von Pawel, J.; Pluzanska, A.; Gatzemeier, U.; Grous, J.; Ochs, J.S.; Averbush, S.D.; Wolf, M.K.; Rennie, P.; Fandi, A.; Johnson, D.H. J. Clin. Oncol., 2004, 22(5), 777-84.
53. Herbst, R.S.; Giaccone, G.; Schiller, J.H.; Natale, R.B.; Miller, V.; Manegold, C.; Scagliotti, G.; Rosell, R.; Oliff, I.; Reeves, J.A.; Wolf, M.K.; Kerbs, A.D.; Averbuch, S.D.; Ochs, J.S.; Grous, J.; Fandi, A.; Johnson, D.H. J. Clin. Oncol., 2004, 22(5), 785-94.
54. Herbst, R.S.; Prager, D.; Hermann, R.; Fehrenbacher, L.; Johnson, B.E.; Sandler, A.; Kris, M.G.; Tran, H.T.; Klein, P.; Li, X.; Ramies, D.; Johnson, D.H.; Miller, V.A.; TRIBUTE Investigator Group. J. Clin. Oncol., 2005, 23(25), 5892-9.
55. Mass, R.D.; Press, M.F.; Anderson, S.; Cobleigh, M.A.; Vogel, C.L.; Dybdal, N.; Leiberman, G.; Slamon, D.J. Breast Cancer, 2005, 6(3), 240-6.
56. Bell, D.W.; Lynch, T.J.; Haserlat, S.M.; Harris, P.L.; Okimoto, R.A.; Brannigan, B.W.; Sgroi, D.C.; Muir, B.; Riemenschenider, M.J.; Iacona, R.B.; Krebs, A.D.; Johnson, D.H.; Giaccone, G.; Herbst, R.S.; Manegold, C.; Fukuoka, M.; Kris, M.G.; Baselga, J.; Ochs, J.S.; Haber, D.A. J. Clin. Oncol., 2005, 23(31), 8081-92.
57. Demonty, G.; Bernard-Marty, C.; Puglisi, F.; Mancini, I.; Piccart, M. Eur. J. Cancer, 2007, 43(3), 497-509.