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Volumn 48, Issue 5, 2004, Pages 1495-1502

Efficacy of Novel Hemagglutinin-Neuraminidase Inhibitors BCX 2798 and BCX 2855 against Human Parainfluenza Viruses In Vitro and In Vivo

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; BCX 2798; BCX 2855; HN PROTEIN; UNCLASSIFIED DRUG;

EID: 2142698613     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.48.5.1495-1502.2004     Document Type: Article
Times cited : (84)

References (44)
  • 3
    • 0028076285 scopus 로고
    • Regions on the hemagglutinin-neuraminidase proteins of human parainfluenza virus type-1 and Sendai virus important for membrane fusion
    • Bousse, T., T. Takimoto, W. L. Gorman, T. Takahashi, and A. Portner. 1994. Regions on the hemagglutinin-neuraminidase proteins of human parainfluenza virus type-1 and Sendai virus important for membrane fusion. Virology 204:506-514.
    • (1994) Virology , vol.204 , pp. 506-514
    • Bousse, T.1    Takimoto, T.2    Gorman, W.L.3    Takahashi, T.4    Portner, A.5
  • 4
    • 0035837042 scopus 로고    scopus 로고
    • Two regions of the P protein are required to be active with the L protein for human parainfluenza virus type 1 RNA polymerase activity
    • Bousse, T., T. Takimoto, T. Matrosovich, and A. Portner. 2001. Two regions of the P protein are required to be active with the L protein for human parainfluenza virus type 1 RNA polymerase activity. Virology 283:306-314.
    • (2001) Virology , vol.283 , pp. 306-314
    • Bousse, T.1    Takimoto, T.2    Matrosovich, T.3    Portner, A.4
  • 5
    • 0000422978 scopus 로고    scopus 로고
    • Parainfluenza viruses
    • D. M. Knipe and P. M. Howley (ed.), Lippincott/The Williams & Wilkins Co., Philadelphia, Pa.
    • Chanock, R. M., B. R. Murphy, and P. L. Collins. 2001. Parainfluenza viruses, p. 1341-1379. In D. M. Knipe and P. M. Howley (ed.), Fields virology, 4th ed. Lippincott/The Williams & Wilkins Co., Philadelphia, Pa.
    • (2001) Fields Virology, 4th Ed. , pp. 1341-1379
    • Chanock, R.M.1    Murphy, B.R.2    Collins, P.L.3
  • 6
    • 0017582117 scopus 로고
    • Model systems for studying the pathogenesis of infections causing bronchiolitis in man
    • Collier, A. M., and W. A. Clyde, Jr. 1977. Model systems for studying the pathogenesis of infections causing bronchiolitis in man. Pediatr. Res. 11:243-246.
    • (1977) Pediatr. Res. , vol.11 , pp. 243-246
    • Collier, A.M.1    Clyde Jr., W.A.2
  • 8
    • 0033762350 scopus 로고    scopus 로고
    • Crystal structure of the multifunctional paramyxovirus hemagglutinin-neuraminidase
    • Crennell, S., T. Takimoto, A. Portner, and G. Taylor. 2000. Crystal structure of the multifunctional paramyxovirus hemagglutinin-neuraminidase. Nat. Struct. Biol. 7:1068-1074.
    • (2000) Nat. Struct. Biol. , vol.7 , pp. 1068-1074
    • Crennell, S.1    Takimoto, T.2    Portner, A.3    Taylor, G.4
  • 9
    • 0019029982 scopus 로고
    • Pathogenesis of Sendai virus infection in mice: On the possible role of interferon on the development of disease
    • Degre, M., and H. Rollag, Jr. 1980. Pathogenesis of Sendai virus infection in mice: on the possible role of interferon on the development of disease. Acta Pathol. Microbiol. Scand. 88:177-181.
    • (1980) Acta Pathol. Microbiol. Scand. , vol.88 , pp. 177-181
    • Degre, M.1    Rollag Jr., H.2
  • 10
    • 0023084783 scopus 로고
    • Analysis of mutation in human cells by using an Epstein-Barr virus shuttle system
    • Du Bridge, R. Tang, H. C. Hsia, P. M. Leong, J. H. Miller, and M. P. Calos. 1987. Analysis of mutation in human cells by using an Epstein-Barr virus shuttle system. Mol. Cell. Biol. 6:379-387.
    • (1987) Mol. Cell. Biol. , vol.6 , pp. 379-387
    • Bridge, D.1    Tang, R.2    Hsia, H.C.3    Leong, P.M.4    Miller, J.H.5    Calos, M.P.6
  • 11
    • 0028803778 scopus 로고
    • Inhibition of replication of avian influenza viruses by neuraminidase inhibitor 4-guanidino-2,4-dideoxy-2,3-dehydro-N-acetylneuraminic acid
    • Gubareva, L. V., C. R. Penn, and R. G. Webster. 1995. Inhibition of replication of avian influenza viruses by neuraminidase inhibitor 4-guanidino-2,4-dideoxy-2,3-dehydro-N-acetylneuraminic acid. Virology 212:323-330.
    • (1995) Virology , vol.212 , pp. 323-330
    • Gubareva, L.V.1    Penn, C.R.2    Webster, R.G.3
  • 13
    • 0033530264 scopus 로고    scopus 로고
    • Use of the oral neuraminidase inhibitor oseltamivir in experimental human influenza: Randomized controlled trials for prevention and treatment
    • Hayden, F. G., J. J. Treanor, R. S. Fritz, M. Lobo, R. F. Betts, M. Miller, N. Kinnersley, R. G. Mills, P. Ward, and S. E. Straus. 1999. Use of the oral neuraminidase inhibitor oseltamivir in experimental human influenza: randomized controlled trials for prevention and treatment. JAMA 282:1240-1246.
    • (1999) JAMA , vol.282 , pp. 1240-1246
    • Hayden, F.G.1    Treanor, J.J.2    Fritz, R.S.3    Lobo, M.4    Betts, R.F.5    Miller, M.6    Kinnersley, N.7    Mills, R.G.8    Ward, P.9    Straus, S.E.10
  • 14
    • 0028229945 scopus 로고
    • Epidemiology and cost of infection with human parainfluenza virus types 1 and 2 in young children
    • Henrickson, K. J., S. M. Kuhn, and L. L. Savatski. 1994. Epidemiology and cost of infection with human parainfluenza virus types 1 and 2 in young children. Clin. Infect. Dis. 18:770-779.
    • (1994) Clin. Infect. Dis. , vol.18 , pp. 770-779
    • Henrickson, K.J.1    Kuhn, S.M.2    Savatski, L.L.3
  • 15
    • 0026637939 scopus 로고
    • Biological activity of paramyxovirus fusion protein: Factors influencing formation of syncytia
    • Horvath, C. M., R. G. Paterson, M. A. Shaughnessy, R. Wood, and R. A. Lamb. 1992. Biological activity of paramyxovirus fusion protein: factors influencing formation of syncytia. J. Virol. 66:4564-4569.
    • (1992) J. Virol. , vol.66 , pp. 4564-4569
    • Horvath, C.M.1    Paterson, R.G.2    Shaughnessy, M.A.3    Wood, R.4    Lamb, R.A.5
  • 16
    • 0026525004 scopus 로고
    • Functional interaction between the fusion protein and hemagglutinin-neuraminidase of human parainfluenza viruses
    • Hu, X., R. Ray, and R. W. Compans. 1992. Functional interaction between the fusion protein and hemagglutinin-neuraminidase of human parainfluenza viruses. J. Virol. 66:1528-1534.
    • (1992) J. Virol. , vol.66 , pp. 1528-1534
    • Hu, X.1    Ray, R.2    Compans, R.W.3
  • 17
    • 33845382806 scopus 로고
    • Nonparametric estimation from incomplete observations
    • Kaplan, E. L, and P. Meier. 1958. Nonparametric estimation from incomplete observations. J. Am. Stat. Assoc. 53:457-481.
    • (1958) J. Am. Stat. Assoc. , vol.53 , pp. 457-481
    • Kaplan, E.L.1    Meier, P.2
  • 18
    • 0030155657 scopus 로고    scopus 로고
    • Initiation of Sendai virus multiplication from transfected cDNA or RNA with negative or positive sense
    • Kato, A., Y. Sakai, T. Shioba, T. Kondo, M. Nakanishi, and Y. Nagai. 1996. Initiation of Sendai virus multiplication from transfected cDNA or RNA with negative or positive sense. Genes Cells 1:569-579.
    • (1996) Genes Cells , vol.1 , pp. 569-579
    • Kato, A.1    Sakai, Y.2    Shioba, T.3    Kondo, T.4    Nakanishi, M.5    Nagai, Y.6
  • 20
    • 0028218591 scopus 로고
    • Parainfluenza viral infections in pediatric outpatients: Seasonal patterns and clinical characteristics
    • Knott, A. M., C. E. Long, and C. B. Hall. 1994. Parainfluenza viral infections in pediatric outpatients: seasonal patterns and clinical characteristics. Pediatr. Infect. Dis. J. 13:269-273.
    • (1994) Pediatr. Infect. Dis. J. , vol.13 , pp. 269-273
    • Knott, A.M.1    Long, C.E.2    Hall, C.B.3
  • 21
    • 0001178028 scopus 로고    scopus 로고
    • The paramyxoviruses
    • B. N. Fields, D. M. Knipe, and P. M. Howley (ed.), Lippincott-Raven Publishers, Philadelphia, Pa.
    • Lamb, R. A., and D. Kolakofsky. 1996. The paramyxoviruses, p. 577-604. In B. N. Fields, D. M. Knipe, and P. M. Howley (ed.), Fields virology, 3rd ed. Lippincott-Raven Publishers, Philadelphia, Pa.
    • (1996) Fields Virology, 3rd Ed. , pp. 577-604
    • Lamb, R.A.1    Kolakofsky, D.2
  • 22
    • 0000492794 scopus 로고
    • New frontiers opened by the exploration of host cell receptors
    • D. W. Kingsbury (ed.), Plenum Press, Inc., New York, N.Y.
    • Markwell, M. A. K. 1991. New frontiers opened by the exploration of host cell receptors, p. 407-425. In D. W. Kingsbury (ed.), The paramyxoviruses. Plenum Press, Inc., New York, N.Y.
    • (1991) The Paramyxoviruses , pp. 407-425
    • Markwell, M.A.K.1
  • 23
    • 0030716943 scopus 로고    scopus 로고
    • Pediatric hospitalization for croup (laryngotracheobronchitis): Biennial increases associated with human parainfluenza virus 1 epidemics
    • Marx, A., T. J. Torok, R. C. Holman, M. J. Clarke, and L. J. Anderson. 1997. Pediatric hospitalization for croup (laryngotracheobronchitis): biennial increases associated with human parainfluenza virus 1 epidemics. J. Infect. Dis. 176:1423-1427.
    • (1997) J. Infect. Dis. , vol.176 , pp. 1423-1427
    • Marx, A.1    Torok, T.J.2    Holman, R.C.3    Clarke, M.J.4    Anderson, L.J.5
  • 24
    • 0016418372 scopus 로고
    • An animal model for studying infection and immunity to and attenuation of human parainfluenza viruses
    • Mascoli, C. C., D. P. Metzgar, E. J. Larson, A. A. Fuscaldo, and T. A. Gower. 1975. An animal model for studying infection and immunity to and attenuation of human parainfluenza viruses. Dev. Biol. Stand. 28:414-421.
    • (1975) Dev. Biol. Stand. , vol.28 , pp. 414-421
    • Mascoli, C.C.1    Metzgar, D.P.2    Larson, E.J.3    Fuscaldo, A.A.4    Gower, T.A.5
  • 26
    • 0019829849 scopus 로고
    • The cotton rat as an experimental model of human parainfluenza virus 3 disease
    • Murphy, T. F., E. J. Dubovi, and W. A. Clyde, Jr. 1981. The cotton rat as an experimental model of human parainfluenza virus 3 disease. Exp. Lung Res. 2:97-109.
    • (1981) Exp. Lung Res. , vol.2 , pp. 97-109
    • Murphy, T.F.1    Dubovi, E.J.2    Clyde Jr., W.A.3
  • 27
    • 0018421350 scopus 로고
    • Fluorometric assay of neuraminidase with a sodium (4-methylumbelliferyl-α-D-N-acetylneuraminate) substrate
    • Potier, M., L. Mameli, M. Belishem, L. Dallaire, and S. B. Melancon. 1979. Fluorometric assay of neuraminidase with a sodium (4-methylumbelliferyl-α-D-N-acetylneuraminate) substrate. Anal. Biochem. 94:287-296.
    • (1979) Anal. Biochem. , vol.94 , pp. 287-296
    • Potier, M.1    Mameli, L.2    Belishem, M.3    Dallaire, L.4    Melancon, S.B.5
  • 28
    • 0030893879 scopus 로고    scopus 로고
    • Epidemiology and clinical impact of parainfluenza virus infections in otherwise healthy infants and young children <5 years old
    • Reed, G., P. H. Jewett, J. Thompson, S. Tollefson, and P. F. Wright. 1997. Epidemiology and clinical impact of parainfluenza virus infections in otherwise healthy infants and young children <5 years old. J. Infect. Dis. 175: 807-813.
    • (1997) J. Infect. Dis. , vol.175 , pp. 807-813
    • Reed, G.1    Jewett, P.H.2    Thompson, J.3    Tollefson, S.4    Wright, P.F.5
  • 29
    • 0027981472 scopus 로고
    • Inhibition of influenza virus replication in mice by GG167 (4-guanidino-2,4-dideoxy-2,3-dehydro-N-acetylneuraminic acid) is consistent with extracellular activity of viral neuraminidase (sialidase)
    • Ryan, D. M., J. Ticehurst, M. H. Dempsey, and C. R. Penn. 1994. Inhibition of influenza virus replication in mice by GG167 (4-guanidino-2,4-dideoxy-2,3-dehydro-N-acetylneuraminic acid) is consistent with extracellular activity of viral neuraminidase (sialidase). Antimicrob. Agents Chemother. 38:2270-2275.
    • (1994) Antimicrob. Agents Chemother. , vol.38 , pp. 2270-2275
    • Ryan, D.M.1    Ticehurst, J.2    Dempsey, M.H.3    Penn, C.R.4
  • 30
    • 0004282518 scopus 로고    scopus 로고
    • SAS Institute, Inc., Cary, N.C.
    • SAS Institute. 1999. SAS/STAT user's guide, version 8, vol. 2. SAS Institute, Inc., Cary, N.C.
    • (1999) SAS/STAT User's Guide, Version 8 , vol.2
  • 32
    • 0030761711 scopus 로고    scopus 로고
    • Detection of an interaction between the HN and F proteins in Newcastle disease virus-infected cells
    • Stone-Hulslander, J., and T. G. Morrison. 1997. Detection of an interaction between the HN and F proteins in Newcastle disease virus-infected cells. J. Virol. 71:6287-6295.
    • (1997) J. Virol. , vol.71 , pp. 6287-6295
    • Stone-Hulslander, J.1    Morrison, T.G.2
  • 33
    • 0034712777 scopus 로고    scopus 로고
    • Crystallization of Newcastle disease virus hemagglutinin-neuraminidase glycoprotein
    • Takimoto, T., G. L. Taylor, S. L. Crennell, R. A. Scroggs, and A. Portner. 2000. Crystallization of Newcastle disease virus hemagglutinin-neuraminidase glycoprotein. Virology 270:208-214.
    • (2000) Virology , vol.270 , pp. 208-214
    • Takimoto, T.1    Taylor, G.L.2    Crennell, S.L.3    Scroggs, R.A.4    Portner, A.5
  • 34
    • 0036891868 scopus 로고    scopus 로고
    • Role of the hemagglutinin-neuraminidase protein in the mechanism of paramyxovirus-cell membrane fusion
    • Takimoto, T., G. L. Taylor, H. C. Connaris, S. J. Crennell, and A. Portner. 2002. Role of the hemagglutinin-neuraminidase protein in the mechanism of paramyxovirus-cell membrane fusion. J. Virol. 76:13028-13033.
    • (2002) J. Virol. , vol.76 , pp. 13028-13033
    • Takimoto, T.1    Taylor, G.L.2    Connaris, H.C.3    Crennell, S.J.4    Portner, A.5
  • 35
    • 0033981784 scopus 로고    scopus 로고
    • A live attenuated recombinant chimeric parainfluenza virus (PIV) candidate vaccine containing the hemagglutinin-neuraminidase and fusion glycoproteins of PIV1 and the remaining proteins from PIV3 induces resistance to PIV1 even in animals immune to PIV3
    • Tao, T., F. Davoodi, C. J. Cho, M. H. Skiadopoulos, A. P. Durbin, P. L. Collins, and B. R. Murphy. 2000. A live attenuated recombinant chimeric parainfluenza virus (PIV) candidate vaccine containing the hemagglutinin-neuraminidase and fusion glycoproteins of PIV1 and the remaining proteins from PIV3 induces resistance to PIV1 even in animals immune to PIV3. Vaccine 18:1359-1366.
    • (2000) Vaccine , vol.18 , pp. 1359-1366
    • Tao, T.1    Davoodi, F.2    Cho, C.J.3    Skiadopoulos, M.H.4    Durbin, A.P.5    Collins, P.L.6    Murphy, B.R.7
  • 36
    • 0028325249 scopus 로고
    • Molecular modeling studies on ligand binding to sialidase from influenza virus and the mechanism of catalysis
    • Taylor, N. R., and M. von Itzstein. 1994. Molecular modeling studies on ligand binding to sialidase from influenza virus and the mechanism of catalysis. J. Med. Chem. 37:616-624.
    • (1994) J. Med. Chem. , vol.37 , pp. 616-624
    • Taylor, N.R.1    Von Itzstein, M.2
  • 37
    • 84870557540 scopus 로고
    • Evaluation of the trypan blue technique for determination of cell viability
    • Tennant, J. R. 1964. Evaluation of the trypan blue technique for determination of cell viability. Transplantation 2:685-694.
    • (1964) Transplantation , vol.2 , pp. 685-694
    • Tennant, J.R.1
  • 38
    • 0024232637 scopus 로고
    • Isolation of a biologically active soluble form of the hemagglutinin-neuraminidase protein of Sendai virus
    • Thompson, S. D., W. G. Laver, K. G., Murti, and A. Portner. 1988. Isolation of a biologically active soluble form of the hemagglutinin-neuraminidase protein of Sendai virus. J. Virol. 62:4653-4660.
    • (1988) J. Virol. , vol.62 , pp. 4653-4660
    • Thompson, S.D.1    Laver, W.G.2    Murti, K.G.3    Portner, A.4
  • 39
    • 0020629047 scopus 로고
    • Structure of the influenza virus glycoprotein antigen neuraminidase at 2.9 Å resolution
    • Varghese, J. N., W. G. Laver, and P. M. Colman. 1983. Structure of the influenza virus glycoprotein antigen neuraminidase at 2.9 Å resolution. Nature 303:35-40.
    • (1983) Nature , vol.303 , pp. 35-40
    • Varghese, J.N.1    Laver, W.G.2    Colman, P.M.3
  • 42
    • 0027162942 scopus 로고
    • 4-Guanidino-2,4-dideoxy-2,3-dehydro-N-acetylneuraminic acid is a highly effective inhibitor both of the sialidase (neuraminidase) and growth of a wide range of influenza A and B viruses in vitro
    • Woods, J. M., R. C. Bethell, J. A. V. Coates, N. Healy, S. A. Hiscox, B. A. Pearson, D. M. Ryan, J. Ticehurst, J. Tilling, S. M. Walcott, and C. R. Renn. 1993. 4-Guanidino-2,4-dideoxy-2,3-dehydro-N-acetylneuraminic acid is a highly effective inhibitor both of the sialidase (neuraminidase) and growth of a wide range of influenza A and B viruses in vitro. Antimicrob. Agents Chemother. 37:1473-1479.
    • (1993) Antimicrob. Agents Chemother. , vol.37 , pp. 1473-1479
    • Woods, J.M.1    Bethell, R.C.2    Coates, J.A.V.3    Healy, N.4    Hiscox, S.A.5    Pearson, B.A.6    Ryan, D.M.7    Ticehurst, J.8    Tilling, J.9    Walcott, S.M.10    Renn, C.R.11
  • 43
    • 0031060164 scopus 로고    scopus 로고
    • Association of the parainfluenza virus fusion and hemagglutinin-neuraminidase glycoproteins on cell surfaces
    • Yao, Q., X. Hu, and R. W. Compans. 1997. Association of the parainfluenza virus fusion and hemagglutinin-neuraminidase glycoproteins on cell surfaces. J. Virol. 71:650-656.
    • (1997) J. Virol. , vol.71 , pp. 650-656
    • Yao, Q.1    Hu, X.2    Compans, R.W.3
  • 44
    • 0017569553 scopus 로고
    • A naturally occurring epizootic caused by Sendai virus in breeding and aging rodent colonies. I. Infection in the mouse
    • Zurcher, C., J. D. Burek, M. C. Van Nunen, and S. P. Meihuizen. 1977. A naturally occurring epizootic caused by Sendai virus in breeding and aging rodent colonies. I. Infection in the mouse. Lab. Anim. Sci. 27:955-962.
    • (1977) Lab. Anim. Sci. , vol.27 , pp. 955-962
    • Zurcher, C.1    Burek, J.D.2    Van Nunen, M.C.3    Meihuizen, S.P.4


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