Suppression of acute Ixodes scapularis-induced Borrelia burgdorferi infection using tumor necrosis factor-α, interleukin-2, and interferon-γ

Journal of Infectious Diseases

Volumn 173, Issue 1, 1996, Pages 187-195

  Zeidner, Nordin ^a   Dreitz, Matthew ^b   Belasco, Debra ^b   Fish, Durland ^b  

^a ACN Research Consultants   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 2; NEUTRALIZING ANTIBODY; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY TITER; ARTICLE; BACTERIAL GROWTH; BIOPSY; BORRELIA BURGDORFERI; BORRELIA INFECTION; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; IMMUNOBLOTTING; INFECTION PREVENTION; INTRAPERITONEAL DRUG ADMINISTRATION; IXODES; MOUSE; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; TICK;

EID: 0030053040     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1093/infdis/173.1.187     Document Type: Article

References (9)

1. Centers for Disease Control and Prevention. MMWR Morb Mortal Wkly Rep 1995;44:459-62.
2. Barbour AG, Hayes SF. Biology of Borrelia species. Microbiol Rev 1986;50:381-400.
3. Brown RN, Lane RS. Lyme disease in California: a novel enzootic transmission cycle of Borrelia burgdorferi. Science 1992;256:1439-42.
4. Schaible UE, Kramer MD, Eichmann K, Modolell M, Museteanu C, Simon MM. Monoclonal antibodies specific for the outer surface protein A (OspA) of Borrelia burgdorferi prevent Lyme borreliosis in severe combined immunodeficiency (scid) mice. Proc Natl Acad Sci 1990;87:3768-72.
5. Fikrig E, Barthold SW, Kantor FS, Flavell RA. Long-term protection of mice from Lyme disease by vaccination with OspA. Infect Immun 1992;60:773-7.
6. Fikrig E, Telford SR, Barthold SW, Kantor FS, Spielman A, Flavell RA. Elimination of Borrelia burgdorferi from vector ticks feeding on OspA-immunized mice. Proc Natl Acad Sci 1992;89:5418-21.
7. Preac-Mursic V, Wilske B, Patsouris E, et al. Active immunization with pC protein of Borrelia burgdorferi protects gerbils against B. burgdorferi infection. Infection 1992;20:342-9.
8. Stover K, Bansal GP, Hanson MS, et al. Protective immunity elicited by recombinant bacille Calmette-Guérin (BCG) expressing outer surface protein A (OspA) lipoprotein: a candidate Lyme disease vaccine. J Exp Med 1993;178:197-209.
9. Norton-Hughes CA, Engstrom SM, Coleman LA, Kodner CB, Johnson RC. Protective immunity is induced by a Borrelia burgdorferi mutant that lacks OspA and OspB. Infect Immun 1993;61:5115-22.