메뉴 건너뛰기




Volumn 590, Issue 1-3, 2008, Pages 136-149

Evidence for serotonin synthesis-dependent regulation of in vitro neuronal firing rates in the midbrain raphe complex

Author keywords

5 HT1A autoreceptor; Dorsal raphe nucleus; MDMA; Serotonin; Tryptophan; Tryptophan hydroxylase

Indexed keywords

3,4 METHYLENEDIOXYMETHAMPHETAMINE; FLUOXETINE; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; PARGYLINE; SEROTONIN; SEROTONIN 1A RECEPTOR; TRYPTOPHAN;

EID: 48049099909     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2008.06.014     Document Type: Article
Times cited : (33)

References (84)
  • 2
    • 42349117001 scopus 로고    scopus 로고
    • Elevated expression of tryptophan hydroxylase-2 mRNA at the neuronal level in the dorsal and median raphe nuclei of depressed suicides
    • Bach-Mizrachi H., Underwood M.D., Tin A., Ellis S.P., Mann J.J., and Arango V. Elevated expression of tryptophan hydroxylase-2 mRNA at the neuronal level in the dorsal and median raphe nuclei of depressed suicides. Mol. Psychiatry 13 (2008) 507-513
    • (2008) Mol. Psychiatry , vol.13 , pp. 507-513
    • Bach-Mizrachi, H.1    Underwood, M.D.2    Tin, A.3    Ellis, S.P.4    Mann, J.J.5    Arango, V.6
  • 3
    • 0032970989 scopus 로고    scopus 로고
    • A review of central 5-HT receptors and their function
    • Barnes N.M., and Sharp T. A review of central 5-HT receptors and their function. Neuropharmacology 38 (1999) 1083-1152
    • (1999) Neuropharmacology , vol.38 , pp. 1083-1152
    • Barnes, N.M.1    Sharp, T.2
  • 4
    • 0842327827 scopus 로고    scopus 로고
    • Median and dorsal raphe neurons are not electrophysiologically identical
    • Beck S.G., Pan Y.Z., Akanwa A.C., and Kirby L.G. Median and dorsal raphe neurons are not electrophysiologically identical. J. Neurophysiol. 91 (2004) 994-1005
    • (2004) J. Neurophysiol. , vol.91 , pp. 994-1005
    • Beck, S.G.1    Pan, Y.Z.2    Akanwa, A.C.3    Kirby, L.G.4
  • 6
    • 15944411354 scopus 로고    scopus 로고
    • More tryptophan hydroxylase in the brainstem dorsal raphe nucleus in depressed suicides
    • Boldrini M., Underwood M.D., Mann J.J., and Arango V. More tryptophan hydroxylase in the brainstem dorsal raphe nucleus in depressed suicides. Brain Res. 1041 (2005) 19-28
    • (2005) Brain Res. , vol.1041 , pp. 19-28
    • Boldrini, M.1    Underwood, M.D.2    Mann, J.J.3    Arango, V.4
  • 7
    • 33646684688 scopus 로고    scopus 로고
    • Increased tryptophan hydroxylase immunoreactivity in the dorsal raphe nucleus of alcohol-dependent, depressed suicide subjects is restricted to the dorsal subnucleus
    • Bonkale W.L., Turecki G., and Austin M.C. Increased tryptophan hydroxylase immunoreactivity in the dorsal raphe nucleus of alcohol-dependent, depressed suicide subjects is restricted to the dorsal subnucleus. Synapse 60 (2006) 81-85
    • (2006) Synapse , vol.60 , pp. 81-85
    • Bonkale, W.L.1    Turecki, G.2    Austin, M.C.3
  • 9
    • 27144536263 scopus 로고    scopus 로고
    • Amygdala responsiveness is modulated by tryptophan hydroxylase-2 gene variation
    • Canli T., Congdon E., Gutknecht L., Constable R.T., and Lesch K.P. Amygdala responsiveness is modulated by tryptophan hydroxylase-2 gene variation. J. Neural Transm. 112 (2005) 1479-1485
    • (2005) J. Neural Transm. , vol.112 , pp. 1479-1485
    • Canli, T.1    Congdon, E.2    Gutknecht, L.3    Constable, R.T.4    Lesch, K.P.5
  • 10
    • 0014843495 scopus 로고
    • Accumulation of 5-hydroxytryptophan in mouse brain after decarboxylase inhibition
    • Carlsson A., and Lindqvist M. Accumulation of 5-hydroxytryptophan in mouse brain after decarboxylase inhibition. J. Pharm. Pharmacol. 22 (1970) 726-727
    • (1970) J. Pharm. Pharmacol. , vol.22 , pp. 726-727
    • Carlsson, A.1    Lindqvist, M.2
  • 11
    • 0015440803 scopus 로고
    • Simultaneous measurement of tyrosine and tryptophan hydroxylase activities in brain in vivo using an inhibitor of the aromatic amino acid decarboxylase
    • Carlsson A., Davis J.N., Kehr W., Lindqvist M., and Atack C.V. Simultaneous measurement of tyrosine and tryptophan hydroxylase activities in brain in vivo using an inhibitor of the aromatic amino acid decarboxylase. Naunyn-Schmiedeberg's Arch. Pharmacol. 275 (1972) 153-168
    • (1972) Naunyn-Schmiedeberg's Arch. Pharmacol. , vol.275 , pp. 153-168
    • Carlsson, A.1    Davis, J.N.2    Kehr, W.3    Lindqvist, M.4    Atack, C.V.5
  • 12
  • 13
    • 0027456428 scopus 로고
    • Physiopharmacological interactions between stress hormones and central serotonergic systems
    • Chaouloff F. Physiopharmacological interactions between stress hormones and central serotonergic systems. Brain Res. Brain Res. Rev. 18 (1993) 1-32
    • (1993) Brain Res. Brain Res. Rev. , vol.18 , pp. 1-32
    • Chaouloff, F.1
  • 14
    • 0027970049 scopus 로고
    • WAY-100635 and GR127935: effects on 5-hydroxytryptamine-containing neurones
    • Craven R., Grahame-Smith D., and Newberry N. WAY-100635 and GR127935: effects on 5-hydroxytryptamine-containing neurones. Eur. J. Pharmacol. 271 (1994) R1-R3
    • (1994) Eur. J. Pharmacol. , vol.271
    • Craven, R.1    Grahame-Smith, D.2    Newberry, N.3
  • 15
    • 2642582531 scopus 로고    scopus 로고
    • Differential expression of 5HT-1A, alpha 1b adrenergic, CRF-R1, and CRF-R2 receptor mRNA in serotonergic, gamma-aminobutyric acidergic, and catecholaminergic cells of the rat dorsal raphe nucleus
    • Day H.E., Greenwood B.N., Hammack S.E., Watkins L.R., Fleshner M., Maier S.F., and Campeau S. Differential expression of 5HT-1A, alpha 1b adrenergic, CRF-R1, and CRF-R2 receptor mRNA in serotonergic, gamma-aminobutyric acidergic, and catecholaminergic cells of the rat dorsal raphe nucleus. J. Comp. Neurol. 474 (2004) 364-378
    • (2004) J. Comp. Neurol. , vol.474 , pp. 364-378
    • Day, H.E.1    Greenwood, B.N.2    Hammack, S.E.3    Watkins, L.R.4    Fleshner, M.5    Maier, S.F.6    Campeau, S.7
  • 17
    • 0028818986 scopus 로고
    • Differential activation of the 5-hydroxytryptamine-containing neurons of the midbrain raphe of the rat in response to randomly presented inescapable sound
    • Dilts R.P., and Boadle-Biber M.C. Differential activation of the 5-hydroxytryptamine-containing neurons of the midbrain raphe of the rat in response to randomly presented inescapable sound. Neurosci. Lett. 199 (1995) 78-80
    • (1995) Neurosci. Lett. , vol.199 , pp. 78-80
    • Dilts, R.P.1    Boadle-Biber, M.C.2
  • 20
    • 0018677277 scopus 로고
    • Serotonin synthesis and release in brain slices: independence of tryptophan
    • Elks M.L., Youngblood W.W., and Kizer J.S. Serotonin synthesis and release in brain slices: independence of tryptophan. Brain Res. 172 (1979) 471-486
    • (1979) Brain Res. , vol.172 , pp. 471-486
    • Elks, M.L.1    Youngblood, W.W.2    Kizer, J.S.3
  • 21
  • 22
    • 0028030278 scopus 로고
    • Single-unit responses of serotonergic dorsal raphe neurons to 5-HT1A agonist and antagonist drug administration in behaving cats
    • Fornal C.A., Litto W.J., Metzler C.W., Marrosu F., Tada K., and Jacobs B.L. Single-unit responses of serotonergic dorsal raphe neurons to 5-HT1A agonist and antagonist drug administration in behaving cats. J. Pharmacol. Exp. Ther. 270 (1994) 1345-1358
    • (1994) J. Pharmacol. Exp. Ther. , vol.270 , pp. 1345-1358
    • Fornal, C.A.1    Litto, W.J.2    Metzler, C.W.3    Marrosu, F.4    Tada, K.5    Jacobs, B.L.6
  • 23
    • 0030425699 scopus 로고    scopus 로고
    • WAY-100635, a potent and selective 5-hydroxytryptamine1A antagonist, increases serotonergic neuronal activity in behaving cats: comparison with (S)-WAY-100135
    • Fornal C.A., Metzler C.W., Gallegos R.A., Veasey S.C., McCreary A.C., and Jacobs B.L. WAY-100635, a potent and selective 5-hydroxytryptamine1A antagonist, increases serotonergic neuronal activity in behaving cats: comparison with (S)-WAY-100135. J. Pharmacol. Exp. Ther. 278 (1996) 752-762
    • (1996) J. Pharmacol. Exp. Ther. , vol.278 , pp. 752-762
    • Fornal, C.A.1    Metzler, C.W.2    Gallegos, R.A.3    Veasey, S.C.4    McCreary, A.C.5    Jacobs, B.L.6
  • 24
    • 0015501424 scopus 로고
    • Partial purification and characterization of tryptophan hydroxylase from rabbit hindbrain
    • Friedman P.A., Kappelman A.H., and Kaufman S. Partial purification and characterization of tryptophan hydroxylase from rabbit hindbrain. J. Biol. Chem. 247 (1972) 4165-4173
    • (1972) J. Biol. Chem. , vol.247 , pp. 4165-4173
    • Friedman, P.A.1    Kappelman, A.H.2    Kaufman, S.3
  • 25
    • 0017258088 scopus 로고
    • Inhibition of firing of raphe neurones by tryptophan and 5-hydroxytryptophan: blockade by inhibiting serotonin synthesis with Ro-4-4602
    • Gallager D.W., and Aghajanian G.K. Inhibition of firing of raphe neurones by tryptophan and 5-hydroxytryptophan: blockade by inhibiting serotonin synthesis with Ro-4-4602. Neuropharmacology 15 (1976) 149-156
    • (1976) Neuropharmacology , vol.15 , pp. 149-156
    • Gallager, D.W.1    Aghajanian, G.K.2
  • 26
    • 0031048599 scopus 로고    scopus 로고
    • Blockage of muscle and neuronal nicotinic acetylcholine receptors by fluoxetine (Prozac)
    • Garcia-Colunga J., Awad J.N., and Miledi R. Blockage of muscle and neuronal nicotinic acetylcholine receptors by fluoxetine (Prozac). Proc. Natl. Acad. Sci. U. S. A, 94 (1997) 2041-2044
    • (1997) Proc. Natl. Acad. Sci. U. S. A , vol.94 , pp. 2041-2044
    • Garcia-Colunga, J.1    Awad, J.N.2    Miledi, R.3
  • 27
    • 26944497596 scopus 로고    scopus 로고
    • Early life experience alters behavior during social defeat: focus on serotonergic systems
    • Gardner K.L., Thrivikraman K.V., Lightman S.L., Plotsky P.M., and Lowry C.A. Early life experience alters behavior during social defeat: focus on serotonergic systems. Neuroscience 136 (2005) 181-191
    • (2005) Neuroscience , vol.136 , pp. 181-191
    • Gardner, K.L.1    Thrivikraman, K.V.2    Lightman, S.L.3    Plotsky, P.M.4    Lowry, C.A.5
  • 28
    • 0028981518 scopus 로고
    • Interaction between a selective 5-HT1A receptor antagonist and an SSRI in vivo: effects on 5-HT cell firing and extracellular 5-HT
    • Gartside S.E., Umbers V., Hajos M., and Sharp T. Interaction between a selective 5-HT1A receptor antagonist and an SSRI in vivo: effects on 5-HT cell firing and extracellular 5-HT. Br. J. Pharmacol. 115 (1995) 1064-1070
    • (1995) Br. J. Pharmacol. , vol.115 , pp. 1064-1070
    • Gartside, S.E.1    Umbers, V.2    Hajos, M.3    Sharp, T.4
  • 29
    • 0031405613 scopus 로고    scopus 로고
    • Acute effects of 3,4-methylenedioxymethamphetamine (MDMA) on 5-HT cell firing and release: comparison between dorsal and median raphe 5-HT systems
    • Gartside S.E., McQuade R., and Sharp T. Acute effects of 3,4-methylenedioxymethamphetamine (MDMA) on 5-HT cell firing and release: comparison between dorsal and median raphe 5-HT systems. Neuropharmacology 36 (1997) 1697-1703
    • (1997) Neuropharmacology , vol.36 , pp. 1697-1703
    • Gartside, S.E.1    McQuade, R.2    Sharp, T.3
  • 30
    • 0030934086 scopus 로고    scopus 로고
    • Inhibition of 5-HT cell firing in the DRN by non-selective 5-HT reuptake inhibitors: studies on the role of 5-HT1A autoreceptors and noradrenergic mechanisms
    • Gartside S.E., Umbers V., and Sharp T. Inhibition of 5-HT cell firing in the DRN by non-selective 5-HT reuptake inhibitors: studies on the role of 5-HT1A autoreceptors and noradrenergic mechanisms. Psychopharmacology (Berl) 130 (1997) 261-268
    • (1997) Psychopharmacology (Berl) , vol.130 , pp. 261-268
    • Gartside, S.E.1    Umbers, V.2    Sharp, T.3
  • 34
    • 0035947219 scopus 로고    scopus 로고
    • Different tonic regulation of neuronal activity in the rat dorsal raphe and medial prefrontal cortex via 5-HT(1A) receptors
    • Hajos M., Hoffmann W.E., Tetko I.V., Hyland B., Sharp T., and Villa A.E. Different tonic regulation of neuronal activity in the rat dorsal raphe and medial prefrontal cortex via 5-HT(1A) receptors. Neurosci. Lett. 304 (2001) 129-132
    • (2001) Neurosci. Lett. , vol.304 , pp. 129-132
    • Hajos, M.1    Hoffmann, W.E.2    Tetko, I.V.3    Hyland, B.4    Sharp, T.5    Villa, A.E.6
  • 35
    • 0037333836 scopus 로고    scopus 로고
    • DOPA cyclohexyl ester potently inhibits aglycemia-induced release of glutamate in rat striatal slices
    • Hashimoto M., Miyamae T., Yamamoto I., and Goshima Y. DOPA cyclohexyl ester potently inhibits aglycemia-induced release of glutamate in rat striatal slices. Neurosci. Res. 45 (2003) 335-344
    • (2003) Neurosci. Res. , vol.45 , pp. 335-344
    • Hashimoto, M.1    Miyamae, T.2    Yamamoto, I.3    Goshima, Y.4
  • 36
    • 0030979442 scopus 로고    scopus 로고
    • -deprenyl (selegiline) limits the repetitive firing of action potentials in rat hippocampal CA1 neurons via a dopaminergic mechanism
    • Huang C.C., Tsai J.J., and Hsu K.S. -deprenyl (selegiline) limits the repetitive firing of action potentials in rat hippocampal CA1 neurons via a dopaminergic mechanism. Brain Res. 753 (1997) 27-35
    • (1997) Brain Res. , vol.753 , pp. 27-35
    • Huang, C.C.1    Tsai, J.J.2    Hsu, K.S.3
  • 37
    • 0026515597 scopus 로고
    • Structure and function of the brain serotonin system
    • Jacobs B.L., and Azmitia E.C. Structure and function of the brain serotonin system. Physiol. Rev. 72 (1992) 165-229
    • (1992) Physiol. Rev. , vol.72 , pp. 165-229
    • Jacobs, B.L.1    Azmitia, E.C.2
  • 38
    • 0026357345 scopus 로고
    • Activity of brain serotonergic neurons in the behaving animal
    • Jacobs B.L., and Fornal C.A. Activity of brain serotonergic neurons in the behaving animal. Pharmacol. Rev. 43 (1991) 563-578
    • (1991) Pharmacol. Rev. , vol.43 , pp. 563-578
    • Jacobs, B.L.1    Fornal, C.A.2
  • 39
    • 0036849055 scopus 로고    scopus 로고
    • 5-HT1A receptor-mediated autoinhibition does not function at physiological firing rates: evidence from in vitro electrophysiological studies in the rat dorsal raphe nucleus
    • Johnson D.A., Gartside S.E., and Ingram C.D. 5-HT1A receptor-mediated autoinhibition does not function at physiological firing rates: evidence from in vitro electrophysiological studies in the rat dorsal raphe nucleus. Neuropharmacology 43 (2002) 959-965
    • (2002) Neuropharmacology , vol.43 , pp. 959-965
    • Johnson, D.A.1    Gartside, S.E.2    Ingram, C.D.3
  • 41
    • 21644482673 scopus 로고    scopus 로고
    • Fluoxetine inhibits ATP-induced [Ca(2+)](i) increase in PC12 cells by inhibiting both extracellular Ca(2+) influx and Ca(2+) release from intracellular stores
    • Kim H.J., Choi J.S., Lee Y.M., Shim E.Y., Hong S.H., Kim M.J., Min D.S., Rhie D.J., Kim M.S., Jo Y.H., Hahn S.J., and Yoon S.H. Fluoxetine inhibits ATP-induced [Ca(2+)](i) increase in PC12 cells by inhibiting both extracellular Ca(2+) influx and Ca(2+) release from intracellular stores. Neuropharmacology 49 (2005) 265-274
    • (2005) Neuropharmacology , vol.49 , pp. 265-274
    • Kim, H.J.1    Choi, J.S.2    Lee, Y.M.3    Shim, E.Y.4    Hong, S.H.5    Kim, M.J.6    Min, D.S.7    Rhie, D.J.8    Kim, M.S.9    Jo, Y.H.10    Hahn, S.J.11    Yoon, S.H.12
  • 42
    • 0037450448 scopus 로고    scopus 로고
    • Distinguishing characteristics of serotonin and non-serotonin-containing cells in the dorsal raphe nucleus: electrophysiological and immunohistochemical studies
    • Kirby L.G., Pernar L., Valentino R.J., and Beck S.G. Distinguishing characteristics of serotonin and non-serotonin-containing cells in the dorsal raphe nucleus: electrophysiological and immunohistochemical studies. Neuroscience 116 (2003) 669-683
    • (2003) Neuroscience , vol.116 , pp. 669-683
    • Kirby, L.G.1    Pernar, L.2    Valentino, R.J.3    Beck, S.G.4
  • 43
    • 0015510739 scopus 로고
    • Tryptophan hydroxylase activity and synaptosomal uptake of serotonin in discrete brain regions after midbrain raphe lesions: correlations with serotonin levels and histochemical fluorescence
    • Kuhar M.J., Aghajanian G.K., and Roth R.H. Tryptophan hydroxylase activity and synaptosomal uptake of serotonin in discrete brain regions after midbrain raphe lesions: correlations with serotonin levels and histochemical fluorescence. Brain Res. 44 (1972) 165-176
    • (1972) Brain Res. , vol.44 , pp. 165-176
    • Kuhar, M.J.1    Aghajanian, G.K.2    Roth, R.H.3
  • 44
    • 0019321085 scopus 로고
    • Tryptophan hydroxylase. The role of oxygen, iron, and sulfhydryl groups as determinants of stability and catalytic activity
    • Kuhn D.M., Ruskin B., and Lovenberg W. Tryptophan hydroxylase. The role of oxygen, iron, and sulfhydryl groups as determinants of stability and catalytic activity. J. Biol. Chem. 255 (1980) 4137-4143
    • (1980) J. Biol. Chem. , vol.255 , pp. 4137-4143
    • Kuhn, D.M.1    Ruskin, B.2    Lovenberg, W.3
  • 45
    • 16244362038 scopus 로고    scopus 로고
    • Somatodendritic autoreceptor regulation of serotonergic neurons: dependence on l-tryptophan and tryptophan hydroxylase-activating kinases
    • Liu R.J., Lambe E.K., and Aghajanian G.K. Somatodendritic autoreceptor regulation of serotonergic neurons: dependence on l-tryptophan and tryptophan hydroxylase-activating kinases. Eur. J. Neurosci. 21 (2005) 945-958
    • (2005) Eur. J. Neurosci. , vol.21 , pp. 945-958
    • Liu, R.J.1    Lambe, E.K.2    Aghajanian, G.K.3
  • 46
    • 0022494079 scopus 로고
    • Exogenous tryptophan increases synthesis, storage, and intraneuronal metabolism of 5-hydroxytryptamine in the rat hypothalamus
    • Lookingland K.J., Shannon N.J., Chapin D.S., and Moore K.E. Exogenous tryptophan increases synthesis, storage, and intraneuronal metabolism of 5-hydroxytryptamine in the rat hypothalamus. J. Neurochem. 47 (1986) 205-212
    • (1986) J. Neurochem. , vol.47 , pp. 205-212
    • Lookingland, K.J.1    Shannon, N.J.2    Chapin, D.S.3    Moore, K.E.4
  • 47
    • 33846216741 scopus 로고    scopus 로고
    • Nested association between genetic variation in tryptophan hydroxylase II, bipolar affective disorder, and suicide attempts
    • Lopez V.A., tera-Wadleigh S., Cardona I., Kassem L., and McMahon F.J. Nested association between genetic variation in tryptophan hydroxylase II, bipolar affective disorder, and suicide attempts. Biol. Psychiatry 61 (2007) 181-186
    • (2007) Biol. Psychiatry , vol.61 , pp. 181-186
    • Lopez, V.A.1    tera-Wadleigh, S.2    Cardona, I.3    Kassem, L.4    McMahon, F.J.5
  • 48
    • 0036854562 scopus 로고    scopus 로고
    • Functional subsets of serotonergic neurones: implications for control of the hypothalamic-pituitary-adrenal axis
    • Lowry C.A. Functional subsets of serotonergic neurones: implications for control of the hypothalamic-pituitary-adrenal axis. J. Neuroendocrinol. 14 (2002) 911-923
    • (2002) J. Neuroendocrinol. , vol.14 , pp. 911-923
    • Lowry, C.A.1
  • 49
    • 0034667548 scopus 로고    scopus 로고
    • Corticotropin-releasing factor increases in vitro firing rates of serotonergic neurons in the rat dorsal raphe nucleus: evidence for activation of a topographically organized mesolimbocortical serotonergic system
    • Lowry C.A., Rodda J.E., Lightman S.L., and Ingram C.D. Corticotropin-releasing factor increases in vitro firing rates of serotonergic neurons in the rat dorsal raphe nucleus: evidence for activation of a topographically organized mesolimbocortical serotonergic system. J. Neurosci. 20 (2000) 7728-7736
    • (2000) J. Neurosci. , vol.20 , pp. 7728-7736
    • Lowry, C.A.1    Rodda, J.E.2    Lightman, S.L.3    Ingram, C.D.4
  • 51
    • 0032145210 scopus 로고    scopus 로고
    • The spectrum of behaviors influenced by serotonin
    • Lucki I. The spectrum of behaviors influenced by serotonin. Biol. Psychiatry 44 (1998) 151-162
    • (1998) Biol. Psychiatry , vol.44 , pp. 151-162
    • Lucki, I.1
  • 52
    • 19844365569 scopus 로고    scopus 로고
    • Stressor controllability and learned helplessness: the roles of the dorsal raphe nucleus, serotonin, and corticotropin-releasing factor
    • Maier S.F., and Watkins L.R. Stressor controllability and learned helplessness: the roles of the dorsal raphe nucleus, serotonin, and corticotropin-releasing factor. Neurosci. Biobehav. Rev. 29 (2005) 829-841
    • (2005) Neurosci. Biobehav. Rev. , vol.29 , pp. 829-841
    • Maier, S.F.1    Watkins, L.R.2
  • 53
    • 8644277997 scopus 로고    scopus 로고
    • Serotonergic and nonserotonergic dorsal raphe neurons are pharmacologically and electrophysiologically heterogeneous
    • Marinelli S., Schnell S.A., Hack S.P., Christie M.J., Wessendorf M.W., and Vaughan C.W. Serotonergic and nonserotonergic dorsal raphe neurons are pharmacologically and electrophysiologically heterogeneous. J. Neurophysiol. 92 (2004) 3532-3537
    • (2004) J. Neurophysiol. , vol.92 , pp. 3532-3537
    • Marinelli, S.1    Schnell, S.A.2    Hack, S.P.3    Christie, M.J.4    Wessendorf, M.W.5    Vaughan, C.W.6
  • 54
    • 48049091444 scopus 로고    scopus 로고
    • Chronic stress induces alterations in serotonin-related gene expression in a model of CRF dysregulation
    • Society for Neuroscience, Atlanta, GA Online
    • McEuen J.G., and Bale T.L. Chronic stress induces alterations in serotonin-related gene expression in a model of CRF dysregulation. Program No.505.1.2006 Abstract Viewer/Itinerary Planner (2006), Society for Neuroscience, Atlanta, GA Online
    • (2006) Program No.505.1.2006 Abstract Viewer/Itinerary Planner
    • McEuen, J.G.1    Bale, T.L.2
  • 55
    • 13244292476 scopus 로고    scopus 로고
    • Different properties of the central and peripheral forms of human tryptophan hydroxylase
    • McKinney J., Knappskog P.M., and Haavik J. Different properties of the central and peripheral forms of human tryptophan hydroxylase. J. Neurochem. 92 (2005) 311-320
    • (2005) J. Neurochem. , vol.92 , pp. 311-320
    • McKinney, J.1    Knappskog, P.M.2    Haavik, J.3
  • 56
    • 0142216081 scopus 로고    scopus 로고
    • The neurobiology and control of anxious states
    • Millan M.J. The neurobiology and control of anxious states. Prog. Neurobiol. 70 (2003) 83-244
    • (2003) Prog. Neurobiol. , vol.70 , pp. 83-244
    • Millan, M.J.1
  • 57
    • 33645452696 scopus 로고    scopus 로고
    • Multi-target strategies for the improved treatment of depressive states: conceptual foundations and neuronal substrates, drug discovery and therapeutic application
    • Millan M.J. Multi-target strategies for the improved treatment of depressive states: conceptual foundations and neuronal substrates, drug discovery and therapeutic application. Pharmacol. Ther. 110 (2006) 135-370
    • (2006) Pharmacol. Ther. , vol.110 , pp. 135-370
    • Millan, M.J.1
  • 58
    • 24044457631 scopus 로고    scopus 로고
    • Differential autoinhibition of 5-hydroxytryptamine neurons by 5-hydroxytryptamine in the dorsal raphe nucleus
    • Mlinar B., Tatini F., Ballini C., Nencioni S., Della C.L., and Corradetti R. Differential autoinhibition of 5-hydroxytryptamine neurons by 5-hydroxytryptamine in the dorsal raphe nucleus. Neuroreport 16 (2005) 1351-1355
    • (2005) Neuroreport , vol.16 , pp. 1351-1355
    • Mlinar, B.1    Tatini, F.2    Ballini, C.3    Nencioni, S.4    Della, C.L.5    Corradetti, R.6
  • 59
    • 0029670670 scopus 로고    scopus 로고
    • Effects of 8-OHDPAT and 5-HT1A antagonists WAY100135 and WAY100635, on guinea-pig behaviour and dorsal raphe 5-HT neurone firing
    • Mundey M.K., Fletcher A., and Marsden C.A. Effects of 8-OHDPAT and 5-HT1A antagonists WAY100135 and WAY100635, on guinea-pig behaviour and dorsal raphe 5-HT neurone firing. Br. J. Pharmacol. 117 (1996) 750-756
    • (1996) Br. J. Pharmacol. , vol.117 , pp. 750-756
    • Mundey, M.K.1    Fletcher, A.2    Marsden, C.A.3
  • 66
    • 0033031820 scopus 로고    scopus 로고
    • Influence of vesicular storage and monoamine oxidase activity on [11C]phenylephrine kinetics: studies in isolated rat heart
    • Raffel D.M., and Wieland D.M. Influence of vesicular storage and monoamine oxidase activity on [11C]phenylephrine kinetics: studies in isolated rat heart. J. Nucl. Med. 40 (1999) 323-330
    • (1999) J. Nucl. Med. , vol.40 , pp. 323-330
    • Raffel, D.M.1    Wieland, D.M.2
  • 67
    • 0017571782 scopus 로고
    • Relation between brain 5-HIAA levels and the release of serotonin into brain synapses
    • Reinhard Jr. J.F., and Wurtman R.J. Relation between brain 5-HIAA levels and the release of serotonin into brain synapses. Life Sci. 21 (1977) 1741-1746
    • (1977) Life Sci. , vol.21 , pp. 1741-1746
    • Reinhard Jr., J.F.1    Wurtman, R.J.2
  • 68
    • 0021345428 scopus 로고
    • Determination of monoamines in brain nuclei by high performance liquid chromatography with electrochemical detection: young vs. middle aged rats
    • Renner K.J., and Luine V.N. Determination of monoamines in brain nuclei by high performance liquid chromatography with electrochemical detection: young vs. middle aged rats. Life Sci. 34 (1984) 2193-2199
    • (1984) Life Sci. , vol.34 , pp. 2193-2199
    • Renner, K.J.1    Luine, V.N.2
  • 71
    • 0027731280 scopus 로고
    • Amphetamine derivatives interact with both plasma-membrane and secretory vesicle biogenic-amine transporters
    • Schuldiner S., Steinermordoch S., Yelin R., Wall S.C., and Rudnick G. Amphetamine derivatives interact with both plasma-membrane and secretory vesicle biogenic-amine transporters. Mol. Pharmacol. 44 (1993) 1227-1231
    • (1993) Mol. Pharmacol. , vol.44 , pp. 1227-1231
    • Schuldiner, S.1    Steinermordoch, S.2    Yelin, R.3    Wall, S.C.4    Rudnick, G.5
  • 72
    • 0031053197 scopus 로고    scopus 로고
    • Effects of co-administration of a monoamine oxidase inhibitor and a 5-HT1A receptor antagonist on 5-hydroxytryptamine cell firing and release
    • Sharp T., Gartside S.E., and Umbers V. Effects of co-administration of a monoamine oxidase inhibitor and a 5-HT1A receptor antagonist on 5-hydroxytryptamine cell firing and release. Eur. J. Pharmacol. 320 (1997) 15-19
    • (1997) Eur. J. Pharmacol. , vol.320 , pp. 15-19
    • Sharp, T.1    Gartside, S.E.2    Umbers, V.3
  • 73
    • 0024449871 scopus 로고
    • MDMA (3,4-methylenedioxymethamphetamine) inhibits the firing of dorsal raphe neurons in brain slices via release of serotonin
    • Sprouse J.S., Bradberry C.W., Roth R.H., and Aghajanian G.K. MDMA (3,4-methylenedioxymethamphetamine) inhibits the firing of dorsal raphe neurons in brain slices via release of serotonin. Eur. J. Pharmacol. 167 (1989) 375-383
    • (1989) Eur. J. Pharmacol. , vol.167 , pp. 375-383
    • Sprouse, J.S.1    Bradberry, C.W.2    Roth, R.H.3    Aghajanian, G.K.4
  • 74
    • 0025255548 scopus 로고
    • 3,4-Methylenedioxymethamphetamine-induced release of serotonin and inhibition of dorsal raphe cell firing: potentiation by l-tryptophan
    • Sprouse J.S., Bradberry C.W., Roth R.H., and Aghajanian G.K. 3,4-Methylenedioxymethamphetamine-induced release of serotonin and inhibition of dorsal raphe cell firing: potentiation by l-tryptophan. Eur. J. Pharmacol. 178 (1990) 313-320
    • (1990) Eur. J. Pharmacol. , vol.178 , pp. 313-320
    • Sprouse, J.S.1    Bradberry, C.W.2    Roth, R.H.3    Aghajanian, G.K.4
  • 75
    • 0019464864 scopus 로고
    • Distribution of serotonin-immunoreactivity in the central nervous-system of the rat - cell-bodies and terminals
    • Steinbusch H.W.M. Distribution of serotonin-immunoreactivity in the central nervous-system of the rat - cell-bodies and terminals. Neuroscience 6 (1981) 557-618
    • (1981) Neuroscience , vol.6 , pp. 557-618
    • Steinbusch, H.W.M.1
  • 77
    • 23944508567 scopus 로고    scopus 로고
    • Serotonin metabolism in directly developing frog embryos during paternal care
    • Ten Eyck G.R., Ronan P.J., Renner K.J., and Summers C.H. Serotonin metabolism in directly developing frog embryos during paternal care. Neurosci. Lett. 388 (2005) 100-105
    • (2005) Neurosci. Lett. , vol.388 , pp. 100-105
    • Ten Eyck, G.R.1    Ronan, P.J.2    Renner, K.J.3    Summers, C.H.4
  • 78
    • 0021792432 scopus 로고
    • Calcium regulates the activity of serotonin-containing dorsal raphe neurons in vitro
    • Trulson M.E., and Crisp T. Calcium regulates the activity of serotonin-containing dorsal raphe neurons in vitro. Brain Res. Bull. 15 (1985) 107-110
    • (1985) Brain Res. Bull. , vol.15 , pp. 107-110
    • Trulson, M.E.1    Crisp, T.2
  • 79
    • 0023095428 scopus 로고
    • A comparison of the electrophysiological and pharmacological properties of serotonin-containing neurons in the nucleus raphe dorsalis, raphe medianus and raphe pallidus recorded from mouse brain slices in vitro: role of autoreceptors
    • Trulson M.E., and Frederickson C.J. A comparison of the electrophysiological and pharmacological properties of serotonin-containing neurons in the nucleus raphe dorsalis, raphe medianus and raphe pallidus recorded from mouse brain slices in vitro: role of autoreceptors. Brain Res. Bull. 18 (1987) 179-190
    • (1987) Brain Res. Bull. , vol.18 , pp. 179-190
    • Trulson, M.E.1    Frederickson, C.J.2
  • 80
    • 0017112274 scopus 로고
    • Dose-response relationships between systemically administered l-tryptophan or l-5-hydroxytryptophan and raphe unit activity in the rat
    • Trulson M.E., and Jacobs B.L. Dose-response relationships between systemically administered l-tryptophan or l-5-hydroxytryptophan and raphe unit activity in the rat. Neuropharmacology 15 (1976) 339-344
    • (1976) Neuropharmacology , vol.15 , pp. 339-344
    • Trulson, M.E.1    Jacobs, B.L.2
  • 82
    • 0021023465 scopus 로고
    • Electrophysiological and pharmacological characterization of serotonergic dorsal raphe neurons recorded extracellularly and intracellularly in rat brain slices
    • Vandermaelen C.P., and Aghajanian G.K. Electrophysiological and pharmacological characterization of serotonergic dorsal raphe neurons recorded extracellularly and intracellularly in rat brain slices. Brain Res. 289 (1983) 109-119
    • (1983) Brain Res. , vol.289 , pp. 109-119
    • Vandermaelen, C.P.1    Aghajanian, G.K.2
  • 83
    • 0023183119 scopus 로고
    • The continuing problem of false positives in repeated measures ANOVA in psychophysiology: a multivariate solution
    • Vasey M.W., and Thayer J.F. The continuing problem of false positives in repeated measures ANOVA in psychophysiology: a multivariate solution. Psychophysiology 24 (1987) 479-486
    • (1987) Psychophysiology , vol.24 , pp. 479-486
    • Vasey, M.W.1    Thayer, J.F.2
  • 84
    • 5044238471 scopus 로고    scopus 로고
    • SNP and haplotype analysis of a novel tryptophan hydroxylase isoform (TPH2) gene provide evidence for association with major depression
    • Zill P., Baghai T.C., Zwanzger P., Schule C., Eser D., Rupprecht R., Moller H.J., Bondy B., and Ackenheil M. SNP and haplotype analysis of a novel tryptophan hydroxylase isoform (TPH2) gene provide evidence for association with major depression. Mol. Psychiatry 9 (2004) 1030-1036
    • (2004) Mol. Psychiatry , vol.9 , pp. 1030-1036
    • Zill, P.1    Baghai, T.C.2    Zwanzger, P.3    Schule, C.4    Eser, D.5    Rupprecht, R.6    Moller, H.J.7    Bondy, B.8    Ackenheil, M.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.