Dimethyl amiloride improves glucose homeostasis in mouse models of type 2 diabetes

American Journal of Physiology - Endocrinology and Metabolism

Volumn 294, Issue 6, 2008, Pages

  Gunawardana, Subhadra C ^a   Head, W Steven ^a   Piston, David W ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

cell memory; Insulin secretion; Pancreatic islets

Indexed keywords

5 (N,N DIMETHYL)AMILORIDE; ARGININE; GLUCOSE; INSULIN; NEURONAL NITRIC OXIDE SYNTHASE; OXOGLUTARATE DEHYDROGENASE; 2 AMINOBICYCLO(2,2,1)HEPTANE 2 CARBOXYLIC ACID; 2 OXOISOCAPROIC ACID; 2-AMINOBICYCLO(2,2,1)HEPTANE-2-CARBOXYLIC ACID; 5 DIMETHYLAMILORIDE; 5-DIMETHYLAMILORIDE; ALPHA-KETOISOCAPROIC ACID; AMILORIDE; AMINO ACID; DRUG DERIVATIVE; N(G) NITROARGININE METHYL ESTER; OXOACID; SODIUM CALCIUM EXCHANGE PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME INHIBITION; FEMALE; GLUCOSE HOMEOSTASIS; INSULIN RELEASE; MALE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; ANIMAL; BLOOD; C57BL MOUSE; DISEASE MODEL; DRUG ANTAGONISM; DRUG EFFECT; DRUG POTENTIATION; ENZYMOLOGY; GENETICS; GLUCOSE BLOOD LEVEL; HOMEOSTASIS; METABOLISM; MITOCHONDRION; MOUSE MUTANT; PH; SECRETION;

AMILORIDE; AMINO ACIDS, CYCLIC; ANIMALS; ARGININE; BLOOD GLUCOSE; DIABETES MELLITUS, TYPE 2; DISEASE MODELS, ANIMAL; DRUG SYNERGISM; HOMEOSTASIS; HYDROGEN-ION CONCENTRATION; INSULIN; INSULIN-SECRETING CELLS; KETO ACIDS; KETOGLUTARATE DEHYDROGENASE COMPLEX; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MITOCHONDRIA; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE TYPE I; SODIUM-CALCIUM EXCHANGER;

EID: 47549106143     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00748.2007     Document Type: Article

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