Involvement of the GABA/benzodiazepine receptor in the axiolytic-like effect of nociceptin/orphanin FQ

European Journal of Pharmacology

Volumn 590, Issue 1-3, 2008, Pages 185-189

  Uchiyama, Hidemori ^a   Yamaguchi, Taku ^c   Toda, Akihisa ^b   Hiranita, Takato ^a   Watanabe, Shigenori ^a   Eyanagi, Reiko ^b  

^a KYUSHU UNIVERSITY   (Japan)

^b DAIICHI UNIVERSITY OF PHARMACY   (Japan)

^c HOKKAIDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Amygdale; Anxiety; GABA benzodiazepine receptor; Nociceptin orphanin FQ

Indexed keywords

1 (1 CYCLOOCTYLMETHYL 3 HYDROXYMETHYL 4 PIPERIDYL) 3 ETHYL 1,3 DIHYDRO 2H BENZIMIDAZOL 2 ONE; 4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID RECEPTOR; BENZODIAZEPINE RECEPTOR; BICUCULLINE; FLUMAZENIL; NOCICEPTIN;

AMYGDALOID NUCLEUS; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANXIETY; ARTICLE; CONTROLLED STUDY; ELEVATED PLUS MAZE TEST; HIPPOCAMPUS; MALE; MAZE TEST; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT; RECEPTOR BINDING; TRANQUILIZING ACTIVITY;

AMYGDALA; ANIMALS; ANTI-ANXIETY AGENTS; MALE; MICE; OPIOID PEPTIDES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GABA-A;

EID: 48049088974     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2008.05.031     Document Type: Article

References (37)

1. Anton B., Fein J., To T., Li X., Silberstein L., and Evans C.J. Immunohistochemical localization of ORL-1 in the central nervous system of the rat. J. Comp. Neurol. 368 (1996) 229-251
2. Bonetti E.P., Pieri L., Cumin R., Schaffner R., Pierri M., Gamzu E.R., Müller R.K.M., and Haefely W. Benzodiazepine antagonist Ro 15-1788: neurological and behavioral effects. Psychopharmacology 78 (1982) 8-18
3. + channels in rat periaqueductal gray slices. Neuropharmacology 42 (2002) 987-992
4. Corbett R., Fielding S., Cornfelt M., and Dunn R.W. GABA mimetic agents display anxiolytic-like effects in the social interaction and elevated plus-maze procedures. Psychopharmacology 104 (1991) 312-316
5. Corda M.G., and Biggio G. Proconflict effect of GABA receptor complex antagonists reversal by diazepam. Neuropharmacology 25 (1986) 541-544
6. Dalvi A., and Rodgers R.J. GABAergi influences on plus-maze behaviour in mice. Psychopharmacology 128 (1996) 380-397
7. File S.E., Pellow S., and Wilks L. The sedative effects of CL 218, 872, like those of chlordiazepoxide, are reversed by benzodiazepine antagonists. Psychopharmacology 85 (1985) 295-300
8. File S.E., Zangrossi Jr. H., and Andrews N. Social interaction and elevated plus-maze tests: changes in release and uptake of 5-HT and GABA. Neuropharmacology 32 (1993) 217-221
9. Gavioli E.C., and Caló G. Antidepressant- and anxiolytic-like effects of nociceptin/orphanin FQ receptor ligands. Naunyn-Schmiedeberg's Arch. Pharmacol. 372 (2006) 319-330
10. Gonzalez L.E., Ouagazzal A.M., and File S.E. Stimulation of benzodiazepine receptors in the dorsal hippocampus and median raphe reveals differential GABAergic control in two animal tests of anxiety. Eur. J. Neurosci. 10 (1998) 3673-3680
11. Green S., and Vale A.L. Role of amygdaloid nuclei in the anxiolytic effects of benzodiazepines in rats. Behav. Pharmacol. 3 (1992) 261-264
12. Haley T.J., and McCormick W.G. Pharmacological effects produced by intracerebral injection of drugs in the conscious mouse. Br. J. Pharmacol. 12 (1957) 12-15
13. Hodges H., Green S., and Glenn B. Evidence that the amygdala is involved in benzodiazepine and serotonergic effects on punished responding but not discrimination. Psychopharmacology 92 (1987) 491-504
14. Hunkeler W., Möhler H., Pieri L., Polc P., Bonetti E.P., Cumin R., Schaffner R., and Haefley W. Selective antagonists of benzodiazepines. Nature 290 (1981) 514-516
15. Jenck F., Moreau J.-L., Martin J.R., Kilpatrick G.J., Reinscheid R.K., Monsma Jr. F.J., Nothacker H.-P., and Civelli O. Orphanin FQ acts as an anxiolytic to attenuate behavioral responses to stress. Br. J. Pharmacol. 94 (1997) 14854-14858
16. Jenck F., Wichman J., Dautzenberg F.M., Moreau J.-L., Ouagazzal A.M., Martin J.R., Lundstrom K., Cesura A.M., Poli S.M., Roever S., Kolczewski S., Adam G., and Kilpatrick G. A synthetic agonist at the orphanin FQ/nociceptin receptor ORL1: Anxiolytic profile in the rat. Proc. Natl. Acad. Sci. U. S. A. 97 (2000) 4938-4943
17. 1A agonistic anxiolytic. Neuropharmacology 30 (1991) 475-480
18. Kataoka Y., Shibata Z., Yamashita K., and Ueki S. Differential mechanisms involved in the anticonflict action of benzodiazepines injected into the central amygdala and mammillary body. Brain Res. 416 (1987) 243-247
19. Kawamoto H., Ozaki S., Itoh Y., Miyaji M., Arai S., Nakashima H., Ohta H., and Iwasawa Y. Discovery of the first potent and selective small molecule opioid receptor-like (ORL1) antagonist:1-{(3R,4R)-1-cyclooctylmethyl-3-hydroxymethyl-4-piperidyl}-3-ethyl-1,3-dihydro-2H-benzimidazol-2-one (J-113397). J. Med. Chem. 42 (1999) 5061-5063
20. Köster A., Montkowski A., Schulz S., Stube E.-M., Knaudt K., Jenck F., Moreau J.-L., Nothacker H.-P., Civelli O., and Reinscheid R.K. Targeted disruption of the orphanin FQ/nociceptin gene increases stress susceptibility and impairs stress adaptation in mice. Proc. Natl. Acad. Sci. U. S. A. 96 (1999) 10444-10449
21. LeDoux J.E., Cicchetti P., Xagoraris A., and Romanski L.M. The lateral amygdaloid nucleus: sensory interface of the amygdala in fear conditioning. J. Neurosci. 10 (1990) 1062-1069
22. Meis S., and Pape H.C. Control of glutamate and GABA release by nociceptin/orphanin FQ in the rat lateral amygdala. J. Physiol. 532 (2001) 701-712
23. Meunier J.-C., Mollereau C., Toll L., Suaudeau C., Moisand C., Alvinerie P., Butour J.-L., Guillemot J.-C., Ferrara P., Monsarrat B., Mazarguil H., Vassart G., Parmentier M., and Costentin J. Isolation and structure of the endogenous agonist of opioid receptor-like ORL1 receptor. Nature 377 (1995) 532-535
24. Murphy N.P., and Maidment N.T. Orphanin FQ/nociceptin modulation of mesolimbic dopamine transmission determined by microdialysis. J. Neurochem. 73 (1999) 179-186
25. 14Tyr]-orphanin FQ binding. J. Comp. Neurol. 412 (1999) 563-605
26. Neal C.R., Mansour A., Reinscheid R.K., Nothacker H.-P., Civelli O., Akil H., and Watson S.J. Localization of orphanin FQ (nociceptin) peptide and messenger RNA in the central nervous system of the rat. J. Comp. Neurol. 406 (1999) 503-547
27. Nothacker H.-P., Reinscheid R.K., Mansour A., Henninges R.A., Ardati A., Monsma Jr. F.J., Watson S.J., and Civelli O. Primary structure and tissue distribution of the orphanin FQ precursor. Proc. Natl. Acad. Sci. U. S. A. 93 (1996) 8677-8682
28. Ozaki S., Kawamoto H., Itoh Y., Miyaji M., Azuma T., Ichikawa D., Nambu H., Iguchi T., Iwasawa Y., and Ohta H. In vitro and in vivo pharmacological characterization of J-113397, a potent and selective non-peptidyl ORL1 receptor antagonist. Eur. J. Pharmacol. 402 (2000) 45-53
29. Paxinos G., and Watson C.H. The Rat Brain in Stereotaxic Coordinates (1986), Academic Press, London
30. Pesold C., and Treit D. The central and basolateral amygdala differentially mediate the anxiolytic effects of benzodiazepines. Brain Res. 671 (1995) 213-221
31. Przegaliński E., Tatarczyńska E., and Chojnacka-Wójcik E. The influence of the benzodiazepine receptor antagonist flumazenil on the anxiolytic-like effects of CGP 37849 and ACPC in rats. Neuropharmacology 39 (2000) 1858-1864
32. Areceptor research. Synapse 21 (1995) 189-274
33. Reinscheid R.K., Nothacker H.P., Bourson A., Ardati A., Henningsen R.A., Bunzow J.R., Grandy D.K., Langen H., Monsma Jr. F.J., and Civelli O. Orphanin FQ: a neuropeptide that activates an opioid-like G protein-coupled receptor. Science 270 (1995) 792-794
34. Scheel-Krüger J., and Peterson E.N. Anticonflict effect of the benzodiazepines mediated by a GABA ergic mechanism in the amygdala. Eur. J. Pharmacol. 82 (1982) 115-116
35. Shibata K., Kataoka Y., Gomita Y., and Ueki S. Localization of the site of the anticonflict action of benzodiazepines in the amygdaloid nucleus of rats. Brain Res. 234 (1982) 442-446
36. Uchiyama H., Toda A., Hiranita T., Watanabe S., and Eyanagi R. Role of amygdaloid nuclei in the anxiolytic-like effect of nociceptin/orphanin FQ in rats. Neurosci. Lett. 431 (2008) 66-70
37. Zorumski C.F., and Enberg K.E. Insights into the structure and function of GABA/benzodiazepine receptors: ion channels and psychiatry. Am. J. Psychiatry 148 (1991) 162-173