Effect of a specific neutrophil elastase inhibitor, ONO-5046, on endotoxin-induced acute lung injury

American Journal of Respiratory and Critical Care Medicine

Volumn 153, Issue 1, 1996, Pages 391-397

  Sakamaki, Fumio ^b   Ishizaka, Akitoshi ^a   Urano, Tetsuya ^b   Sayama, Koichi ^b   Nakamura, Hidetoshi ^b   Terashima, Takeshi ^b   Waki, Yasuhiro ^b   Tasaka, Sadatomo ^b   Hasegawa, Naoki ^b   Sato, Kiyoyuki ^b   Nakagawa, Naoki ^b   Obata, Takaaki ^b   Kanazawa, Minoru ^b  

^a KEIO UNIVERSITY   (Japan)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ESCHERICHIA COLI ENDOTOXIN; LEUKOCYTE ELASTASE; SIVELESTAT;

ADULT RESPIRATORY DISTRESS SYNDROME; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; DRUG EFFECT; ESCHERICHIA COLI; GUINEA PIG; MALE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PRIORITY JOURNAL;

EID: 9044244530     PISSN: 1073449X     EISSN: None     Source Type: Journal    
DOI: 10.1164/ajrccm.153.1.8542148     Document Type: Article

References (36)

1. Matthay, M. A. 1990. The adult respiratory distress syndrome - definition and prognosis. Clin. Chest Med. 11:575-580.
2. Weiland, J. E., W. B. Davis, J. F. Holter, J. R. Mohammed, P. M. Dorinsky, and J. E. Gadek. 1986. Lung neutrophils in the adult respiratory distress syndrome - clinical and pathophysiologic significance. Am. Rev. Respir. Dis. 133:218-225.
3. Fowler, A. A., T. M. Hyers, B. J. Fisher, D. E. Bechard, R. M. Centor, and R. O. Webster. 1987. The adult respiratory distress syndrome - cell populations and soluble mediators in the air spaces of patients at high risk. Am. Rev. Respir. Dis. 136:1225-1231.
4. Brigham, K. L., and B. Meyrick. 1986. Endotoxin and lung injury. Am. Rev. Respir. Dis. 133:913-927.
5. Ishizaka, A., K. E. Stephens, H. D. Tazelaar, E. W. Hall, P. O'Hanley, and T. A. Raffin. 1988. Pulmonary edema after Escherichia coli peritonitis correlates with thiobarbituric acid reactive materials in bronchoalveolar lavage fluid. Am. Rev. Respir. Dis. 137:783-789.
6. Rinaldo, J. E., J. H. Dauber, J. Christman, and R. M. Rogers. 1984. Neutrophil alveolitis following endotoxemia. Enhancement by previous exposure to hyperoxia. Am. Rev. Respir. Dis. 130:1065-1071.
7. Snapper, J. R., G. R. Bernard, J. M. Hinson, Jr., A. A. Hutchison, J. E. Loyd, M. L. Ogletree, and K. L. Brigham. 1983. Endotoxemia induced leukopenia in sheep: correlation with lung vascular permeability and hypoxemia but not with pulmonary hypertension. Am. Rev. Respir. Dis. 127:306-309.
8. Sibille, Y., and H. Y. Reynolds. 1990. Macrophage and polymorphonuclear neutrophils in lung defense and injury. Am. Rev. Respir. Dis. 141:471-501.
9. Brain, J. D. 1988. Lung macrophages: how many kinds are there? What do they do? Am. Rev. Respir. Dis. 137:507-509.
10. Senior, R. M., and E. J. Campbell. 1983. Neutral proteinases from human inflammatory cells. Clin. Lab. Med. 3:645-666.
11. Wright, D. G. 1988. Human neutrophil degranulation. Methods Enzymol. 162:538-551.
12. Gadek, J. E., G. A. Fells, D. G. Wright, and R. G. Crystal. 1980. Human neutrophil elastase functions as a type III collagen collagenase. Biophys. Res. Commun. 95:1815-1822.
13. Janoff, A. 1985. Elastase in tissue injury. Annu. Rev. Med. 36:207-216.
14. Karlinsky, J., and G. L. Snider. 1978. Animal models of emphysema. Am. Rev. Respir. Dis. 117:1109-1133.
15. Lee, C. T., A. M. Fein, M. Lippmann, H. Holtzman, P. Kimbel, and G. Weinbaum. 1981. Elastolytic activity in pulmonary lavage fluid from patients with adult respiratory distress syndrome. N. Engl. J. Med. 304:192-196.
16. Cochrane, C. G., R. G. Spragg, S. D. Revak, A. B. Cohen, and W. W. McGuire. 1983. The presence of neutrophil elastase and evidence of oxidation activity in bronchoalveolar lavage fluid of patients with adult respiratory distress syndrome. Am. Rev. Respir. Dis. 127:S25-S27.
17. Idell, S., U. Kucich, A. Fein, F. Kueppers, H. L. James, P. N. Walsh, G. Weinbaum, R. W. Colman, and A. B. Cohen. 1985. Neutrophil elastase-releasing factors in bronchoalveolar lavage from patients with adult respiratory distress syndrome. Am. Rev. Respir. Dis. 132:1098-1105.
18. Crapo, J. D., B. Barry, H. Foscue, and J. Shelburne. 1980. Structural and biochemical changes in rat lungs occurring during exposure to lethal and adaptive doses of oxygen. Am. Rev. Respir. Dis. 122: 123-143.
19. Kawabata, K., M. Suzuki, M. Sugitani, K. Imaki, M. Toda, and T. Miyamoto. 1991. ONO-5046, a novel inhibitor of human neutrophil elastase. Biochem. Biophys. Res. Commun. 177:814-820.
20. Ford-Hutchinson, A. W., and J. F. Evans. 1988. Chemotaxis: neutrophil aggregation and chemokinesis assays. Methods Enzymol. 162: 72-78.
21. Nakao, A., R. A. Partis, G. P. Jung, and R. A. Mueller. 1987. SC-39026, a specific human neutrophil elastase inhibitor. Biochem. Biophys. Res. Commun. 147:666-674.
22. Komatsu, H., M. Nagasawa, and T. Okumoto. 1993. Inhibition of leukocyte adhesion to endothelial cells of human umbilical vein by Y-24180, an antagonist of platelet activating factor. Int. J. Immunopharmacol. 15:737-744.
23. Ishizaka, A., Z. Wu, K. E. Stephens, H. Harada, R. S. Hogue, P. T. O'Hanley, and T. A. Raffin. 1988. Attenuation of acute lung injury in septic guinea pigs by pentoxifylline. Am. Rev. Respir. Dis. 138: 376-382.
24. Stephens, K. E., A. Ishizaka, Z. Wu, J. W. Larrick, and T. A. Raffin. 1988. Granulocyte depletion prevents tumor necrosis factor-mediated acute lung injury in guinea pigs, Am. Rev. Respir. Dis. 138:1300-1307.
25. Opresko, L., H. S. Wiley, and R. A. Wallance. 1980. Proteins iodinated by the chloramine-T method appear to be degraded at abnormally rapid rate after endocytosis. Proc. Natl. Acad. Sci. U.S.A. 77:1556-1560.
26. Kanazawa, M., N. Hasegawa, T. Urano, K. Sayama, S. Tasaka, F. Sakamaki, H. Nakamura, Y. Waki, T. Terashima, S. Fujishima, and A. Ishizaka. 1994. Regional lung hematocrit variation and assessment of acute lung injury. J. Appl. Physiol. 77:567-573.
27. Meyrick, B. 1986. Pathology of the adult respiratory distress syndrome. Crit. Care Clin. 2:405-428.
28. Worthen, G. S., C. Haslett, A. J. Rees, R. S. Gumbay, J. E. Henson, and P. M. Henson. 1987. Neutrophil-mediated pulmonary vascular injury: synergistic effect of trace amounts of lipopolysaccharide and neutrophil stimuli on vascular permeability and neutrophil sequestration in the lung. Am. Rev. Respir. Dis. 136:19-28.
29. Kanazawa, M., A. Ishizaka, N. Hasegawa, Y. Suzuki, and T. Yokoyama. 1992. Granulocyte colony-stimulating factor does not enhance endotoxin-induced acute lung injury in guinea pigs. Am. Rev. Respir. Dis. 145:1030-1035.
30. Heflin, A. C., and K. L. Brigham. 1981. Prevention by granulocyte depletion of increased vascular permeability of sheep lung following endotoxemia. J. Clin. Invest. 68:1253-1260.
31. Weiss, S. J. 1989. Tissue destruction by neutrophils. N. Engl. J. Med. 320:365-376.
32. Travis, J. 1988. Structure, function, and control of neutrophil proteinases. Am. J. Med. 84:37-43.
33. Yoshimura, K., S. Nakagawa, S. Koyama, T. Kobayashi, and T. Homma. 1994. Roles of neutrophil elastase and superoxide anion in leukotriene B4-induced lung injury in rabbit. J. Appl. Physiol. 76: 91-96.
34. Kubo, K., T. Kobayashi, T. Hayano, T. Koizumi, T. Honda, M. Sekiguchi, and A. Sakai. 1994. Effects of ONO-5046, a specific neutrophil elastase inhibitor, on endotoxin-induced lung injury in sheep. J. Appl. Physiol. 77:1333-1340.
35. Okada, Y., S. Watanabe, I. Nakanishi, J. Kishi, T. Hayakawa, W. Watorek, J. Travis, and H. Nagase. 1988. Inactivation of tissue inhibitor of metalloproteinase by neutrophil elastase and other serine proteinase. FEBS Lett. 229:157-160.
36. Woodman, R. C., P. H. Reinhardt, S. Kanwar, F. L. Johnston, and P. Kubes. 1993. Effects of human neutrophil elastase (HNE) on neutrophil function in vitro and in inflamed microvessels. Blood 82: 2188-2195.