Characterization of novel aryl-ether, biaryl, and fluorene aspartic acid and diaminopropionic acid analogs as potent inhibitors of the high-affinity glutamate transporter EAAT2

Molecular Pharmacology

Volumn 68, Issue 4, 2005, Pages 974-982

  Dunlop, John ^a   McIlvain, H Beal ^a   Carrick, Tikva A ^a   Jow, Brian ^a   Lu, Qiang ^a   Kowal, Dianne ^a   Lin, Steven ^a   Greenfield, Alexander ^a   Grosanu, Cristina ^a   Fan, Kristi ^a   Petroski, Robert ^b   Williams, John ^b   Foster, Alan ^b   Butera, John ^a  

^a PFIZER INC   (United States)

^b NEUROCRINE BIOSCIENCES INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 [[(4' CHLORO 2 METHYL 1,1' BIPHENYL 4 YL)CARBONYL]AMINO]ALANINE; AMINO ACID RECEPTOR BLOCKING AGENT; ASPARTIC ACID; ASPARTIC ACID DERIVATIVE; ETHER DERIVATIVE; EXCITATORY AMINO ACID TRANSPORTER; FLUORENE DERIVATIVE; GLUTAMATE TRANSPORTER; IONOTROPIC RECEPTOR; METABOTROPIC RECEPTOR; N 4 (2' METHYL 1,1' BIPHENYL 4 YL)ASPARAGINE; N 4 [4 (2 BROMO 4,5 DIFLUOROPHENOXY)PHENYL]ASPARAGINE; N 4 [7 (TRIFLUOROMETHYL) 9H FLUOREN 2 YL]ASPARAGINE; PROPIONIC ACID DERIVATIVE; UNCLASSIFIED DRUG; WAY 211686; WAY 212922; WAY 213394; WAY 213613;

ANIMAL CELL; ARTICLE; BRAIN REGION; BRAIN SYNAPTOSOME; CONTROLLED STUDY; DRUG POTENCY; EMBRYO; FOREBRAIN; HUMAN; HUMAN CELL; IC 50; KINETICS; NONHUMAN; OOCYTE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN TRANSPORT; RAT; XENOPUS LAEVIS;

ANIMALS; ASPARTIC ACID; CELL LINE; CHO CELLS; CRICETINAE; EXCITATORY AMINO ACID TRANSPORTER 2; HUMANS; MODELS, MOLECULAR; PROPIONIC ACIDS; RATS; SYNAPTOSOMES; XENOPUS LAEVIS;

EID: 25144521444     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.105.012005     Document Type: Article

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