Sphingosine kinase inhibitor suppresses dendritic cell migration by regulating chemokine receptor expression and impairing p38 mitogen-activated protein kinase

Immunology

Volumn 121, Issue 4, 2007, Pages 533-544

  Jung, In Duk ^a   Lee, Jun Sik ^b   Kim, Yong Joo ^a   Jeong, Young Il ^b   Lee, Chang Min ^a   Lee, Min Goo ^c   Ahn, Soon Choel ^a   Park, Yeong Min ^a  

^a Pusan National University School of Medicine   (South Korea)

^b Pusan National University   (South Korea)

^c Korea University College of Medicine   (South Korea)

Author keywords

Chemokine receptor; Dendritic cell; Migration; Sphingosine kinase

Indexed keywords

CHEMOKINE RECEPTOR; CHEMOKINE RECEPTOR CCR7; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHOTRANSFERASE INHIBITOR; SPHINGOSINE KINASE;

ADAPTIVE IMMUNITY; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL MIGRATION; DENDRITIC CELL; DOWN REGULATION; ENZYME ACTIVATION; ENZYME INHIBITION; INNATE IMMUNITY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; CELLS, CULTURED; CHEMOKINES, CC; CHEMOTAXIS, LEUKOCYTE; DENDRITIC CELLS; ENZYME ACTIVATION; ENZYME INHIBITORS; INTERLEUKIN-10; INTERLEUKIN-12; LIPOPOLYSACCHARIDES; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); RECEPTORS, CHEMOKINE;

EID: 34447098146     PISSN: 00192805     EISSN: 13652567     Source Type: Journal    
DOI: 10.1111/j.1365-2567.2007.02601.x     Document Type: Article

References (43)

1. Steinman RM, Hawiger D, Nussenzweig MC. Tolerogenic dendritic cells. Annu Rev Immunol 2003 21 : 685 711.
2. Banchereau J, Steinman RM. Dendritic cells and the control of immunity. Nature 1998 392 : 245 52.
3. Randolph GJ, Angeli V, Swartz MA. Dendritic-cell trafficking to lymph nodes through lymphatic vessels. Nat Rev Immunol 2005 5 : 617 28.
4. Cyster JG. Chemokines and the homing of dendritic cells to the T cell areas of lymphoid organs. J Exp Med 1999 189 : 447 50.
5. Allavena P, Sica A, Vecchi A, Locati M, Sozzani S, Mantovani A. The chemokine receptor switch paradigm and dendritic cell migration: its significance in tumor tissues. Immunol Rev 2000 177 : 141 9.
6. Cavanagh LL, Von Andrian UH. Travellers in many guises: the origins and destinations of dendritic cells. Immunol Cell Biol 2002 80 : 448 62.
7. Sozzani S, Allavena P, Vecchi A, Mantovani A. The role of chemokines in the regulation of dendritic cell trafficking. J Leukoc Biol 1999 66 : 1 9.
8. Sallusto F, Lanzavecchia A. Understanding dendritic cell and T-lymphocyte traffic through the analysis of chemokine receptor expression. Immunol Rev 2000 177 : 134 40.
9. Forster R, Schubel A, Breitfeld D, Kremmer E, Renner-Muller I, Wolf E, Lipp M. CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs. Cell 1999 99 : 23 33.
10. Jin Y, Knudsen E, Wang L, Bryceson Y, Damaj B, Gessani S, Maghazachi AA. Sphingosine 1-phosphate is a novel inhibitor of T-cell proliferation. Blood 2003 101 : 4909 15.
11. Baumruker T, Prieschl EE. Sphingolipids and the regulation of the immune response. Semin Immunol 2002 14 : 57 63.
12. Spiegel S. Sphingosine 1-phosphate: a prototype of a new class of second messengers. J Leukoc Biol 1999 65 : 341 4.
13. Ott VL, Cambier JC. Introduction: multifaceted roles of lipids and their catabolites in immune cell signaling. Semin Immunol 2002 14 : 1 6.
14. Idzko M, Panther E, Corinti S et al. Sphingosine 1-phosphate induces chemotaxis of immature and modulates cytokine-release in mature human dendritic cells for emergence of Th2 immune responses. Faseb J 2002 16 : 625 7.
15. Czeloth N, Bernhardt G, Hofmann F, Genth H, Forster R. Sphingosine-1-phosphate mediates migration of mature dendritic cells. J Immunol 2005 175 : 2960 7.
16. Igarashi Y, Hakomori S, Toyokuni T et al. Effect of chemically well-defined sphingosine and its N-methyl derivatives on protein kinase C and src kinase activities. Biochemistry 1989 28 : 6796 800.
17. Megidish T, White T, Takio K, Titani K, Igarashi Y, Hakomori S. The signal modulator protein 14-3-3 is a target of sphingosine- or N,N-dimethylsphingosine-dependent kinase in 3T3 (A31) cells. Biochem Biophys Res Commun 1995 216 : 739 47.
18. King CC, Zenke FT, Dawson PE, Dutil EM, Newton AC, Hemmings BA, Bokoch GM. Sphingosine is a novel activator of 3-phosphoinositide-dependent kinase 1. J Biol Chem 2000 275 : 18108 13.
19. McDonald OB, Hannun YA, Reynolds CH, Sahyoun N. Activation of casein kinase II by sphingosine. J Biol Chem 1991 266 : 21773 6.
20. French KJ, Schrecengost RS, Lee BD, Zhuang Y, Smith SN, Eberly JL, Yun JK, Smith CD. Discovery and evaluation of inhibitors of human sphingosine kinase. Cancer Res 2003 63 : 5962 9.
21. Inaba K, Inaba M, Romani N, Aya H, Deguchi M, Ikehara S, Muramatsu S, Steinman RM. Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor. J Exp Med 1992 176 : 1693 702.
22. Wuyts A, Menten P, Van Osselaer N, Van Damme J. Assays for chemotaxis. Meth Mol Biol 2004 249 : 153 66.
23. Kanegasaki S, Nomura Y, Nitta N et al. A novel optical assay system for the quantitative measurement of chemotaxis. J Immunol Meth 2003 282 : 1 11.
24. de Jong EC, Smits HH, Kapsenberg ML. Dendritic cell-mediated T cell polarization. Springer Semin Immunopathol 2005 26 : 289 307.
25. Langrish CL, McKenzie BS, Wilson NJ, de Waal Malefyt R, Kastelein RA, Cua DJ. IL-12 and IL-23: master regulators of innate and adaptive immunity. Immunol Rev 2004 202 : 96 105.
26. Rescigno M, Martino M, Sutherland CL, Gold MR, Ricciardi-Castagnoli P. Dendritic cell survival and maturation are regulated by different signaling pathways. J Exp Med 1998 188 : 2175 80.
27. Spiegel S, Milstien S. Sphingosine-1-phosphate: an enigmatic signalling lipid. Nat Rev Mol Cell Biol 2003 4 : 397 407.
28. Saba JD, Hla T. Point-counterpoint of sphingosine 1-phosphate metabolism. Circ Res 2004 94 : 724 34.
29. Anliker B, Chun J. Lysophospholipid G protein-coupled receptors. J Biol Chem 2004 279 : 20555 8.
30. Arrighi JF, Rebsamen M, Rousset F, Kindler V, Hauser C. A critical role for p38 mitogen-activated protein kinase in the maturation of human blood-derived dendritic cells induced by lipopolysaccharide, TNF-alpha, and contact sensitizers. J Immunol 2001 166 : 3837 45.
31. Shlomchik WD, Couzens MS, Tang CB, McNiff J, Robert ME, Liu J, Shlomchik MJ, Emerson SG. Prevention of graft versus host disease by inactivation of host antigen-presenting cells. Science 1999 285 : 412 5.
32. Kadowaki N, Antonenko S, Ho S, Rissoan MC, Soumelis V, Porcelli SA, Lanier LL, Liu YJ. Distinct cytokine profiles of neonatal natural killer T cells after expansion with subsets of dendritic cells. J Exp Med 2001 193 : 1221 6.
33. Sallusto F, Cella M, Danieli C, Lanzavecchia A. Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment. Downregulation by cytokines and bacterial products. J Exp Med 1995 182 : 389 400.
34. Triantaphyllopoulos KA, Williams RO, Tailor H, Chernajovsky Y. Amelioration of collagen-induced arthritis and suppression of interferon-gamma, interleukin-12, and tumor necrosis factor alpha production by interferon-beta gene therapy. Arthritis Rheum 1999 42 : 90 9.
35. Sallusto F, Schaerli P, Loetscher P, Schaniel C, Lenig D, Mackay CR, Qin S, Lanzavecchia A. Rapid and coordinated switch in chemokine receptor expression during dendritic cell maturation. Eur J Immunol 1998 28 : 2760 9.
36. Yoneyama H, Matsuno K, Matsushimaa K. Migration of dendritic cells. Int J Hematol 2005 81 : 204 7.
37. Blenis J. Signal transduction via the MAP kinases: proceed at your own RSK. Proc Natl Acad Sci USA 1993 90 : 5889 92.
38. Rani CS, Wang F, Fuior E et al. Divergence in signal transduction pathways of platelet-derived growth factor (PDGF) and epidermal growth factor (EGF) receptors. Involvement of sphingosine 1-phosphate in PDGF but not EGF signaling. J Biol Chem 1997 272 : 10777 83.
39. Xia P, Gamble JR, Rye KA et al. Tumor necrosis factor-alpha induces adhesion molecule expression through the sphingosine kinase pathway. Proc Natl Acad Sci USA 1998 95 : 14196 201.
40. Rakhit S, Conway AM, Tate R, Bower T, Pyne NJ, Pyne S. Sphingosine 1-phosphate stimulation of the p42/p44 mitogen-activated protein kinase pathway in airway smooth muscle. Role of endothelial differentiation gene 1, c-Src tyrosine kinase and phosphoinositide 3-kinase. Biochem J 1999 338 : 643 9.
41. Sato K, Nagayama H, Tadokoro K, Juji T, Takahashi TA. Extracellular signal-regulated kinase, stress-activated protein kinase/c-Jun N-terminal kinase, and p38mapk are involved in IL-10-mediated selective repression of TNF-alpha-induced activation and maturation of human peripheral blood monocyte-derived dendritic cells. J Immunol 1999 162 : 3865 72.
42. Puig-Kroger A, Relloso M, Fernandez-Capetillo O, Zubiaga A, Silva A, Bernabeu C, Corbi AL. Extracellular signal-regulated protein kinase signaling pathway negatively regulates the phenotypic and functional maturation of monocyte-derived human dendritic cells. Blood 2001 98 : 2175 82.
43. Iijima N, Yanagawa Y, Clingan JM, Onoe K. CCR7-mediated c-Jun N-terminal kinase activation regulates cell migration in mature dendritic cells. Int Immunol 2005 17 : 1201 12.