Influence of vesicular storage and monoamine oxidase activity on [11C]phenylephrine kinetics: Studies in isolated rat heart

Journal of Nuclear Medicine

Volumn 40, Issue 2, 1999, Pages 323-330

  Raffel, David M ^a,b   Wieland, Donald M ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

Author keywords

11C epinephrine; 11C hydroxyephredrine; 11C phenylephrine; Norepinephrine transporter; PET; Sympathetic nervous system

Indexed keywords

AMINE OXIDASE (FLAVIN CONTAINING); CARBON 11; PHENYLEPHRINE;

ANIMAL EXPERIMENT; ARTICLE; ENZYME ACTIVITY; HEART SCINTISCANNING; ISOTOPE LABELING; MALE; MEMBRANE VESICLE; NONHUMAN; NORADRENALIN RELEASE; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RAT; TRANSPORT KINETICS;

ANIMALS; CARBON RADIOISOTOPES; DEUTERIUM; MALE; MONOAMINE OXIDASE; MONOAMINE OXIDASE INHIBITORS; MYOCARDIUM; NOREPINEPHRINE; PARGYLINE; PHENYLEPHRINE; RATS; RATS, SPRAGUE-DAWLEY; RESERPINE; SYNAPTIC VESICLES;

EID: 0033031820     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. del Rosario RB, Jung Y-W, Chakraborty PK, Sherman PS, Wieland DM. Synthesis and preliminary evaluation of [C-11] phenylephrine for mapping heart neuronal function. Nucl Med Biol. 1996;23:611-616.
2. Rosenspire KC, Haka MS, Van Dort ME, et al. Synthesis and preliminary evaluation of carbon-11-meta-hydroxyephedrine: a false transmitter agent for heart neuronal imaging. J Nucl Med. 1990;31:1328-1334.
3. 11C]epinephrine for routine PET studies in humans. Nucl Med Biol. 1993;20:939-944.
4. Raffel DM, Corbett JR, Schwaiger M, Wieland DM. Mechanism-based strategies for mapping heart sympathetic nerve function. Nucl Med Biol. 1995;22:1019-1026.
5. Raffel DM, Corbett JR, del Rosario RB, et al. Clinical evaluation of carbon-11-phenylephrine: MAO sensitive marker of cardiac sympathetic neurons. J Nucl Med. 1996;37:1923-1931.
6. IIC](-)-α-α-dideutero-phenylephrine for in vivo kinetic isotope studies. J Labelled Compounds Radiopharm. 1995;36:625-630.
7. Taegtmeyer H, Hems R, Krebs HA. Utilization of energy providing substrates in the isolated working rat heart. Biochem J. 1980;186:701-711.
8. Burgen ASV, Iversen LL. The inhibition of noradrenaline uptake by sympathomimetic amines in the rat isolated heart. Br J Pharmacol. 1965;25:34-49.
9. Novick WJ. The effect of age and thyroid hormones on the monoamine oxidase of rat heart. Endocrinology. 1961;69:55-59.
10. Horita A. Cardiac monoamine oxidase in rat. Nature. 1967;215:411-412.
11. Strolin Benedetti M. Dostert P, Tipton KF. Developmental aspects of the monoamine-degrading enzyme monoamine oxidase. Dev Pharmacol Ther. 1992; 18:191-200.
12. Bevington PR. Data Reduction and Error Analysis for the Physical Sciences. New York, NY: McGraw-Hill; 1969.
13. 3H-(-)-phenylephrine in the perfused rat heart. Naunyn Schmeidebergs Arch Pharmacol. 1980;314:237-247.
14. Walter A, Gutknecht J. Permeability of small nonelectrolytes through lipid bilayer membranes. J Membr Biol. 1986;90:207-217.
15. DeGrado TR, Hutchins GD, Toorongian SA, Wieland DM, Schwaiger M. Myocardial kinetics of carbon-11-meta-hydroxyephedrine: retention mechanisms and effects of norepinephrine. J Nucl Med. 1993;34:1287-1293.
16. Nguyen NTB, DeGrado TR, Chakraborty P, Wieland DM, Schwaiger M. Myocardial kinetics of C-11 epinephrine in the isolated working rat heart. J Nucl Med. 1997;38:780-785.
17. Iversen LL. The inhihition of noradrenaline uptake by drugs. Adv Drug Res. 1965;2:5-23.
18. Graefe KH, Bönisch H, Trendelenburg U. Time-dependent changes in neuronal net uptake of noradrenaline after pretreatment with pargyline and/or reserpine. Naunyn Schmiedebergs Arch Pharmacol. 1971;271:1-28.
19. Lowe MC, Horita A. Stability of cardiac monoamine oxidase activity after chemical sympathectomy with 6-hydroxydopamine. Nature. 1970;228:175-176.
20. Mack F, Bonisch H. Dissociation constants and lipophilicity of catecholamines and related compounds. Naunyn Schmiedebergs Arch Pharmacol. 1979;310:1-9.