Protective effects of mecamylamine and atropine against α4β2 nicotinic receptor expression and functional toxicity in paraoxon-treated rats

Environmental Toxicology and Pharmacology

Volumn 26, Issue 2, 2008, Pages 247-254

  Mehrani, Hossein ^a   Asadi, Bahman ^a   Golmanesh, Leila ^a  

^a BAQIYATALLAH UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Acetylcholinesterase; Atropine; Lethality; Mecamylamine; MRNA; Nicotinic acetylcholine receptor; Paraoxon

Indexed keywords

ACETYLCHOLINESTERASE; ATROPINE; MECAMYLAMINE; MESSENGER RNA; NICOTINIC RECEPTOR; NICOTINIC RECEPTOR BLOCKING AGENT; ORGANOPHOSPHATE PESTICIDE; PARAOXON;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; DRUG EFFICACY; DRUG RECEPTOR BINDING; ENZYME ACTIVITY; ENZYME INHIBITION; INTOXICATION; INVOLUNTARY MOVEMENT; MALE; MONOTHERAPY; NERVE INJURY; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN EXPRESSION; RAT;

ANIMALIA; RATTUS;

EID: 47849085623     PISSN: 13826689     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.etap.2008.05.003     Document Type: Article

References (40)

1. Bakry N.M., El-Rashidy A.H., Eldefrawi A.T., and Eldefrawi M.E. Direct action of organophosphates anticholinesterase on nicotinic and muscarinic acetylcholine receptors. J. Biochem. Toxicol. 3 (2006) 235-259
2. Banerjee S., Punzi J.S., and Abood L.G. 3H-mecamylamine binding and the brain nicotinic receptor. Soc. Neurosci. Abstr. 16 (1990) 1143
3. Bowden C.A., and Krenzelok E.P. Clinical applications of commonly used contemporary antidotes: a US perspective. Drug Saf. 16 (1997) 9-47
4. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities, of protein utilizing the principle of protein dye binding. Anal. Biochem. 72 (1976) 248-254
5. Dawson R.M. Review of oximes available for treatment of nerve agent poisoning. J. Appl. Toxicol. 14 (1994) 317-331
6. Golmanesh L., Mehrani H., and Tabei M. Simple procedures for purification and stabilization of Human serum paraoxonase-1. J. Biochem. Biophys. Methods 70 (2008) 1037-1042
7. Gotti C., Riganti L., Vailati S., and Clementi F. Brain neuronal nicotinic receptors as new targets for drug discovery. Curr. Pharm. Des. 12 (2006) 407-428
8. Hassel B. Nicotinic mechanisms contribute to soman-induced symptoms and lethality. NeuroToxicology 27 (2006) 501-507
9. Heyl W.C., Harris L.W., and Stitcher D.L. Effects of carbamates on whole blood cholinesterase activity: chemical protection against soman. Drug Chem. Toxicol. 13 (1980) 319-332
10. Holstege C.P., Kirk M., and Sidell F.R. Chemical warfare. Nerve agent poisoning. Crit. Care Clin. 13 (1997) 923-942
11. Jett D.A., Abdallah E.A., El-Fakahany E.E., Eldefrawi M.E., and Eldfrawi A.T. High-affinity activation by paraoxon of a muscarinic receptor subtype in rat brain striatum. Pestic. Biochem. Physiol. 39 (1991) 149-157
12. Kassa J. Review of oximes in the antidotal treatment of poisoning by organophosphorus nerve agents. J. Toxicol. Clin. Toxicol. 40 (2002) 803-816
13. Katz E.J., Cortes V.I., Eldefrawi M.E., and Eldefrawi A.T. Chlorpyrifos, parathion, and their oxons bind to and desensitize a nicotinic acetylcholine receptor: relevance to their toxicities. Toxicol. Appl. Pharmacol. 146 (1997) 227-236
14. Kobayashi H., Yayuma A., and Chiba K.I. Cholinergic system of brain tissue in rats poisoned with the organophosphate O,O-dimethyl O-(2,2-dichlorovinyl) phosphate. Toxicol. Appl. Pharmacol. 82 (1986) 32-39
15. Krutak-krol H., and Domino E.E. Comparative effects of diazepam and midazolam on paraoxon toxicity in rats. Toxicol. Appl. Pharmacol. 81 (1985) 545-550
16. Levin E.D. Nicotinic systems and cognitive function. Psychopharmacology 108 (1992) 417-431
17. Lewis R.J. Dangerous Properties of Industrial Materials. 9th ed. vols. 1-3 (1996), Van Nostrand Reinhold, New York, NY p. 2457
18. Maelicke A., Schrattenholz A., Samochocki M., Radina M., and Albuquerque E.X. Allosterically potentiating ligands of nicotinic receptors as a treatment strategy for Alzheimer's disease. Behav. Brain Res. 113 (2000) 199-206
19. Mehrani H. Protective effect of polyurethane immobilized human butyrylcholinesterase against parathion inhalation in rat. Environ. Toxicol. Pharmacol. 16 (2004) 179-185
20. Mehrani H. Simplified procedures for purification and stabilization of human plasma butyrylcholinesterase. Process Biochem. 39 (2004) 877-882
21. Mehrani H., and Golmanesh L. Evaluation of nicotinic receptors agonists and antagonists against paraoxon exposed PC12 cells. Environ. Toxicol. Pharmacol. 26 (2008) 22-29
22. Millar N.S. Assembly and subunit diversity of nicotinic acetylcholine receptors. Biochem. Soc. Trans. 31 (2003) 869-874
23. Munro N.B., Watson A.P., Ambrose K.R., and Griffinm G.D. Treating exposure to chemical warfare agents: implications for health care providers and community emergency planning. Environ. Health Perspect. 89 (1990) 205-215
24. Oortgiesen M., Van Kleef R.G., Zwart R., Van den Beukel I., and Vijerberg H.P. Nicotinic receptors of different species exhibit differential sensitivities to nitromethylene and organophosphorus pesticides. Altern. Lab. Anim. 24 (1996) 367-376
25. Papke R.L., Sanberg P.R., and Shytle R.D. Analysis of mecamylamine stereoisomers on human nicotinic receptor subtypes. J. Pharmacol. Exp. Ther. 297 (2001) 646-656
26. Paterson D., and Nordberg A. Neuronal nicotinic receptors in the human brain. Prog. Neurobiol. 61 (2000) 75-111
27. Picciotto M.R., Caldarone B.J., King S.L., and Zachariou V. Nicotinic receptors in the brain: links between molecular biology and behavior. Neuropsychopharmacology 22 (2000) 451-465
28. Pond A.L., Coyne C.P., Chambers H.W., and Chambers J.E. Identification and isolation of two rat serum proteins with A-esterase activity toward paraoxon and chlorpyrifos-oxon. Biochem. Pharmacol. 52 (1996) 363-369
29. Pope C., Karanth J., and Liu J. Pharmacology and toxicology of cholinesterase inhibitors: uses and misuses of a common mechanism of action. Environ. Toxicol. Pharmacol. 19 (2005) 433-444
30. Rahimi R., Nikfar S., and Abdollahi M. Increased morbidity and mortality in acute human organophosphate-poisoned patients treated by oximes: a meta-analysis of clinical trials. Hum. Exp. Toxicol. 25 (2006) 157-162
31. Ray D.E., and Richards P.G. The potential for toxic effects of chronic, low-dose exposure to organophosphates. Toxicol. Lett. 120 (2001) 343-351
32. Shaikh J., Karanth S., Chakraborty D., Pruett S., and Pope C.N. Effects of daily stress or repeated paraoxon exposures on subacute pyridostigmine toxicity in rats. Arch. Toxicol. 77 (2003) 576-583
33. Smulders C.J., Bueters T.J., Vailati S., van Kleef R.G., and Vijverberg H.P. Block of neuronal nicotinic acetylcholine receptors by organophosphate insecticides. Toxicol. Sci. 82 (2004) 545-554
34. Soreq H., and Seidman S. Acetylcholinesterase-New roles for an old actor. Nat. Rev. Neurosci. 2 (2001) 294-302
35. Thompson C.M., and Richardson R.J. Anticholinesterase insecticides. In: Marrs T.C., and Ballantyne B. (Eds). Pesticide Toxicology and International Regulation (Current Toxicology Series) (2004), John Wiley and Sons Ltd., Chichester 89-127
36. 3 acetylcholine receptors. Altern. Lab. Anim. 24 (1996) 191-199
37. Worek F., Backer M., Thiermann H., Szinicz L., Mast U., Klimmek R., and Eyer P. Reappraisal of indications and limitations of oxime therapy in organophosphate poisoning. Hum. Exp. Toxicol. 16 (1997) 466-472
38. 2 subunits in response to nanomolar concentrations of the β-amyloid peptide1-42. Neurochem. Int. 47 (2005) 281-290
39. Young M.T., Shytle R.D., and Sanberg P.R. Mecamylamine new therapeutic and toxicity/risk profile. Clin. Ther. 23 (2001) 532-565
40. Zaniewska M., McCreary A.C., Przegaliñski E., and Filip M. Evaluation of the role of nicotinic acetylcholine receptor subtypes and cannabinoid system in the discriminative stimulus effects of nicotine in rats. Eur. J. Pharmacol. 540 (2006) 96-106