2-Deoxy-2,3-didehydro-N-acetylneuraminic acid analogs structurally modified by thiocarbamoylalkyl groups at the C-4 position: Synthesis and biological evaluation as inhibitors of human parainfluenza virus type 1

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 14, 2008, Pages 6783-6788

  Ikeda, Kiyoshi ^a   Sato, Kazuki ^a   Nishino, Reiko ^a   Aoyama, Shinya ^a   Suzuki, Takashi ^a,b   Sato, Masayuki ^a  

^a UNIVERSITY OF SHIZUOKA   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

4 O Thiocarbamoylethyl Neu5Ac derivative; 4 O Thiocarbamoylpropyl Neu5Ac derivative; Human parainfluenza virus type 1 sialidase inhibition; Sialic acid

Indexed keywords

2 DEOXY 2,3 DIDEHYDRO ACETYLNEURAMINIC ACID DERIVATIVE; 5 ACETAMIDO 2,6 ANHYDRO 3,5 DIDEOXY 4 O (3 THIOCARBAMOYLETHYL) GLYCERO GALACTO NON 2 ENOIC ACID; 5 ACETAMIDO 2,6 ANHYDRO 3,5 DIDEOXY 4 O (3 THIOCARBAMOYLPROPYL) GLYCERO GALACTO NON 2 ENOIC ACID; ANTIVIRUS AGENT; LIVER EXTRACT; METHYL 5 ACETAMIDO 2,6 ANHYDRO 4 O (2 CYANOETHYL) 3 5 DIDEOXY 7,8,9 TRI O ACETYL GLYCERO GALACTO NON 2 ENONATE; METHYL 5 ACETAMIDO 2,6 ANHYDRO 4 O (2 CYANOETHYL) 3 5 DIDEOXY 8,9 O ISOPROPYLIDENE GLYCERO GALACTO NON 2 ENONATE; METHYL 5 ACETAMIDO 2,6 ANHYDRO 4 O (2 THIOCARBAMOYLETHYL) 3 5 DIDEOXY 7,8,9 TRI O ACETYL GLYCERO GALACTO NON 2 ENONATE; METHYL 5 ACETAMIDO 2,6 ANHYDRO 4 O (3 CYANOPROPYL) 3 5 DIDEOXY 7,8,9 TRI O ACETYL GLYCERO GALACTO NON 2 ENONATE; METHYL 5 ACETAMIDO 2,6 ANHYDRO 4 O (3 CYANOPROPYL) 3 5 DIDEOXY 8,9 O ISOPROPYLIDENE GLYCERO GALACTO NON 2 ENONATE; METHYL 5 ACETAMIDO 2,6 ANHYDRO 4 O (3 THIOCARBAMOYLPROPYL) 3 5 DIDEOXY 7,8,9 TRI O ACETYL GLYCERO GALACTO NON 2 ENONATE; NEURAMINIC ACID DERIVATIVE; SIALIDASE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG INHIBITION; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; NONHUMAN; PARAINFLUENZA VIRUS 1; VIRUS INHIBITION;

ANTIVIRAL AGENTS; ENZYME INHIBITORS; HUMANS; N-ACETYLNEURAMINIC ACID; NEURAMINIDASE; PARAINFLUENZA VIRUS 1, HUMAN; STRUCTURE-ACTIVITY RELATIONSHIP; THIOCARBAMATES;

HUMAN PARAINFLUENZA VIRUS 1;

EID: 47349097819     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.05.055     Document Type: Article

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