Carnitine worsens both injury and recovery of contractile function after transient ichemia in perfused rat heart

Journal of Physiology and Biochemistry

Volumn 64, Issue 1, 2008, Pages 1-8

  Di R ^a   Lorita, J ^a   Sooley, M ^a   Ramirez I ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

Author keywords

Anaerobiosis; Carnitine; Heart; Heart rate; Inotropy; Langendorff perfusion; Tissue injury

Indexed keywords

CARNITINE; LACTIC ACID;

AEROBIC EXERCISE; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIET SUPPLEMENTATION; GLUCOSE OXIDATION; HEART INJURY; HEART MUSCLE CONTRACTILE FORCE; HEART MUSCLE CONTRACTILITY; HEART MUSCLE ISCHEMIA; HEART PERFORMANCE; HEART PERFUSION; HEART RATE; MALE; NONHUMAN; RAT; REPERFUSION; TISSUE INJURY;

RATTUS;

EID: 47349124572     PISSN: 11387548     EISSN: None     Source Type: Journal    
DOI: 10.1007/bf03168229     Document Type: Article

References (26)

1. Alvarez de Sotomayor, M., Mingorance, C., Rodríguez-Rodríguez, R., Marhuenda, E., and Herrera, M.D. (2007): L-Carnitine and its propionate: improvement of endothelial function in SHR through superoxide dismutase-dependent mechanisms. Free Radical Res, 41, 884-891.
2. Apstein, C.S. (2000): Increased glycolytic substrate protection improves ischemic cardiac dysfunction and reduces injury. Am Heart J, 139, S107-S114.
3. Barnett, C., Costill, D.L., Vukovich, M.D., Cole, K.J., Goodpaster, B.H., Trappe, S.W., and Fink, W.J. (1994): Effect of L-carnitine supplementation on muscle and blood carnitine content and lactate accumulation during high-intensity sprint cycling. Int J Sport Nutr, 4, 280-288.
4. Brass, E.P. (2004): Carnitine and sports medicine: use or abuse? Ann NY Acad Sci, 1033, 67-78.
5. Broderick, T.L., Quinney, H. A., Barker, C.C., and Lopaschuk, G. D. (1993): Beneficial effect of carnitine on mechanical recovery of rat hearts reperfused after a transient period of global ischemia is accompanied by a stimulation of glucose oxidation. Circulation, 87, 972-981.
6. Broderick, T.L., Quinney, H.A., and Lopaschuk, G. D. (1992): Carnitine Stimulation of Glucose Oxidation in the Fatty Acid Perfused Isolated Working Rat Heart. J Biol Chem, 267, 3758-3763.
7. Calo, L.A., Pagnin, E., Davis, P.A., Semplicini, A., Nicolai, R., Calvani, M., and Pessina, A.C. (2006): Antioxidant effect of L-carnitine and its short chain esters - Relevance for the protection from oxidative stress related cardiovascular damage. Int J Cardiol, 107, 54-60.
8. Ferrari, R., Merli, E., Cicchitelli, G., Mele, D., Fucili, A., and Ceconi, C. (2004): Therapeutic effects of L-carnitine and propionyl-L-carnitine on cardiovascular diseases: a review. Ann NY Acad Sci, 1033, 79-91.
9. Folts, J. D., Shug, A. L., Koke, J. R., and Bittar, N. (1978): Protection of the ischemic dog myocardium with carnitine. Am J Cardiol, 41, 1209-1214.
10. Gómez-Amores, L., Mate, A., Revilla, E., Santa-María, C., and Vazquez, C. M. (2006): Antioxidant activity of propionyl-L-carnitine in liver and heart of spontaneously hypertensive rats. Life Sci, 78, 1945-1952.
11. Gorostiaga, E. M., Maurer, C.A., and Eclache, J.P. (1989): Decrease in respiratory quotient during exercise following L-carnitine supplementation. Int J Sports Med, 10, 169-174.
12. Gutmann, I. and Wahlefeld, A.W. (1974): L-(+)-lactate. Determination with lactate dehydrogenase and NAD. In Methods in Enzymatic Analysis. Vol. 3 (Bergmeyer, H. U., ed.), Academic Press, New York, pp. 1464-1468.
13. Jordan, J.E., Zhao, Z.Q., and Vinten-Johansen, J. (1999): The role of neutrophils in myocardial ischemia-reperfusion injury. Cardiovasc Res, 43, 860-878.
14. Liedtke, A.J. and Nellis, S.H. (1979): Effects of carnitine in ischemic and fatty acid supplemented swine hearts. J Clin Invest, 64, 440-447.
15. Liedtke, A.J., Nellis, S.H., and Whitesell, L.F. (1981): Effects of carnitine isomers on fatty acid metabolism in ischemic swine hearts. Circ Res, 48, 859-866.
16. Loster, H. and Bohm, U. (2001): L-carnitine reduces malondialdehyde concentrations in isolated rat hearts in dependence on perfusion conditions. Mol Cell Biochem, 217, 83-90.
17. Luptak, I., Yan, J., Cui, L., Jain, M., Liao, R., and Tian, R. (2007): Long-term effects of increased glucose entry on mouse hearts during normal aging and ischemic stress. Circulation, 116, 901-909.
18. Opie, L.H. and Sack, M.N. (2002): Metabolic plasticity and the promotion of cardiac protection in ischemia and ischemic preconditioning. J Mol Cell Cardiol, 34, 1077-1089.
19. Piper, H.M., Abdallah, Y., and Schafer, C. (2004): The first minutes of reperfusion: a window of opportunity for cardioprotection. Cardiovasc Res, 61, 365-371.
20. Piper, H.M. and Garcia-Dorado, D. (1999): Prime causes of rapid cardiomyocyte death during reperfusion. Ann Thorac Surg, 68, 1913-1919.
21. Randle, P. J., Garland, P. B., Hales, C. N., and Newsholme, E.A. (1963): The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet, 1, 785-789.
22. Rebouche, C.J. (2004): Kinetics, pharmacokinetics, and regulation of L-carnitine and acetyl-L-carnitine metabolism. Ann NY Acad Sci, 1033, 30-41.
23. Rebouche, C.J. and Seim, H. (1998): Carnitine metabolism and its regulation in microorganisms and mammals. Annu Rev Nutr, 18, 39-61.
24. Rosalki, S.B. (1967); An improved procedure for serum creatine phosphokinase determination. J Lab Clin Med, 69, 696-705.
25. Siliprandi, N., Di Lisa, F., Pieralisi, G., Ripari, P., Maccari, F., Menabo, R., Giamberardino, M.A., and Vecchiet, L. (1990): Metabolic changes induced by maximal exercise in human subjects following L-carnitine administration. Biochim Biophys Acta, 1034, 17-21.
26. Soop, M., Bjorkman, O., Cederblad, G., Hagenfeldt, L., and Wahren, J. (1988): Influence of carnitine supplementation on muscle substrate and carnitine metabolism during exercise. J Appl. Pbysiol, 64, 2394-2399.