Sphingosine kinase inhibitor suppresses IL-18-induced interferon-gamma production through inhibition of p38 MAPK activation in human NK cells

Biochemical and Biophysical Research Communications

Volumn 374, Issue 1, 2008, Pages 74-78

  Cheon, Soyoung ^a   Song, Seok Bean ^a   Jung, Minkyung ^a   Park, Yoorim ^a   Bang, Jung Wook ^b   Kim, Tae Sung ^c   Park, Hyunjeong ^d   Kim, Cherl hyun ^e   Yang, Yool hee ^f   Bang, Sa Ik ^f   Cho, Daeho ^a  

^a Sookmyung Women's University   (South Korea)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

^c Korea University   (South Korea)

^d The Catholic University of Korea   (South Korea)

^e Dankook University   (South Korea)

^f Sungkyunkwan University School of Medicine   (South Korea)

Author keywords

Interferon gamma; Interleukin 18; NK cell; p38MAPK; Sphingosine kinase

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ENZYME INHIBITOR; GAMMA INTERFERON; INTERLEUKIN 18; MITOGEN ACTIVATED PROTEIN KINASE P38; SPHINGOSINE 1 PHOSPHATE; SPHINGOSINE KINASE; SPHINGOSINE KINASE 1; SPHINGOSINE KINASE 2;

APOPTOSIS; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; INNATE IMMUNITY; NATURAL KILLER CELL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SECOND MESSENGER; SIGNAL TRANSDUCTION;

CELL LINE; ENZYME ACTIVATION; HUMANS; INTERFERON TYPE II; INTERLEUKIN-18; KILLER CELLS, NATURAL; LYSOPHOSPHOLIPIDS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PROTEIN KINASE INHIBITORS; SPHINGOSINE;

EID: 47749148735     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2008.06.091     Document Type: Article

References (25)

1. Freud A.G., Becknell B., Roychowdhury S., Mao H.C., Ferketich A.K., Nuovo G.J., Hughes T.L., Marburger T.B., Sung J., Baiocchi R.A., Guimond M., and Caligiuri M.A. A human CD34(+) subset resides in lymph nodes and differentiates into CD56bright natural killer cells. Immunity 22 (2005) 295-304
2. Zamai L., Ponti C., Mirandola P., Gobbi G., Papa S., Galeotti L., Cocco L., and Vitale M. NK cells and cancer. J. Immunol. 178 (2007) 4011-4016
3. Babu S., Blauvelt C.P., and Nutman T.B. Filarial parasites induce NK cell activation, type 1 and type 2 cytokine secretion, and subsequent apoptotic cell death. J. Immunol. 179 (2007) 2445-2456
4. Kalina U., Kauschat D., Koyama N., Nuernberger H., Ballas K., Koschmieder S., Bug G., Hofmann W.K., Hoelzer D., and Ottmann O.G. IL-18 activates STAT3 in the natural killer cell line 92, augments cytotoxic activity, and mediates IFN-gamma production by the stress kinase p38 and by the extracellular regulated kinases p44erk-1 and p42erk-21. J. Immunol. 165 (2000) 1307-1313
5. Gu Y., Kuida K., Tsutsui H., Ku G., Hsiao K., Fleming M.A., Hayashi N., Higashino K., Okamura H., Nakanishi K., Kurimoto M., Tanimoto T., Flavell R.A., Sato V., Harding M.W., Livingston D.J., and Su M.S. Activation of interferon-gamma inducing factor mediated by interleukin-1beta converting enzyme. Science 275 (1997) 206-209
6. Maceyka M., Payne S.G., Milstien S., and Spiegel S. Sphingosine kinase, sphingosine-1-phosphate, and apoptosis. Biochim. Biophys. Acta 1585 (2002) 193-201
7. Hla T. Signaling and biological actions of sphingosine 1-phosphate. Pharmacol. Res. 47 (2003) 401-407
8. Rosen H., and Goetzl E.J. Sphingosine 1-phosphate and its receptors: an autocrine and paracrine network. Nat. Rev. Immunol. 5 (2005) 560-570
9. 2+ signals triggered by different phospholipid pathways in antigen stimulation of human mast cells. J. Biol. Chem. 277 (2002) 17255-17262
10. Cifone M.G., De Maria R., Roncaioli P., Rippo M.R., Azuma M., Lanier L.L., Santoni A., and Testi R. Apoptotic signaling through CD95 (Fas/Apo-1) activates an acidic sphingomyelinase. J. Exp. Med. 180 (1994) 1547-5152
11. Maeda Y., Matsuyuki H., Shimano K., Kataoka H., Sugahara K., and Chiba K. Migration of CD4 T cells and dendritic cells toward sphingosine 1-phosphate (S1P) is mediated by different receptor subtypes: S1P regulates the functions of murine mature dendritic cells via S1P receptor type 3. J. Immunol. 178 (2007) 3437-3446
12. Wei S.H., Rosen H., Matheu M.P., Sanna M.G., Wang S.K., Jo E., Wong C.H., Parker I., and Cahalan M.D. Sphingosine 1-phosphate type 1 receptor agonism inhibits transendothelial migration of medullary T cells to lymphatic sinuses. Nat. Immunol. 6 (2005) 1228-1235
13. Wang W., Huang M.C., and Goetzl E.J. Type 1 sphingosine 1-phosphate G protein-coupled receptor (S1P1) mediation of enhanced IL-4 generation by CD4 T cells from S1P1 transgenic mice. J. Immunol. 178 (2007) 4885-4890
14. Igarashi Y., Hakomori S., Toyokuni T., Dean B., Fujita S., Sugimoto M., Ogawa T., el-Ghendy K., and Racker E. Effect of chemically well-defined sphingosine and its N-methyl derivatives on protein kinase C and src kinase activities. Biochemistry 28 (1989) 6796-6800
15. French K.J., Schrecengost R.S., Lee B.D., Zhuang Y., Smith S.N., Eberly J.L., Yun J.K., and Smith C.D. Discovery and evaluation of inhibitors of human sphingosine kinase. Cancer Res. 63 (2003) 5962-5969
16. Tam Y.K., Maki G., Miyagawa B., Hennemann B., Tonn T., and Klingemann H.G. Characterization of genetically altered, interleukin 2-independent natural killer cell lines suitable for adoptive cellular immunotherapy. Hum. Gene Ther. 10 (1999) 1359-1373
17. Wu W., Mosterller R.D., and Broek D. Sphingosine kinase protects lipopolysaccharide-activated macrophages from apoptosis. Mol. Cell. Biol. 24 (2004) 7359-7369
18. Jung I.D., Lee J.S., Jeong Y.I., Lee C.M., Lee M.G., Ahn S.C., and Park Y.M. Sphingosine kinase inhibitor suppresses dendritic cell migration by regulating chemokine receptor expression and impairing p38 mitogen-activated protein kinase. Immunology 121 (2007) 533-544
19. Chen X.L., Grey J.Y., Thomas S., Qiu F.H., Medford R.M., Wasserman M.A., and Kunssh C. Sphingosine kinase-1 mediates TNF-alpha-induced MCP-1 gene expression in endothelial cells: upregulation by oscillatory flow. Am. J. Physiol. Heart Circ. Physiol. 287 (2004) 1452-1458
20. Jung I.D., Lee J.S., Kim Y.J., Jeong Y.I., Lee C.M., Baumruker T., Billlich A., Banno Y., Lee M.G., Ahn S.C., Park W.S., Han J., and Park Y.M. Sphingosine kinase inhibitor suppresses a Th1 polarization via the inhibition of immunostimulatory activity in murine bone marrow-derived dendritic cells. Int. Immunol. 19 (2007) 411-426
21. Nagiec M.M., Skrzypek M., Nagiec E.E., Lester R.L., and Dickson R.C. The LCB4 (YOR171c) and LCB5 (YLR260w) genes of Saccharomyces encode sphingoid long chain base kinases. J. Biol. Chem. 273 (1998) 19437-19442
22. Fukuda Y., Kihara A., and Igarashi Y. Distribution of sphingosine kinase activity in mouse tissues: contribution of SPHK1. Biochem. Biophys. Res. Commun. 309 (2003) 155-160
23. Blenis J. Signal transduction via the MAP kinases: proceed at your own RSK. Proc. Natl. Acad. Sci. USA 90 (1993) 5889-5892
24. Robertson M.J., Williams B.T., Christopherson II K., Brahmi Z., and Hromas R. Regulation of human natural killer cell migration and proliferation by the exodus subfamily of CC chemokines. Cell. Immunol. 199 (2000) 8-14
25. Pisegna S., Pirozzi G., Piccoli M., Frati L., Santoni A., and Palmieri G. p38 MAPK activation controls the TLR3-mediated up-regulation of cytotoxicity and cytokine production in human NK cells. Blood 104 (2004) 4157-4164