Parasitic loranthus from Loranthaceae rather than Viscaceae potently inhibits fatty acid synthase and reduces body weight in mice

Journal of Ethnopharmacology

Volumn 118, Issue 3, 2008, Pages 473-478

  Wang, Yan ^a   Deng, Min ^b   Zhang, Shu Yan ^a   Zhou, Zhe Kun ^b   Tian, Wei Xi ^a  

^a UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

^b KUNMING INSTITUTE OF BOTANY   (China)

Author keywords

Fatty acid synthase; Loranthaceae; Obesity; Parasitic loranthus; Viscaceae

Indexed keywords

FATTY ACID SYNTHASE; FATTY ACID SYNTHASE INHIBITOR; FENFLURAMINE; PLANT EXTRACT; TAXILLUS CHINENSIS EXTRACT;

ANIMAL EXPERIMENT; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; ENZYME INHIBITION; FATTY ACID SYNTHESIS; FEMALE; FOOD INTAKE; MEDICINAL PLANT; MOUSE; NONHUMAN; OBESITY; TAXILLUS CHINENSIS; WEIGHT REDUCTION;

ANIMALS; ANTI-OBESITY AGENTS; BODY WEIGHT; DRUGS, CHINESE HERBAL; EATING; ENZYME INHIBITORS; FATTY ACID SYNTHETASE COMPLEX; FEMALE; LORANTHACEAE; MICE; PLANT EXTRACTS; VISCACEAE;

ANIMALIA; LORANTHACEAE; LORANTHUS; MUS; SANTALACEAE; TAXILLUS; TAXILLUS CHINENSIS;

EID: 47749109824     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2008.05.016     Document Type: Article

References (27)

1. Bouchard C. Inhibition of food intake by inhibitors of fatty acid synthase. The New England Journal of Medicine 21 (2000) 1888-1889
2. Calle E.E., Rodriguez C., Walker-Thurmond K., and Thun M.J. Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. The New England Journal of Medicine 348 (2003) 1625-1638
3. Chiu H.H., and Michael G.G. Loranthaceae. Flora of China 5 (2003) 220-239
4. Gong Z.N., Wang Z.T., Xu L.S., Xu G.J., and Wu J.R. Studies on medicinal plants of Loranthaceae in China. Chinese Wild Plant Resources 1 (1996) 11-15
5. Gong Z.N., Wang Z.T., Xu L.S., Xu G.J., and Wu J.R. Research on the original plants of crude drug "Sang ji sheng" (Ramulus taxilli). Shizhen Journal of Traditional Chinese Medicine Research 8 (1997) 99-101
6. Greenwald P. Lifestyle and medical approaches to cancer prevention. Recent Results in Cancer Research 16 (2005) 1-15
7. Guo C., Wei D., Chen H., and Zeng X. A review of the study on anti-obesity therapies with traditional Chinese medicine. Journal of Chinese Medicinal Materials 25 (2002) 534-537
8. Jiangsu New Medical College, 1997. Dictionary of Chinese Medicine [M]. Shanghai Science and Technology Publishers, Shanghai, pp. 1970-1973.
9. Kao Y.H., Hiipakka R.A., and Liao S. Modulation of endocrine systems and food intake by green tea epigallocatechin gallate. Endocrinology 141 (2000) 980-987
10. Kuhajda F.P., Pizer E.S., Li J.N., Mani N.S., Frehywot G.L., and Townsend C.A. Synthesis and antitumor activity of an inhibitor of fatty acid synthase. Proceedings of the National Academy of Sciences of USA 97 (2000) 3450-3454
11. Leonhardt M., Hrupka B., and Langhans W. New approaches in the pharmacological treatment of obesity. European Journal of Nutrition 38 (1999) 1-13
12. Li B.H., and Tian W.X. Inhibitory Effects of Flavonoids on Animal Fatty Acid Synthase. Journal of Biochemistry 135 (2004) 85-91
13. Loftus T.M., Jaworsky D.E., Frehywot G.L., Townsend C.A., Ronnett G.V., Lane M.D., and Kuhajda F.P. Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors. Science 288 (2000) 2379-2381
14. Mobbs C.V., and Makimura H. Block the FAS, lose the fat. Nature Medicine 8 (2002) 335-336
15. National Pharmacopoeia Committee, 2000. Pharmacopoeia of the People's Republic of China. Chemical Industry Press, Beijing, p. 246.
16. Smith S. The animal fatty acid synthase: one gene, one polypeptide, seven enzymes. The Journal of the Federation of American Societies for Experimental Biology 8 (1994) 1248-1259
17. Soulie J.M., Sheplock G.J., Tian W.X., and Hsu R.Y. Transient kinetic studies of fatty acid synthetase. A kinetic self-editing mechanism for the loading of acetyl and malonyl residues and the role of coenzyme A. Journal of Biological Chemistry 259 (1984) 134-140
18. Tang C.L. Loranthaceae. Flora of China 26 (1986) 86-158
19. Tian W.X., and Cai H. The denaturation and inactivation of fatty acid synthase from duck liver in guanidine hydrochloride. Acta Biophysica Sinica (Chinese) 10 (1994) 6-12
20. Tian W.X., Hsu R.Y., and Wang Y.S. Studies on the reactivity of the essential sulfhydryl groups as a conformational probe for the fatty acid synthetase of chicken liver. Inactivation by 5,5′-dithiobis-(2-nitrobenzoic acid) and intersubunit cross-linking of the inactivated enzyme. Journal of Biological Chemistry 260 (1985) 11375-11387
21. Vance D., Goldberg I., Mitsuhashi O., and Bloch K. Inhibition of fatty acid synthatase by the antibiotic cerulenin. Biochemical and Biophysical Research Communications 48 (1972) 649-655
22. Wakil S.J. Fatty acid synthase, a proficient multifunctional enzyme. Biochemistry 28 (1989) 4523-4530
23. Wang X., Song K.S., Guo Q.X., and Tian W.X. The galloyl moiety of green tea catechins is the critical structural feature to inhibit fatty-acid synthase. Biochemical Pharmacology 66 (2003) 2039-2047
24. Wang X., and Tian W. Green tea epigallocatechin gallate: a natural inhibitor of fatty-acid synthase. Biochemical and Biophysical Research Communications 288 (2001) 1200-1206
25. Wang Y., Zhang S.Y., Ma X.F., and Tian W.X. Potent inhibition of fatty acid synthase by parasitic loranthus (Taxillus chinensis (DC.) Danser) and its constituent avicularin. Journal of Enzyme Inhibition and Medicinal Chemistry 21 (2006) 87-93
26. Xie Y.M., and Wong W.L. Reducing fat with traditional Chinese medicine. Symposium International Conference of Weight Reducing. Beijing (2000) 132
27. Zhou H.H., and Wu J.R. Preliminary studies of Sang Ji Sheng and Hu Ji Sheng. Journal of Guiyang College of Traditional Chinese Medicine 21 (1999) 59-60